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Protein

Testis-specific serine/threonine-protein kinase 6

Gene

TSSK6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1 Publication1
Active sitei135Proton acceptorPROSITE-ProRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Spermatogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9BXA6

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine/threonine-protein kinase 6 (EC:2.7.11.12 Publications)
Short name:
TSK-6
Short name:
TSSK-6
Short name:
Testis-specific kinase 6
Alternative name(s):
Cancer/testis antigen 72
Short name:
CT72
Serine/threonine-protein kinase SSTK
Small serine/threonine kinase
Gene namesi
Name:TSSK6Imported
Synonyms:SSTKImported
ORF Names:FKSG82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178093.13
HGNCiHGNC:30410 TSSK6
MIMi610712 gene
neXtProtiNX_Q9BXA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41K → M: Loss of kinase activity. Loss of binding to TSACC. 2 Publications1
Mutagenesisi135D → N: Loss of kinase activity. No effect of binding to TSACC. 2 Publications1

Organism-specific databases

OpenTargetsiENSG00000178093
PharmGKBiPA142670682

Chemistry databases

ChEMBLiCHEMBL3627582

Polymorphism and mutation databases

BioMutaiTSSK6
DMDMi74761315

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277461 – 273Testis-specific serine/threonine-protein kinase 6Add BLAST273

Post-translational modificationi

Autophosphorylated.1 Publication
Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9BXA6
PeptideAtlasiQ9BXA6
PRIDEiQ9BXA6
ProteomicsDBi79391

PTM databases

PhosphoSitePlusiQ9BXA6

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000178093 Expressed in 92 organ(s), highest expression level in left testis
CleanExiHS_TSSK6
ExpressionAtlasiQ9BXA6 baseline and differential
GenevisibleiQ9BXA6 HS

Interactioni

Subunit structurei

Interacts with HSP90; this interaction stabilizes and activates TSSK6 (By similarity). Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082383EBI-851883,EBI-352572

Protein-protein interaction databases

BioGridi123835, 22 interactors
IntActiQ9BXA6, 18 interactors
STRINGi9606.ENSP00000354168

Chemistry databases

BindingDBiQ9BXA6

Structurei

3D structure databases

ProteinModelPortaliQ9BXA6
SMRiQ9BXA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 267Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00770000120521
HOGENOMiHOG000233016
HOVERGENiHBG101110
InParanoidiQ9BXA6
KOiK08811
OMAiPCVPEAR
OrthoDBiEOG091G0EZI
PhylomeDBiQ9BXA6
TreeFamiTF105333

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BXA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGDKLLSEL GYKLGRTIGE GSYSKVKVAT SKKYKGTVAI KVVDRRRAPP
60 70 80 90 100
DFVNKFLPRE LSILRGVRHP HIVHVFEFIE VCNGKLYIVM EAAATDLLQA
110 120 130 140 150
VQRNGRIPGV QARDLFAQIA GAVRYLHDHH LVHRDLKCEN VLLSPDERRV
160 170 180 190 200
KLTDFGFGRQ AHGYPDLSTT YCGSAAYASP EVLLGIPYDP KKYDVWSMGV
210 220 230 240 250
VLYVMVTGCM PFDDSDIAGL PRRQKRGVLY PEGLELSERC KALIAELLQF
260 270
SPSARPSAGQ VARNCWLRAG DSG
Length:273
Mass (Da):30,331
Last modified:June 1, 2001 - v1
Checksum:i998934C72963C7CE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMZ2R4GMZ2_HUMAN
Testis-specific serine/threonine-pr...
TSSK6
109Annotation score:

Sequence cautioni

The sequence BAB71697 differs from that shown. Reason: Frameshift at positions 104 and 169.Curated
The sequence BAD18805 differs from that shown. Reason: Frameshift at position 247.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329483 mRNA Translation: AAK48827.1
AF348077 mRNA Translation: AAK29414.1
AK058166 mRNA Translation: BAB71697.1 Frameshift.
AK172841 mRNA Translation: BAD18805.1 Frameshift.
AK313767 mRNA Translation: BAG36505.1
CH471106 Genomic DNA Translation: EAW84824.1
BC014611 mRNA Translation: AAH14611.1
CCDSiCCDS12403.1
RefSeqiNP_114426.1, NM_032037.3
UniGeneiHs.532711
Hs.666780

Genome annotation databases

EnsembliENST00000585580; ENSP00000466477; ENSG00000178093
ENST00000587522; ENSP00000466056; ENSG00000178093
GeneIDi83983
KEGGihsa:83983
UCSCiuc002nmq.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329483 mRNA Translation: AAK48827.1
AF348077 mRNA Translation: AAK29414.1
AK058166 mRNA Translation: BAB71697.1 Frameshift.
AK172841 mRNA Translation: BAD18805.1 Frameshift.
AK313767 mRNA Translation: BAG36505.1
CH471106 Genomic DNA Translation: EAW84824.1
BC014611 mRNA Translation: AAH14611.1
CCDSiCCDS12403.1
RefSeqiNP_114426.1, NM_032037.3
UniGeneiHs.532711
Hs.666780

3D structure databases

ProteinModelPortaliQ9BXA6
SMRiQ9BXA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123835, 22 interactors
IntActiQ9BXA6, 18 interactors
STRINGi9606.ENSP00000354168

Chemistry databases

BindingDBiQ9BXA6
ChEMBLiCHEMBL3627582

PTM databases

PhosphoSitePlusiQ9BXA6

Polymorphism and mutation databases

BioMutaiTSSK6
DMDMi74761315

Proteomic databases

PaxDbiQ9BXA6
PeptideAtlasiQ9BXA6
PRIDEiQ9BXA6
ProteomicsDBi79391

Protocols and materials databases

DNASUi83983
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585580; ENSP00000466477; ENSG00000178093
ENST00000587522; ENSP00000466056; ENSG00000178093
GeneIDi83983
KEGGihsa:83983
UCSCiuc002nmq.4 human

Organism-specific databases

CTDi83983
EuPathDBiHostDB:ENSG00000178093.13
GeneCardsiTSSK6
H-InvDBiHIX0174374
HGNCiHGNC:30410 TSSK6
MIMi610712 gene
neXtProtiNX_Q9BXA6
OpenTargetsiENSG00000178093
PharmGKBiPA142670682
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00770000120521
HOGENOMiHOG000233016
HOVERGENiHBG101110
InParanoidiQ9BXA6
KOiK08811
OMAiPCVPEAR
OrthoDBiEOG091G0EZI
PhylomeDBiQ9BXA6
TreeFamiTF105333

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9BXA6

Miscellaneous databases

GenomeRNAii83983
PROiPR:Q9BXA6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178093 Expressed in 92 organ(s), highest expression level in left testis
CleanExiHS_TSSK6
ExpressionAtlasiQ9BXA6 baseline and differential
GenevisibleiQ9BXA6 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSSK6_HUMAN
AccessioniPrimary (citable) accession number: Q9BXA6
Secondary accession number(s): B2R9F8, Q6ZMC4, Q96LJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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