UniProtKB - Q9BXA6 (TSSK6_HUMAN)
Testis-specific serine/threonine-protein kinase 6
TSSK6
Functioni
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).
By similarity1 PublicationCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | ATPPROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 135 | Proton acceptorPROSITE-ProRule annotation1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 26 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- peptidyl-serine phosphorylation Source: Ensembl
- protein phosphorylation Source: UniProtKB
- sperm chromatin condensation Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Differentiation, Spermatogenesis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9BXA6 |
SignaLinki | Q9BXA6 |
Names & Taxonomyi
Protein namesi | Recommended name: Testis-specific serine/threonine-protein kinase 6 (EC:2.7.11.12 Publications)Short name: TSK-6 Short name: TSSK-6 Short name: Testis-specific kinase 6 Alternative name(s): Cancer/testis antigen 72 Short name: CT72 Serine/threonine-protein kinase SSTK Small serine/threonine kinase |
Gene namesi | ORF Names:FKSG82 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30410, TSSK6 |
MIMi | 610712, gene |
neXtProti | NX_Q9BXA6 |
VEuPathDBi | HostDB:ENSG00000178093 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 41 | K → M: Loss of kinase activity. Loss of binding to TSACC. 2 Publications | 1 | |
Mutagenesisi | 135 | D → N: Loss of kinase activity. No effect of binding to TSACC. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 83983 |
OpenTargetsi | ENSG00000178093 |
PharmGKBi | PA142670682 |
Miscellaneous databases
Pharosi | Q9BXA6, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3627582 |
Genetic variation databases
BioMutai | TSSK6 |
DMDMi | 74761315 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227746 | 1 – 273 | Testis-specific serine/threonine-protein kinase 6Add BLAST | 273 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | Q9BXA6 |
PaxDbi | Q9BXA6 |
PeptideAtlasi | Q9BXA6 |
PRIDEi | Q9BXA6 |
ProteomicsDBi | 79391 |
PTM databases
PhosphoSitePlusi | Q9BXA6 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000178093, Expressed in left testis and 117 other tissues |
ExpressionAtlasi | Q9BXA6, baseline and differential |
Genevisiblei | Q9BXA6, HS |
Organism-specific databases
HPAi | ENSG00000178093, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with HSP90; this interaction stabilizes and activates TSSK6 (By similarity).
Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity.
Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.
By similarity2 PublicationsBinary interactionsi
Q9BXA6
With | #Exp. | IntAct |
---|---|---|
HSP90AB1 [P08238] | 3 | EBI-851883,EBI-352572 |
Protein-protein interaction databases
BioGRIDi | 123835, 28 interactors |
IntActi | Q9BXA6, 18 interactors |
STRINGi | 9606.ENSP00000466477 |
Chemistry databases
BindingDBi | Q9BXA6 |
Miscellaneous databases
RNActi | Q9BXA6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 267 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 256 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000160464 |
InParanoidi | Q9BXA6 |
OMAi | KEARGYP |
OrthoDBi | 947464at2759 |
PhylomeDBi | Q9BXA6 |
TreeFami | TF105333 |
Family and domain databases
CDDi | cd14164, STKc_TSSK6-like, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR042710, TSSK6_STKc |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSGDKLLSEL GYKLGRTIGE GSYSKVKVAT SKKYKGTVAI KVVDRRRAPP
60 70 80 90 100
DFVNKFLPRE LSILRGVRHP HIVHVFEFIE VCNGKLYIVM EAAATDLLQA
110 120 130 140 150
VQRNGRIPGV QARDLFAQIA GAVRYLHDHH LVHRDLKCEN VLLSPDERRV
