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Protein

Zinc finger protein 471

Gene

ZNF471

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 471
Alternative name(s):
EZFIT-related protein 1
Gene namesi
Name:ZNF471
Synonyms:ERP1, KIAA1396
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196263.7
HGNCiHGNC:23226 ZNF471
neXtProtiNX_Q9BX82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196263
PharmGKBiPA134940750

Polymorphism and mutation databases

BioMutaiZNF471
DMDMi37999856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476031 – 626Zinc finger protein 471Add BLAST626

Proteomic databases

PaxDbiQ9BX82
PeptideAtlasiQ9BX82
PRIDEiQ9BX82
ProteomicsDBi79379

PTM databases

iPTMnetiQ9BX82
PhosphoSitePlusiQ9BX82

Expressioni

Gene expression databases

BgeeiENSG00000196263
CleanExiHS_ZNF471
ExpressionAtlasiQ9BX82 baseline and differential
GenevisibleiQ9BX82 HS

Organism-specific databases

HPAiHPA066695

Interactioni

Protein-protein interaction databases

BioGridi121626, 10 interactors
IntActiQ9BX82, 1 interactor
STRINGi9606.ENSP00000309161

Structurei

3D structure databases

ProteinModelPortaliQ9BX82
SMRiQ9BX82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri543 – 565C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 593C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9BX82
KOiK09228
OMAiPFSDWES
OrthoDBiEOG091G02KC
PhylomeDBiQ9BX82
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BX82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVEVVKVMP QDLVTFKDVA IDFSQEEWQW MNPAQKRLYR SMMLENYQSL
60 70 80 90 100
VSLGLCISKP YVISLLEQGR EPWEMTSEMT RSPFSDWESI YVTQELPLKQ
110 120 130 140 150
FMYDDACMEG ITSYGLECST FEENWKWEDL FEKQMGSHEM FSKKEIITHK
160 170 180 190 200
ETITKETEFK YTKFGKCIHL ENIEESIYNH TSDKKSFSKN SMVIKHKKVY
210 220 230 240 250
VGKKLFKCNE CDKTFTHSSS LTVHFRIHTG EKPYACEECG KAFKQRQHLA
260 270 280 290 300
QHHRTHTGEK LFECKECRKA FKQSEHLIQH QRIHTGEKPY KCKECRKAFR
310 320 330 340 350
QPAHLAQHQR IHTGEKPYEC KECGKAFSDG SSFARHQRCH TGKRPYECIE
360 370 380 390 400
CGKAFRYNTS FIRHWRSYHT GEKPFNCIDC GKAFSVHIGL ILHRRIHTGE
410 420 430 440 450
KPYKCGVCGK TFSSGSSRTV HQRIHTGEKP YECDICGKDF SHHASLTQHQ
460 470 480 490 500
RVHSGEKPYE CKECGKAFRQ NVHLVSHLRI HTGEKPYECK ECGKAFRISS
510 520 530 540 550
QLATHQRIHT GEKPYECIEC GNAFKQRSHL AQHQKTHTGE KPYECNECGK
560 570 580 590 600
AFSQTSNLTQ HQRIHTGEKP YKCTECGKAF SDSSSCAQHQ RLHTGQRPYQ
610 620
CFECGKAFRR KLSLICHQRS HTGEEP
Length:626
Mass (Da):73,009
Last modified:June 1, 2001 - v1
Checksum:i7F47ACFB04CE99AA
GO
Isoform 2 (identifier: Q9BX82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-247: DWESIYVTQE...ECGKAFKQRQ → EFILVKNHMH...LIVGKPSVFT
     248-626: Missing.

Note: No experimental confirmation available.
Show »
Length:247
Mass (Da):28,176
Checksum:i29DE370951019E57
GO

Sequence cautioni

The sequence AAC32422 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61Y → C in CAD38551 (PubMed:17974005).Curated1
Sequence conflicti407V → A in CAD38551 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052836192M → I1 PublicationCorresponds to variant dbSNP:rs11667052Ensembl.1
Natural variantiVAR_061951309Q → R. Corresponds to variant dbSNP:rs45487092Ensembl.1
Natural variantiVAR_035583361F → C in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_052837406G → D3 PublicationsCorresponds to variant dbSNP:rs3752176Ensembl.1
Natural variantiVAR_052838556S → C1 PublicationCorresponds to variant dbSNP:rs16987303Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05595586 – 247DWESI…FKQRQ → EFILVKNHMHVRNVEKPSSK GNTLLNITEHILERNSLNVK NVGKPSNKVNTLFSIKEFIL EKNHINVRNAEKPSDSLHTL LSIREFILERNPMNVKNVAK PSVMARLLLDIRDVTLAKDP MNVLSVGRLLGITHLLFVTG GVIILERSLLIALIVGKPSV FT in isoform 2. 1 PublicationAdd BLAST162
Alternative sequenceiVSP_055956248 – 626Missing in isoform 2. 1 PublicationAdd BLAST379

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352026 mRNA Translation: AAK30252.1
AK291416 mRNA Translation: BAF84105.1
AK293908 mRNA Translation: BAG57293.1
AL831845 mRNA Translation: CAD38551.1
AC004696 Genomic DNA No translation available.
AC005498 Genomic DNA Translation: AAC32422.1 Sequence problems.
BC125221 mRNA Translation: AAI25222.1
BC125222 mRNA Translation: AAI25223.1
AB037817 mRNA Translation: BAA92634.1
CCDSiCCDS12945.1 [Q9BX82-1]
RefSeqiNP_001308697.1, NM_001321768.1
NP_065864.2, NM_020813.3 [Q9BX82-1]
XP_011525450.1, XM_011527148.1 [Q9BX82-1]
UniGeneiHs.230188
Hs.710590

Genome annotation databases

EnsembliENST00000308031; ENSP00000309161; ENSG00000196263 [Q9BX82-1]
ENST00000591537; ENSP00000466224; ENSG00000196263 [Q9BX82-2]
GeneIDi57573
KEGGihsa:57573
UCSCiuc002qnh.4 human [Q9BX82-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN471_HUMAN
AccessioniPrimary (citable) accession number: Q9BX82
Secondary accession number(s): B4DF32
, O75260, Q08AD6, Q08AD7, Q8N3V1, Q9P2F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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