UniProtKB - Q9BX66 (SRBS1_HUMAN)
Sorbin and SH3 domain-containing protein 1
SORBS1
Functioni
GO - Molecular functioni
- actin binding Source: ProtInc
- cytoskeletal protein binding Source: ProtInc
- insulin receptor binding Source: UniProtKB
- signaling receptor complex adaptor activity Source: BHF-UCL
GO - Biological processi
- cell-matrix adhesion Source: ProtInc
- cellular response to insulin stimulus Source: BHF-UCL
- focal adhesion assembly Source: UniProtKB
- insulin receptor signaling pathway Source: UniProtKB
- muscle contraction Source: Reactome
- positive regulation of glucose import Source: UniProtKB
- positive regulation of glycogen biosynthetic process Source: BHF-UCL
- positive regulation of insulin receptor signaling pathway Source: UniProtKB
- positive regulation of lipid biosynthetic process Source: BHF-UCL
- positive regulation of protein localization to plasma membrane Source: BHF-UCL
- stress fiber assembly Source: UniProtKB
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9BX66 |
Reactomei | R-HSA-445355, Smooth Muscle Contraction |
SignaLinki | Q9BX66 |
SIGNORi | Q9BX66 |
Names & Taxonomyi
Protein namesi | Recommended name: Sorbin and SH3 domain-containing protein 1Alternative name(s): Ponsin SH3 domain protein 5 SH3P12 c-Cbl-associated protein Short name: CAP |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14565, SORBS1 |
MIMi | 605264, gene |
neXtProti | NX_Q9BX66 |
VEuPathDBi | HostDB:ENSG00000095637.21 |
Subcellular locationi
Cytoskeleton
Nucleus
- Nucleus By similarity
- Nucleus matrix By similarity
Plasma membrane
Other locations
Note: Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.By similarity
Cytoskeleton
- centrosome Source: HPA
- stress fiber Source: UniProtKB
Cytosol
- cytosol Source: BHF-UCL
Nucleus
- nuclear matrix Source: UniProtKB-SubCell
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- adherens junction Source: UniProtKB
- cell-substrate junction Source: UniProtKB
- focal adhesion Source: HPA
- membrane raft Source: UniProtKB
- zonula adherens Source: ProtInc
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10580 |
OpenTargetsi | ENSG00000095637 |
PharmGKBi | PA37899 |
Miscellaneous databases
Pharosi | Q9BX66, Tbio |
Genetic variation databases
BioMutai | SORBS1 |
DMDMi | 317373504 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072185 | 1 – 1292 | Sorbin and SH3 domain-containing protein 1Add BLAST | 1292 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 82 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 86 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 89 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 242 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 259 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 341 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 344 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 350 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 369 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 374 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 465 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 472 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 481 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 536 | Phosphotyrosine; by ABL1By similarity | 1 | ||
Modified residuei | 556 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 609 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 640 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 654 | Phosphotyrosine; by ABL1By similarity | 1 | ||
Modified residuei | 665 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 708 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 713 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 862 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 937 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 945 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 953 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1240 | Phosphotyrosine; by ABL1By similarity | 1 | ||
Isoform 41 Publication (identifier: Q9BX66-4) | |||||
Modified residuei | 105 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 346 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 603 | PhosphoserineCombined sources | 1 | ||
