SORBS1

Functionⁱ

Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).By similarity

GO - Molecular functionⁱ

actin binding
Source: ProtInc
Traceable author statementⁱ
- "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions."
  Mandai K., Nakanishi H., Satoh A., Takahashi K., Satoh K., Nishioka H., Mizoguchi A., Takai Y.
  J. Cell Biol. 144:1001-1017(1999) [PubMed] [Europe PMC] [Abstract]
cytoskeletal protein binding
Source: ProtInc
Traceable author statementⁱ
- "Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions."
  Mandai K., Nakanishi H., Satoh A., Takahashi K., Satoh K., Nishioka H., Mizoguchi A., Takai Y.
  J. Cell Biol. 144:1001-1017(1999) [PubMed] [Europe PMC] [Abstract]
insulin receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.1
  "Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B."
  Lin W.-H., Huang C.-J., Liu M.-W., Chang H.-M., Chen Y.-J., Tai T.-Y., Chuang L.-M.
  Genomics 74:12-20(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, INTERACTION WITH ABL1 AND INSULIN RECEPTOR, VARIANT PRO-61.
signaling receptor complex adaptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- Ref.1
  "Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B."
  Lin W.-H., Huang C.-J., Liu M.-W., Chang H.-M., Chen Y.-J., Tai T.-Y., Chuang L.-M.
  Genomics 74:12-20(2001) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, INTERACTION WITH ABL1 AND INSULIN RECEPTOR, VARIANT PRO-61.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BX66
Reactomeⁱ	R-HSA-445355, Smooth Muscle Contraction
SignaLinkⁱ	Q9BX66
SIGNORⁱ	Q9BX66

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sorbin and SH3 domain-containing protein 1 Alternative name(s): Ponsin SH3 domain protein 5 SH3P12 c-Cbl-associated protein Short name: CAP
Gene namesⁱ	Name:SORBS1Imported Synonyms:KIAA0894, KIAA1296, SH3D5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14565, SORBS1
MIMⁱ	605264, gene
neXtProtⁱ	NX_Q9BX66
VEuPathDBⁱ	HostDB:ENSG00000095637.21

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10580
Open Targets More...OpenTargetsⁱ	ENSG00000095637
PharmGKBⁱ	PA37899

Miscellaneous databases

Pharosⁱ	Q9BX66, Tbio

Pharosⁱ

Q9BX66, Tbio

Genetic variation databases

BioMutaⁱ	SORBS1
DMDMⁱ	317373504

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072185	1 – 1292	Sorbin and SH3 domain-containing protein 1Add BLAST		1292

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	82	PhosphothreonineBy similarity	1
Modified residueⁱ	86	PhosphoserineCombined sources	1
Modified residueⁱ	89	PhosphoserineCombined sources	1
Modified residueⁱ	242	PhosphoserineCombined sources	1
Modified residueⁱ	259	PhosphoserineCombined sources	1
Modified residueⁱ	341	PhosphoserineCombined sources	1
Modified residueⁱ	344	PhosphothreonineBy similarity	1
Modified residueⁱ	350	PhosphoserineCombined sources	1
Modified residueⁱ	369	PhosphoserineBy similarity	1
Modified residueⁱ	374	PhosphoserineBy similarity	1
Modified residueⁱ	465	PhosphoserineBy similarity	1
Modified residueⁱ	472	PhosphoserineCombined sources	1
Modified residueⁱ	481	PhosphoserineCombined sources	1
Modified residueⁱ	536	Phosphotyrosine; by ABL1By similarity	1
Modified residueⁱ	556	PhosphoserineCombined sources	1
Modified residueⁱ	609	PhosphoserineBy similarity	1
Modified residueⁱ	640	PhosphoserineBy similarity	1
Modified residueⁱ	654	Phosphotyrosine; by ABL1By similarity	1
Modified residueⁱ	665	PhosphoserineCombined sources	1
Modified residueⁱ	708	PhosphothreonineCombined sources	1
Modified residueⁱ	713	PhosphoserineBy similarity	1
Modified residueⁱ	862	PhosphothreonineCombined sources	1
Modified residueⁱ	937	PhosphotyrosineCombined sources	1
Modified residueⁱ	945	PhosphoserineCombined sources	1
Modified residueⁱ	953	PhosphoserineBy similarity	1
Modified residueⁱ	1240	Phosphotyrosine; by ABL1By similarity	1
Isoform 41 Publication (identifier: Q9BX66-4)
Modified residueⁱ	105	PhosphoserineCombined sources	1
Modified residueⁱ	346	PhosphoserineCombined sources	1
Modified residueⁱ	603	PhosphoserineCombined sources	1
Isoform 81 Publication (identifier: Q9BX66-8)
Modified residueⁱ	114	PhosphoserineCombined sources	1
Modified residueⁱ	730	PhosphoserineCombined sources	1
Isoform 12 (identifier: Q9BX66-12)
Modified residueⁱ	114	PhosphoserineCombined sources	1
Modified residueⁱ	1213	PhosphoserineCombined sources	1
Isoform 61 Publication (identifier: Q9BX66-6)
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	452	PhosphoserineCombined sources	1
Modified residueⁱ	765	PhosphoserineCombined sources	1
Isoform 9Curated (identifier: Q9BX66-9)
Modified residueⁱ	146	PhosphoserineCombined sources	1
Modified residueⁱ	387	PhosphoserineCombined sources	1
Modified residueⁱ	700	PhosphoserineCombined sources	1
Isoform 7Curated (identifier: Q9BX66-7)
Modified residueⁱ	469	PhosphoserineCombined sources	1
Isoform 10Curated (identifier: Q9BX66-10)
Modified residueⁱ	478	PhosphoserineCombined sources	1
Modified residueⁱ	735	PhosphoserineCombined sources	1
Isoform 51 Publication (identifier: Q9BX66-5)
Modified residueⁱ	923	PhosphoserineCombined sources	1

Post-translational modificationⁱ

O-glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BX66
jPOSTⁱ	Q9BX66
MassIVEⁱ	Q9BX66
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BX66
PaxDbⁱ	Q9BX66
PeptideAtlas More...PeptideAtlasⁱ	Q9BX66
PRIDEⁱ	Q9BX66
ProteomicsDBⁱ	79354 [Q9BX66-1] 79355 [Q9BX66-10] 79356 [Q9BX66-11] 79357 [Q9BX66-12] 79358 [Q9BX66-2] 79359 [Q9BX66-3] 79360 [Q9BX66-4] 79361 [Q9BX66-5] 79362 [Q9BX66-6] 79363 [Q9BX66-7] 79364 [Q9BX66-8] 79365 [Q9BX66-9]

PTM databases

iPTMnetⁱ	Q9BX66
PhosphoSitePlusⁱ	Q9BX66

Expressionⁱ

Tissue specificityⁱ

Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000095637, Expressed in blood vessel layer and 240 other tissues
ExpressionAtlasⁱ	Q9BX66, baseline and differential
Genevisibleⁱ	Q9BX66, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000095637, Tissue enhanced (smooth)

HPAⁱ

ENSG00000095637, Tissue enhanced (smooth)

Interactionⁱ

Subunit structureⁱ

Interacts (via third SH3 domain) with the Ten-1 ICD form of TENM1; the interaction induces the translocation of SORBS1 to the nucleus.

Interacts with INSM1 (By similarity).

Interacts with the long isoform of AFDN and with VCL. AFDN and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex.

Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1.

Interacts with the insulin receptor but dissociates from it following insulin stimulation.

Also interacts with SCA7, PTK2/FAK1 and flotillin.

Interacts (via SH3 domain 2) with PXN.

