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Entry version 154 (11 Dec 2019)
Sequence version 2 (01 Jun 2002)
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Protein

Transient receptor potential cation channel subfamily M member 6

Gene

TRPM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1780ATPBy similarity1
Binding sitei1804ATPBy similarity1
Binding sitei1876ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1909ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1923Proton acceptorBy similarity1
Binding sitei1925ATPBy similarity1
Binding sitei1933ATPBy similarity1
Metal bindingi1966ZincBy similarity1
Metal bindingi1968ZincBy similarity1
Metal bindingi1972ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1950 – 1956ATPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3295583 TRP channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.4.5.8 the transient receptor potential ca(2+) channel (trp-cc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 6 (EC:2.7.11.1)
Alternative name(s):
Channel kinase 2
Melastatin-related TRP cation channel 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPM6
Synonyms:CHAK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119121.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17995 TRPM6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607009 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BX84

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 741CytoplasmicSequence analysisAdd BLAST741
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei742 – 762HelicalSequence analysisAdd BLAST21
Topological domaini763 – 841ExtracellularSequence analysisAdd BLAST79
Transmembranei842 – 862HelicalSequence analysisAdd BLAST21
Topological domaini863 – 905CytoplasmicSequence analysisAdd BLAST43
Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 939ExtracellularSequence analysisAdd BLAST13
Transmembranei940 – 960HelicalSequence analysisAdd BLAST21
Topological domaini961 – 972CytoplasmicSequence analysisAdd BLAST12
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Topological domaini994 – 1012ExtracellularSequence analysisAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei1013 – 1033Pore-formingSequence analysisAdd BLAST21
Topological domaini1034 – 1047ExtracellularSequence analysisAdd BLAST14
Transmembranei1048 – 1068HelicalSequence analysisAdd BLAST21
Topological domaini1069 – 2022CytoplasmicSequence analysisAdd BLAST954

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypomagnesemia 1 (HOMG1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to a primary defect in intestinal magnesium absorption. It is characterized by low levels of serum magnesium alongside with a normal renal magnesium secretion, secondary hypocalcemia and calcinocis. Affected individuals show neurologic symptoms of hypomagnesemic hypocalcemia, including seizures and muscle spasms, during infancy. Hypocalcemia is secondary to parathyroid failure resulting from magnesium deficiency. Untreated, the disorder may be fatal or may result in neurological damage.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019963141S → L in HOMG1; impairs heterodimer formation resulting in intracellular retention. 2 PublicationsCorresponds to variant dbSNP:rs121912625EnsemblClinVar.1
Natural variantiVAR_071480708L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_071481872E → G in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0714821053Y → C in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0714831143L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0714841754S → N in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1804K → R: Abolishes kinase activity but does not affect expression levels or binding to RACK1. 1 Publication1
Mutagenesisi1851T → A: Significantly decreases autophosphorylation. Does not alter binding to RACK1 but prevents inhibition by RACK1. 1 Publication1
Mutagenesisi1851T → D: Significantly decreases autophosphorylation. Does not alter binding to RACK1 or inhibition by RACK1. 1 Publication1

Keywords - Diseasei

Disease mutation, Primary hypomagnesemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
140803

MalaCards human disease database

More...
MalaCardsi
TRPM6
MIMi602014 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000119121

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
30924 Primary hypomagnesemia with secondary hypocalcemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38479

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9BX84 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1628470

Drug and drug target database

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DrugBanki
DB09481 Magnesium carbonate

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
498

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TRPM6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56404951

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002153291 – 2022Transient receptor potential cation channel subfamily M member 6Add BLAST2022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1851Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BX84

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BX84

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BX84

PeptideAtlas

More...
PeptideAtlasi
Q9BX84

PRoteomics IDEntifications database

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PRIDEi
Q9BX84

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
79380 [Q9BX84-1]
79381 [Q9BX84-2]
79382 [Q9BX84-3]
79383 [Q9BX84-4]
79384 [Q9BX84-5]
79385 [Q9BX84-6]
79386 [Q9BX84-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BX84

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BX84

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119121 Expressed in 106 organ(s), highest expression level in colonic mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BX84 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BX84 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells).

Interacts (via kinase domain) with RACK1.

