Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9BX26 (SYCP2_HUMAN)

Entry version 149 (02 Dec 2020)
Sequence version 2 (10 Oct 2002)
Previous versions | rss
Add a publicationFeedback
Protein

Synaptonemal complex protein 2

Gene

SYCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Meiosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BX26

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1221632, Meiotic synapsis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptonemal complex protein 2
Short name:
SCP-2
Alternative name(s):
Synaptonemal complex lateral element protein
Short name:
hsSCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYCP2
Synonyms:SCP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000196074.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:11490, SYCP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604105, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BX26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 1 (SPGF1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder characterized by azoospermia due to spermatogenic arrest during meiosis. Meiotic arrest is characterized by germ cells that enter meiosis and undergo the first chromosomal reduction from 4n to 2n, but that are then unable to proceed further. This results in tubules containing spermatocytes as the latest developmental stage of germ cells. Meiotically arrested spermatocytes accumulate in the tubules and degenerate. Both autosomal recessive and autosomal dominant inheritance have been reported.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		10388

MalaCards human disease database

More...MalaCardsi		SYCP2
MIMi258150, phenotype

Open Targets

More...OpenTargetsi		ENSG00000196074

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36272

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BX26, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYCP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		23822155

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000723661 – 1530Synaptonemal complex protein 2Add BLAST1530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei457PhosphoserineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei471PhosphothreonineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei519PhosphoserineBy similarity1
Modified residuei529PhosphoserineBy similarity1
Modified residuei538PhosphoserineBy similarity1
Modified residuei619PhosphothreonineBy similarity1
Modified residuei660PhosphoserineBy similarity1
Modified residuei664PhosphoserineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei938PhosphothreonineBy similarity1
Modified residuei1136PhosphoserineBy similarity1
Modified residuei1138PhosphoserineBy similarity1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1161PhosphoserineBy similarity1
Modified residuei1177PhosphoserineBy similarity1
Modified residuei1189PhosphothreonineBy similarity1
Modified residuei1204PhosphoserineBy similarity1
Modified residuei1234PhosphoserineBy similarity1
Modified residuei1253PhosphoserineBy similarity1
Modified residuei1295PhosphoserineBy similarity1
Modified residuei1297PhosphoserineBy similarity1
Modified residuei1339PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BX26

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BX26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BX26

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BX26

PeptideAtlas

More...PeptideAtlasi		Q9BX26

PRoteomics IDEntifications database

More...PRIDEi		Q9BX26

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79343

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9BX26

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BX26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BX26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196074, Expressed in testis and 149 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BX26, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BX26, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196074, Group enriched (breast, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the lateral elements of synaptonemal complexes. Heterodimer with SYCP3 (By similarity).

Interacts with SMC1A and SMC3 (By similarity).

Interacts with TEX11 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115660, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q9BX26, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350162

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BX26, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BX26

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi655 – 660Poly-Ser6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SYCP2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVM5, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063859

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BX26

Identification of Orthologs from Complete Genome Data

More...OMAi		MAHERNV

Database of Orthologous Groups

More...OrthoDBi		285929at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BX26

TreeFam database of animal gene trees

More...TreeFami		TF332368

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024835, SYCP1/2
IPR024832, SYCP2
IPR041322, SYCP2_ARLD
IPR040560, SYCP2_SLD

