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UniProtKB - Q9BX74 (TM2D1_HUMAN)
Protein
TM2 domain-containing protein 1
Gene
TM2D1
Organism
Homo sapiens (Human)
Status
Functioni
May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
2 PublicationsCaution
Was originally (PubMed:11278849) thought to modulate amyloid-beta toxicity by coupling to G protein. However, PubMed:12836168 showed that this effect is not direct.1 Publication
GO - Molecular functioni
- amyloid-beta binding Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- apoptotic signaling pathway Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q9BX74 |
SignaLinki | Q9BX74 |
Names & Taxonomyi
Protein namesi | Recommended name: TM2 domain-containing protein 1Alternative name(s): Amyloid-beta-binding protein Short name: hBBP |
Gene namesi | Name:TM2D1 Synonyms:BBP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24142, TM2D1 |
MIMi | 610080, gene |
neXtProti | NX_Q9BX74 |
VEuPathDBi | HostDB:ENSG00000162604 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 119 – 136 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 83941 |
OpenTargetsi | ENSG00000162604 |
PharmGKBi | PA142670798 |
Miscellaneous databases
Pharosi | Q9BX74, Tdark |
Genetic variation databases
BioMutai | TM2D1 |
DMDMi | 74752423 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 37 | 1 PublicationAdd BLAST | 37 | |
ChainiPRO_5000060231 | 38 – 207 | TM2 domain-containing protein 1Add BLAST | 170 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 87 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9BX74 |
PaxDbi | Q9BX74 |
PeptideAtlasi | Q9BX74 |
PRIDEi | Q9BX74 |
ProteomicsDBi | 79374 |
PTM databases
GlyConnecti | 1813, 1 N-Linked glycan (1 site) |
GlyGeni | Q9BX74, 5 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9BX74 |
PhosphoSitePlusi | Q9BX74 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000162604, Expressed in endothelial cell and 246 other tissues |
ExpressionAtlasi | Q9BX74, baseline and differential |
Genevisiblei | Q9BX74, HS |
Organism-specific databases
HPAi | ENSG00000162604, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with APP beta-APP42 (amyloid-beta protein 42).
1 PublicationBinary interactionsi
Q9BX74
With | #Exp. | IntAct |
---|---|---|
APLP2 - isoform 5 [Q06481-5] | 3 | EBI-25832057,EBI-25646567 |
APP [P05067] | 3 | EBI-25832057,EBI-77613 |
CASP1 - isoform Gamma [P29466-3] | 3 | EBI-25832057,EBI-12248206 |
Protein-protein interaction databases
BioGRIDi | 123824, 6 interactors |
IntActi | Q9BX74, 3 interactors |
STRINGi | 9606.ENSP00000475700 |
Miscellaneous databases
RNActi | Q9BX74, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the TM2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4272, Eukaryota |
GeneTreei | ENSGT00940000157668 |
HOGENOMi | CLU_110523_1_0_1 |
InParanoidi | Q9BX74 |
OMAi | ETFRKPH |
OrthoDBi | 1004046at2759 |
PhylomeDBi | Q9BX74 |
Family and domain databases
InterProi | View protein in InterPro IPR007829, TM2 |
Pfami | View protein in Pfam PF05154, TM2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q9BX74-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAWPSGPS APEAVTARLV GVLWFVSVTT GPWGAVATSA GGEESLKCED
60 70 80 90 100
LKVGQYICKD PKINDATQEP VNCTNYTAHV SCFPAPNITC KDSSGNETHF
110 120 130 140 150
TGNEVGFFKP ISCRNVNGYS YKVAVALSLF LGWLGADRFY LGYPALGLLK
160 170 180 190 200
FCTVGFCGIG SLIDFILISM QIVGPSDGSS YIIDYYGTRL TRLSITNETF
RKTQLYP
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3KPW4 | U3KPW4_HUMAN | TM2 domain-containing protein 1 | TM2D1 | 186 | Annotation score: | ||
