UniProtKB - Q9BX26 (SYCP2_HUMAN)
Protein
Synaptonemal complex protein 2
Gene
SYCP2
Organism
Homo sapiens (Human)
Status
Functioni
Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.By similarity
GO - Molecular functioni
- DNA binding Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- female meiotic nuclear division Source: GO_Central
- fertilization Source: Ensembl
- male genitalia morphogenesis Source: Ensembl
- male meiotic nuclear division Source: GO_Central
- meiotic nuclear division Source: GO_Central
- negative regulation of apoptotic process Source: Ensembl
- synaptonemal complex assembly Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Cell cycle, Cell division, Meiosis |
Enzyme and pathway databases
PathwayCommonsi | Q9BX26 |
Reactomei | R-HSA-1221632, Meiotic synapsis |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptonemal complex protein 2Short name: SCP-2 Alternative name(s): Synaptonemal complex lateral element protein Short name: hsSCP2 |
Gene namesi | Name:SYCP2 Synonyms:SCP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196074.12 |
HGNCi | HGNC:11490, SYCP2 |
MIMi | 604105, gene |
neXtProti | NX_Q9BX26 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Note: In axial/lateral elements of the tripartite segments of synaptonemal complexes.By similarity
Nucleus
- condensed nuclear chromosome, centromeric region Source: GO_Central
- lateral element Source: UniProtKB
- nucleus Source: UniProtKB
- synaptonemal complex Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Spermatogenic failure 1 (SPGF1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder characterized by azoospermia due to spermatogenic arrest during meiosis. Meiotic arrest is characterized by germ cells that enter meiosis and undergo the first chromosomal reduction from 4n to 2n, but that are then unable to proceed further. This results in tubules containing spermatocytes as the latest developmental stage of germ cells. Meiotically arrested spermatocytes accumulate in the tubules and degenerate. Both autosomal recessive and autosomal dominant inheritance have been reported.
Related information in OMIMOrganism-specific databases
DisGeNETi | 10388 |
MalaCardsi | SYCP2 |
MIMi | 258150, phenotype |
OpenTargetsi | ENSG00000196074 |
PharmGKBi | PA36272 |
Miscellaneous databases
Pharosi | Q9BX26, Tbio |
Polymorphism and mutation databases
BioMutai | SYCP2 |
DMDMi | 23822155 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072366 | 1 – 1530 | Synaptonemal complex protein 2Add BLAST | 1530 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 457 | PhosphoserineBy similarity | 1 | |
Modified residuei | 465 | PhosphoserineBy similarity | 1 | |
Modified residuei | 471 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 494 | PhosphoserineBy similarity | 1 | |
Modified residuei | 519 | PhosphoserineBy similarity | 1 | |
Modified residuei | 529 | PhosphoserineBy similarity | 1 | |
Modified residuei | 538 | PhosphoserineBy similarity | 1 | |
Modified residuei | 619 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 660 | PhosphoserineBy similarity | 1 | |
Modified residuei | 664 | PhosphoserineBy similarity | 1 | |
Modified residuei | 936 | PhosphoserineBy similarity | 1 | |
Modified residuei | 938 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1136 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1138 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1145 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1161 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1177 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1189 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1204 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1234 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1253 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1295 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1297 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1339 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BX26 |
jPOSTi | Q9BX26 |
MassIVEi | Q9BX26 |
PaxDbi | Q9BX26 |
PeptideAtlasi | Q9BX26 |
PRIDEi | Q9BX26 |
ProteomicsDBi | 79343 |
PTM databases
CarbonylDBi | Q9BX26 |
iPTMneti | Q9BX26 |
PhosphoSitePlusi | Q9BX26 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196074, Expressed in testis and 149 other tissues |
ExpressionAtlasi | Q9BX26, baseline and differential |
Genevisiblei | Q9BX26, HS |
Organism-specific databases
HPAi | ENSG00000196074, Group enriched (breast, testis) |
Interactioni
Subunit structurei
Component of the lateral elements of synaptonemal complexes. Heterodimer with SYCP3 (By similarity).
