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Protein

Sal-like protein 3

Gene

SALL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri739 – 761C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri977 – 999C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1005 – 1027C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 3
Alternative name(s):
Zinc finger protein 796
Zinc finger protein SALL3
Short name:
hSALL3
Gene namesi
Name:SALL3
Synonyms:ZNF796
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000256463.8
HGNCiHGNC:10527 SALL3
MIMi605079 gene
neXtProtiNX_Q9BXA9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27164
OpenTargetsiENSG00000256463
PharmGKBiPA34935

Polymorphism and mutation databases

BioMutaiSALL3
DMDMi296452896

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470241 – 1300Sal-like protein 3Add BLAST1300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei1177PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BXA9
MaxQBiQ9BXA9
PaxDbiQ9BXA9
PeptideAtlasiQ9BXA9
PRIDEiQ9BXA9
ProteomicsDBi79393
79394 [Q9BXA9-2]
79395 [Q9BXA9-3]
79396 [Q9BXA9-4]

PTM databases

iPTMnetiQ9BXA9
PhosphoSitePlusiQ9BXA9

Expressioni

Tissue specificityi

Widely expressed in adult with highest levels in heart. Expressed in fetal brain (in neurons of hippocampus, cortex, mediodorsal and ventrolateral thalamic nuclei, putamen, cerebellum and brainstem).

Developmental stagei

In fetal brain of the 24th gestational week.

Gene expression databases

BgeeiENSG00000256463 Expressed in 83 organ(s), highest expression level in forebrain
CleanExiHS_SALL3
ExpressionAtlasiQ9BXA9 baseline and differential
GenevisibleiQ9BXA9 HS

Organism-specific databases

HPAiHPA016656

Interactioni

Protein-protein interaction databases

BioGridi118043, 7 interactors
STRINGi9606.ENSP00000441823

Structurei

3D structure databases

ProteinModelPortaliQ9BXA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 201Poly-Ala4
Compositional biasi213 – 216Poly-Gln4
Compositional biasi897 – 902Poly-Ser6

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri420 – 442C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri739 – 761C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri977 – 999C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1005 – 1027C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1074 Eukaryota
ENOG410ZE3Z LUCA
GeneTreeiENSGT00550000074555
HOGENOMiHOG000231986
HOVERGENiHBG058921
InParanoidiQ9BXA9
KOiK19871
OMAiRSQVAMM
OrthoDBiEOG091G00R1
PhylomeDBiQ9BXA9
TreeFamiTF317003

