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Entry version 142 (16 Oct 2019)
Sequence version 2 (10 Oct 2002)
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Protein

Synaptonemal complex protein 2

Gene

SYCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1221632 Meiotic synapsis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptonemal complex protein 2
Short name:
SCP-2
Alternative name(s):
Synaptonemal complex lateral element protein
Short name:
hsSCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYCP2
Synonyms:SCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11490 SYCP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604105 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BX26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10388

Open Targets

More...
OpenTargetsi
ENSG00000196074

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36272

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BX26

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYCP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23822155

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000723661 – 1530Synaptonemal complex protein 2Add BLAST1530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei457PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei471PhosphothreonineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei519PhosphoserineBy similarity1
Modified residuei529PhosphoserineBy similarity1
Modified residuei538PhosphoserineBy similarity1
Modified residuei619PhosphothreonineBy similarity1
Modified residuei660PhosphoserineBy similarity1
Modified residuei664PhosphoserineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei938PhosphothreonineBy similarity1
Modified residuei1136PhosphoserineBy similarity1
Modified residuei1138PhosphoserineBy similarity1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1161PhosphoserineBy similarity1
Modified residuei1177PhosphoserineBy similarity1
Modified residuei1189PhosphothreonineBy similarity1
Modified residuei1204PhosphoserineBy similarity1
Modified residuei1234PhosphoserineBy similarity1
Modified residuei1253PhosphoserineBy similarity1
Modified residuei1295PhosphoserineBy similarity1
Modified residuei1297PhosphoserineBy similarity1
Modified residuei1339PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BX26

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BX26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BX26

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BX26

PeptideAtlas

More...
PeptideAtlasi
Q9BX26

PRoteomics IDEntifications database

More...
PRIDEi
Q9BX26

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79343

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9BX26

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BX26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BX26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196074 Expressed in 133 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BX26 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BX26 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA062401
HPA065613

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the lateral elements of synaptonemal complexes. Heterodimer with SYCP3 (By similarity).

Interacts with SMC1A and SMC3 (By similarity).

Interacts with TEX11 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115660, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BX26, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BX26

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi655 – 660Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SYCP2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIGE Eukaryota
ENOG4111I7G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231579

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BX26

KEGG Orthology (KO)

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KOi
K19529

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLMSLFM

Database of Orthologous Groups

More...
OrthoDBi
285929at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BX26

TreeFam database of animal gene trees

More...
TreeFami
TF332368

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024835 SYCP1/2
IPR024832 SYCP2
IPR041322 SYCP2_ARLD
IPR040560 SYCP2_SLD