Isoform 81 Publication (identifier: Q9BX66-8) | |||||
Modified residuei | 114 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 730 | PhosphoserineCombined sources | 1 | ||
Isoform 12 (identifier: Q9BX66-12) | |||||
Modified residuei | 114 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1213 | PhosphoserineCombined sources | 1 | ||
Isoform 61 Publication (identifier: Q9BX66-6) | |||||
Modified residuei | 137 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 452 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 765 | PhosphoserineCombined sources | 1 | ||
Isoform 9Curated (identifier: Q9BX66-9) | |||||
Modified residuei | 146 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 387 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 700 | PhosphoserineCombined sources | 1 | ||
Isoform 7Curated (identifier: Q9BX66-7) | |||||
Modified residuei | 469 | PhosphoserineCombined sources | 1 | ||
Isoform 10Curated (identifier: Q9BX66-10) | |||||
Modified residuei | 478 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 735 | PhosphoserineCombined sources | 1 | ||
Isoform 51 Publication (identifier: Q9BX66-5) | |||||
Modified residuei | 923 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9BX66 |
jPOSTi | Q9BX66 |
MassIVEi | Q9BX66 |
MaxQBi | Q9BX66 |
PaxDbi | Q9BX66 |
PeptideAtlasi | Q9BX66 |
PRIDEi | Q9BX66 |
ProteomicsDBi | 79354 [Q9BX66-1] 79355 [Q9BX66-10] 79356 [Q9BX66-11] 79357 [Q9BX66-12] 79358 [Q9BX66-2] 79359 [Q9BX66-3] 79360 [Q9BX66-4] 79361 [Q9BX66-5] 79362 [Q9BX66-6] 79363 [Q9BX66-7] 79364 [Q9BX66-8] 79365 [Q9BX66-9] |
PTM databases
iPTMneti | Q9BX66 |
PhosphoSitePlusi | Q9BX66 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000095637, Expressed in blood vessel layer and 240 other tissues |
ExpressionAtlasi | Q9BX66, baseline and differential |
Genevisiblei | Q9BX66, HS |
Organism-specific databases
HPAi | ENSG00000095637, Tissue enhanced (smooth) |
Interactioni
Subunit structurei
Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus.
Interacts with INSM1 (By similarity).
Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex.
Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1.
Interacts with the insulin receptor but dissociates from it following insulin stimulation.
Also interacts with SCA7, PTK2/FAK1 and flotillin.
Interacts (via SH3 domain 2) with PXN.
By similarity4 PublicationsBinary interactionsi
Hide detailsQ9BX66
Isoform 7 [Q9BX66-7]
With | #Exp. | IntAct |
---|---|---|
RTN4IP1 [Q8WWV3] | 3 | EBI-17775963,EBI-743502 |
GO - Molecular functioni
- actin binding Source: ProtInc
- cytoskeletal protein binding Source: ProtInc
- insulin receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115831, 54 interactors |
CORUMi | Q9BX66 |
IntActi | Q9BX66, 45 interactors |
MINTi | Q9BX66 |
STRINGi | 9606.ENSP00000360293 |
Miscellaneous databases
RNActi | Q9BX66, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9BX66 |
SMRi | Q9BX66 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BX66 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 366 – 469 | SoHoPROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 793 – 852 | SH3 1PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 867 – 928 | SH3 2PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 1231 – 1292 | SH3 3PROSITE-ProRule annotationAdd BLAST | 62 |
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG4225, Eukaryota |
GeneTreei | ENSGT00940000158658 |
HOGENOMi | CLU_003951_1_1_1 |
InParanoidi | Q9BX66 |
OMAi | HAITSEW |
OrthoDBi | 228183at2759 |
PhylomeDBi | Q9BX66 |
TreeFami | TF320680 |
Family and domain databases
CDDi | cd11919, SH3_Sorbs1_1, 1 hit cd11922, SH3_Sorbs1_2, 1 hit cd11916, SH3_Sorbs1_3, 1 hit |
InterProi | View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003127, SoHo_dom IPR035606, SORBS1_SH3 IPR035610, SORBS1_SH3_1 IPR035611, SORBS1_SH3_2 |
Pfami | View protein in Pfam PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit PF02208, Sorb, 1 hit |
SMARTi | View protein in SMART SM00326, SH3, 3 hits SM00459, Sorb, 1 hit |
SUPFAMi | SSF50044, SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 3 hits PS50831, SOHO, 1 hit |
s (12+)i Sequence
Sequence statusi: Complete.