By similarity4 Publications

Binary interactionsⁱ

Hide details

Q9BX66

With	#Exp.	IntAct
ABL1 [P00519]	2	EBI-433642,EBI-375543
ATXN7 [O15265]	15	EBI-433642,EBI-708350
HTT [P42858]	4	EBI-433642,EBI-466029
INPPL1 [O15357]	5	EBI-433642,EBI-1384248
PAK2 [Q13177]	2	EBI-433642,EBI-1045887
RIN3 [Q6NSK7]	3	EBI-433642,EBI-21369851
Dnm2 [P39052] from Rattus norvegicus.	5	EBI-433642,EBI-349613
H671_4g13114 [A0A061I5T4] from Cricetulus griseus.	2	EBI-433642,EBI-2504267

Isoform 7 [Q9BX66-7]

With	#Exp.	IntAct
RTN4IP1 [Q8WWV3]	3	EBI-17775963,EBI-743502

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	115831, 54 interactors
CORUMⁱ	Q9BX66
IntActⁱ	Q9BX66, 45 interactors
Molecular INTeraction database More...MINTⁱ	Q9BX66
STRINGⁱ	9606.ENSP00000360293

Miscellaneous databases

RNActⁱ	Q9BX66, protein

RNActⁱ

Q9BX66, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	796 – 802	Combined sources	7
Beta strandⁱ	808 – 811	Combined sources	4
Beta strandⁱ	819 – 825	Combined sources	7
Beta strandⁱ	827 – 835	Combined sources	9
Beta strandⁱ	838 – 843	Combined sources	6
Helixⁱ	844 – 846	Combined sources	3
Beta strandⁱ	847 – 849	Combined sources	3
Beta strandⁱ	863 – 865	Combined sources	3
Beta strandⁱ	870 – 874	Combined sources	5
Beta strandⁱ	882 – 885	Combined sources	4
Beta strandⁱ	893 – 899	Combined sources	7
Beta strandⁱ	901 – 908	Combined sources	8
Turnⁱ	910 – 912	Combined sources	3
Beta strandⁱ	915 – 919	Combined sources	5
Helixⁱ	920 – 922	Combined sources	3
Beta strandⁱ	923 – 927	Combined sources	5
Beta strandⁱ	1230 – 1233	Combined sources	4
Beta strandⁱ	1235 – 1240	Combined sources	6
Beta strandⁱ	1257 – 1263	Combined sources	7
Beta strandⁱ	1267 – 1273	Combined sources	7
Turnⁱ	1274 – 1276	Combined sources	3
Beta strandⁱ	1279 – 1283	Combined sources	5
Beta strandⁱ	1286 – 1289	Combined sources	4

Show more details

3D structure databases

BMRBⁱ	Q9BX66
SMRⁱ	Q9BX66
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BX66

EvolutionaryTraceⁱ

Q9BX66

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	366 – 469	SoHoPROSITE-ProRule annotationAdd BLAST	104
Domainⁱ	793 – 852	SH3 1PROSITE-ProRule annotationAdd BLAST	60
Domainⁱ	867 – 928	SH3 2PROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	1231 – 1292	SH3 3PROSITE-ProRule annotationAdd BLAST	62

Keywords - Domainⁱ

Repeat, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG4225, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158658
HOGENOMⁱ	CLU_003951_1_1_1
InParanoidⁱ	Q9BX66
OMAⁱ	HAITSEW
Database of Orthologous Groups More...OrthoDBⁱ	228183at2759
PhylomeDBⁱ	Q9BX66
TreeFamⁱ	TF320680

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11919, SH3_Sorbs1_1, 1 hit cd11922, SH3_Sorbs1_2, 1 hit cd11916, SH3_Sorbs1_3, 1 hit
InterProⁱ	View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003127, SoHo_dom IPR035606, SORBS1_SH3 IPR035610, SORBS1_SH3_1 IPR035611, SORBS1_SH3_2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit PF02208, Sorb, 1 hit
SMARTⁱ	View protein in SMART SM00326, SH3, 3 hits SM00459, Sorb, 1 hit
SUPFAMⁱ	SSF50044, SSF50044, 3 hits
PROSITEⁱ	View protein in PROSITE PS50002, SH3, 3 hits PS50831, SOHO, 1 hit

Sequences (12+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 12 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 12 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 Publication (identifier: Q9BX66-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA 
        60         70         80         90        100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP 
       110        120        130        140        150
GLEPEPSSAD EWRLSSSADA NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT 
       160        170        180        190        200
SSSAAQPEVI VVPLYLVNTD RGQEGTARPP TPLGPLGCVP TIPATASAAS 
       210        220        230        240        250
PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS FSPPPPLVPP 
       260        270        280        290        300
APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA 
       310        320        330        340        350
YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS 
       360        370        380        390        400
PGKAIEKRAK DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK 
       410        420        430        440        450
QIHKLNRDTP EENPYFPTYK FPELPEIQQT SEEDNPYTPT YQFPASTPSP 
       460        470        480        490        500
KSEDDDSDLY SPRYSFSEDT KSPLSVPRSK SEMSYIDGEK VVKRSATLPL 
       510        520        530        540        550
PARSSSLKSS SERNDWEPPD KKVDTRKYRA EPKSIYEYQP GKSSVLTNEK 
       560        570        580        590        600
MSRDISPEEI DLKNEPWYKF FSELEFGKPP PKKIWDYTPG DCSILPREDR 
       610        620        630        640        650
KTNLDKDLSL CQTELEADLE KMETLNKAPS ANVPQSSAIS PTPEISSETP 
       660        670        680        690        700
GYIYSSNFHA VKRESDGAPG DLTSLENERQ IYKSVLEGGD IPLQGLSGLK 
       710        720        730        740        750
RPSSSASTKD SESPRHFIPA DYLESTEEFI RRRHDDKEKL LADQRRLKRE 
       760        770        780        790        800
QEEADIAARR HTGVIPTHHQ FITNERFGDL LNIDDTAKRK SGSEMRPARA 
       810        820        830        840        850
KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG IFPRTYIELL 
       860        870        880        890        900
PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK GERITLLRQV 
       910        920        930        940        950
DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL PFSSSPSRSA 
       960        970        980        990       1000
TASPQFSSHS KLITPAPSSL PHSRRALSPE MHAVTSEWIS LTVGVPGRRS 
      1010       1020       1030       1040       1050
LALTPPLPPL PEASIYNTDH LALSPRASPS LSLSLPHLSW SDRPTPRSVA 
      1060       1070       1080       1090       1100
SPLALPSPHK TYSLAPTSQA SLHMNGDGGV HTPSSGIHQD SFLQLPLGSS 
      1110       1120       1130       1140       1150
DSVISQLSDA FSSQSKRQPW REESGQYERK AERGAGERGP GGPKISKKSC 
      1160       1170       1180       1190       1200
LKPSDVVRCL STEQRLSDLN TPEESRPGKP LGSAFPGSEA EQTERHRGGE 
      1210       1220       1230       1240       1250
QAGRKAARRG GSQQPQAQQR RVTPDRSQTS QDLFSYQALY SYIPQNDDEL 
      1260       1270       1280       1290 
ELRDGDIVDV MEKCDDGWFV GTSRRTKQFG TFPGNYVKPL YL

Length:1,292

Mass (Da):142,513

Last modified:January 11, 2011 - v3

Checksum:ⁱ70DA4169B6D82F06

GO

Isoform 21 Publication (identifier: Q9BX66-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
434-453: DNPYTPTYQFPASTPSPKSE → TKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTA
955-1117: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA 
        60         70         80         90        100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP 
       110        120        130        140        150
GLEPEPSSAD EWRLSSSADA NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT 
       160        170        180        190        200
SSSAAQPEVI VVPLYLVNTD RGQEGTARPP TPLGPLGCVP TIPATASAAS 
       210        220        230        240        250
PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS FSPPPPLVPP 
       260        270        280        290        300
APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA 
       310        320        330        340        350
YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS 
       360        370        380        390        400
PGKAIEKRAK DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK 
       410        420        430        440        450
QIHKLNRDTP EENPYFPTYK FPELPEIQQT SEETKSCSVM SPRLECSGTV 
       460        470        480        490        500
IAHCSLKLLD SSNPPTSASQ VAGTADDDSD LYSPRYSFSE DTKSPLSVPR 
       510        520        530        540        550
SKSEMSYIDG EKVVKRSATL PLPARSSSLK SSSERNDWEP PDKKVDTRKY 
       560        570        580        590        600
RAEPKSIYEY QPGKSSVLTN EKMSRDISPE EIDLKNEPWY KFFSELEFGK 
       610        620        630        640        650
PPPKKIWDYT PGDCSILPRE DRKTNLDKDL SLCQTELEAD LEKMETLNKA 
       660        670        680        690        700
PSANVPQSSA ISPTPEISSE TPGYIYSSNF HAVKRESDGA PGDLTSLENE 
       710        720        730        740        750
RQIYKSVLEG GDIPLQGLSG LKRPSSSAST KDSESPRHFI PADYLESTEE 
       760        770        780        790        800
FIRRRHDDKE KLLADQRRLK REQEEADIAA RRHTGVIPTH HQFITNERFG 
       810        820        830        840        850
DLLNIDDTAK RKSGSEMRPA RAKFDFKAQT LKELPLQKGD IVYIYKQIDQ 
       860        870        880        890        900
NWYEGEHHGR VGIFPRTYIE LLPPAEKAQP KKLTPVQVLE YGEAIAKFNF 
       910        920        930        940        950
NGDTQVEMSF RKGERITLLR QVDENWYEGR IPGTSRQGIF PITYVDVIKR 
       960        970        980        990       1000
PLVKNPVDYM DLPFSSSPSR SATASPQPWR EESGQYERKA ERGAGERGPG 
      1010       1020       1030       1040       1050
GPKISKKSCL KPSDVVRCLS TEQRLSDLNT PEESRPGKPL GSAFPGSEAE 
      1060       1070       1080       1090       1100
QTERHRGGEQ AGRKAARRGG SQQPQAQQRR VTPDRSQTSQ DLFSYQALYS 
      1110       1120       1130       1140       1150
YIPQNDDELE LRDGDIVDVM EKCDDGWFVG TSRRTKQFGT FPGNYVKPLY 