Interacts with SMC1A and SMC3 (By similarity).
Interacts with TEX11 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 115660, 3 interactors |
IntActi | Q9BX26, 1 interactor |
STRINGi | 9606.ENSP00000350162 |
Miscellaneous databases
RNActi | Q9BX26, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 655 – 660 | Poly-Ser | 6 |
Sequence similaritiesi
Belongs to the SYCP2 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QVM5, Eukaryota |
GeneTreei | ENSGT00530000063859 |
InParanoidi | Q9BX26 |
OMAi | MAHERNV |
OrthoDBi | 285929at2759 |
PhylomeDBi | Q9BX26 |
TreeFami | TF332368 |
Family and domain databases
InterProi | View protein in InterPro IPR024835, SYCP1/2 IPR024832, SYCP2 IPR041322, SYCP2_ARLD IPR040560, SYCP2_SLD |
PANTHERi | PTHR15607, PTHR15607, 1 hit PTHR15607:SF12, PTHR15607:SF12, 1 hit |
Pfami | View protein in Pfam PF18581, SYCP2_ARLD, 1 hit PF18584, SYCP2_SLD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9BX26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPIRPDLQQL EKCIDDALRK NDFKPLKTLL QIDICEDVKI KCSKQFFHKV
60 70 80 90 100
DNLICRELNK EDIHNVSAIL VSVGRCGKNI SVLGQAGLLT MIKQGLIQKM
110 120 130 140 150
VAWFEKSKDI IQSQGNSKDE AVLNMIEDLV DLLLVIHDVS DEGKKQVVES
160 170 180 190 200
FVPRICSLVI DSRVNICIQQ EIIKKMNAML DKMPQDARKI LSNQEMLILM
210 220 230 240 250
SSMGERILDA GDYDLQVGIV EALCRMTTEK QRQELAHQWF SMDFIAKAFK
260 270 280 290 300
RIKDSEFETD CRIFLNLVNG MLGDKRRVFT FPCLSAFLDK YELQIPSDEK
310 320 330 340 350
LEEFWIDFNL GSQTLSFYIA GDNDDHQWEA VTVPEEKVQI YSIEVRESKK
360 370 380 390 400
LLTIILKNTV KISKREGKEL LLYFDASLEI TNVTQKIFGA TKHRESIRKQ
410 420 430 440 450
GISVAKTSLH ILFDASGSQI LVPESQISPV GEELVSLKEK SKSPKEFAKP
460 470 480 490 500
SKYIKNSDKG NRNNSQLEKT TPSKRKMSEA SMIVSGADRY TMRSPVLFSN
510 520 530 540 550
TSIPPRRRRI KPPLQMTSSA EKPSVSQTSE NRVDNAASLK SRSSEGRHRR
560 570 580 590 600
DNIDKHIKTA KCVENTENKN VEFPNQNFSE LQDVIPDSQA AEKRDHTILP
610 620 630 640 650
GVLDNICGNK IHSKWACWTP VTNIELCNNQ RASTSSGDTL NQDIVINKKL
660 670 680 690 700
TKQKSSSSIS DHNSEGTGKV KYKKEQTDHI KIDKAEVEVC KKHNQQQNHP
710 720 730 740 750
KYSGQKNTEN AKQSDWPVES ETTFKSVLLN KTIEESLIYR KKYILSKDVN
760 770 780 790 800
TATCDKNPSA SKNVQSHRKA EKELTSELNS WDSKQKKMRE KSKGKEFTNV
810 820 830 840 850
AESLISQINK RYKTKDDIKS TRKLKESLIN SGFSNKPVVQ LSKEKVQKKS
860 870 880 890 900
YRKLKTTFVN VTSECPVNDV YNFNLNGADD PIIKLGIQEF QATAKEACAD
910 920 930 940 950
RSIRLVGPRN HDELKSSVKT KDKKIITNHQ KKNLFSDTET EYRCDDSKTD
960 970 980 990 1000
ISWLREPKSK PQLIDYSRNK NVKNHKSGKS RSSLEKGQPS SKMTPSKNIT
1010 1020 1030 1040 1050
KKMDKTIPEG RIRLPRKATK TKKNYKDLSN SESECEQEFS HSFKENIPVK
1060 1070 1080 1090 1100
EENIHSRMKT VKLPKKQQKV FCAETEKELS KQWKNSSLLK DAIRDNCLDL
