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Protein

Histidine triad nucleotide-binding protein 2, mitochondrial

Gene

HINT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=128 µM for adenosine 5'-O-p-nitrophenylphosphoramidate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63Purine nucleotide phosphoramidateCombined sources1 Publication1
    Binding sitei80Purine nucleotide phosphoramidateCombined sources1 Publication1
    Binding sitei136Purine nucleotide phosphoramidateCombined sources1 Publication1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei149Tele-AMP-histidine intermediate1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi142 – 145Purine nucleotide phosphoramidateCombined sources1 Publication4
    Nucleotide bindingi149 – 151Purine nucleotide phosphoramidateCombined sources1 Publication3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processApoptosis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
    LigandNucleotide-binding

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histidine triad nucleotide-binding protein 2, mitochondrialCurated (EC:3.-.-.-)
    Short name:
    HINT-21 Publication
    Alternative name(s):
    HINT-31 Publication
    HIT-17kDa1 Publication
    PKCI-1-related HIT protein1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:HINT2Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000137133.10

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:18344 HINT2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609997 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9BX68

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi149H → A: Loss of adenosine phosphoramidase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    84681

    Open Targets

    More...
    OpenTargetsi
    ENSG00000137133

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29287

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    HINT2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    51701612

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000010978618 – 163Histidine triad nucleotide-binding protein 2, mitochondrialAdd BLAST146

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei119N6-acetyllysineBy similarity1
    Modified residuei139N6-acetyllysineBy similarity1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9BX68

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9BX68

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9BX68

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9BX68

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9BX68

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    79368

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q9BX68

    2D gel databases

    USC-OGP 2-DE database

    More...
    OGPi
    Q9BX68

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9BX68

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9BX68

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000137133 Expressed in 198 organ(s), highest expression level in right lobe of liver

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_HINT2

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9BX68 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA020961
    HPA059109

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    124200, 33 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9BX68, 5 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9BX68

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000259667

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1163
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9BX68

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9BX68

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 163HITPROSITE-ProRule annotationAdd BLAST109

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi147 – 151Histidine triad motif5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the HINT family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3275 Eukaryota
    COG0537 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157905

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000061064

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG051906

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9BX68

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NVAKQES

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G1001

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9BX68

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314862

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.428.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR019808 Histidine_triad_CS
    IPR001310 Histidine_triad_HIT
    IPR011146 HIT-like
    IPR036265 HIT-like_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR23089 PTHR23089, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01230 HIT, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00332 HISTRIAD

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54197 SSF54197, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00892 HIT_1, 1 hit
    PS51084 HIT_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BX68-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAAVVLAAG LRAARRAVAA TGVRGGQVRG AAGVTDGNEV AKAQQATPGG
    60 70 80 90 100
    AAPTIFSRIL DKSLPADILY EDQQCLVFRD VAPQAPVHFL VIPKKPIPRI
    110 120 130 140 150
    SQAEEEDQQL LGHLLLVAKQ TAKAEGLGDG YRLVINDGKL GAQSVYHLHI
    160
    HVLGGRQLQW PPG
    Length:163
    Mass (Da):17,162
    Last modified:June 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63A0C15D13749F99
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF356515 mRNA Translation: AAK37562.1
    AY033094 mRNA Translation: AAK53455.1
    AF490476 Genomic DNA Translation: AAM09526.1
    AF356875 mRNA Translation: AAM00221.1
    AL133410 Genomic DNA No translation available.
    CH471071 Genomic DNA Translation: EAW58332.1
    BC047737 mRNA Translation: AAH47737.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS6594.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_115982.1, NM_032593.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.70573

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000259667; ENSP00000259667; ENSG00000137133

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    84681

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:84681

    UCSC genome browser

    More...
    UCSCi
    uc003zyh.4 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF356515 mRNA Translation: AAK37562.1
    AY033094 mRNA Translation: AAK53455.1
    AF490476 Genomic DNA Translation: AAM09526.1
    AF356875 mRNA Translation: AAM00221.1
    AL133410 Genomic DNA No translation available.
    CH471071 Genomic DNA Translation: EAW58332.1
    BC047737 mRNA Translation: AAH47737.1
    CCDSiCCDS6594.1
    RefSeqiNP_115982.1, NM_032593.2
    UniGeneiHs.70573

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4INCX-ray1.19A/B37-163[»]
    4INIX-ray1.65A/B37-163[»]
    4NJXX-ray2.83A/B/C/D1-163[»]
    4NJYX-ray1.32A1-163[»]
    4NJZX-ray2.40A/B/C/D1-163[»]
    4NK0X-ray2.02A/B1-163[»]
    5KM5X-ray2.10A/B26-163[»]
    5KM8X-ray2.00A/B26-163[»]
    5KM9X-ray1.45A/B26-163[»]
    ProteinModelPortaliQ9BX68
    SMRiQ9BX68
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi124200, 33 interactors
    IntActiQ9BX68, 5 interactors
    MINTiQ9BX68
    STRINGi9606.ENSP00000259667

    PTM databases

    iPTMnetiQ9BX68
    PhosphoSitePlusiQ9BX68

    Polymorphism and mutation databases

    BioMutaiHINT2
    DMDMi51701612

    2D gel databases

    OGPiQ9BX68

    Proteomic databases

    EPDiQ9BX68
    MaxQBiQ9BX68
    PaxDbiQ9BX68
    PeptideAtlasiQ9BX68
    PRIDEiQ9BX68
    ProteomicsDBi79368
    TopDownProteomicsiQ9BX68

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    84681
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000259667; ENSP00000259667; ENSG00000137133
    GeneIDi84681
    KEGGihsa:84681
    UCSCiuc003zyh.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    84681
    DisGeNETi84681
    EuPathDBiHostDB:ENSG00000137133.10

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    HINT2
    HGNCiHGNC:18344 HINT2
    HPAiHPA020961
    HPA059109
    MIMi609997 gene
    neXtProtiNX_Q9BX68
    OpenTargetsiENSG00000137133
    PharmGKBiPA29287

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3275 Eukaryota
    COG0537 LUCA
    GeneTreeiENSGT00940000157905
    HOGENOMiHOG000061064
    HOVERGENiHBG051906
    InParanoidiQ9BX68
    OMAiNVAKQES
    OrthoDBiEOG091G1001
    PhylomeDBiQ9BX68
    TreeFamiTF314862

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    HINT2 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    84681

    Protein Ontology

    More...
    PROi
    PR:Q9BX68

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000137133 Expressed in 198 organ(s), highest expression level in right lobe of liver
    CleanExiHS_HINT2
    GenevisibleiQ9BX68 HS

    Family and domain databases

    Gene3Di3.30.428.10, 1 hit
    InterProiView protein in InterPro
    IPR019808 Histidine_triad_CS
    IPR001310 Histidine_triad_HIT
    IPR011146 HIT-like
    IPR036265 HIT-like_sf
    PANTHERiPTHR23089 PTHR23089, 1 hit
    PfamiView protein in Pfam
    PF01230 HIT, 1 hit
    PRINTSiPR00332 HISTRIAD
    SUPFAMiSSF54197 SSF54197, 1 hit
    PROSITEiView protein in PROSITE
    PS00892 HIT_1, 1 hit
    PS51084 HIT_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHINT2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BX68
    Secondary accession number(s): Q5TCW3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2001
    Last modified: December 5, 2018
    This is version 119 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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