This entry describes 12 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 12 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA
60 70 80 90 100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP
110 120 130 140 150
GLEPEPSSAD EWRLSSSADA NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT
160 170 180 190 200
SSSAAQPEVI VVPLYLVNTD RGQEGTARPP TPLGPLGCVP TIPATASAAS
210 220 230 240 250
PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS FSPPPPLVPP
260 270 280 290 300
APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA
310 320 330 340 350
YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS
360 370 380 390 400
PGKAIEKRAK DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK
410 420 430 440 450
QIHKLNRDTP EENPYFPTYK FPELPEIQQT SEEDNPYTPT YQFPASTPSP
460 470 480 490 500
KSEDDDSDLY SPRYSFSEDT KSPLSVPRSK SEMSYIDGEK VVKRSATLPL
510 520 530 540 550
PARSSSLKSS SERNDWEPPD KKVDTRKYRA EPKSIYEYQP GKSSVLTNEK
560 570 580 590 600
MSRDISPEEI DLKNEPWYKF FSELEFGKPP PKKIWDYTPG DCSILPREDR
610 620 630 640 650
KTNLDKDLSL CQTELEADLE KMETLNKAPS ANVPQSSAIS PTPEISSETP
660 670 680 690 700
GYIYSSNFHA VKRESDGAPG DLTSLENERQ IYKSVLEGGD IPLQGLSGLK
710 720 730 740 750
RPSSSASTKD SESPRHFIPA DYLESTEEFI RRRHDDKEKL LADQRRLKRE
760 770 780 790 800
QEEADIAARR HTGVIPTHHQ FITNERFGDL LNIDDTAKRK SGSEMRPARA
810 820 830 840 850
KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG IFPRTYIELL
860 870 880 890 900
PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK GERITLLRQV
910 920 930 940 950
DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL PFSSSPSRSA
960 970 980 990 1000
TASPQFSSHS KLITPAPSSL PHSRRALSPE MHAVTSEWIS LTVGVPGRRS
1010 1020 1030 1040 1050
LALTPPLPPL PEASIYNTDH LALSPRASPS LSLSLPHLSW SDRPTPRSVA
1060 1070 1080 1090 1100
SPLALPSPHK TYSLAPTSQA SLHMNGDGGV HTPSSGIHQD SFLQLPLGSS
1110 1120 1130 1140 1150
DSVISQLSDA FSSQSKRQPW REESGQYERK AERGAGERGP GGPKISKKSC
1160 1170 1180 1190 1200
LKPSDVVRCL STEQRLSDLN TPEESRPGKP LGSAFPGSEA EQTERHRGGE
1210 1220 1230 1240 1250
QAGRKAARRG GSQQPQAQQR RVTPDRSQTS QDLFSYQALY SYIPQNDDEL
1260 1270 1280 1290
ELRDGDIVDV MEKCDDGWFV GTSRRTKQFG TFPGNYVKPL YL
The sequence of this isoform differs from the canonical sequence as follows:
26-57: Missing.
408-453: Missing.
552-635: Missing.
738-793: Missing.
955-1212: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
408-453: Missing.
1213-1213: Q → QLSHHSLRAGPDLTESEKSYV
The sequence of this isoform differs from the canonical sequence as follows:
26-57: Missing.
148-270: Missing.
319-328: Missing.
408-453: Missing.
580-601: Missing.
709-709: K → KVDRKGGNAH...PQSELAPSRG
955-1212: Missing.