The PANTHER Classification System

More...PANTHERi		PTHR15607, PTHR15607, 1 hit
PTHR15607:SF12, PTHR15607:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18581, SYCP2_ARLD, 1 hit
PF18584, SYCP2_SLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BX26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIRPDLQQL EKCIDDALRK NDFKPLKTLL QIDICEDVKI KCSKQFFHKV 
        60         70         80         90        100
DNLICRELNK EDIHNVSAIL VSVGRCGKNI SVLGQAGLLT MIKQGLIQKM 
       110        120        130        140        150
VAWFEKSKDI IQSQGNSKDE AVLNMIEDLV DLLLVIHDVS DEGKKQVVES 
       160        170        180        190        200
FVPRICSLVI DSRVNICIQQ EIIKKMNAML DKMPQDARKI LSNQEMLILM 
       210        220        230        240        250
SSMGERILDA GDYDLQVGIV EALCRMTTEK QRQELAHQWF SMDFIAKAFK 
       260        270        280        290        300
RIKDSEFETD CRIFLNLVNG MLGDKRRVFT FPCLSAFLDK YELQIPSDEK 
       310        320        330        340        350
LEEFWIDFNL GSQTLSFYIA GDNDDHQWEA VTVPEEKVQI YSIEVRESKK 
       360        370        380        390        400
LLTIILKNTV KISKREGKEL LLYFDASLEI TNVTQKIFGA TKHRESIRKQ 
       410        420        430        440        450
GISVAKTSLH ILFDASGSQI LVPESQISPV GEELVSLKEK SKSPKEFAKP 
       460        470        480        490        500
SKYIKNSDKG NRNNSQLEKT TPSKRKMSEA SMIVSGADRY TMRSPVLFSN 
       510        520        530        540        550
TSIPPRRRRI KPPLQMTSSA EKPSVSQTSE NRVDNAASLK SRSSEGRHRR 
       560        570        580        590        600
DNIDKHIKTA KCVENTENKN VEFPNQNFSE LQDVIPDSQA AEKRDHTILP 
       610        620        630        640        650
GVLDNICGNK IHSKWACWTP VTNIELCNNQ RASTSSGDTL NQDIVINKKL 
       660        670        680        690        700
TKQKSSSSIS DHNSEGTGKV KYKKEQTDHI KIDKAEVEVC KKHNQQQNHP 
       710        720        730        740        750
KYSGQKNTEN AKQSDWPVES ETTFKSVLLN KTIEESLIYR KKYILSKDVN 
       760        770        780        790        800
TATCDKNPSA SKNVQSHRKA EKELTSELNS WDSKQKKMRE KSKGKEFTNV 
       810        820        830        840        850
AESLISQINK RYKTKDDIKS TRKLKESLIN SGFSNKPVVQ LSKEKVQKKS 
       860        870        880        890        900
YRKLKTTFVN VTSECPVNDV YNFNLNGADD PIIKLGIQEF QATAKEACAD 
       910        920        930        940        950
RSIRLVGPRN HDELKSSVKT KDKKIITNHQ KKNLFSDTET EYRCDDSKTD 
       960        970        980        990       1000
ISWLREPKSK PQLIDYSRNK NVKNHKSGKS RSSLEKGQPS SKMTPSKNIT 
      1010       1020       1030       1040       1050
KKMDKTIPEG RIRLPRKATK TKKNYKDLSN SESECEQEFS HSFKENIPVK 
      1060       1070       1080       1090       1100
EENIHSRMKT VKLPKKQQKV FCAETEKELS KQWKNSSLLK DAIRDNCLDL 
      1110       1120       1130       1140       1150
SPRSLSGSPS SIEVTRCIEK ITEKDFTQDY DCITKSISPY PKTSSLESLN 
      1160       1170       1180       1190       1200
SNSGVGGTIK SPKNNEKNFL CASESCSPIP RPLFLPRHTP TKSNTIVNRK 
      1210       1220       1230       1240       1250
KISSLVLTQE TQNSNSYSDV SSYSSEERFM EIESPHINEN YIQSKREESH 
      1260       1270       1280       1290       1300
LASSLSKSSE GREKTWFDMP CDATHVSGPT QHLSRKRIYI EDNLSNSNEV 
      1310       1320       1330       1340       1350
EMEEKGERRA NLLPKKLCKI EDADHHIHKM SESVSSLSTN DFSIPWETWQ 
      1360       1370       1380       1390       1400
NEFAGIEMTY ETYERLNSEF KRRNNIRHKM LSYFTTQSWK TAQQHLRTMN 
      1410       1420       1430       1440       1450
HQSQDSRIKK LDKFQFIIIE ELENFEKDSQ SLKDLEKEFV DFWEKIFQKF 
      1460       1470       1480       1490       1500
SAYQKSEQQR LHLLKTSLAK SVFCNTDSEE TVFTSEMCLM KEDMKVLQDR 
      1510       1520       1530
LLKDMLEEEL LNVRRELMSV FMSHERNANV
Length:1,530
Mass (Da):175,639
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3676EB133C53F1FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A341A2A341_HUMAN
Synaptonemal complex protein 2
SYCP2
1,023Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A2M9A2A2M9_HUMAN
Synaptonemal complex protein 2
SYCP2
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A340A2A340_HUMAN
Synaptonemal complex protein 2
SYCP2
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218G → A in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti691K → R in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti794 – 797GKEF → KKKK (PubMed:17974005).Curated4
Sequence conflicti1179I → T in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti1186P → A in CAA70171 (PubMed:10341103).Curated1
Sequence conflicti1222S → R in CAA70171 (PubMed:10341103).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054059353T → K. Corresponds to variant dbSNP:rs13039338Ensembl.1
Natural variantiVAR_014115523P → L. Corresponds to variant dbSNP:rs1359836Ensembl.1
Natural variantiVAR_054060751T → I. Corresponds to variant dbSNP:rs6071006Ensembl.1
Natural variantiVAR_0540611155V → A. Corresponds to variant dbSNP:rs6128714Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y08982 mRNA Translation: CAA70171.1
AL109928 Genomic DNA No translation available.
AL158092 Genomic DNA No translation available.
BC132864 mRNA Translation: AAI32865.1
BC132870 mRNA Translation: AAI32871.1
AL080226 mRNA Translation: CAB45780.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13482.1