L

Show »

Length:1,151

Mass (Da):127,276

Checksum:ⁱC1BD7AD5D5BE1300

GO

Isoform 31 Publication (identifier: Q9BX66-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-215: Missing.
     408-453: Missing.
     602-635: Missing.
     956-975: FSSHSKLITPAPSSLPHSRR → LSHHSLRAGPDLTESEKSYV
     976-1213: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA 
        60         70         80         90        100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP 
       110        120        130        140        150
GLEPEPSSAD EWRLSSSADA NGNAQPSSLA AKGYRSVHPN LPSDKSQRWP 
       160        170        180        190        200
HHSQPARASG SFAPISQTPP SFSPPPPLVP PAPEDLRRVS EPDLTGAVSS 
       210        220        230        240        250
TDSSPLLNEV SSSLIGTDSQ AFPSVSKPSS AYPSTTIVNP TIVLLQHNRE 
       260        270        280        290        300
QQKRLSSLSD PVSERRVGEQ DSAPTQEKPT SPGKAIEKRA KDDSRRVVKS 
       310        320        330        340        350
TQDLSDVSMD EVGIPLRNTE RSKDWYKTMF KQIHKLNRDD DSDLYSPRYS 
       360        370        380        390        400
FSEDTKSPLS VPRSKSEMSY IDGEKVVKRS ATLPLPARSS SLKSSSERND 
       410        420        430        440        450
WEPPDKKVDT RKYRAEPKSI YEYQPGKSSV LTNEKMSRDI SPEEIDLKNE 
       460        470        480        490        500
PWYKFFSELE FGKPPPKKIW DYTPGDCSIL PREDRKSSAI SPTPEISSET 
       510        520        530        540        550
PGYIYSSNFH AVKRESDGAP GDLTSLENER QIYKSVLEGG DIPLQGLSGL 
       560        570        580        590        600
KRPSSSASTK DSESPRHFIP ADYLESTEEF IRRRHDDKEK LLADQRRLKR 
       610        620        630        640        650
EQEEADIAAR RHTGVIPTHH QFITNERFGD LLNIDDTAKR KSGSEMRPAR 
       660        670        680        690        700
AKFDFKAQTL KELPLQKGDI VYIYKQIDQN WYEGEHHGRV GIFPRTYIEL 
       710        720        730        740        750
LPPAEKAQPK KLTPVQVLEY GEAIAKFNFN GDTQVEMSFR KGERITLLRQ 
       760        770        780        790        800
VDENWYEGRI PGTSRQGIFP ITYVDVIKRP LVKNPVDYMD LPFSSSPSRS 
       810        820        830        840        850
ATASPQLSHH SLRAGPDLTE SEKSYVQPQA QQRRVTPDRS QTSQDLFSYQ 
       860        870        880        890        900
ALYSYIPQND DELELRDGDI VDVMEKCDDG WFVGTSRRTK QFGTFPGNYV 

KPLYL

Show »

Length:905

Mass (Da):101,082

Checksum:ⁱC44DB4C9B0526933

GO

Isoform 41 Publication (identifier: Q9BX66-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     101-109: Missing.
     148-270: Missing.
     408-453: Missing.
     552-635: Missing.
     738-793: Missing.
     955-1212: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET 
        60         70         80         90        100
PSSSPASPQE TRQHESKPDE WRLSSSADAN GNAQPSSLAA KGYRSVHPNL 
       110        120        130        140        150
PSDKSQDSSP LLNEVSSSLI GTDSQAFPSV SKPSSAYPST TIVNPTIVLL 
       160        170        180        190        200
QHNREQQKRL SSLSDPVSER RVGEQDSAPT QEKPTSPGKA IEKRAKDDSR 
       210        220        230        240        250
RVVKSTQDLS DVSMDEVGIP LRNTERSKDW YKTMFKQIHK LNRDDDSDLY 
       260        270        280        290        300
SPRYSFSEDT KSPLSVPRSK SEMSYIDGEK VVKRSATLPL PARSSSLKSS 
       310        320        330        340        350
SERNDWEPPD KKVDTRKYRA EPKSIYEYQP GKSSVLTNEK MSSAISPTPE 
       360        370        380        390        400
ISSETPGYIY SSNFHAVKRE SDGAPGDLTS LENERQIYKS VLEGGDIPLQ 
       410        420        430        440        450
GLSGLKRPSS SASTKDSESP RHFIPADYLE STEEFIRRRH DDKEMRPARA 
       460        470        480        490        500
KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG IFPRTYIELL 
       510        520        530        540        550
PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK GERITLLRQV 
       560        570        580        590        600
DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL PFSSSPSRSA 
       610        620        630        640        650
TASPQQPQAQ QRRVTPDRSQ TSQDLFSYQA LYSYIPQNDD ELELRDGDIV 
       660        670        680 
DVMEKCDDGW FVGTSRRTKQ FGTFPGNYVK PLYL

Show »

Length:684

Mass (Da):76,596

Checksum:ⁱ9A417161477CB810

GO

Isoform 51 Publication (identifier: Q9BX66-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-109: Missing.
     431-451: Missing.
     955-1212: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA 
        60         70         80         90        100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP 
       110        120        130        140        150
DEWRLSSSAD ANGNAQPSSL AAKGYRSVHP NLPSDKSQDA TSSSAAQPEV 
       160        170        180        190        200
IVVPLYLVNT DRGQEGTARP PTPLGPLGCV PTIPATASAA SPLTFPTLDD 
       210        220        230        240        250
FIPPHLQRWP HHSQPARASG SFAPISQTPP SFSPPPPLVP PAPEDLRRVS 
       260        270        280        290        300
EPDLTGAVSS TDSSPLLNEV SSSLIGTDSQ AFPSVSKPSS AYPSTTIVNP 
       310        320        330        340        350
TIVLLQHNRE QQKRLSSLSD PVSERRVGEQ DSAPTQEKPT SPGKAIEKRA 
       360        370        380        390        400
KDDSRRVVKS TQDLSDVSMD EVGIPLRNTE RSKDWYKTMF KQIHKLNRDT 
       410        420        430        440        450
PEENPYFPTY KFPELPEIQQ TSEDDDSDLY SPRYSFSEDT KSPLSVPRSK 
       460        470        480        490        500
SEMSYIDGEK VVKRSATLPL PARSSSLKSS SERNDWEPPD KKVDTRKYRA 
       510        520        530        540        550
EPKSIYEYQP GKSSVLTNEK MSRDISPEEI DLKNEPWYKF FSELEFGKPP 
       560        570        580        590        600
PKKIWDYTPG DCSILPREDR KTNLDKDLSL CQTELEADLE KMETLNKAPS 
       610        620        630        640        650
ANVPQSSAIS PTPEISSETP GYIYSSNFHA VKRESDGAPG DLTSLENERQ 
       660        670        680        690        700
IYKSVLEGGD IPLQGLSGLK RPSSSASTKD SESPRHFIPA DYLESTEEFI 
       710        720        730        740        750
RRRHDDKEKL LADQRRLKRE QEEADIAARR HTGVIPTHHQ FITNERFGDL 
       760        770        780        790        800
LNIDDTAKRK SGSEMRPARA KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW 
       810        820        830        840        850
YEGEHHGRVG IFPRTYIELL PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG 
       860        870        880        890        900
DTQVEMSFRK GERITLLRQV DENWYEGRIP GTSRQGIFPI TYVDVIKRPL 
       910        920        930        940        950
VKNPVDYMDL PFSSSPSRSA TASPQQPQAQ QRRVTPDRSQ TSQDLFSYQA 
       960        970        980        990       1000
LYSYIPQNDD ELELRDGDIV DVMEKCDDGW FVGTSRRTKQ FGTFPGNYVK 

PLYL

Show »

