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Protein

Group XIIB secretory phospholipase A2-like protein

Gene

PLA2G12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not known; does not seem to have catalytic activity.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Calcium; via carbonyl oxygenBy similarity1
Metal bindingi91Calcium; via carbonyl oxygenBy similarity1
Metal bindingi93Calcium; via carbonyl oxygenBy similarity1
Metal bindingi116CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Group XIIB secretory phospholipase A2-like protein
Alternative name(s):
Group XIII secretory phospholipase A2-like protein
Short name:
GXIII sPLA2-like
sPLA2-GXIIB
Short name:
GXIIB
Gene namesi
Name:PLA2G12B
Synonyms:PLA2G13
ORF Names:FKSG71
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138308.5
HGNCiHGNC:18555 PLA2G12B
MIMi611653 gene
neXtProtiNX_Q9BX93

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi84647
OpenTargetsiENSG00000138308
PharmGKBiPA38573

Polymorphism and mutation databases

BioMutaiPLA2G12B
DMDMi20178010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000002277220 – 195Group XIIB secretory phospholipase A2-like proteinAdd BLAST176

Proteomic databases

MaxQBiQ9BX93
PaxDbiQ9BX93
PeptideAtlasiQ9BX93
PRIDEiQ9BX93
ProteomicsDBi79387

Expressioni

Tissue specificityi

Strong expression in liver, small intestine and kidney.1 Publication

Gene expression databases

BgeeiENSG00000138308
CleanExiHS_PLA2G12B
GenevisibleiQ9BX93 HS

Organism-specific databases

HPAiHPA057745
HPA059562

Interactioni

Protein-protein interaction databases

BioGridi124170, 4 interactors
STRINGi9606.ENSP00000362123

Structurei

3D structure databases

ProteinModelPortaliQ9BX93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVIH Eukaryota
ENOG410Z7K4 LUCA
GeneTreeiENSGT00390000008798
HOGENOMiHOG000247019
HOVERGENiHBG053577
InParanoidiQ9BX93
KOiK01047
OMAiWGLRHIR
OrthoDBiEOG091G10MQ
PhylomeDBiQ9BX93
TreeFamiTF323302

Family and domain databases

InterProiView protein in InterPro
IPR010711 PLA2G12
IPR036444 PLipase_A2_dom_sf
PANTHERiPTHR12824 PTHR12824, 1 hit
PfamiView protein in Pfam
PF06951 PLA2G12, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BX93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF
60 70 80 90 100
DSFLELLGGK NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES
110 120 130 140 150
MDLGIPAMTK CCNQLDVCYD TCGANKYRCD AKFRWCLHSI CSDLKRSLGF
160 170 180 190
VSKVEAACDS LVDTVFNTVW TLGCRPFMNS QRAACICAEE EKEEL
Length:195
Mass (Da):21,659
Last modified:April 16, 2002 - v2
Checksum:iC00C817F81D68A70
GO
Isoform 2 (identifier: Q9BX93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: Missing.

Show »
Length:194
Mass (Da):21,588
Checksum:i34DBFBFBDF9A22EC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054398157Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349540 mRNA Translation: AAK30168.1
AF339053 mRNA Translation: AAL09472.1
AY358032 mRNA Translation: AAQ92918.1
CH471083 Genomic DNA Translation: EAW54466.1
BC093996 mRNA Translation: AAH93996.1
BC111946 mRNA Translation: AAI11947.1
BC143532 mRNA Translation: AAI43533.1
CCDSiCCDS7319.1 [Q9BX93-1]
RefSeqiNP_001305053.1, NM_001318124.1 [Q9BX93-2]
NP_115951.2, NM_032562.4 [Q9BX93-1]
UniGeneiHs.333175

Genome annotation databases

EnsembliENST00000373032; ENSP00000362123; ENSG00000138308 [Q9BX93-1]
GeneIDi84647
KEGGihsa:84647
UCSCiuc001jtf.2 human [Q9BX93-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPG12B_HUMAN
AccessioniPrimary (citable) accession number: Q9BX93
Secondary accession number(s): B7ZL23, Q52LB2, Q96Q99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: June 20, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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