1110 1120 1130 1140 1150
SPRSLSGSPS SIEVTRCIEK ITEKDFTQDY DCITKSISPY PKTSSLESLN
1160 1170 1180 1190 1200
SNSGVGGTIK SPKNNEKNFL CASESCSPIP RPLFLPRHTP TKSNTIVNRK
1210 1220 1230 1240 1250
KISSLVLTQE TQNSNSYSDV SSYSSEERFM EIESPHINEN YIQSKREESH
1260 1270 1280 1290 1300
LASSLSKSSE GREKTWFDMP CDATHVSGPT QHLSRKRIYI EDNLSNSNEV
1310 1320 1330 1340 1350
EMEEKGERRA NLLPKKLCKI EDADHHIHKM SESVSSLSTN DFSIPWETWQ
1360 1370 1380 1390 1400
NEFAGIEMTY ETYERLNSEF KRRNNIRHKM LSYFTTQSWK TAQQHLRTMN
1410 1420 1430 1440 1450
HQSQDSRIKK LDKFQFIIIE ELENFEKDSQ SLKDLEKEFV DFWEKIFQKF
1460 1470 1480 1490 1500
SAYQKSEQQR LHLLKTSLAK SVFCNTDSEE TVFTSEMCLM KEDMKVLQDR
1510 1520 1530
LLKDMLEEEL LNVRRELMSV FMSHERNANV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A341 | A2A341_HUMAN | Synaptonemal complex protein 2 | SYCP2 | 1,023 | Annotation score: | ||
A2A2M9 | A2A2M9_HUMAN | Synaptonemal complex protein 2 | SYCP2 | 118 | Annotation score: | ||
A2A340 | A2A340_HUMAN | Synaptonemal complex protein 2 | SYCP2 | 208 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | G → A in CAA70171 (PubMed:10341103).Curated | 1 | |
Sequence conflicti | 691 | K → R in CAA70171 (PubMed:10341103).Curated | 1 | |
Sequence conflicti | 794 – 797 | GKEF → KKKK (PubMed:17974005).Curated | 4 | |
Sequence conflicti | 1179 | I → T in CAA70171 (PubMed:10341103).Curated | 1 | |
Sequence conflicti | 1186 | P → A in CAA70171 (PubMed:10341103).Curated | 1 | |
Sequence conflicti | 1222 | S → R in CAA70171 (PubMed:10341103).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054059 | 353 | T → K. Corresponds to variant dbSNP:rs13039338Ensembl. | 1 | |
Natural variantiVAR_014115 | 523 | P → L. Corresponds to variant dbSNP:rs1359836Ensembl. | 1 | |
Natural variantiVAR_054060 | 751 | T → I. Corresponds to variant dbSNP:rs6071006Ensembl. | 1 | |
Natural variantiVAR_054061 | 1155 | V → A. Corresponds to variant dbSNP:rs6128714Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08982 mRNA Translation: CAA70171.1 AL109928 Genomic DNA No translation available. AL158092 Genomic DNA No translation available. BC132864 mRNA Translation: AAI32865.1 BC132870 mRNA Translation: AAI32871.1 AL080226 mRNA Translation: CAB45780.1 |
CCDSi | CCDS13482.1 |
RefSeqi | NP_055073.2, NM_014258.3 XP_011526791.1, XM_011528489.2 |
Genome annotation databases
Ensembli | ENST00000357552; ENSP00000350162; ENSG00000196074 ENST00000371001; ENSP00000360040; ENSG00000196074 |
GeneIDi | 10388 |
KEGGi | hsa:10388 |
UCSCi | uc002yaz.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08982 mRNA Translation: CAA70171.1 AL109928 Genomic DNA No translation available. AL158092 Genomic DNA No translation available. BC132864 mRNA Translation: AAI32865.1 BC132870 mRNA Translation: AAI32871.1 AL080226 mRNA Translation: CAB45780.1 |