2 Publications

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BX84

Protein interaction database and analysis system

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IntActi
Q9BX84, 3 interactors

Molecular INTeraction database

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MINTi
Q9BX84

STRING: functional protein association networks

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STRINGi
9606.ENSP00000354006

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BX84

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BX84 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1750 – 1980Alpha-type protein kinasePROSITE-ProRule annotationAdd BLAST231

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INBW Eukaryota
ENOG410ZSH9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158164

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230920

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BX84

KEGG Orthology (KO)

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KOi
K04981

Identification of Orthologs from Complete Genome Data

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OMAi
YVDMKSI

Database of Orthologous Groups

More...
OrthoDBi
738147at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BX84

TreeFam database of animal gene trees

More...
TreeFami
TF314204

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR029597 TRPM6
IPR041491 TRPM_SLOG
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf

The PANTHER Classification System

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PANTHERi
PTHR13800:SF15 PTHR13800:SF15, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
PF16519 TRPM_tetra, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00811 Alpha_kinase, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform TRPM6a (identifier: Q9BX84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKEQPVLERL QSQKSWIKGV FDKRECSTII PSSKNPHRCT PVCQVCQNLI
60 70 80 90 100
RCYCGRLIGD HAGIDYSWTI SAAKGKESEQ WSVEKHTTKS PTDTFGTINF
110 120 130 140 150
QDGEHTHHAK YIRTSYDTKL DHLLHLMLKE WKMELPKLVI SVHGGIQNFT
160 170 180 190 200
MPSKFKEIFS QGLVKAAETT GAWIITEGIN TGVSKHVGDA LKSHSSHSLR
210 220 230 240 250
KIWTVGIPPW GVIENQRDLI GKDVVCLYQT LDNPLSKLTT LNSMHSHFIL
260 270 280 290 300
SDDGTVGKYG NEMKLRRNLE KYLSLQKIHC RSRQGVPVVG LVVEGGPNVI
310 320 330 340 350
LSVWETVKDK DPVVVCEGTG RAADLLAFTH KHLADEGMLR PQVKEEIICM
360 370 380 390 400
IQNTFNFSLK QSKHLFQILM ECMVHRDCIT IFDADSEEQQ DLDLAILTAL
410 420 430 440 450
LKGTNLSASE QLNLAMAWDR VDIAKKHILI YEQHWKPDAL EQAMSDALVM
460 470 480 490 500
DRVDFVKLLI EYGVNLHRFL TIPRLEELYN TKQGPTNTLL HHLVQDVKQH