Length:1,004

Mass (Da):111,791

Checksum:ⁱ45A17463F7373E8B

GO

Isoform 61 Publication (identifier: Q9BX66-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-109: Missing.
     148-270: Missing.
     580-635: Missing.
     955-1212: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA 
        60         70         80         90        100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP 
       110        120        130        140        150
DEWRLSSSAD ANGNAQPSSL AAKGYRSVHP NLPSDKSQDS SPLLNEVSSS 
       160        170        180        190        200
LIGTDSQAFP SVSKPSSAYP STTIVNPTIV LLQHNREQQK RLSSLSDPVS 
       210        220        230        240        250
ERRVGEQDSA PTQEKPTSPG KAIEKRAKDD SRRVVKSTQD LSDVSMDEVG 
       260        270        280        290        300
IPLRNTERSK DWYKTMFKQI HKLNRDTPEE NPYFPTYKFP ELPEIQQTSE 
       310        320        330        340        350
EDNPYTPTYQ FPASTPSPKS EDDDSDLYSP RYSFSEDTKS PLSVPRSKSE 
       360        370        380        390        400
MSYIDGEKVV KRSATLPLPA RSSSLKSSSE RNDWEPPDKK VDTRKYRAEP 
       410        420        430        440        450
KSIYEYQPGK SSVLTNEKMS RDISPEEIDL KNEPWYKFFS ELEFGKPSSA 
       460        470        480        490        500
ISPTPEISSE TPGYIYSSNF HAVKRESDGA PGDLTSLENE RQIYKSVLEG 
       510        520        530        540        550
GDIPLQGLSG LKRPSSSAST KDSESPRHFI PADYLESTEE FIRRRHDDKE 
       560        570        580        590        600
KLLADQRRLK REQEEADIAA RRHTGVIPTH HQFITNERFG DLLNIDDTAK 
       610        620        630        640        650
RKSGSEMRPA RAKFDFKAQT LKELPLQKGD IVYIYKQIDQ NWYEGEHHGR 
       660        670        680        690        700
VGIFPRTYIE LLPPAEKAQP KKLTPVQVLE YGEAIAKFNF NGDTQVEMSF 
       710        720        730        740        750
RKGERITLLR QVDENWYEGR IPGTSRQGIF PITYVDVIKR PLVKNPVDYM 
       760        770        780        790        800
DLPFSSSPSR SATASPQQPQ AQQRRVTPDR SQTSQDLFSY QALYSYIPQN 
       810        820        830        840 
DDELELRDGD IVDVMEKCDD GWFVGTSRRT KQFGTFPGNY VKPLYL

Show »

Length:846

Mass (Da):95,036

Checksum:ⁱ61FC1B8026A7D9A1

GO

Isoform 7Curated (identifier: Q9BX66-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     101-109: Missing.
     408-453: Missing.
     552-635: Missing.
     795-799: MRPAR → KYDWA
     800-1292: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET 
        60         70         80         90        100
PSSSPASPQE TRQHESKPDE WRLSSSADAN GNAQPSSLAA KGYRSVHPNL 
       110        120        130        140        150
PSDKSQDATS SSAAQPEVIV VPLYLVNTDR GQEGTARPPT PLGPLGCVPT 
       160        170        180        190        200
IPATASAASP LTFPTLDDFI PPHLQRWPHH SQPARASGSF APISQTPPSF 
       210        220        230        240        250
SPPPPLVPPA PEDLRRVSEP DLTGAVSSTD SSPLLNEVSS SLIGTDSQAF 
       260        270        280        290        300
PSVSKPSSAY PSTTIVNPTI VLLQHNREQQ KRLSSLSDPV SERRVGEQDS 
       310        320        330        340        350
APTQEKPTSP GKAIEKRAKD DSRRVVKSTQ DLSDVSMDEV GIPLRNTERS 
       360        370        380        390        400
KDWYKTMFKQ IHKLNRDDDS DLYSPRYSFS EDTKSPLSVP RSKSEMSYID 
       410        420        430        440        450
GEKVVKRSAT LPLPARSSSL KSSSERNDWE PPDKKVDTRK YRAEPKSIYE 
       460        470        480        490        500
YQPGKSSVLT NEKMSSAISP TPEISSETPG YIYSSNFHAV KRESDGAPGD 
       510        520        530        540        550
LTSLENERQI YKSVLEGGDI PLQGLSGLKR PSSSASTKDS ESPRHFIPAD 
       560        570        580        590        600
YLESTEEFIR RRHDDKEKLL ADQRRLKREQ EEADIAARRH TGVIPTHHQF 
       610        620 
ITNERFGDLL NIDDTAKRKS GSEKYDWA

Show »

Length:628

Mass (Da):68,745

Checksum:ⁱ4B5BD67EF6355537

GO

Isoform 81 Publication (identifier: Q9BX66-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     148-270: Missing.
     408-453: Missing.
     580-601: Missing.
     955-1212: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET 
        60         70         80         90        100
PSSSPASPQE TRQHESKPGL EPEPSSADEW RLSSSADANG NAQPSSLAAK 
       110        120        130        140        150
GYRSVHPNLP SDKSQDSSPL LNEVSSSLIG TDSQAFPSVS KPSSAYPSTT 
       160        170        180        190        200
IVNPTIVLLQ HNREQQKRLS SLSDPVSERR VGEQDSAPTQ EKPTSPGKAI 
       210        220        230        240        250
EKRAKDDSRR VVKSTQDLSD VSMDEVGIPL RNTERSKDWY KTMFKQIHKL 
       260        270        280        290        300
NRDDDSDLYS PRYSFSEDTK SPLSVPRSKS EMSYIDGEKV VKRSATLPLP 
       310        320        330        340        350
ARSSSLKSSS ERNDWEPPDK KVDTRKYRAE PKSIYEYQPG KSSVLTNEKM 
       360        370        380        390        400
SRDISPEEID LKNEPWYKFF SELEFGKPTN LDKDLSLCQT ELEADLEKME 
       410        420        430        440        450
TLNKAPSANV PQSSAISPTP EISSETPGYI YSSNFHAVKR ESDGAPGDLT 
       460        470        480        490        500
SLENERQIYK SVLEGGDIPL QGLSGLKRPS SSASTKDSES PRHFIPADYL 
       510        520        530        540        550
ESTEEFIRRR HDDKEKLLAD QRRLKREQEE ADIAARRHTG VIPTHHQFIT 
       560        570        580        590        600
NERFGDLLNI DDTAKRKSGS EMRPARAKFD FKAQTLKELP LQKGDIVYIY 
       610        620        630        640        650
KQIDQNWYEG EHHGRVGIFP RTYIELLPPA EKAQPKKLTP VQVLEYGEAI 
       660        670        680        690        700
AKFNFNGDTQ VEMSFRKGER ITLLRQVDEN WYEGRIPGTS RQGIFPITYV 
       710        720        730        740        750
DVIKRPLVKN PVDYMDLPFS SSPSRSATAS PQQPQAQQRR VTPDRSQTSQ 
       760        770        780        790        800
DLFSYQALYS YIPQNDDELE LRDGDIVDVM EKCDDGWFVG TSRRTKQFGT 
       810 
FPGNYVKPLY L

Show »

Length:811

Mass (Da):91,055

Checksum:ⁱ019F4E7E811AFDF5

GO

Isoform 9Curated (identifier: Q9BX66-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-270: Missing.
     408-453: Missing.
     552-635: Missing.
     955-1212: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA 
        60         70         80         90        100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP 
       110        120        130        140        150
GLEPEPSSAD EWRLSSSADA NGNAQPSSLA AKGYRSVHPN LPSDKSQDSS 
       160        170        180        190        200
PLLNEVSSSL IGTDSQAFPS VSKPSSAYPS TTIVNPTIVL LQHNREQQKR 
       210        220        230        240        250
LSSLSDPVSE RRVGEQDSAP TQEKPTSPGK AIEKRAKDDS RRVVKSTQDL 
       260        270        280        290        300
SDVSMDEVGI PLRNTERSKD WYKTMFKQIH KLNRDDDSDL YSPRYSFSED 
       310        320        330        340        350
TKSPLSVPRS KSEMSYIDGE KVVKRSATLP LPARSSSLKS SSERNDWEPP 
       360        370        380        390        400
DKKVDTRKYR AEPKSIYEYQ PGKSSVLTNE KMSSAISPTP EISSETPGYI 
       410        420        430        440        450
YSSNFHAVKR ESDGAPGDLT SLENERQIYK SVLEGGDIPL QGLSGLKRPS 
       460        470        480        490        500
SSASTKDSES PRHFIPADYL ESTEEFIRRR HDDKEKLLAD QRRLKREQEE 
       510        520        530        540        550
ADIAARRHTG VIPTHHQFIT NERFGDLLNI DDTAKRKSGS EMRPARAKFD 
       560        570        580        590        600
FKAQTLKELP LQKGDIVYIY KQIDQNWYEG EHHGRVGIFP RTYIELLPPA 
       610        620        630        640        650
EKAQPKKLTP VQVLEYGEAI AKFNFNGDTQ VEMSFRKGER ITLLRQVDEN 
       660        670        680        690        700
WYEGRIPGTS RQGIFPITYV DVIKRPLVKN PVDYMDLPFS SSPSRSATAS 
       710        720        730        740        750
PQQPQAQQRR VTPDRSQTSQ DLFSYQALYS YIPQNDDELE LRDGDIVDVM 
       760        770        780 
EKCDDGWFVG TSRRTKQFGT FPGNYVKPLY L

Show »