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R303 | S4R303_HUMAN | Sorbin and SH3 domain-containing pr... | SORBS1 | 393 | Annotation score: | ||
A0A0U1RQI5 | A0A0U1RQI5_HUMAN | Sorbin and SH3 domain-containing pr... | SORBS1 | 507 | Annotation score: | ||
Q5T925 | Q5T925_HUMAN | Sorbin and SH3 domain-containing pr... | SORBS1 | 186 | Annotation score: | ||
A0A3B3IRR9 | A0A3B3IRR9_HUMAN | Sorbin and SH3 domain-containing pr... | SORBS1 | 143 | Annotation score: | ||
A0A3B3IRW8 | A0A3B3IRW8_HUMAN | Sorbin and SH3 domain-containing pr... | SORBS1 | 381 | Annotation score: | ||
S4R406 | S4R406_HUMAN | Sorbin and SH3 domain-containing pr... | SORBS1 | 145 | Annotation score: | ||
A0A3B3IT56 | A0A3B3IT56_HUMAN | Sorbin and SH3 domain-containing pr... | SORBS1 | 188 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 9 | S → P in CAJ97431 (PubMed:17462669).Curated | 1 | ||
Sequence conflicti | 18 | P → S in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 18 | P → S in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 110 | D → G in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 110 | D → G in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 113 | R → K in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 113 | R → K in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 131 | A → V in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 131 | A → V in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 134 | Y → S in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 134 | Y → S in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 226 – 228 | RAS → SAC in AAF22175 (PubMed:11532984).Curated | 3 | ||
Sequence conflicti | 264 | T → P in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 292 – 295 | PSVS → SSEC in AAD27647 (PubMed:11374898).Curated | 4 | ||
Sequence conflicti | 292 – 295 | PSVS → SSEC in AAF22175 (PubMed:11532984).Curated | 4 | ||
Sequence conflicti | 481 | S → R in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 489 | E → V in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 489 | E → V in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 607 | D → E in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 610 | L → F in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 644 | E → G in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 644 | E → G in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 679 | R → S in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 679 | R → S in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 690 | D → V in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 690 | D → V in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 694 | Q → R in CAJ97431 (PubMed:17462669).Curated | 1 | ||
Sequence conflicti | 695 | G → D in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 695 | G → D in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 710 | D → N in AAD27647 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 710 | D → N in AAF22175 (PubMed:11532984).Curated | 1 | ||
Sequence conflicti | 1156 | V → G in AAK37563 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 1156 | V → G in AAK37564 (PubMed:11374898).Curated | 1 | ||
Isoform 21 Publication (identifier: Q9BX66-2) | |||||
Sequence conflicti | 435 | K → E in AAK37564 (PubMed:11374898).Curated | 1 | ||
Sequence conflicti | 452 – 455 | AHCS → SRCG in AAK37564 (PubMed:11374898).Curated | 4 | ||
Sequence conflicti | 463 | N → D in AAK37564 (PubMed:11374898).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047652 | 61 | L → P8 PublicationsCorresponds to variant dbSNP:rs943542Ensembl. | 1 | |