The PANTHER Classification System

More...
PANTHERi
PTHR15607 PTHR15607, 1 hit
PTHR15607:SF12 PTHR15607:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18581 SYCP2_ARLD, 1 hit
PF18584 SYCP2_SLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BX26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIRPDLQQL EKCIDDALRK NDFKPLKTLL QIDICEDVKI KCSKQFFHKV
60 70 80 90 100
DNLICRELNK EDIHNVSAIL VSVGRCGKNI SVLGQAGLLT MIKQGLIQKM
110 120 130 140 150
VAWFEKSKDI IQSQGNSKDE AVLNMIEDLV DLLLVIHDVS DEGKKQVVES
160 170 180 190 200
FVPRICSLVI DSRVNICIQQ EIIKKMNAML DKMPQDARKI LSNQEMLILM
210 220 230 240 250
SSMGERILDA GDYDLQVGIV EALCRMTTEK QRQELAHQWF SMDFIAKAFK
260 270 280 290 300
RIKDSEFETD CRIFLNLVNG MLGDKRRVFT FPCLSAFLDK YELQIPSDEK
310 320 330 340 350
LEEFWIDFNL GSQTLSFYIA GDNDDHQWEA VTVPEEKVQI YSIEVRESKK
360 370 380 390 400
LLTIILKNTV KISKREGKEL LLYFDASLEI TNVTQKIFGA TKHRESIRKQ
410 420 430 440 450
GISVAKTSLH ILFDASGSQI LVPESQISPV GEELVSLKEK SKSPKEFAKP
460 470 480 490 500
SKYIKNSDKG NRNNSQLEKT TPSKRKMSEA SMIVSGADRY TMRSPVLFSN
510 520 530 540 550
TSIPPRRRRI KPPLQMTSSA EKPSVSQTSE NRVDNAASLK SRSSEGRHRR
560 570 580 590 600
DNIDKHIKTA KCVENTENKN VEFPNQNFSE LQDVIPDSQA AEKRDHTILP
610 620 630 640 650
GVLDNICGNK IHSKWACWTP VTNIELCNNQ RASTSSGDTL NQDIVINKKL
660 670 680 690 700
TKQKSSSSIS DHNSEGTGKV KYKKEQTDHI KIDKAEVEVC KKHNQQQNHP
710 720 730 740 750
KYSGQKNTEN AKQSDWPVES ETTFKSVLLN KTIEESLIYR KKYILSKDVN
760 770 780 790 800
TATCDKNPSA SKNVQSHRKA EKELTSELNS WDSKQKKMRE KSKGKEFTNV
810 820 830 840 850
AESLISQINK RYKTKDDIKS TRKLKESLIN SGFSNKPVVQ LSKEKVQKKS
860 870 880 890 900
YRKLKTTFVN VTSECPVNDV YNFNLNGADD PIIKLGIQEF QATAKEACAD
910 920 930 940 950
RSIRLVGPRN HDELKSSVKT KDKKIITNHQ KKNLFSDTET EYRCDDSKTD
960 970 980 990 1000
ISWLREPKSK PQLIDYSRNK NVKNHKSGKS RSSLEKGQPS SKMTPSKNIT
1010 1020 1030 1040 1050
KKMDKTIPEG RIRLPRKATK TKKNYKDLSN SESECEQEFS HSFKENIPVK
1060 1070 1080 1090 1100
EENIHSRMKT VKLPKKQQKV FCAETEKELS KQWKNSSLLK DAIRDNCLDL
1110 1120 1130 1140 1150
SPRSLSGSPS SIEVTRCIEK ITEKDFTQDY DCITKSISPY PKTSSLESLN
1160 1170 1180 1190 1200
SNSGVGGTIK SPKNNEKNFL CASESCSPIP RPLFLPRHTP TKSNTIVNRK
1210 1220 1230 1240 1250
KISSLVLTQE TQNSNSYSDV SSYSSEERFM EIESPHINEN YIQSKREESH
1260 1270 1280 1290 1300
LASSLSKSSE GREKTWFDMP CDATHVSGPT QHLSRKRIYI EDNLSNSNEV
1310 1320 1330 1340 1350
EMEEKGERRA NLLPKKLCKI EDADHHIHKM SESVSSLSTN DFSIPWETWQ
1360 1370 1380 1390 1400
NEFAGIEMTY ETYERLNSEF KRRNNIRHKM LSYFTTQSWK TAQQHLRTMN
1410 1420 1430 1440 1450
HQSQDSRIKK LDKFQFIIIE ELENFEKDSQ SLKDLEKEFV DFWEKIFQKF
1460 1470 1480 1490 1500
SAYQKSEQQR LHLLKTSLAK SVFCNTDSEE TVFTSEMCLM KEDMKVLQDR
1510 1520 1530
LLKDMLEEEL LNVRRELMSV FMSHERNANV
Length:1,530
Mass (Da):175,639
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3676EB133C53F1FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A341A2A341_HUMAN
Synaptonemal complex protein 2
SYCP2
1,023Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A2M9A2A2M9_HUMAN
Synaptonemal complex protein 2
SYCP2
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A340A2A340_HUMAN
Synaptonemal complex protein 2
SYCP2
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218G → A in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti691K → R in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti794 – 797GKEF → KKKK (PubMed:17974005).Curated4
Sequence conflicti1179I → T in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti1186P → A in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti1222S → R in CAA70171 (PubMed:10341103).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054059353T → K. Corresponds to variant dbSNP:rs13039338Ensembl.1
Natural variantiVAR_014115523P → L. Corresponds to variant dbSNP:rs1359836Ensembl.1
Natural variantiVAR_054060751T → I. Corresponds to variant dbSNP:rs6071006Ensembl.1
Natural variantiVAR_0540611155V → A. Corresponds to variant dbSNP:rs6128714Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y08982 mRNA Translation: CAA70171.1
AL109928 Genomic DNA No translation available.
AL158092 Genomic DNA No translation available.
BC132864 mRNA Translation: AAI32865.1
BC132870 mRNA Translation: AAI32871.1
AL080226 mRNA Translation: CAB45780.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13482.1