NCBI Reference Sequences

More...RefSeqi		NP_055073.2, NM_014258.3
XP_011526791.1, XM_011528489.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357552; ENSP00000350162; ENSG00000196074
ENST00000371001; ENSP00000360040; ENSG00000196074

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10388

UCSC genome browser

More...UCSCi		uc002yaz.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08982 mRNA Translation: CAA70171.1
AL109928 Genomic DNA No translation available.
AL158092 Genomic DNA No translation available.
BC132864 mRNA Translation: AAI32865.1
BC132870 mRNA Translation: AAI32871.1
AL080226 mRNA Translation: CAB45780.1
CCDSiCCDS13482.1
RefSeqiNP_055073.2, NM_014258.3
XP_011526791.1, XM_011528489.2

3D structure databases

SMRiQ9BX26
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115660, 3 interactors
IntActiQ9BX26, 1 interactor
STRINGi9606.ENSP00000350162

PTM databases

CarbonylDBiQ9BX26
iPTMnetiQ9BX26
PhosphoSitePlusiQ9BX26

Polymorphism and mutation databases

BioMutaiSYCP2
DMDMi23822155

Proteomic databases

EPDiQ9BX26
jPOSTiQ9BX26
MassIVEiQ9BX26
PaxDbiQ9BX26
PeptideAtlasiQ9BX26
PRIDEiQ9BX26
ProteomicsDBi79343

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		58383, 90 antibodies

Genome annotation databases

EnsembliENST00000357552; ENSP00000350162; ENSG00000196074
ENST00000371001; ENSP00000360040; ENSG00000196074
GeneIDi10388
KEGGihsa:10388
UCSCiuc002yaz.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10388
DisGeNETi10388
EuPathDBiHostDB:ENSG00000196074.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYCP2
HGNCiHGNC:11490, SYCP2
HPAiENSG00000196074, Group enriched (breast, testis)
MalaCardsiSYCP2
MIMi258150, phenotype
604105, gene
neXtProtiNX_Q9BX26
OpenTargetsiENSG00000196074
PharmGKBiPA36272

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVM5, Eukaryota
GeneTreeiENSGT00530000063859
InParanoidiQ9BX26
OMAiMAHERNV
OrthoDBi285929at2759
PhylomeDBiQ9BX26
TreeFamiTF332368

Enzyme and pathway databases

PathwayCommonsiQ9BX26
ReactomeiR-HSA-1221632, Meiotic synapsis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10388, 3 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYCP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10388
PharosiQ9BX26, Tbio

Protein Ontology

More...PROi		PR:Q9BX26
RNActiQ9BX26, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196074, Expressed in testis and 149 other tissues
ExpressionAtlasiQ9BX26, baseline and differential
GenevisibleiQ9BX26, HS

Family and domain databases

InterProiView protein in InterPro
IPR024835, SYCP1/2
IPR024832, SYCP2
IPR041322, SYCP2_ARLD
IPR040560, SYCP2_SLD
PANTHERiPTHR15607, PTHR15607, 1 hit
PTHR15607:SF12, PTHR15607:SF12, 1 hit
PfamiView protein in Pfam
PF18581, SYCP2_ARLD, 1 hit
PF18584, SYCP2_SLD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYCP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BX26
Secondary accession number(s): A2RUE5
, O75763, Q5JX11, Q9NTX8, Q9UG27
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: December 2, 2020
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again