Natural variantiVAR_019653 | 74 | R → W1 PublicationCorresponds to variant dbSNP:rs757431022Ensembl. | 1 | |
Natural variantiVAR_047653 | 175 | G → V. Corresponds to variant dbSNP:rs7081076Ensembl. | 1 | |
Natural variantiVAR_035661 | 195 | T → A in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_019654 | 237 | T → A Has a protective role in both obesity and diabetes. 1 PublicationCorresponds to variant dbSNP:rs2281939Ensembl. | 1 | |
Natural variantiVAR_047654 | 485 | Y → C. Corresponds to variant dbSNP:rs35808802Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050895 | 26 – 57 | Missing in isoform 4, isoform 7, isoform 8, isoform 10 and isoform 12. 4 PublicationsAdd BLAST | 32 | |
Alternative sequenceiVSP_050896 | 101 – 109 | Missing in isoform 4, isoform 5, isoform 6 and isoform 7. 4 Publications | 9 | |
Alternative sequenceiVSP_050898 | 147 – 215 | Missing in isoform 3. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_050899 | 148 – 270 | Missing in isoform 4, isoform 6, isoform 8, isoform 9 and isoform 12. 5 PublicationsAdd BLAST | 123 | |
Alternative sequenceiVSP_041193 | 319 – 328 | Missing in isoform 12. Curated | 10 | |
Alternative sequenceiVSP_050900 | 408 – 453 | Missing in isoform 3, isoform 4, isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 6 PublicationsAdd BLAST | 46 | |
Alternative sequenceiVSP_050901 | 431 – 451 | Missing in isoform 5. 3 PublicationsAdd BLAST | 21 | |
Alternative sequenceiVSP_050902 | 434 – 453 | DNPYT…SPKSE → TKSCSVMSPRLECSGTVIAH CSLKLLDSSNPPTSASQVAG TA in isoform 2. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_050903 | 552 – 635 | Missing in isoform 4, isoform 7, isoform 9 and isoform 10. 4 PublicationsAdd BLAST | 84 | |
Alternative sequenceiVSP_050905 | 580 – 635 | Missing in isoform 6. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_050904 | 580 – 601 | Missing in isoform 8 and isoform 12. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_050906 | 602 – 635 | Missing in isoform 3. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_041194 | 709 | K → KVDRKGGNAHMISSSSVHSR TFNTSNALGPVCKHKKPLSA AKACISEILPSKFKPRLSAP SALLQEQKSILLPSEKAQSC ENLCVSGSLNDSKRGLPLQV GGSIENLLMRSRRDYDSKSS STMSLQEYSTSGRRPCPLSR KAGMQFTMLYRDMHQINRSG LFLGSISSSSSVRDLASHFE KSSLALSRGELGPSQEGSEH IPKHTVSSRITAFEQLIQRS RSMPSLDLSGRLSKSPTPVL SRGSLTSARSAESLLESTKL HPKEMDGMNSSGVYASPTCS NMAHHALSFRGLVPSEPLST CSDDVDRCSNISTDSREGSG GSVHGDFPKHRLNKCKGTCP ASYTRFTTIRKHEQQQTSRQ PEWRLDARGDKSTLLRNIYL MSPLPFRLKKPLHHHPRQPS PGDSSGLLVGQKPDLPSQPH QDQPPSGGKPVVPTRLSSRH TMARLSRSSEPSQERPTALE DYPRAINNGNSVPYSDHSLD RNNNPQSELAPSRG in isoform 12. Curated | 1 | |
Alternative sequenceiVSP_050907 | 738 – 793 | Missing in isoform 4 and isoform 10. 2 PublicationsAdd BLAST | 56 | |
Alternative sequenceiVSP_050908 | 795 – 799 | MRPAR → KYDWA in isoform 7. 1 Publication | 5 | |
Alternative sequenceiVSP_050909 | 800 – 1292 | Missing in isoform 7. 1 PublicationAdd BLAST | 493 | |
Alternative sequenceiVSP_050911 | 955 – 1212 | Missing in isoform 4, isoform 5, isoform 6, isoform 8, isoform 9, isoform 10 and isoform 12. 7 PublicationsAdd BLAST | 258 | |
Alternative sequenceiVSP_050910 | 955 – 1117 | Missing in isoform 2. 1 PublicationAdd BLAST | 163 | |
Alternative sequenceiVSP_050912 | 956 – 975 | FSSHS…PHSRR → LSHHSLRAGPDLTESEKSYV in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_050913 | 976 – 1213 | Missing in isoform 3. 1 PublicationAdd BLAST | 238 | |