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9BXA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRKQAKPQ HLKSDEELLP PDGAPEHAAP GEGAEDADSG PESRSGGEET
60 70 80 90 100
SVCEKCCAEF FKWADFLEHQ RSCTKLPPVL IVHEDAPAPP PEDFPEPSPA
110 120 130 140 150
SSPSERAESE AAEEAGAEGA EGEARPVEKE AEPMDAEPAG DTRAPRPPPA
160 170 180 190 200
APAPPTPAYG APSTNVTLEA LLSTKVAVAQ FSQGARAAGG SGAGGGVAAA
210 220 230 240 250
AVPLILEQLM ALQQQQIHQL QLIEQIRSQV ALMQRPPPRP SLSPAAAPSA
260 270 280 290 300
PGPAPSQLPG LAALPLSAGA PAAAIAGSGP AAPAAFEGAQ PLSRPESGAS
310 320 330 340 350
TPGGPAEPSA PAAPSAAPAP AAPAPAPAPQ SAASSQPQSA STPPALAPGS
360 370 380 390 400
LLGAAPGLPS PLLPQTSASG VIFPNPLVSI AATANALDPL SALMKHRKGK
410 420 430 440 450
PPNVSVFEPK ASAEDPFFKH KCRFCAKVFG SDSALQIHLR SHTGERPFKC
460 470 480 490 500
NICGNRFSTK GNLKVHFQRH KEKYPHIQMN PYPVPEYLDN VPTCSGIPYG
510 520 530 540 550
MSLPPEKPVT TWLDSKPVLP TVPTSVGLQL PPTVPGAHGY ADSPSATPAS
560 570 580 590 600
RSPQRPSPAS SECASLSPGL NHVESGVSAT AESPQSLLGG PPLTKAEPVS
610 620 630 640 650
LPCTNARAGD APVGAQASAA PTSVDGAPTS LGSPGLPAVS EQFKAQFPFG
660 670 680 690 700
GLLDSMQTSE TSKLQQLVEN IDKKMTDPNQ CVICHRVLSC QSALKMHYRT
710 720 730 740 750
HTGERPFKCK ICGRAFTTKG NLKTHFGVHR AKPPLRVQHS CPICQKKFTN
760 770 780 790 800
AVVLQQHIRM HMGGQIPNTP LPEGFQDAMD SELAYDDKNA ETLSSYDDDM
810 820 830 840 850
DENSMEDDAE LKDAATDPAK PLLSYAGSCP PSPPSVISSI AALENQMKMI
860 870 880 890 900
DSVMSCQQLT GLKSVENGSG ESDRLSNDSS SAVGDLESRS AGSPALSESS
910 920 930 940 950
SSQALSPAPS NGESFRSKSP GLGAPEEPQE IPLKTERPDS PAAAPGSGGA
960 970 980 990 1000
PGRAGIKEEA PFSLLFLSRE RGKCPSTVCG VCGKPFACKS ALEIHYRSHT
1010 1020 1030 1040 1050
KERPFVCALC RRGCSTMGNL KQHLLTHRLK ELPSQLFDPN FALGPSQSTP
1060 1070 1080 1090 1100
SLISSAAPTM IKMEVNGHGK AMALGEGPPL PAGVQVPAGP QTVMGPGLAP
1110 1120 1130 1140 1150
MLAPPPRRTP KQHNCQSCGK TFSSASALQI HERTHTGEKP FGCTICGRAF
1160 1170 1180 1190 1200
TTKGNLKVHM GTHMWNNAPA RRGRRLSVEN PMALLGGDAL KFSEMFQKDL
1210 1220 1230 1240 1250
AARAMNVDPS FWNQYAAAIT NGLAMKNNEI SVIQNGGIPQ LPVSLGGSAL
1260 1270 1280 1290 1300
PPLGSMASGM DKARTGSSPP IVSLDKASSE TAASRPFTRF IEDNKEIGIN
Length:1,300
Mass (Da):135,346
Last modified:May 18, 2010 - v2
Checksum:i9D0347FE2C9A6967
GO
Isoform 1 (identifier: Q9BXA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     973-1044: Missing.

Note: Lacks two zinc finger domains. Major isoform with isoform 2.
Show »
Length:1,228
Mass (Da):127,332
Checksum:i0ED24F438F720F28
GO
Isoform 2 (identifier: Q9BXA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     973-1044: Missing.

Note: Lacks two zinc finger domains. Major isoform with isoform 1.
Show »
Length:1,095
Mass (Da):113,164
Checksum:i226DEA7691D918FE
GO
Isoform 4 (identifier: Q9BXA9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:1,167
Mass (Da):121,179
Checksum:i583C3C859AFDC4AB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3L8I3L3L8_HUMAN
Sal-like protein 3
SALL3
150Annotation score:
A9JR48A9JR48_HUMAN
SALL3 protein
SALL3
959Annotation score:
A0A087WXW6A0A087WXW6_HUMAN
Sal-like protein 3
SALL3
960Annotation score:
A0A140TA70A0A140TA70_HUMAN
Sal-like protein 3
SALL3
1,300Annotation score:
A0A140TA74A0A140TA74_HUMAN
Sal-like protein 3
SALL3
1,224Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91P → H in AAK18311 (Ref. 1) Curated1
Sequence conflicti91P → H in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti235R → C in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti787D → N in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti797 – 802DDDMDE → NDNLDK in CAB65124 (PubMed:10610715).Curated6
Sequence conflicti808D → N in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti1138E → K in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti1141F → S in CAB65124 (PubMed:10610715).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035552143R → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_059887533T → A. Corresponds to variant dbSNP:rs7240860Ensembl.1
Natural variantiVAR_014132593L → V1 PublicationCorresponds to variant dbSNP:rs2447437Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068321 – 133Missing in isoform 2 and isoform 4. CuratedAdd BLAST133
Alternative sequenceiVSP_006833973 – 1044Missing in isoform 1 and isoform 2. CuratedAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347021 Genomic DNA Translation: AAK18311.1
AJ007421 Genomic DNA Translation: CAB65124.1
AC099689 Genomic DNA No translation available.
CCDSiCCDS12013.1 [Q9BXA9-1]
RefSeqiNP_741996.2, NM_171999.3 [Q9BXA9-1]
UniGeneiHs.700557