Length:781

Mass (Da):87,199

Checksum:ⁱEDB752BF6DB3E4E1

GO

Isoform 10Curated (identifier: Q9BX66-10) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     408-453: Missing.
     552-635: Missing.
     738-793: Missing.
     955-1212: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET 
        60         70         80         90        100
PSSSPASPQE TRQHESKPGL EPEPSSADEW RLSSSADANG NAQPSSLAAK 
       110        120        130        140        150
GYRSVHPNLP SDKSQDATSS SAAQPEVIVV PLYLVNTDRG QEGTARPPTP 
       160        170        180        190        200
LGPLGCVPTI PATASAASPL TFPTLDDFIP PHLQRWPHHS QPARASGSFA 
       210        220        230        240        250
PISQTPPSFS PPPPLVPPAP EDLRRVSEPD LTGAVSSTDS SPLLNEVSSS 
       260        270        280        290        300
LIGTDSQAFP SVSKPSSAYP STTIVNPTIV LLQHNREQQK RLSSLSDPVS 
       310        320        330        340        350
ERRVGEQDSA PTQEKPTSPG KAIEKRAKDD SRRVVKSTQD LSDVSMDEVG 
       360        370        380        390        400
IPLRNTERSK DWYKTMFKQI HKLNRDDDSD LYSPRYSFSE DTKSPLSVPR 
       410        420        430        440        450
SKSEMSYIDG EKVVKRSATL PLPARSSSLK SSSERNDWEP PDKKVDTRKY 
       460        470        480        490        500
RAEPKSIYEY QPGKSSVLTN EKMSSAISPT PEISSETPGY IYSSNFHAVK 
       510        520        530        540        550
RESDGAPGDL TSLENERQIY KSVLEGGDIP LQGLSGLKRP SSSASTKDSE 
       560        570        580        590        600
SPRHFIPADY LESTEEFIRR RHDDKEMRPA RAKFDFKAQT LKELPLQKGD 
       610        620        630        640        650
IVYIYKQIDQ NWYEGEHHGR VGIFPRTYIE LLPPAEKAQP KKLTPVQVLE 
       660        670        680        690        700
YGEAIAKFNF NGDTQVEMSF RKGERITLLR QVDENWYEGR IPGTSRQGIF 
       710        720        730        740        750
PITYVDVIKR PLVKNPVDYM DLPFSSSPSR SATASPQQPQ AQQRRVTPDR 
       760        770        780        790        800
SQTSQDLFSY QALYSYIPQN DDELELRDGD IVDVMEKCDD GWFVGTSRRT 
       810 
KQFGTFPGNY VKPLYL

Show »

Length:816

Mass (Da):90,218

Checksum:ⁱ490FCF5615BF69DB

GO

Isoform 11 (identifier: Q9BX66-11) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
408-453: Missing.
1213-1213: Q → QLSHHSLRAGPDLTESEKSYV

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKATADP LRARSISAVK IIPVKTVKNA 
        60         70         80         90        100
SGLVLPTDMD LTKICTGKGA VTLRASSSYR ETPSSSPASP QETRQHESKP 
       110        120        130        140        150
GLEPEPSSAD EWRLSSSADA NGNAQPSSLA AKGYRSVHPN LPSDKSQDAT 
       160        170        180        190        200
SSSAAQPEVI VVPLYLVNTD RGQEGTARPP TPLGPLGCVP TIPATASAAS 
       210        220        230        240        250
PLTFPTLDDF IPPHLQRWPH HSQPARASGS FAPISQTPPS FSPPPPLVPP 
       260        270        280        290        300
APEDLRRVSE PDLTGAVSST DSSPLLNEVS SSLIGTDSQA FPSVSKPSSA 
       310        320        330        340        350
YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP VSERRVGEQD SAPTQEKPTS 
       360        370        380        390        400
PGKAIEKRAK DDSRRVVKST QDLSDVSMDE VGIPLRNTER SKDWYKTMFK 
       410        420        430        440        450
QIHKLNRDDD SDLYSPRYSF SEDTKSPLSV PRSKSEMSYI DGEKVVKRSA 
       460        470        480        490        500
TLPLPARSSS LKSSSERNDW EPPDKKVDTR KYRAEPKSIY EYQPGKSSVL 
       510        520        530        540        550
TNEKMSRDIS PEEIDLKNEP WYKFFSELEF GKPPPKKIWD YTPGDCSILP 
       560        570        580        590        600
REDRKTNLDK DLSLCQTELE ADLEKMETLN KAPSANVPQS SAISPTPEIS 
       610        620        630        640        650
SETPGYIYSS NFHAVKRESD GAPGDLTSLE NERQIYKSVL EGGDIPLQGL 
       660        670        680        690        700
SGLKRPSSSA STKDSESPRH FIPADYLEST EEFIRRRHDD KEKLLADQRR 
       710        720        730        740        750
LKREQEEADI AARRHTGVIP THHQFITNER FGDLLNIDDT AKRKSGSEMR 
       760        770        780        790        800
PARAKFDFKA QTLKELPLQK GDIVYIYKQI DQNWYEGEHH GRVGIFPRTY 
       810        820        830        840        850
IELLPPAEKA QPKKLTPVQV LEYGEAIAKF NFNGDTQVEM SFRKGERITL 
       860        870        880        890        900
LRQVDENWYE GRIPGTSRQG IFPITYVDVI KRPLVKNPVD YMDLPFSSSP 
       910        920        930        940        950
SRSATASPQF SSHSKLITPA PSSLPHSRRA LSPEMHAVTS EWISLTVGVP 
       960        970        980        990       1000
GRRSLALTPP LPPLPEASIY NTDHLALSPR ASPSLSLSLP HLSWSDRPTP 
      1010       1020       1030       1040       1050
RSVASPLALP SPHKTYSLAP TSQASLHMNG DGGVHTPSSG IHQDSFLQLP 
      1060       1070       1080       1090       1100
LGSSDSVISQ LSDAFSSQSK RQPWREESGQ YERKAERGAG ERGPGGPKIS 
      1110       1120       1130       1140       1150
KKSCLKPSDV VRCLSTEQRL SDLNTPEESR PGKPLGSAFP GSEAEQTERH 
      1160       1170       1180       1190       1200
RGGEQAGRKA ARRGGSQLSH HSLRAGPDLT ESEKSYVQPQ AQQRRVTPDR 
      1210       1220       1230       1240       1250
SQTSQDLFSY QALYSYIPQN DDELELRDGD IVDVMEKCDD GWFVGTSRRT 
      1260 
KQFGTFPGNY VKPLYL

Show »

Length:1,266

Mass (Da):139,401

Checksum:ⁱ857F07CDCB13B97E

GO

Isoform 12 (identifier: Q9BX66-12) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     26-57: Missing.
     148-270: Missing.
     319-328: Missing.
     408-453: Missing.
     580-601: Missing.
     709-709: K → KVDRKGGNAH...PQSELAPSRG
     955-1212: Missing.