Alternative sequenceiVSP_039210 | 1213 | Q → QLSHHSLRAGPDLTESEKSY V in isoform 11. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DL3 | NMR | - | A | 796-850 | [»] | |
2ECZ | NMR | - | A | 870-926 | [»] | |
2LJ0 | NMR | - | A | 1228-1292 | [»] | |
2LJ1 | NMR | - | A | 1228-1291 | [»] | |
2MOX | NMR | - | A | 791-930 | [»] | |
2O2W | X-ray | 2.27 | A | 870-930 | [»] | |
2O31 | X-ray | 1.50 | A | 870-930 | [»] | |
2O9S | X-ray | 0.83 | A | 870-930 | [»] | |
2O9V | X-ray | 1.63 | A | 870-930 | [»] | |
4LN2 | X-ray | 1.00 | A | 866-930 | [»] | |
4LNP | X-ray | 1.41 | A | 794-854 | [»] | |
BMRBi | Q9BX66 | |||||
SMRi | Q9BX66 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115831, 54 interactors |
CORUMi | Q9BX66 |
IntActi | Q9BX66, 45 interactors |
MINTi | Q9BX66 |
STRINGi | 9606.ENSP00000360293 |
PTM databases
iPTMneti | Q9BX66 |
PhosphoSitePlusi | Q9BX66 |
Genetic variation databases
BioMutai | SORBS1 |
DMDMi | 317373504 |
Proteomic databases
EPDi | Q9BX66 |
jPOSTi | Q9BX66 |
MassIVEi | Q9BX66 |
MaxQBi | Q9BX66 |
PaxDbi | Q9BX66 |
PeptideAtlasi | Q9BX66 |
PRIDEi | Q9BX66 |
ProteomicsDBi | 79354 [Q9BX66-1] 79355 [Q9BX66-10] 79356 [Q9BX66-11] 79357 [Q9BX66-12] 79358 [Q9BX66-2] 79359 [Q9BX66-3] 79360 [Q9BX66-4] 79361 [Q9BX66-5] 79362 [Q9BX66-6] 79363 [Q9BX66-7] 79364 [Q9BX66-8] 79365 [Q9BX66-9] |
Protocols and materials databases
ABCDi | Q9BX66, 4 sequenced antibodies |
Antibodypediai | 30624, 256 antibodies |
DNASUi | 10580 |
Genome annotation databases
Organism-specific databases
CTDi | 10580 |
DisGeNETi | 10580 |
GeneCardsi | SORBS1 |
HGNCi | HGNC:14565, SORBS1 |
HPAi | ENSG00000095637, Tissue enhanced (smooth) |
MIMi | 605264, gene |
neXtProti | NX_Q9BX66 |
OpenTargetsi | ENSG00000095637 |
PharmGKBi | PA37899 |
VEuPathDBi | HostDB:ENSG00000095637.21 |
HUGEi | Search... Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4225, Eukaryota |
GeneTreei | ENSGT00940000158658 |
HOGENOMi | CLU_003951_1_1_1 |
InParanoidi | Q9BX66 |
OMAi | HAITSEW |
OrthoDBi | 228183at2759 |
PhylomeDBi | Q9BX66 |
TreeFami | TF320680 |
Enzyme and pathway databases
PathwayCommonsi | Q9BX66 |
Reactomei | R-HSA-445355, Smooth Muscle Contraction |
SignaLinki | Q9BX66 |
SIGNORi | Q9BX66 |
Miscellaneous databases
BioGRID-ORCSi | 10580, 5 hits in 997 CRISPR screens |
ChiTaRSi | SORBS1, human |
EvolutionaryTracei | Q9BX66 |
GeneWikii | SORBS1 |
GenomeRNAii | 10580 |
Pharosi | Q9BX66, Tbio |
PROi | PR:Q9BX66 |
RNActi | Q9BX66, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000095637, Expressed in blood vessel layer and 240 other tissues |
ExpressionAtlasi | Q9BX66, baseline and differential |
Genevisiblei | Q9BX66, HS |
Family and domain databases
CDDi | cd11919, SH3_Sorbs1_1, 1 hit cd11922, SH3_Sorbs1_2, 1 hit cd11916, SH3_Sorbs1_3, 1 hit |
InterProi | View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003127, SoHo_dom IPR035606, SORBS1_SH3 IPR035610, SORBS1_SH3_1 IPR035611, SORBS1_SH3_2 |
Pfami | View protein in Pfam PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit PF02208, Sorb, 1 hit |
SMARTi | View protein in SMART SM00326, SH3, 3 hits SM00459, Sorb, 1 hit |
SUPFAMi | SSF50044, SSF50044, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 3 hits PS50831, SOHO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRBS1_HUMAN | |
Accessioni | Q9BX66Primary (citable) accession number: Q9BX66 Secondary accession number(s): A0AED4 Q9Y338 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | January 11, 2011 | |
Last modified: | April 7, 2021 | |
This is version 194 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references