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Entry version 172 (07 Oct 2020)
Sequence version 2 (18 May 2010)
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Protein

Sal-like protein 3

Gene

SALL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri51 – 73C2H2-type 1; atypical1 PublicationPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri739 – 761C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri977 – 999C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1005 – 1027C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BXA9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sal-like protein 3
Alternative name(s):
Zinc finger protein 796
Zinc finger protein SALL3
Short name:
hSALL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SALL3
Synonyms:ZNF796
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000256463.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10527, SALL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605079, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BXA9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27164

Open Targets

More...
OpenTargetsi
ENSG00000256463

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34935

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BXA9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SALL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452896

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470241 – 1300Sal-like protein 3Add BLAST1300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei109PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei1177PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BXA9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BXA9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BXA9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BXA9

PeptideAtlas

More...
PeptideAtlasi
Q9BXA9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BXA9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79393 [Q9BXA9-1]
79394 [Q9BXA9-2]
79395 [Q9BXA9-3]
79396 [Q9BXA9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BXA9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BXA9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult with highest levels in heart. Expressed in fetal brain (in neurons of hippocampus, cortex, mediodorsal and ventrolateral thalamic nuclei, putamen, cerebellum and brainstem).

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In fetal brain of the 24th gestational week.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000256463, Expressed in ventricular zone and 97 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BXA9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BXA9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000256463, Tissue enhanced (brain, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118043, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441823

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BXA9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi198 – 201Poly-Ala4
Compositional biasi213 – 216Poly-Gln4
Compositional biasi897 – 902Poly-Ser6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 73C2H2-type 1; atypical1 PublicationPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri739 – 761C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri977 – 999C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1005 – 1027C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1113 – 1135C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1141 – 1163C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1074, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159356

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BXA9

KEGG Orthology (KO)

More...
KOi
K19871

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGEERMH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BXA9