« Hide

        10         20         30         40         50
MSSECDGGSK AVMNGLAPGS NGQDKDMDLT KICTGKGAVT LRASSSYRET 
        60         70         80         90        100
PSSSPASPQE TRQHESKPGL EPEPSSADEW RLSSSADANG NAQPSSLAAK 
       110        120        130        140        150
GYRSVHPNLP SDKSQDSSPL LNEVSSSLIG TDSQAFPSVS KPSSAYPSTT 
       160        170        180        190        200
IVNPTIVLLQ HNRDPVSERR VGEQDSAPTQ EKPTSPGKAI EKRAKDDSRR 
       210        220        230        240        250
VVKSTQDLSD VSMDEVGIPL RNTERSKDWY KTMFKQIHKL NRDDDSDLYS 
       260        270        280        290        300
PRYSFSEDTK SPLSVPRSKS EMSYIDGEKV VKRSATLPLP ARSSSLKSSS 
       310        320        330        340        350
ERNDWEPPDK KVDTRKYRAE PKSIYEYQPG KSSVLTNEKM SRDISPEEID 
       360        370        380        390        400
LKNEPWYKFF SELEFGKPTN LDKDLSLCQT ELEADLEKME TLNKAPSANV 
       410        420        430        440        450
PQSSAISPTP EISSETPGYI YSSNFHAVKR ESDGAPGDLT SLENERQIYK 
       460        470        480        490        500
SVLEGGDIPL QGLSGLKRPS SSASTKVDRK GGNAHMISSS SVHSRTFNTS 
       510        520        530        540        550
NALGPVCKHK KPLSAAKACI SEILPSKFKP RLSAPSALLQ EQKSILLPSE 
       560        570        580        590        600
KAQSCENLCV SGSLNDSKRG LPLQVGGSIE NLLMRSRRDY DSKSSSTMSL 
       610        620        630        640        650
QEYSTSGRRP CPLSRKAGMQ FTMLYRDMHQ INRSGLFLGS ISSSSSVRDL 
       660        670        680        690        700
ASHFEKSSLA LSRGELGPSQ EGSEHIPKHT VSSRITAFEQ LIQRSRSMPS 
       710        720        730        740        750
LDLSGRLSKS PTPVLSRGSL TSARSAESLL ESTKLHPKEM DGMNSSGVYA 
       760        770        780        790        800
SPTCSNMAHH ALSFRGLVPS EPLSTCSDDV DRCSNISTDS REGSGGSVHG 
       810        820        830        840        850
DFPKHRLNKC KGTCPASYTR FTTIRKHEQQ QTSRQPEWRL DARGDKSTLL 
       860        870        880        890        900
RNIYLMSPLP FRLKKPLHHH PRQPSPGDSS GLLVGQKPDL PSQPHQDQPP 
       910        920        930        940        950
SGGKPVVPTR LSSRHTMARL SRSSEPSQER PTALEDYPRA INNGNSVPYS 
       960        970        980        990       1000
DHSLDRNNNP QSELAPSRGD SESPRHFIPA DYLESTEEFI RRRHDDKEKL 
      1010       1020       1030       1040       1050
LADQRRLKRE QEEADIAARR HTGVIPTHHQ FITNERFGDL LNIDDTAKRK 
      1060       1070       1080       1090       1100
SGSEMRPARA KFDFKAQTLK ELPLQKGDIV YIYKQIDQNW YEGEHHGRVG 
      1110       1120       1130       1140       1150
IFPRTYIELL PPAEKAQPKK LTPVQVLEYG EAIAKFNFNG DTQVEMSFRK 
      1160       1170       1180       1190       1200
GERITLLRQV DENWYEGRIP GTSRQGIFPI TYVDVIKRPL VKNPVDYMDL 
      1210       1220       1230       1240       1250
PFSSSPSRSA TASPQQPQAQ QRRVTPDRSQ TSQDLFSYQA LYSYIPQNDD 
      1260       1270       1280       1290 
ELELRDGDIV DVMEKCDDGW FVGTSRRTKQ FGTFPGNYVK PLYL

Note: Derived from mouse ortholog data.Curated

Show »

Length:1,294

Mass (Da):143,741

Checksum:ⁱ770EBDC6412A6C03

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

S4R303	S4R303_HUMAN	Sorbin and SH3 domain-containing pr... Sorbin and SH3 domain-containing protein 1	SORBS1	393	Annotation score:
A0A0U1RQI5	A0A0U1RQI5_HUMAN	Sorbin and SH3 domain-containing pr... Sorbin and SH3 domain-containing protein 1	SORBS1	507	Annotation score:
Q5T925	Q5T925_HUMAN	Sorbin and SH3 domain-containing pr... Sorbin and SH3 domain-containing protein 1	SORBS1	186	Annotation score:
A0A3B3IRR9	A0A3B3IRR9_HUMAN	Sorbin and SH3 domain-containing pr... Sorbin and SH3 domain-containing protein 1	SORBS1	143	Annotation score:
A0A3B3IRW8	A0A3B3IRW8_HUMAN	Sorbin and SH3 domain-containing pr... Sorbin and SH3 domain-containing protein 1	SORBS1	381	Annotation score:
S4R406	S4R406_HUMAN	Sorbin and SH3 domain-containing pr... Sorbin and SH3 domain-containing protein 1	SORBS1	145	Annotation score:
A0A3B3IT56	A0A3B3IT56_HUMAN	Sorbin and SH3 domain-containing pr... Sorbin and SH3 domain-containing protein 1	SORBS1	188	Annotation score:

Sequence cautionⁱ

The sequence AAB93496 differs from that shown. Reason: Frameshift.Curated

The sequence BAA92534 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	9	S → P in CAJ97431 (PubMed:17462669).Curated	1
Sequence conflictⁱ	18	P → S in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	18	P → S in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	110	D → G in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	110	D → G in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	113	R → K in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	113	R → K in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	131	A → V in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	131	A → V in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	134	Y → S in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	134	Y → S in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	226 – 228	RAS → SAC in AAF22175 (PubMed:11532984).Curated	3
Sequence conflictⁱ	264	T → P in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	292 – 295	PSVS → SSEC in AAD27647 (PubMed:11374898).Curated	4
Sequence conflictⁱ	292 – 295	PSVS → SSEC in AAF22175 (PubMed:11532984).Curated	4
Sequence conflictⁱ	481	S → R in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	489	E → V in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	489	E → V in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	607	D → E in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	610	L → F in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	644	E → G in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	644	E → G in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	679	R → S in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	679	R → S in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	690	D → V in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	690	D → V in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	694	Q → R in CAJ97431 (PubMed:17462669).Curated	1
Sequence conflictⁱ	695	G → D in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	695	G → D in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	710	D → N in AAD27647 (PubMed:11374898).Curated	1
Sequence conflictⁱ	710	D → N in AAF22175 (PubMed:11532984).Curated	1
Sequence conflictⁱ	1156	V → G in AAK37563 (PubMed:11374898).Curated	1
Sequence conflictⁱ	1156	V → G in AAK37564 (PubMed:11374898).Curated	1
Isoform 21 Publication (identifier: Q9BX66-2)
Sequence conflictⁱ	435	K → E in AAK37564 (PubMed:11374898).Curated	1
Sequence conflictⁱ	452 – 455	AHCS → SRCG in AAK37564 (PubMed:11374898).Curated	4
Sequence conflictⁱ	463	N → D in AAK37564 (PubMed:11374898).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047652	61	L → P8 PublicationsCorresponds to variant dbSNP:rs943542Ensembl.	1
Natural variantⁱVAR_019653	74	R → W1 PublicationCorresponds to variant dbSNP:rs757431022Ensembl.	1
Natural variantⁱVAR_047653	175	G → V. Corresponds to variant dbSNP:rs7081076Ensembl.	1
Natural variantⁱVAR_035661	195	T → A in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_019654	237	T → A Has a protective role in both obesity and diabetes. 1 PublicationCorresponds to variant dbSNP:rs2281939Ensembl.	1
Natural variantⁱVAR_047654	485	Y → C. Corresponds to variant dbSNP:rs35808802Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_050895	26 – 57	Missing in isoform 4, isoform 7, isoform 8, isoform 10 and isoform 12. 4 PublicationsAdd BLAST	32
Alternative sequenceⁱVSP_050896	101 – 109	Missing in isoform 4, isoform 5, isoform 6 and isoform 7. 4 Publications	9
Alternative sequenceⁱVSP_050898	147 – 215	Missing in isoform 3. 1 PublicationAdd BLAST	69
Alternative sequenceⁱVSP_050899	148 – 270	Missing in isoform 4, isoform 6, isoform 8, isoform 9 and isoform 12. 5 PublicationsAdd BLAST	123
Alternative sequenceⁱVSP_041193	319 – 328	Missing in isoform 12. Curated	10
Alternative sequenceⁱVSP_050900	408 – 453	Missing in isoform 3, isoform 4, isoform 7, isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 6 PublicationsAdd BLAST	46
Alternative sequenceⁱVSP_050901	431 – 451	Missing in isoform 5. 3 PublicationsAdd BLAST	21
Alternative sequenceⁱVSP_050902	434 – 453	DNPYT…SPKSE → TKSCSVMSPRLECSGTVIAH CSLKLLDSSNPPTSASQVAG TA in isoform 2. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_050903	552 – 635	Missing in isoform 4, isoform 7, isoform 9 and isoform 10. 4 PublicationsAdd BLAST	84
Alternative sequenceⁱVSP_050905	580 – 635	Missing in isoform 6. 1 PublicationAdd BLAST	56
Alternative sequenceⁱVSP_050904	580 – 601	Missing in isoform 8 and isoform 12. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_050906	602 – 635	Missing in isoform 3. 1 PublicationAdd BLAST	34
Alternative sequenceⁱVSP_041194	709	K → KVDRKGGNAHMISSSSVHSR TFNTSNALGPVCKHKKPLSA AKACISEILPSKFKPRLSAP SALLQEQKSILLPSEKAQSC ENLCVSGSLNDSKRGLPLQV GGSIENLLMRSRRDYDSKSS STMSLQEYSTSGRRPCPLSR KAGMQFTMLYRDMHQINRSG LFLGSISSSSSVRDLASHFE KSSLALSRGELGPSQEGSEH IPKHTVSSRITAFEQLIQRS RSMPSLDLSGRLSKSPTPVL SRGSLTSARSAESLLESTKL HPKEMDGMNSSGVYASPTCS NMAHHALSFRGLVPSEPLST CSDDVDRCSNISTDSREGSG GSVHGDFPKHRLNKCKGTCP ASYTRFTTIRKHEQQQTSRQ PEWRLDARGDKSTLLRNIYL MSPLPFRLKKPLHHHPRQPS PGDSSGLLVGQKPDLPSQPH QDQPPSGGKPVVPTRLSSRH TMARLSRSSEPSQERPTALE DYPRAINNGNSVPYSDHSLD RNNNPQSELAPSRG in isoform 12. Curated	1
Alternative sequenceⁱVSP_050907	738 – 793	Missing in isoform 4 and isoform 10. 2 PublicationsAdd BLAST	56
Alternative sequenceⁱVSP_050908	795 – 799	MRPAR → KYDWA in isoform 7. 1 Publication	5
Alternative sequenceⁱVSP_050909	800 – 1292	Missing in isoform 7. 1 PublicationAdd BLAST	493
Alternative sequenceⁱVSP_050911	955 – 1212	Missing in isoform 4, isoform 5, isoform 6, isoform 8, isoform 9, isoform 10 and isoform 12. 7 PublicationsAdd BLAST	258
Alternative sequenceⁱVSP_050910	955 – 1117	Missing in isoform 2. 1 PublicationAdd BLAST	163
Alternative sequenceⁱVSP_050912	956 – 975	FSSHS…PHSRR → LSHHSLRAGPDLTESEKSYV in isoform 3. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_050913	976 – 1213	Missing in isoform 3. 1 PublicationAdd BLAST	238
Alternative sequenceⁱVSP_039210	1213	Q → QLSHHSLRAGPDLTESEKSY V in isoform 11. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136380 mRNA Translation: AAD27647.1 AF356525 mRNA Translation: AAK37563.1 AF356526 mRNA Translation: AAK37564.1 AF356527 mRNA Translation: AAK37565.1 AF330623 mRNA Translation: AAK57479.1 AF330624 mRNA Translation: AAK57480.1 AF136381 mRNA Translation: AAF22175.1 AJ489942 mRNA Translation: CAD34588.1 AM260536 mRNA Translation: CAJ97431.1 AB037717 mRNA Translation: BAA92534.1 Different initiation. AL117472 mRNA Translation: CAB55947.1 AL158165 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49999.1 CH471066 Genomic DNA Translation: EAW50007.1 BC042612 mRNA Translation: AAH42612.1 BC152463 mRNA Translation: AAI52464.1 U70668 mRNA Translation: AAB93496.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31252.1 [Q9BX66-4] CCDS31253.1 [Q9BX66-9] CCDS31254.1 [Q9BX66-2] CCDS31255.1 [Q9BX66-1] CCDS31256.1 [Q9BX66-3] CCDS73169.1 [Q9BX66-11] CCDS7442.1 [Q9BX66-10] CCDS76326.1 [Q9BX66-8] CCDS76327.1 [Q9BX66-5]
PIRⁱ	T17257
NCBI Reference Sequences More...RefSeqⁱ	NP_001030126.1, NM_001034954.1 [Q9BX66-1] NP_001030127.1, NM_001034955.1 [Q9BX66-2] NP_001030128.1, NM_001034956.1 [Q9BX66-3] NP_001030129.1, NM_001034957.1 NP_001277223.1, NM_001290294.1 [Q9BX66-11] NP_001277224.1, NM_001290295.1 NP_001277225.1, NM_001290296.1 [Q9BX66-5] NP_001277226.1, NM_001290297.1 [Q9BX66-8] NP_001277227.1, NM_001290298.1 [Q9BX66-6] NP_006425.2, NM_006434.2 [Q9BX66-4] NP_056200.1, NM_015385.3 [Q9BX66-10] NP_079267.1, NM_024991.2 [Q9BX66-9] XP_006717652.1, XM_006717589.1 [Q9BX66-5]