510 520 530 540 550
TLLSGYRITL IDIGLVVEYL IGRAYRSNYT RKHFRALYNN LYRKYKHQRH
560 570 580 590 600
SSGNRNESAE STLHSQFIRT AQPYKFKEKS IVLHKSRKKS KEQNVSDDPE
610 620 630 640 650
STGFLYPYND LLVWAVLMKR QKMAMFFWQH GEEATVKAVI ACILYRAMAH
660 670 680 690 700
EAKESHMVDD ASEELKNYSK QFGQLALDLL EKAFKQNERM AMTLLTYELR
710 720 730 740 750
NWSNSTCLKL AVSGGLRPFV SHTCTQMLLT DMWMGRLKMR KNSWLKIIIS
760 770 780 790 800
IILPPTILTL EFKSKAEMSH VPQSQDFQFM WYYSDQNASS SKESASVKEY
810 820 830 840 850
DLERGHDEKL DENQHFGLES GHQHLPWTRK VYEFYSAPIV KFWFYTMAYL
860 870 880 890 900
AFLMLFTYTV LVEMQPQPSV QEWLVSIYIF TNAIEVVREI CISEPGKFTQ
910 920 930 940 950
KVKVWISEYW NLTETVAIGL FSAGFVLRWG DPPFHTAGRL IYCIDIIFWF
960 970 980 990 1000
SRLLDFFAVN QHAGPYVTMI AKMTANMFYI VIIMAIVLLS FGVARKAILS
1010 1020 1030 1040 1050
PKEPPSWSLA RDIVFEPYWM IYGEVYAGEI DVCSSQPSCP PGSFLTPFLQ
1060 1070 1080 1090 1100
AVYLFVQYII MVNLLIAFFN NVYLDMESIS NNLWKYNRYR YIMTYHEKPW
1110 1120 1130 1140 1150
LPPPLILLSH VGLLLRRLCC HRAPHDQEEG DVGLKLYLSK EDLKKLHDFE
1160 1170 1180 1190 1200
EQCVEKYFHE KMEDVNCSCE ERIRVTSERV TEMYFQLKEM NEKVSFIKDS
1210 1220 1230 1240 1250
LLSLDSQVGH LQDLSALTVD TLKVLSAVDT LQEDEALLAK RKHSTCKKLP
1260 1270 1280 1290 1300
HSWSNVICAE VLGSMEIAGE KKYQYYSMPS SLLRSLAGGR HPPRVQRGAL
1310 1320 1330 1340 1350
LEITNSKREA TNVRNDQERQ ETQSSIVVSG VSPNRQAHSK YGQFLLVPSN
1360 1370 1380 1390 1400
LKRVPFSAET VLPLSRPSVP DVLATEQDIQ TEVLVHLTGQ TPVVSDWASV
1410 1420 1430 1440 1450
DEPKEKHEPI AHLLDGQDKA EQVLPTLSCT PEPMTMSSPL SQAKIMQTGG
1460 1470 1480 1490 1500
GYVNWAFSEG DETGVFSIKK KWQTCLPSTC DSDSSRSEQH QKQAQDSSLS
1510 1520 1530 1540 1550
DNSTRSAQSS ECSEVGPWLQ PNTSFWINPL RRYRPFARSH SFRFHKEEKL
1560 1570 1580 1590 1600
MKICKIKNLS GSSEIGQGAW VKAKMLTKDR RLSKKKKNTQ GLQVPIITVN
1610 1620 1630 1640 1650
ACSQSDQLNP EPGENSISEE EYSKNWFTVS KFSHTGVEPY IHQKMKTKEI
1660 1670 1680 1690 1700
GQCAIQISDY LKQSQEDLSK NSLWNSRSTN LNRNSLLKSS IGVDKISASL
1710 1720 1730 1740 1750
KSPQEPHHHY SAIERNNLMR LSQTIPFTPV QLFAGEEITV YRLEESSPLN
1760 1770 1780 1790 1800
LDKSMSSWSQ RGRAAMIQVL SREEMDGGLR KAMRVVSTWS EDDILKPGQV
1810 1820 1830 1840 1850
FIVKSFLPEV VRTWHKIFQE STVLHLCLRE IQQQRAAQKL IYTFNQVKPQ
1860 1870 1880 1890 1900
TIPYTPRFLE VFLIYCHSAN QWLTIEKYMT GEFRKYNNNN GDEITPTNTL
1910 1920 1930 1940 1950
EELMLAFSHW TYEYTRGELL VLDLQGVGEN LTDPSVIKPE VKQSRGMVFG
1960 1970 1980 1990 2000
PANLGEDAIR NFIAKHHCNS CCRKLKLPDL KRNDYSPERI NSTFGLEIKI
2010 2020
ESAEEPPARE TGRNSPEDDM QL
Length:2,022
Mass (Da):231,708
Last modified:June 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59346B3BE3300466
GO
Isoform TRPM6b (identifier: Q9BX84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MIILSK

