UniProtKB - Q9BX93 (PG12B_HUMAN)
Protein
Group XIIB secretory phospholipase A2-like protein
Gene
PLA2G12B
Organism
Homo sapiens (Human)
Status
Functioni
Not known; does not seem to have catalytic activity.
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 89 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 91 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 93 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 116 | CalciumBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: InterPro
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- cholesterol homeostasis Source: GO_Central
- lipid catabolic process Source: InterPro
- phospholipid metabolic process Source: InterPro
- triglyceride homeostasis Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BX93 |
Names & Taxonomyi
Protein namesi | Recommended name: Group XIIB secretory phospholipase A2-like proteinAlternative name(s): Group XIII secretory phospholipase A2-like protein Short name: GXIII sPLA2-like sPLA2-GXIIB Short name: GXIIB |
Gene namesi | Name:PLA2G12B Synonyms:PLA2G13 ORF Names:FKSG71 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18555, PLA2G12B |
MIMi | 611653, gene |
neXtProti | NX_Q9BX93 |
VEuPathDBi | HostDB:ENSG00000138308.5 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 84647 |
OpenTargetsi | ENSG00000138308 |
PharmGKBi | PA38573 |
Miscellaneous databases
Pharosi | Q9BX93, Tdark |
Genetic variation databases
BioMutai | PLA2G12B |
DMDMi | 20178010 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000022772 | 20 – 195 | Group XIIB secretory phospholipase A2-like proteinAdd BLAST | 176 |
Proteomic databases
jPOSTi | Q9BX93 |
MassIVEi | Q9BX93 |
MaxQBi | Q9BX93 |
PaxDbi | Q9BX93 |
PeptideAtlasi | Q9BX93 |
PRIDEi | Q9BX93 |
ProteomicsDBi | 79387 [Q9BX93-1] |
Expressioni
Tissue specificityi
Strong expression in liver, small intestine and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000138308, Expressed in liver and 59 other tissues |
Genevisiblei | Q9BX93, HS |
Organism-specific databases
HPAi | ENSG00000138308, Group enriched (intestine, liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124170, 4 interactors |
IntActi | Q9BX93, 1 interactor |
STRINGi | 9606.ENSP00000362123 |
Miscellaneous databases
RNActi | Q9BX93, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the phospholipase A2 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QQU1, Eukaryota |
GeneTreei | ENSGT00390000008798 |
HOGENOMi | CLU_093969_1_1_1 |
InParanoidi | Q9BX93 |
OMAi | KNGICQY |
OrthoDBi | 1299904at2759 |
PhylomeDBi | Q9BX93 |
TreeFami | TF323302 |
Family and domain databases
InterProi | View protein in InterPro IPR010711, PLA2G12 IPR036444, PLipase_A2_dom_sf |
PANTHERi | PTHR12824, PTHR12824, 1 hit |
Pfami | View protein in Pfam PF06951, PLA2G12, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9BX93-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF
60 70 80 90 100
DSFLELLGGK NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES
110 120 130 140 150
MDLGIPAMTK CCNQLDVCYD TCGANKYRCD AKFRWCLHSI CSDLKRSLGF
160 170 180 190
VSKVEAACDS LVDTVFNTVW TLGCRPFMNS QRAACICAEE EKEEL
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054398 | 157 | Missing in isoform 2. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF349540 mRNA Translation: AAK30168.1 AF339053 mRNA Translation: AAL09472.1 AY358032 mRNA Translation: AAQ92918.1 CH471083 Genomic DNA Translation: EAW54466.1 BC093996 mRNA Translation: AAH93996.1 BC111946 mRNA Translation: AAI11947.1 BC143532 mRNA Translation: AAI43533.1 |
CCDSi | CCDS7319.1 [Q9BX93-1] |
RefSeqi | NP_001305053.1, NM_001318124.1 [Q9BX93-2] NP_115951.2, NM_032562.4 [Q9BX93-1] |
Genome annotation databases
Ensembli | ENST00000373032; ENSP00000362123; ENSG00000138308 [Q9BX93-1] |
GeneIDi | 84647 |
KEGGi | hsa:84647 |
UCSCi | uc001jtf.2, human [Q9BX93-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF349540 mRNA Translation: AAK30168.1 AF339053 mRNA Translation: AAL09472.1 AY358032 mRNA Translation: AAQ92918.1 CH471083 Genomic DNA Translation: EAW54466.1 BC093996 mRNA Translation: AAH93996.1 BC111946 mRNA Translation: AAI11947.1 BC143532 mRNA Translation: AAI43533.1 |
CCDSi | CCDS7319.1 [Q9BX93-1] |
RefSeqi | NP_001305053.1, NM_001318124.1 [Q9BX93-2] NP_115951.2, NM_032562.4 [Q9BX93-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 124170, 4 interactors |
IntActi | Q9BX93, 1 interactor |
STRINGi | 9606.ENSP00000362123 |
Genetic variation databases
BioMutai | PLA2G12B |
DMDMi | 20178010 |
Proteomic databases
jPOSTi | Q9BX93 |
MassIVEi | Q9BX93 |
MaxQBi | Q9BX93 |
PaxDbi | Q9BX93 |
PeptideAtlasi | Q9BX93 |
PRIDEi | Q9BX93 |
ProteomicsDBi | 79387 [Q9BX93-1] |
Protocols and materials databases
Antibodypediai | 45352, 38 antibodies |
Genome annotation databases
Ensembli | ENST00000373032; ENSP00000362123; ENSG00000138308 [Q9BX93-1] |
GeneIDi | 84647 |
KEGGi | hsa:84647 |
UCSCi | uc001jtf.2, human [Q9BX93-1] |
Organism-specific databases
CTDi | 84647 |
DisGeNETi | 84647 |
GeneCardsi | PLA2G12B |
HGNCi | HGNC:18555, PLA2G12B |
HPAi | ENSG00000138308, Group enriched (intestine, liver) |
MIMi | 611653, gene |
neXtProti | NX_Q9BX93 |
OpenTargetsi | ENSG00000138308 |
PharmGKBi | PA38573 |
VEuPathDBi | HostDB:ENSG00000138308.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQU1, Eukaryota |
GeneTreei | ENSGT00390000008798 |
HOGENOMi | CLU_093969_1_1_1 |
InParanoidi | Q9BX93 |
OMAi | KNGICQY |
OrthoDBi | 1299904at2759 |
PhylomeDBi | Q9BX93 |
TreeFami | TF323302 |
Enzyme and pathway databases
PathwayCommonsi | Q9BX93 |
Miscellaneous databases
BioGRID-ORCSi | 84647, 3 hits in 874 CRISPR screens |
GenomeRNAii | 84647 |
Pharosi | Q9BX93, Tdark |
PROi | PR:Q9BX93 |
RNActi | Q9BX93, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138308, Expressed in liver and 59 other tissues |
Genevisiblei | Q9BX93, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010711, PLA2G12 IPR036444, PLipase_A2_dom_sf |
PANTHERi | PTHR12824, PTHR12824, 1 hit |
Pfami | View protein in Pfam PF06951, PLA2G12, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00014, ER_TARGET, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PG12B_HUMAN | |
Accessioni | Q9BX93Primary (citable) accession number: Q9BX93 Secondary accession number(s): B7ZL23, Q52LB2, Q96Q99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | April 16, 2002 | |
Last modified: | February 10, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families