Genome annotation databases

EnsembliENST00000536229; ENSP00000439975; ENSG00000256463 [Q9BXA9-3]
ENST00000537592; ENSP00000441823; ENSG00000256463 [Q9BXA9-1]
ENST00000575389; ENSP00000458360; ENSG00000256463 [Q9BXA9-2]
ENST00000614883; ENSP00000478953; ENSG00000277015 [Q9BXA9-1]
ENST00000631929; ENSP00000488140; ENSG00000277015 [Q9BXA9-2]
ENST00000633643; ENSP00000488722; ENSG00000277015 [Q9BXA9-3]
GeneIDi27164
KEGGihsa:27164
UCSCiuc002lmt.4 human [Q9BXA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347021 Genomic DNA Translation: AAK18311.1
AJ007421 Genomic DNA Translation: CAB65124.1
AC099689 Genomic DNA No translation available.
CCDSiCCDS12013.1 [Q9BXA9-1]
RefSeqiNP_741996.2, NM_171999.3 [Q9BXA9-1]
UniGeneiHs.700557

3D structure databases

ProteinModelPortaliQ9BXA9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118043, 7 interactors
STRINGi9606.ENSP00000441823

PTM databases

iPTMnetiQ9BXA9
PhosphoSitePlusiQ9BXA9

Polymorphism and mutation databases

BioMutaiSALL3
DMDMi296452896

Proteomic databases

EPDiQ9BXA9
MaxQBiQ9BXA9
PaxDbiQ9BXA9
PeptideAtlasiQ9BXA9
PRIDEiQ9BXA9
ProteomicsDBi79393
79394 [Q9BXA9-2]
79395 [Q9BXA9-3]
79396 [Q9BXA9-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000536229; ENSP00000439975; ENSG00000256463 [Q9BXA9-3]
ENST00000537592; ENSP00000441823; ENSG00000256463 [Q9BXA9-1]
ENST00000575389; ENSP00000458360; ENSG00000256463 [Q9BXA9-2]
ENST00000614883; ENSP00000478953; ENSG00000277015 [Q9BXA9-1]
ENST00000631929; ENSP00000488140; ENSG00000277015 [Q9BXA9-2]
ENST00000633643; ENSP00000488722; ENSG00000277015 [Q9BXA9-3]
GeneIDi27164
KEGGihsa:27164
UCSCiuc002lmt.4 human [Q9BXA9-1]

Organism-specific databases

CTDi27164
DisGeNETi27164
EuPathDBiHostDB:ENSG00000256463.8
GeneCardsiSALL3
HGNCiHGNC:10527 SALL3
HPAiHPA016656
MIMi605079 gene
neXtProtiNX_Q9BXA9
OpenTargetsiENSG00000256463
PharmGKBiPA34935
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1074 Eukaryota
ENOG410ZE3Z LUCA
GeneTreeiENSGT00550000074555
HOGENOMiHOG000231986
HOVERGENiHBG058921
InParanoidiQ9BXA9
KOiK19871
OMAiRSQVAMM
OrthoDBiEOG091G00R1
PhylomeDBiQ9BXA9
TreeFamiTF317003

Miscellaneous databases

GeneWikiiSALL3
GenomeRNAii27164
PROiPR:Q9BXA9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000256463 Expressed in 83 organ(s), highest expression level in forebrain
CleanExiHS_SALL3
ExpressionAtlasiQ9BXA9 baseline and differential
GenevisibleiQ9BXA9 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSALL3_HUMAN
AccessioniPrimary (citable) accession number: Q9BXA9
Secondary accession number(s): Q9UGH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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