TreeFam database of animal gene trees

More...
TreeFami
TF317003

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9BXA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRKQAKPQ HLKSDEELLP PDGAPEHAAP GEGAEDADSG PESRSGGEET
60 70 80 90 100
SVCEKCCAEF FKWADFLEHQ RSCTKLPPVL IVHEDAPAPP PEDFPEPSPA
110 120 130 140 150
SSPSERAESE AAEEAGAEGA EGEARPVEKE AEPMDAEPAG DTRAPRPPPA
160 170 180 190 200
APAPPTPAYG APSTNVTLEA LLSTKVAVAQ FSQGARAAGG SGAGGGVAAA
210 220 230 240 250
AVPLILEQLM ALQQQQIHQL QLIEQIRSQV ALMQRPPPRP SLSPAAAPSA
260 270 280 290 300
PGPAPSQLPG LAALPLSAGA PAAAIAGSGP AAPAAFEGAQ PLSRPESGAS
310 320 330 340 350
TPGGPAEPSA PAAPSAAPAP AAPAPAPAPQ SAASSQPQSA STPPALAPGS
360 370 380 390 400
LLGAAPGLPS PLLPQTSASG VIFPNPLVSI AATANALDPL SALMKHRKGK
410 420 430 440 450
PPNVSVFEPK ASAEDPFFKH KCRFCAKVFG SDSALQIHLR SHTGERPFKC
460 470 480 490 500
NICGNRFSTK GNLKVHFQRH KEKYPHIQMN PYPVPEYLDN VPTCSGIPYG
510 520 530 540 550
MSLPPEKPVT TWLDSKPVLP TVPTSVGLQL PPTVPGAHGY ADSPSATPAS
560 570 580 590 600
RSPQRPSPAS SECASLSPGL NHVESGVSAT AESPQSLLGG PPLTKAEPVS
610 620 630 640 650
LPCTNARAGD APVGAQASAA PTSVDGAPTS LGSPGLPAVS EQFKAQFPFG
660 670 680 690 700
GLLDSMQTSE TSKLQQLVEN IDKKMTDPNQ CVICHRVLSC QSALKMHYRT
710 720 730 740 750
HTGERPFKCK ICGRAFTTKG NLKTHFGVHR AKPPLRVQHS CPICQKKFTN
760 770 780 790 800
AVVLQQHIRM HMGGQIPNTP LPEGFQDAMD SELAYDDKNA ETLSSYDDDM
810 820 830 840 850
DENSMEDDAE LKDAATDPAK PLLSYAGSCP PSPPSVISSI AALENQMKMI
860 870 880 890 900
DSVMSCQQLT GLKSVENGSG ESDRLSNDSS SAVGDLESRS AGSPALSESS
910 920 930 940 950
SSQALSPAPS NGESFRSKSP GLGAPEEPQE IPLKTERPDS PAAAPGSGGA
960 970 980 990 1000
PGRAGIKEEA PFSLLFLSRE RGKCPSTVCG VCGKPFACKS ALEIHYRSHT
1010 1020 1030 1040 1050
KERPFVCALC RRGCSTMGNL KQHLLTHRLK ELPSQLFDPN FALGPSQSTP
1060 1070 1080 1090 1100
SLISSAAPTM IKMEVNGHGK AMALGEGPPL PAGVQVPAGP QTVMGPGLAP
1110 1120 1130 1140 1150
MLAPPPRRTP KQHNCQSCGK TFSSASALQI HERTHTGEKP FGCTICGRAF
1160 1170 1180 1190 1200
TTKGNLKVHM GTHMWNNAPA RRGRRLSVEN PMALLGGDAL KFSEMFQKDL
1210 1220 1230 1240 1250
AARAMNVDPS FWNQYAAAIT NGLAMKNNEI SVIQNGGIPQ LPVSLGGSAL
1260 1270 1280 1290 1300
PPLGSMASGM DKARTGSSPP IVSLDKASSE TAASRPFTRF IEDNKEIGIN
Length:1,300
Mass (Da):135,346
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D0347FE2C9A6967
GO
Isoform 1 (identifier: Q9BXA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     973-1044: Missing.

Note: Lacks two zinc finger domains. Major isoform with isoform 2.Curated
Show »
Length:1,228
Mass (Da):127,332
Checksum:i0ED24F438F720F28
GO
Isoform 2 (identifier: Q9BXA9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     973-1044: Missing.

Note: Lacks two zinc finger domains. Major isoform with isoform 1.Curated
Show »
Length:1,095
Mass (Da):113,164
Checksum:i226DEA7691D918FE
GO
Isoform 4 (identifier: Q9BXA9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Show »
Length:1,167
Mass (Da):121,179
Checksum:i583C3C859AFDC4AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9JR48A9JR48_HUMAN
SALL3 protein
SALL3
959Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXW6A0A087WXW6_HUMAN
Sal-like protein 3
SALL3
960Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA70A0A140TA70_HUMAN
Sal-like protein 3
SALL3
1,300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140TA74A0A140TA74_HUMAN
Sal-like protein 3
SALL3
1,224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3L8I3L3L8_HUMAN
Sal-like protein 3
SALL3
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91P → H in AAK18311 (Ref. 1) Curated1
Sequence conflicti91P → H in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti235R → C in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti787D → N in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti797 – 802DDDMDE → NDNLDK in CAB65124 (PubMed:10610715).Curated6
Sequence conflicti808D → N in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti1138E → K in CAB65124 (PubMed:10610715).Curated1
Sequence conflicti1141F → S in CAB65124 (PubMed:10610715).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035552143R → H in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_059887533T → A. Corresponds to variant dbSNP:rs7240860Ensembl.1
Natural variantiVAR_014132593L → V1 PublicationCorresponds to variant dbSNP:rs2447437Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0068321 – 133Missing in isoform 2 and isoform 4. CuratedAdd BLAST133
Alternative sequenceiVSP_006833973 – 1044Missing in isoform 1 and isoform 2. CuratedAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF347021 Genomic DNA Translation: AAK18311.1
AJ007421 Genomic DNA Translation: CAB65124.1
AC099689 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS12013.1 [Q9BXA9-1]