Show »
Length:2,017
Mass (Da):231,041
Checksum:iC96D328F3E9B2A9E
GO
Isoform TRPM6c (identifier: Q9BX84-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MKEQPVLERLQ → MTAPVT

Show »
Length:2,017
Mass (Da):230,956
Checksum:i7F49198CADF3F64D
GO
Isoform TRPM6t (identifier: Q9BX84-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1926-1943: GVGENLTDPSVIKPEVKQ → ALWFWDSMLKARLGGWRM
     1944-2022: Missing.

Show »
Length:1,943
Mass (Da):223,124
Checksum:i15F59730C0F345EC
GO
Isoform M6-kinase 1 (identifier: Q9BX84-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-1595: Missing.

Note: Lacks the ion channel region.Curated
Show »
Length:973
Mass (Da):111,301
Checksum:i4B6503C01BF3F3B6
GO
Isoform M6-kinase 2 (identifier: Q9BX84-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     500-1666: Missing.

Note: Lacks the ion channel region.Curated
Show »
Length:855
Mass (Da):97,520
Checksum:i924C00E589E6FED0
GO
Isoform M6-kinase 3 (identifier: Q9BX84-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     281-281: R → P
     282-1734: Missing.

Note: Lacks the ion channel region.Curated
Show »
Length:569
Mass (Da):65,083
Checksum:i7BF7F1E5163459EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96LV9Q96LV9_HUMAN
Transient receptor potential cation...
TRPM6 hCG_1984503
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04238775G → V in a lung adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1193127627Ensembl.1
Natural variantiVAR_019963141S → L in HOMG1; impairs heterodimer formation resulting in intracellular retention. 2 PublicationsCorresponds to variant dbSNP:rs121912625EnsemblClinVar.1
Natural variantiVAR_042388338M → I1 PublicationCorresponds to variant dbSNP:rs56155062EnsemblClinVar.1
Natural variantiVAR_071480708L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_071481872E → G in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_052380948F → L. Corresponds to variant dbSNP:rs13290391Ensembl.1
Natural variantiVAR_0423891007W → C in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0714821053Y → C in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0199641071N → D. Corresponds to variant dbSNP:rs2274922EnsemblClinVar.1
Natural variantiVAR_0714831143L → P in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1
Natural variantiVAR_0423901243H → R1 PublicationCorresponds to variant dbSNP:rs55694430Ensembl.1
Natural variantiVAR_0423911274Q → R1 PublicationCorresponds to variant dbSNP:rs34608911EnsemblClinVar.1
Natural variantiVAR_0199651393V → I1 PublicationCorresponds to variant dbSNP:rs3750425EnsemblClinVar.1
Natural variantiVAR_0199661584K → E1 PublicationCorresponds to variant dbSNP:rs2274924EnsemblClinVar.1
Natural variantiVAR_0423921663Q → R No effect on function or cell membrane localization. 2 PublicationsCorresponds to variant dbSNP:rs55679040EnsemblClinVar.1
Natural variantiVAR_0423931673L → S1 PublicationCorresponds to variant dbSNP:rs56254742Ensembl.1
Natural variantiVAR_0423941724T → I1 PublicationCorresponds to variant dbSNP:rs56290308EnsemblClinVar.1
Natural variantiVAR_0714841754S → N in HOMG1; loss of function; no effect on cell membrane localization. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0120691 – 11MKEQPVLERLQ → MIILSK in isoform TRPM6b. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0120701 – 11MKEQPVLERLQ → MTAPVT in isoform TRPM6c. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_012071281R → P in isoform M6-kinase 3. 1 Publication1
Alternative sequenceiVSP_012072282 – 1734Missing in isoform M6-kinase 3. 1 PublicationAdd BLAST1453
Alternative sequenceiVSP_012073500 – 1666Missing in isoform M6-kinase 2. 1 PublicationAdd BLAST1167
Alternative sequenceiVSP_012074547 – 1595Missing in isoform M6-kinase 1. 1 PublicationAdd BLAST1049
Alternative sequenceiVSP_0120751926 – 1943GVGEN…PEVKQ → ALWFWDSMLKARLGGWRM in isoform TRPM6t. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0120761944 – 2022Missing in isoform TRPM6t. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF350881 mRNA Translation: AAK31202.2
AF448232 mRNA Translation: AAM21562.1
AY333282 mRNA Translation: AAR03487.1
AY333283 mRNA Translation: AAR03488.1
AY333284 mRNA Translation: AAR03489.1
AY333285 mRNA Translation: AAR03490.1
AY333286 mRNA Translation: AAR03491.1
AY333287 mRNA Translation: AAR03492.1
AY333288 mRNA Translation: AAR03493.1
AL354795 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55318.1 [Q9BX84-3]
CCDS55319.1 [Q9BX84-2]
CCDS6647.1 [Q9BX84-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001170781.1, NM_001177310.1 [Q9BX84-2]
NP_001170782.1, NM_001177311.1 [Q9BX84-3]
NP_060132.3, NM_017662.4 [Q9BX84-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360774; ENSP00000354006; ENSG00000119121 [Q9BX84-1]
ENST00000361255; ENSP00000354962; ENSG00000119121 [Q9BX84-3]
ENST00000449912; ENSP00000396672; ENSG00000119121 [Q9BX84-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140803