Genome annotation databases

Ensemblⁱ	ENST00000277982; ENSP00000277982; ENSG00000095637 [Q9BX66-2] ENST00000306402; ENSP00000302556; ENSG00000095637 [Q9BX66-9] ENST00000354106; ENSP00000277984; ENSG00000095637 [Q9BX66-5] ENST00000361941; ENSP00000355136; ENSG00000095637 [Q9BX66-1] ENST00000371227; ENSP00000360271; ENSG00000095637 [Q9BX66-11] ENST00000371239; ENSP00000360283; ENSG00000095637 [Q9BX66-8] ENST00000371241; ENSP00000360285; ENSG00000095637 [Q9BX66-4] ENST00000371245; ENSP00000360291; ENSG00000095637 [Q9BX66-3] ENST00000371246; ENSP00000360292; ENSG00000095637 [Q9BX66-2] ENST00000371247; ENSP00000360293; ENSG00000095637 [Q9BX66-1] ENST00000371249; ENSP00000360295; ENSG00000095637 [Q9BX66-10] ENST00000607232; ENSP00000475901; ENSG00000095637 [Q9BX66-12]
GeneIDⁱ	10580
KEGGⁱ	hsa:10580
UCSC genome browser More...UCSCⁱ	uc001kko.4, human [Q9BX66-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BX66	Sorbin and SH3 domain containing 1		LOXAF		1291	UniRef50_Q9BX66
sorbin and SH3 domain-containing protein 1 isoform X1		DIPOR		1285
sorbin and SH3 domain-containing protein 1 isoform X35		MESAU		1261
sorbin and SH3 domain-containing protein 1 isoform X22		VICPA		1216
Uncharacterized protein		GULGU		1201
+114
Q9BX66-2	Sorbin and SH3 domain containing 1		PANPA		1069	UniRef50_Q9BX66-2
Sorbin and SH3 domain containing 1		MACNE		1277
cDNA FLJ53695, highly similar to Homo sapiens sorbin and SH3 domain containing 1 (SORBS1), transcript variant 5, mRNA		HUMAN		496
cDNA FLJ53322, highly similar to Homo sapiens sorbin and SH3 domain containing 1 (SORBS1), transcript variant 5, mRNA		HUMAN		428
+16
Q9BX66-3	Sorbin and SH3 domain containing 1		SAIBB		905	UniRef50_Q9BX66-3
Uncharacterized protein		RHIBE		905
SORBS1 isoform 9		PONAB		905
Uncharacterized protein		AOTNA		905
Sorbin and SH3 domain-containing protein 1		RAT		938
+20
Q9BX66-4	Isoform 4 of Sorbin and SH3 domain-containing protein 1		MOUSE		714	UniRef50_Q62417-4
sorbin and SH3 domain-containing protein 1 isoform X18		Bison bison bison		741
Uncharacterized protein		MARMO		740
sorbin and SH3 domain-containing protein 1 isoform X4		TURTR		741
sorbin and SH3 domain-containing protein 1 isoform X36		VICPA		754
+115
Q9BX66-5	sorbin and SH3 domain-containing protein 1 isoform X31		SAPAP		1004	UniRef50_Q9BX66-5
Uncharacterized protein		AOTNA		1004
Sorbin and SH3 domain containing 1		SAIBB		1004
Uncharacterized protein		COLAP		1004
SORBS1 isoform 14		PANTR		1004
+6
Q9BX66-8	Sorbin and SH3 domain containing 1		MOLMO		770	UniRef50_Q9BX66-8
sorbin and SH3 domain-containing protein 1 isoform X8		BALAS		834
Sorbin and SH3 domain containing 1		HORSE		843
Sorbin and SH3 domain containing 1		SPAAU		743
sorbin and SH3 domain-containing protein 1 isoform X30		BOSIN		834
+112
Q9BX66-9	Isoform 3 of Sorbin and SH3 domain-containing protein 1		MOUSE		724	UniRef50_Q62417-3
sorbin and SH3 domain-containing protein 1 isoform X27		pale spear-nosed bat		782
sorbin and SH3 domain-containing protein 1 isoform X35		VICPA		763
sorbin and SH3 domain-containing protein 1 isoform X4		BALAS		782
sorbin and SH3 domain-containing protein 1 isoform X33		PHYMC		782
+164
Q9BX66-10	sorbin and SH3 domain-containing protein 1 isoform X41		PANPR		847	UniRef50_Q9BX66-10
SORBS1 isoform 4		PANTR		816
Sorbin and SH3 domain-containing protein 1		ALLMI		795
Uncharacterized protein		AOTNA		816
sorbin and SH3 domain-containing protein 1 isoform X36		ALLSI		797
+66
Q9BX66-11	SRBS1 protein (Fragment)		CROCR		1249	UniRef50_Q9BX66-11
Uncharacterized protein		CERAT		1266
sorbin and SH3 domain-containing protein 1 isoform X37		MESAU		1227
sorbin and SH3 domain-containing protein 1 isoform X25		MESAU		1259
+20
Q9BX66-12	Sorbin and SH3 domain containing 1		SAIBB		1294	UniRef50_Q9BX66-12
sorbin and SH3 domain-containing protein 1 isoform X33		PHACI		1173
SORBS1 isoform 7		PONAB		1294
Uncharacterized protein		RHIRO		1294
Uncharacterized protein		NOMLE		1293
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF136380 mRNA Translation: AAD27647.1 AF356525 mRNA Translation: AAK37563.1 AF356526 mRNA Translation: AAK37564.1 AF356527 mRNA Translation: AAK37565.1 AF330623 mRNA Translation: AAK57479.1 AF330624 mRNA Translation: AAK57480.1 AF136381 mRNA Translation: AAF22175.1 AJ489942 mRNA Translation: CAD34588.1 AM260536 mRNA Translation: CAJ97431.1 AB037717 mRNA Translation: BAA92534.1 Different initiation. AL117472 mRNA Translation: CAB55947.1 AL158165 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49999.1 CH471066 Genomic DNA Translation: EAW50007.1 BC042612 mRNA Translation: AAH42612.1 BC152463 mRNA Translation: AAI52464.1 U70668 mRNA Translation: AAB93496.1 Frameshift.
CCDSⁱ	CCDS31252.1 [Q9BX66-4] CCDS31253.1 [Q9BX66-9] CCDS31254.1 [Q9BX66-2] CCDS31255.1 [Q9BX66-1] CCDS31256.1 [Q9BX66-3] CCDS73169.1 [Q9BX66-11] CCDS7442.1 [Q9BX66-10] CCDS76326.1 [Q9BX66-8] CCDS76327.1 [Q9BX66-5]
PIRⁱ	T17257
RefSeqⁱ	NP_001030126.1, NM_001034954.1 [Q9BX66-1] NP_001030127.1, NM_001034955.1 [Q9BX66-2] NP_001030128.1, NM_001034956.1 [Q9BX66-3] NP_001030129.1, NM_001034957.1 NP_001277223.1, NM_001290294.1 [Q9BX66-11] NP_001277224.1, NM_001290295.1 NP_001277225.1, NM_001290296.1 [Q9BX66-5] NP_001277226.1, NM_001290297.1 [Q9BX66-8] NP_001277227.1, NM_001290298.1 [Q9BX66-6] NP_006425.2, NM_006434.2 [Q9BX66-4] NP_056200.1, NM_015385.3 [Q9BX66-10] NP_079267.1, NM_024991.2 [Q9BX66-9] XP_006717652.1, XM_006717589.1 [Q9BX66-5]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DL3	NMR	-	A	796-850	[»]
	2ECZ	NMR	-	A	870-926	[»]
	2LJ0	NMR	-	A	1228-1292	[»]
	2LJ1	NMR	-	A	1228-1291	[»]
	2MOX	NMR	-	A	791-930	[»]
	2O2W	X-ray	2.27	A	870-930	[»]
	2O31	X-ray	1.50	A	870-930	[»]
	2O9S	X-ray	0.83	A	870-930	[»]
	2O9V	X-ray	1.63	A	870-930	[»]
	4LN2	X-ray	1.00	A	866-930	[»]
	4LNP	X-ray	1.41	A	794-854	[»]
BMRBⁱ	Q9BX66
SMRⁱ	Q9BX66
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115831, 54 interactors
CORUMⁱ	Q9BX66
IntActⁱ	Q9BX66, 45 interactors
MINTⁱ	Q9BX66
STRINGⁱ	9606.ENSP00000360293