NCBI Reference Sequences

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RefSeqi
NP_741996.2, NM_171999.3 [Q9BXA9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000536229; ENSP00000439975; ENSG00000256463 [Q9BXA9-3]
ENST00000537592; ENSP00000441823; ENSG00000256463 [Q9BXA9-1]
ENST00000575389; ENSP00000458360; ENSG00000256463 [Q9BXA9-2]
ENST00000614883; ENSP00000478953; ENSG00000277015 [Q9BXA9-1]
ENST00000631929; ENSP00000488140; ENSG00000277015 [Q9BXA9-2]
ENST00000633643; ENSP00000488722; ENSG00000277015 [Q9BXA9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27164

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27164

UCSC genome browser

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UCSCi
uc002lmt.4, human [Q9BXA9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347021 Genomic DNA Translation: AAK18311.1
AJ007421 Genomic DNA Translation: CAB65124.1
AC099689 Genomic DNA No translation available.
CCDSiCCDS12013.1 [Q9BXA9-1]
RefSeqiNP_741996.2, NM_171999.3 [Q9BXA9-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi118043, 8 interactors
STRINGi9606.ENSP00000441823

PTM databases

iPTMnetiQ9BXA9
PhosphoSitePlusiQ9BXA9

Polymorphism and mutation databases

BioMutaiSALL3
DMDMi296452896

Proteomic databases

jPOSTiQ9BXA9
MassIVEiQ9BXA9
MaxQBiQ9BXA9
PaxDbiQ9BXA9
PeptideAtlasiQ9BXA9
PRIDEiQ9BXA9
ProteomicsDBi79393 [Q9BXA9-1]
79394 [Q9BXA9-2]
79395 [Q9BXA9-3]
79396 [Q9BXA9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49173, 26 antibodies

Genome annotation databases

EnsembliENST00000536229; ENSP00000439975; ENSG00000256463 [Q9BXA9-3]
ENST00000537592; ENSP00000441823; ENSG00000256463 [Q9BXA9-1]
ENST00000575389; ENSP00000458360; ENSG00000256463 [Q9BXA9-2]
ENST00000614883; ENSP00000478953; ENSG00000277015 [Q9BXA9-1]
ENST00000631929; ENSP00000488140; ENSG00000277015 [Q9BXA9-2]
ENST00000633643; ENSP00000488722; ENSG00000277015 [Q9BXA9-3]
GeneIDi27164
KEGGihsa:27164
UCSCiuc002lmt.4, human [Q9BXA9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27164
DisGeNETi27164
EuPathDBiHostDB:ENSG00000256463.8

GeneCards: human genes, protein and diseases

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GeneCardsi
SALL3
HGNCiHGNC:10527, SALL3
HPAiENSG00000256463, Tissue enhanced (brain, vagina)
MIMi605079, gene
neXtProtiNX_Q9BXA9
OpenTargetsiENSG00000256463
PharmGKBiPA34935

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1074, Eukaryota
GeneTreeiENSGT00940000159356
InParanoidiQ9BXA9
KOiK19871
OMAiMGEERMH
PhylomeDBiQ9BXA9
TreeFamiTF317003

Enzyme and pathway databases

PathwayCommonsiQ9BXA9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
27164, 3 hits in 891 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SALL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27164
PharosiQ9BXA9, Tbio

Protein Ontology

More...
PROi
PR:Q9BXA9
RNActiQ9BXA9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000256463, Expressed in ventricular zone and 97 other tissues
ExpressionAtlasiQ9BXA9, baseline and differential
GenevisibleiQ9BXA9, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 10 hits
SUPFAMiSSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSALL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BXA9
Secondary accession number(s): Q9UGH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 18, 2010
Last modified: October 7, 2020
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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