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140803

UCSC genome browser

More...
UCSCi
uc004ajk.1 human [Q9BX84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF350881 mRNA Translation: AAK31202.2
AF448232 mRNA Translation: AAM21562.1
AY333282 mRNA Translation: AAR03487.1
AY333283 mRNA Translation: AAR03488.1
AY333284 mRNA Translation: AAR03489.1
AY333285 mRNA Translation: AAR03490.1
AY333286 mRNA Translation: AAR03491.1
AY333287 mRNA Translation: AAR03492.1
AY333288 mRNA Translation: AAR03493.1
AL354795 Genomic DNA No translation available.
CCDSiCCDS55318.1 [Q9BX84-3]
CCDS55319.1 [Q9BX84-2]
CCDS6647.1 [Q9BX84-1]
RefSeqiNP_001170781.1, NM_001177310.1 [Q9BX84-2]
NP_001170782.1, NM_001177311.1 [Q9BX84-3]
NP_060132.3, NM_017662.4 [Q9BX84-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

CORUMiQ9BX84
IntActiQ9BX84, 3 interactors
MINTiQ9BX84
STRINGi9606.ENSP00000354006

Chemistry databases

BindingDBiQ9BX84
ChEMBLiCHEMBL1628470
DrugBankiDB09481 Magnesium carbonate
GuidetoPHARMACOLOGYi498

Protein family/group databases

TCDBi1.A.4.5.8 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ9BX84
PhosphoSitePlusiQ9BX84

Polymorphism and mutation databases

BioMutaiTRPM6
DMDMi56404951

Proteomic databases

MassIVEiQ9BX84
MaxQBiQ9BX84
PaxDbiQ9BX84
PeptideAtlasiQ9BX84
PRIDEiQ9BX84
ProteomicsDBi79380 [Q9BX84-1]
79381 [Q9BX84-2]
79382 [Q9BX84-3]
79383 [Q9BX84-4]
79384 [Q9BX84-5]
79385 [Q9BX84-6]
79386 [Q9BX84-7]

Genome annotation databases

EnsembliENST00000360774; ENSP00000354006; ENSG00000119121 [Q9BX84-1]
ENST00000361255; ENSP00000354962; ENSG00000119121 [Q9BX84-3]
ENST00000449912; ENSP00000396672; ENSG00000119121 [Q9BX84-2]
GeneIDi140803
KEGGihsa:140803
UCSCiuc004ajk.1 human [Q9BX84-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140803
DisGeNETi140803
EuPathDBiHostDB:ENSG00000119121.21

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRPM6
HGNCiHGNC:17995 TRPM6
MalaCardsiTRPM6
MIMi602014 phenotype
607009 gene
neXtProtiNX_Q9BX84
OpenTargetsiENSG00000119121
Orphaneti30924 Primary hypomagnesemia with secondary hypocalcemia
PharmGKBiPA38479

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INBW Eukaryota
ENOG410ZSH9 LUCA
GeneTreeiENSGT00940000158164
HOGENOMiHOG000230920
InParanoidiQ9BX84
KOiK04981
OMAiYVDMKSI
OrthoDBi738147at2759
PhylomeDBiQ9BX84
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRPM6 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TRPM6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140803
PharosiQ9BX84 Tchem

Protein Ontology

More...
PROi
PR:Q9BX84
RNActiQ9BX84 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119121 Expressed in 106 organ(s), highest expression level in colonic mucosa
ExpressionAtlasiQ9BX84 baseline and differential
GenevisibleiQ9BX84 HS

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR011009 Kinase-like_dom_sf
IPR004166 MHCK_EF2_kinase
IPR029597 TRPM6
IPR041491 TRPM_SLOG
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF15 PTHR13800:SF15, 1 hit
PfamiView protein in Pfam
PF02816 Alpha_kinase, 1 hit
PF00520 Ion_trans, 1 hit
PF18139 LSDAT_euk, 1 hit
PF16519 TRPM_tetra, 1 hit
SMARTiView protein in SMART
SM00811 Alpha_kinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51158 ALPHA_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BX84
Secondary accession number(s): Q6VPR8
, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2002
Last modified: December 11, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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