160 170 180 190 200
KLTDFGFGRQ AHGYPDLSTT YCGSAAYASP EVLLGIPYDP KKYDVWSMGV
210 220 230 240 250
VLYVMVTGCM PFDDSDIAGL PRRQKRGVLY PEGLELSERC KALIAELLQF
260 270
SPSARPSAGQ VARNCWLRAG DSG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GMZ2 | R4GMZ2_HUMAN | Testis-specific serine/threonine-pr... | TSSK6 | 109 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF329483 mRNA Translation: AAK48827.1 AF348077 mRNA Translation: AAK29414.1 AK058166 mRNA Translation: BAB71697.1 Frameshift. AK172841 mRNA Translation: BAD18805.1 Frameshift. AK313767 mRNA Translation: BAG36505.1 CH471106 Genomic DNA Translation: EAW84824.1 BC014611 mRNA Translation: AAH14611.1 |
CCDSi | CCDS12403.1 |
RefSeqi | NP_114426.1, NM_032037.3 |
Genome annotation databases
Ensembli | ENST00000585580; ENSP00000466477; ENSG00000178093 ENST00000587522; ENSP00000466056; ENSG00000178093 |
GeneIDi | 83983 |
KEGGi | hsa:83983 |
MANE-Selecti | ENST00000585580.4; ENSP00000466477.1; NM_032037.4; NP_114426.1 |
UCSCi | uc002nmq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF329483 mRNA Translation: AAK48827.1 AF348077 mRNA Translation: AAK29414.1 AK058166 mRNA Translation: BAB71697.1 Frameshift. AK172841 mRNA Translation: BAD18805.1 Frameshift. AK313767 mRNA Translation: BAG36505.1 CH471106 Genomic DNA Translation: EAW84824.1 BC014611 mRNA Translation: AAH14611.1 |
CCDSi | CCDS12403.1 |
RefSeqi | NP_114426.1, NM_032037.3 |
3D structure databases
SMRi | Q9BXA6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123835, 28 interactors |
IntActi | Q9BXA6, 18 interactors |
STRINGi | 9606.ENSP00000466477 |
Chemistry databases
BindingDBi | Q9BXA6 |
ChEMBLi | CHEMBL3627582 |
PTM databases
PhosphoSitePlusi | Q9BXA6 |
Genetic variation databases
BioMutai | TSSK6 |
DMDMi | 74761315 |
Proteomic databases
MassIVEi | Q9BXA6 |
PaxDbi | Q9BXA6 |
PeptideAtlasi | Q9BXA6 |
PRIDEi | Q9BXA6 |
ProteomicsDBi | 79391 |
Protocols and materials databases
Antibodypediai | 28486, 170 antibodies from 24 providers |
DNASUi | 83983 |
Genome annotation databases
Ensembli | ENST00000585580; ENSP00000466477; ENSG00000178093 ENST00000587522; ENSP00000466056; ENSG00000178093 |
GeneIDi | 83983 |
KEGGi | hsa:83983 |
MANE-Selecti | ENST00000585580.4; ENSP00000466477.1; NM_032037.4; NP_114426.1 |
UCSCi | uc002nmq.4, human |
Organism-specific databases
CTDi | 83983 |
DisGeNETi | 83983 |
GeneCardsi | TSSK6 |
HGNCi | HGNC:30410, TSSK6 |
HPAi | ENSG00000178093, Tissue enriched (testis) |
MIMi | 610712, gene |
neXtProti | NX_Q9BXA6 |
OpenTargetsi | ENSG00000178093 |
PharmGKBi | PA142670682 |
VEuPathDBi | HostDB:ENSG00000178093 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000160464 |
InParanoidi | Q9BXA6 |
OMAi | KEARGYP |
OrthoDBi | 947464at2759 |
PhylomeDBi | Q9BXA6 |
TreeFami | TF105333 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9BXA6 |
SignaLinki | Q9BXA6 |
Miscellaneous databases
BioGRID-ORCSi | 83983, 25 hits in 1077 CRISPR screens |
ChiTaRSi | TSSK6, human |
GenomeRNAii | 83983 |
Pharosi | Q9BXA6, Tbio |
PROi | PR:Q9BXA6 |
RNActi | Q9BXA6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178093, Expressed in left testis and 117 other tissues |
ExpressionAtlasi | Q9BXA6, baseline and differential |
Genevisiblei | Q9BXA6, HS |
Family and domain databases
CDDi | cd14164, STKc_TSSK6-like, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR042710, TSSK6_STKc |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSSK6_HUMAN | |
Accessioni | Q9BXA6Primary (citable) accession number: Q9BXA6 Secondary accession number(s): B2R9F8, Q6ZMC4, Q96LJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families