J3KPA2 | J3KPA2_HUMAN | TM2 domain containing 1, isoform CR... | TM2D1 hCG_1780983 | 269 | Annotation score: | ||
U3KPS6 | U3KPS6_HUMAN | TM2 domain-containing protein 1 | TM2D1 | 53 | Annotation score: | ||
U3KQS3 | U3KQS3_HUMAN | TM2 domain-containing protein 1 | TM2D1 | 104 | Annotation score: | ||
U3KQ44 | U3KQ44_HUMAN | TM2 domain-containing protein 1 | TM2D1 | 76 | Annotation score: | ||
U3KQF9 | U3KQF9_HUMAN | TM2 domain-containing protein 1 | TM2D1 | 77 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF353990 mRNA Translation: AAK35064.1 AC099791 Genomic DNA No translation available. BC029486 mRNA Translation: AAH29486.1 |
CCDSi | CCDS65554.1 |
RefSeqi | NP_114416.1, NM_032027.2 |
Genome annotation databases
Ensembli | ENST00000294613; ENSP00000294613; ENSG00000162604 ENST00000606498; ENSP00000475700; ENSG00000162604 |
GeneIDi | 83941 |
KEGGi | hsa:83941 |
MANE-Selecti | ENST00000606498.5; ENSP00000475700.1; NM_032027.3; NP_114416.1 |
UCSCi | uc001czz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF353990 mRNA Translation: AAK35064.1 AC099791 Genomic DNA No translation available. BC029486 mRNA Translation: AAH29486.1 |
CCDSi | CCDS65554.1 |
RefSeqi | NP_114416.1, NM_032027.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123824, 6 interactors |
IntActi | Q9BX74, 3 interactors |
STRINGi | 9606.ENSP00000475700 |
PTM databases
GlyConnecti | 1813, 1 N-Linked glycan (1 site) |
GlyGeni | Q9BX74, 5 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9BX74 |
PhosphoSitePlusi | Q9BX74 |
Genetic variation databases
BioMutai | TM2D1 |
DMDMi | 74752423 |
Proteomic databases
MassIVEi | Q9BX74 |
PaxDbi | Q9BX74 |
PeptideAtlasi | Q9BX74 |
PRIDEi | Q9BX74 |
ProteomicsDBi | 79374 |
Protocols and materials databases
Antibodypediai | 46902, 66 antibodies from 17 providers |
DNASUi | 83941 |
Genome annotation databases
Ensembli | ENST00000294613; ENSP00000294613; ENSG00000162604 ENST00000606498; ENSP00000475700; ENSG00000162604 |
GeneIDi | 83941 |
KEGGi | hsa:83941 |
MANE-Selecti | ENST00000606498.5; ENSP00000475700.1; NM_032027.3; NP_114416.1 |
UCSCi | uc001czz.1, human |
Organism-specific databases
CTDi | 83941 |
DisGeNETi | 83941 |
GeneCardsi | TM2D1 |
HGNCi | HGNC:24142, TM2D1 |
HPAi | ENSG00000162604, Low tissue specificity |
MIMi | 610080, gene |
neXtProti | NX_Q9BX74 |
OpenTargetsi | ENSG00000162604 |
PharmGKBi | PA142670798 |
VEuPathDBi | HostDB:ENSG00000162604 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4272, Eukaryota |
GeneTreei | ENSGT00940000157668 |
HOGENOMi | CLU_110523_1_0_1 |
InParanoidi | Q9BX74 |
OMAi | ETFRKPH |
OrthoDBi | 1004046at2759 |
PhylomeDBi | Q9BX74 |
Enzyme and pathway databases
PathwayCommonsi | Q9BX74 |
SignaLinki | Q9BX74 |
Miscellaneous databases
BioGRID-ORCSi | 83941, 60 hits in 1022 CRISPR screens |
ChiTaRSi | TM2D1, human |
GenomeRNAii | 83941 |
Pharosi | Q9BX74, Tdark |
PROi | PR:Q9BX74 |
RNActi | Q9BX74, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162604, Expressed in endothelial cell and 246 other tissues |
ExpressionAtlasi | Q9BX74, baseline and differential |
Genevisiblei | Q9BX74, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007829, TM2 |
Pfami | View protein in Pfam PF05154, TM2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM2D1_HUMAN | |
Accessioni | Q9BX74Primary (citable) accession number: Q9BX74 Secondary accession number(s): A6NDA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families