PTM databases

iPTMnetⁱ	Q9BX66
PhosphoSitePlusⁱ	Q9BX66

Genetic variation databases

BioMutaⁱ	SORBS1
DMDMⁱ	317373504

Proteomic databases

EPDⁱ	Q9BX66
jPOSTⁱ	Q9BX66
MassIVEⁱ	Q9BX66
MaxQBⁱ	Q9BX66
PaxDbⁱ	Q9BX66
PeptideAtlasⁱ	Q9BX66
PRIDEⁱ	Q9BX66
ProteomicsDBⁱ	79354 [Q9BX66-1] 79355 [Q9BX66-10] 79356 [Q9BX66-11] 79357 [Q9BX66-12] 79358 [Q9BX66-2] 79359 [Q9BX66-3] 79360 [Q9BX66-4] 79361 [Q9BX66-5] 79362 [Q9BX66-6] 79363 [Q9BX66-7] 79364 [Q9BX66-8] 79365 [Q9BX66-9]

Protocols and materials databases

ABCDⁱ	Q9BX66, 4 sequenced antibodies
Antibodypediaⁱ	30624, 256 antibodies
The DNASU plasmid repository More...DNASUⁱ	10580

Genome annotation databases

Ensemblⁱ	ENST00000277982; ENSP00000277982; ENSG00000095637 [Q9BX66-2] ENST00000306402; ENSP00000302556; ENSG00000095637 [Q9BX66-9] ENST00000354106; ENSP00000277984; ENSG00000095637 [Q9BX66-5] ENST00000361941; ENSP00000355136; ENSG00000095637 [Q9BX66-1] ENST00000371227; ENSP00000360271; ENSG00000095637 [Q9BX66-11] ENST00000371239; ENSP00000360283; ENSG00000095637 [Q9BX66-8] ENST00000371241; ENSP00000360285; ENSG00000095637 [Q9BX66-4] ENST00000371245; ENSP00000360291; ENSG00000095637 [Q9BX66-3] ENST00000371246; ENSP00000360292; ENSG00000095637 [Q9BX66-2] ENST00000371247; ENSP00000360293; ENSG00000095637 [Q9BX66-1] ENST00000371249; ENSP00000360295; ENSG00000095637 [Q9BX66-10] ENST00000607232; ENSP00000475901; ENSG00000095637 [Q9BX66-12]
GeneIDⁱ	10580
KEGGⁱ	hsa:10580
UCSCⁱ	uc001kko.4, human [Q9BX66-1]

Organism-specific databases

CTDⁱ	10580
DisGeNETⁱ	10580
GeneCardsⁱ	SORBS1
HGNCⁱ	HGNC:14565, SORBS1
HPAⁱ	ENSG00000095637, Tissue enhanced (smooth)
MIMⁱ	605264, gene
neXtProtⁱ	NX_Q9BX66
OpenTargetsⁱ	ENSG00000095637
PharmGKBⁱ	PA37899
VEuPathDBⁱ	HostDB:ENSG00000095637.21
HUGEⁱ	Search... Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4225, Eukaryota
GeneTreeⁱ	ENSGT00940000158658
HOGENOMⁱ	CLU_003951_1_1_1
InParanoidⁱ	Q9BX66
OMAⁱ	HAITSEW
OrthoDBⁱ	228183at2759
PhylomeDBⁱ	Q9BX66
TreeFamⁱ	TF320680

Enzyme and pathway databases

PathwayCommonsⁱ	Q9BX66
Reactomeⁱ	R-HSA-445355, Smooth Muscle Contraction
SignaLinkⁱ	Q9BX66
SIGNORⁱ	Q9BX66

Miscellaneous databases

BioGRID-ORCSⁱ	10580, 5 hits in 997 CRISPR screens
ChiTaRSⁱ	SORBS1, human
EvolutionaryTraceⁱ	Q9BX66
GeneWikiⁱ	SORBS1
GenomeRNAiⁱ	10580
Pharosⁱ	Q9BX66, Tbio
Protein Ontology More...PROⁱ	PR:Q9BX66
RNActⁱ	Q9BX66, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000095637, Expressed in blood vessel layer and 240 other tissues
ExpressionAtlasⁱ	Q9BX66, baseline and differential
Genevisibleⁱ	Q9BX66, HS

Family and domain databases

CDDⁱ	cd11919, SH3_Sorbs1_1, 1 hit cd11922, SH3_Sorbs1_2, 1 hit cd11916, SH3_Sorbs1_3, 1 hit
InterProⁱ	View protein in InterPro IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR003127, SoHo_dom IPR035606, SORBS1_SH3 IPR035610, SORBS1_SH3_1 IPR035611, SORBS1_SH3_2
Pfamⁱ	View protein in Pfam PF00018, SH3_1, 1 hit PF07653, SH3_2, 1 hit PF14604, SH3_9, 1 hit PF02208, Sorb, 1 hit
SMARTⁱ	View protein in SMART SM00326, SH3, 3 hits SM00459, Sorb, 1 hit
SUPFAMⁱ	SSF50044, SSF50044, 3 hits
PROSITEⁱ	View protein in PROSITE PS50002, SH3, 3 hits PS50831, SOHO, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRBS1_HUMAN
Accessionⁱ	Q9BX66Primary (citable) accession number: Q9BX66 Secondary accession number(s): A0AED4 Q9Y338
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	January 11, 2011
	Last modified:	April 7, 2021
	This is version 194 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniRef

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Supporting data

UniProtKB - Q9BX66 (SRBS1_HUMAN)

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Sorbin and SH3 domain-containing protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

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Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q9BX66

Isoform 7 [Q9BX66-7]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

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Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