CCDSi | CCDS13482.1 |
RefSeqi | NP_055073.2, NM_014258.3 XP_011526791.1, XM_011528489.2 |
3D structure databases
SMRi | Q9BX26 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115660, 3 interactors |
IntActi | Q9BX26, 1 interactor |
STRINGi | 9606.ENSP00000350162 |
PTM databases
CarbonylDBi | Q9BX26 |
iPTMneti | Q9BX26 |
PhosphoSitePlusi | Q9BX26 |
Polymorphism and mutation databases
BioMutai | SYCP2 |
DMDMi | 23822155 |
Proteomic databases
EPDi | Q9BX26 |
jPOSTi | Q9BX26 |
MassIVEi | Q9BX26 |
PaxDbi | Q9BX26 |
PeptideAtlasi | Q9BX26 |
PRIDEi | Q9BX26 |
ProteomicsDBi | 79343 |
Protocols and materials databases
Antibodypediai | 58383, 90 antibodies |
Genome annotation databases
Ensembli | ENST00000357552; ENSP00000350162; ENSG00000196074 ENST00000371001; ENSP00000360040; ENSG00000196074 |
GeneIDi | 10388 |
KEGGi | hsa:10388 |
UCSCi | uc002yaz.4, human |
Organism-specific databases
CTDi | 10388 |
DisGeNETi | 10388 |
EuPathDBi | HostDB:ENSG00000196074.12 |
GeneCardsi | SYCP2 |
HGNCi | HGNC:11490, SYCP2 |
HPAi | ENSG00000196074, Group enriched (breast, testis) |
MalaCardsi | SYCP2 |
MIMi | 258150, phenotype 604105, gene |
neXtProti | NX_Q9BX26 |
OpenTargetsi | ENSG00000196074 |
PharmGKBi | PA36272 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVM5, Eukaryota |
GeneTreei | ENSGT00530000063859 |
InParanoidi | Q9BX26 |
OMAi | MAHERNV |
OrthoDBi | 285929at2759 |
PhylomeDBi | Q9BX26 |
TreeFami | TF332368 |
Enzyme and pathway databases
PathwayCommonsi | Q9BX26 |
Reactomei | R-HSA-1221632, Meiotic synapsis |
Miscellaneous databases
BioGRID-ORCSi | 10388, 3 hits in 842 CRISPR screens |
ChiTaRSi | SYCP2, human |
GenomeRNAii | 10388 |
Pharosi | Q9BX26, Tbio |
PROi | PR:Q9BX26 |
RNActi | Q9BX26, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196074, Expressed in testis and 149 other tissues |
ExpressionAtlasi | Q9BX26, baseline and differential |
Genevisiblei | Q9BX26, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024835, SYCP1/2 IPR024832, SYCP2 IPR041322, SYCP2_ARLD IPR040560, SYCP2_SLD |
PANTHERi | PTHR15607, PTHR15607, 1 hit PTHR15607:SF12, PTHR15607:SF12, 1 hit |
Pfami | View protein in Pfam PF18581, SYCP2_ARLD, 1 hit PF18584, SYCP2_SLD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYCP2_HUMAN | |
Accessioni | Q9BX26Primary (citable) accession number: Q9BX26 Secondary accession number(s): A2RUE5 Q9UG27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | October 10, 2002 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations