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Protein

Succinate receptor 1

Gene

SUCNR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for succinate.1 Publication

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate receptor 1
Alternative name(s):
G-protein coupled receptor 91
P2Y purinoceptor 1-like
Gene namesi
Name:SUCNR1
Synonyms:GPR91
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000198829.6
HGNCiHGNC:4542 SUCNR1
MIMi606381 gene
neXtProtiNX_Q9BXA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini5 – 31ExtracellularSequence analysisAdd BLAST27
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 59CytoplasmicSequence analysis7
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 103ExtracellularSequence analysisAdd BLAST23
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 137CytoplasmicSequence analysisAdd BLAST13
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 185ExtracellularSequence analysisAdd BLAST27
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 230CytoplasmicSequence analysisAdd BLAST24
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 281ExtracellularSequence analysisAdd BLAST30
Transmembranei282 – 302Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini303 – 334CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99R → A: Abolishes activation by succinate. 1 Publication1
Mutagenesisi103H → A: Abolishes activation by succinate. 1 Publication1
Mutagenesisi107Y → F: No effect on receptor function. 1 Publication1
Mutagenesisi249H → A: No effect on receptor function. 1 Publication1
Mutagenesisi252R → A: Abolishes activation by succinate. 1 Publication1
Mutagenesisi255R → A: No effect on receptor function. 1 Publication1
Mutagenesisi281R → A: Abolishes activation by succinate. 1 Publication1

Organism-specific databases

DisGeNETi56670
OpenTargetsiENSG00000198829
PharmGKBiPA28934

Chemistry databases

ChEMBLiCHEMBL2150838
DrugBankiDB00139 Succinic acid
GuidetoPHARMACOLOGYi166

Polymorphism and mutation databases

BioMutaiSUCNR1
DMDMi259016146

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701341 – 334Succinate receptor 1Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BXA5
PeptideAtlasiQ9BXA5
PRIDEiQ9BXA5
ProteomicsDBi79390

PTM databases

PhosphoSitePlusiQ9BXA5

Expressioni

Tissue specificityi

Expressed specifically in kidney.1 Publication

Gene expression databases

BgeeiENSG00000198829 Expressed in 88 organ(s), highest expression level in kidney epithelium
CleanExiHS_SUCNR1
GenevisibleiQ9BXA5 HS

Organism-specific databases

HPAiCAB022745

Interactioni

Protein-protein interaction databases

BioGridi121179, 2 interactors
IntActiQ9BXA5, 1 interactor
STRINGi9606.ENSP00000355156

Chemistry databases

BindingDBiQ9BXA5

Structurei

3D structure databases

ProteinModelPortaliQ9BXA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJKI Eukaryota
ENOG410YANU LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG095590
InParanoidiQ9BXA5
KOiK10042
OMAiVMCFFYY
OrthoDBiEOG091G0FDD
PhylomeDBiQ9BXA5
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BXA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGIMAWNAT CKNWLAAEAA LEKYYLSIFY GIEFVVGVLG NTIVVYGYIF
60 70 80 90 100
SLKNWNSSNI YLFNLSVSDL AFLCTLPMLI RSYANGNWIY GDVLCISNRY
110 120 130 140 150
VLHANLYTSI LFLTFISIDR YLIIKYPFRE HLLQKKEFAI LISLAIWVLV
160 170 180 190 200
TLELLPILPL INPVITDNGT TCNDFASSGD PNYNLIYSMC LTLLGFLIPL
210 220 230 240 250
FVMCFFYYKI ALFLKQRNRQ VATALPLEKP LNLVIMAVVI FSVLFTPYHV
260 270 280 290 300
MRNVRIASRL GSWKQYQCTQ VVINSFYIVT RPLAFLNSVI NPVFYFLLGD
310 320 330
HFRDMLMNQL RHNFKSLTSF SRWAHELLLS FREK
Length:334
Mass (Da):38,698
Last modified:September 22, 2009 - v2
Checksum:i33146E1AD87F0E81
GO

Sequence cautioni

The sequence AAK29080 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348078 mRNA Translation: AAK29080.1 Different initiation.
AF247785 mRNA Translation: AAL95690.1
EU432110 mRNA Translation: ABY87909.1
AK290420 mRNA Translation: BAF83109.1
AC068647 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78789.1
BC030948 mRNA Translation: AAH30948.3
CCDSiCCDS3162.1
RefSeqiNP_149039.2, NM_033050.5
UniGeneiHs.133181
Hs.279575
Hs.627102

Genome annotation databases

EnsembliENST00000362032; ENSP00000355156; ENSG00000198829
GeneIDi56670
KEGGihsa:56670
UCSCiuc003ezf.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348078 mRNA Translation: AAK29080.1 Different initiation.
AF247785 mRNA Translation: AAL95690.1
EU432110 mRNA Translation: ABY87909.1
AK290420 mRNA Translation: BAF83109.1
AC068647 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78789.1
BC030948 mRNA Translation: AAH30948.3
CCDSiCCDS3162.1
RefSeqiNP_149039.2, NM_033050.5
UniGeneiHs.133181
Hs.279575
Hs.627102

3D structure databases

ProteinModelPortaliQ9BXA5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121179, 2 interactors
IntActiQ9BXA5, 1 interactor
STRINGi9606.ENSP00000355156

Chemistry databases

BindingDBiQ9BXA5
ChEMBLiCHEMBL2150838
DrugBankiDB00139 Succinic acid
GuidetoPHARMACOLOGYi166

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9BXA5

Polymorphism and mutation databases

BioMutaiSUCNR1
DMDMi259016146

Proteomic databases

PaxDbiQ9BXA5
PeptideAtlasiQ9BXA5
PRIDEiQ9BXA5
ProteomicsDBi79390

Protocols and materials databases

DNASUi56670
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362032; ENSP00000355156; ENSG00000198829
GeneIDi56670
KEGGihsa:56670
UCSCiuc003ezf.3 human

Organism-specific databases

CTDi56670
DisGeNETi56670
EuPathDBiHostDB:ENSG00000198829.6
GeneCardsiSUCNR1
HGNCiHGNC:4542 SUCNR1
HPAiCAB022745
MIMi606381 gene
neXtProtiNX_Q9BXA5
OpenTargetsiENSG00000198829
PharmGKBiPA28934
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJKI Eukaryota
ENOG410YANU LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG095590
InParanoidiQ9BXA5
KOiK10042
OMAiVMCFFYY
OrthoDBiEOG091G0FDD
PhylomeDBiQ9BXA5
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiSUCNR1
GenomeRNAii56670
PROiPR:Q9BXA5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198829 Expressed in 88 organ(s), highest expression level in kidney epithelium
CleanExiHS_SUCNR1
GenevisibleiQ9BXA5 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUCR1_HUMAN
AccessioniPrimary (citable) accession number: Q9BXA5
Secondary accession number(s): A8K305, Q8TDQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: September 22, 2009
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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