NCBI Reference Sequences

More...
RefSeqi
NP_055073.2, NM_014258.3
XP_011526791.1, XM_011528489.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357552; ENSP00000350162; ENSG00000196074
ENST00000371001; ENSP00000360040; ENSG00000196074

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10388

UCSC genome browser

More...
UCSCi
uc002yaz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08982 mRNA Translation: CAA70171.1
AL109928 Genomic DNA No translation available.
AL158092 Genomic DNA No translation available.
BC132864 mRNA Translation: AAI32865.1
BC132870 mRNA Translation: AAI32871.1
AL080226 mRNA Translation: CAB45780.1
CCDSiCCDS13482.1
RefSeqiNP_055073.2, NM_014258.3
XP_011526791.1, XM_011528489.2

3D structure databases

SMRiQ9BX26
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115660, 3 interactors
IntActiQ9BX26, 1 interactor
STRINGi9606.ENSP00000350162

PTM databases

CarbonylDBiQ9BX26
iPTMnetiQ9BX26
PhosphoSitePlusiQ9BX26

Polymorphism and mutation databases

BioMutaiSYCP2
DMDMi23822155

Proteomic databases

EPDiQ9BX26
jPOSTiQ9BX26
MassIVEiQ9BX26
PaxDbiQ9BX26
PeptideAtlasiQ9BX26
PRIDEiQ9BX26
ProteomicsDBi79343

Genome annotation databases

EnsembliENST00000357552; ENSP00000350162; ENSG00000196074
ENST00000371001; ENSP00000360040; ENSG00000196074
GeneIDi10388
KEGGihsa:10388
UCSCiuc002yaz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10388
DisGeNETi10388

GeneCards: human genes, protein and diseases

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GeneCardsi
SYCP2
HGNCiHGNC:11490 SYCP2
HPAiHPA062401
HPA065613
MIMi604105 gene
neXtProtiNX_Q9BX26
OpenTargetsiENSG00000196074
PharmGKBiPA36272

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IIGE Eukaryota
ENOG4111I7G LUCA
GeneTreeiENSGT00530000063859
HOGENOMiHOG000231579
InParanoidiQ9BX26
KOiK19529
OMAiGLMSLFM
OrthoDBi285929at2759
PhylomeDBiQ9BX26
TreeFamiTF332368

Enzyme and pathway databases

ReactomeiR-HSA-1221632 Meiotic synapsis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SYCP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10388
PharosiQ9BX26

Protein Ontology

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PROi
PR:Q9BX26

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196074 Expressed in 133 organ(s), highest expression level in testis
ExpressionAtlasiQ9BX26 baseline and differential
GenevisibleiQ9BX26 HS

Family and domain databases

InterProiView protein in InterPro
IPR024835 SYCP1/2
IPR024832 SYCP2
IPR041322 SYCP2_ARLD
IPR040560 SYCP2_SLD
PANTHERiPTHR15607 PTHR15607, 1 hit
PTHR15607:SF12 PTHR15607:SF12, 1 hit
PfamiView protein in Pfam
PF18581 SYCP2_ARLD, 1 hit
PF18584 SYCP2_SLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYCP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BX26
Secondary accession number(s): A2RUE5
, O75763, Q5JX11, Q9NTX8, Q9UG27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: October 16, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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