Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PHD finger protein 7

Gene

PHF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in spermatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 68C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri96 – 145PHD-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri160 – 208RING-type; degeneratePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 7
Alternative name(s):
Testis development protein NYD-SP6
Gene namesi
Name:PHF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000010318.19
HGNCiHGNC:18458 PHF7
neXtProtiNX_Q9BWX1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000010318
PharmGKBiPA38541

Polymorphism and mutation databases

DMDMi62900704

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559961 – 381PHD finger protein 7Add BLAST381

Proteomic databases

PaxDbiQ9BWX1
PeptideAtlasiQ9BWX1
PRIDEiQ9BWX1
ProteomicsDBi79337

PTM databases

iPTMnetiQ9BWX1
PhosphoSitePlusiQ9BWX1

Expressioni

Tissue specificityi

Highly expressed in Sertoli cells, but not in germ cells in adult testis. Expression in embryonic testis is 30-times lower. Highly expressed in colon, spleen, white blood cells, pancreas, lung, liver, placenta and brain. Detected at lower levels in thymus, small intestine, ovary and kidney.1 Publication

Gene expression databases

BgeeiENSG00000010318 Expressed in 176 organ(s), highest expression level in testis
CleanExiHS_PHF7
ExpressionAtlasiQ9BWX1 baseline and differential
GenevisibleiQ9BWX1 HS

Organism-specific databases

HPAiHPA036283
HPA070305

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBE2D4Q9Y2X83EBI-4307517,EBI-745527

Protein-protein interaction databases

BioGridi119594, 23 interactors
IntActiQ9BWX1, 12 interactors
STRINGi9606.ENSP00000333024

Structurei

3D structure databases

ProteinModelPortaliQ9BWX1
SMRiQ9BWX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri30 – 68C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri96 – 145PHD-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri160 – 208RING-type; degeneratePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00390000005246
HOGENOMiHOG000236336
HOVERGENiHBG053588
InParanoidiQ9BWX1
OMAiFFGEYKS
OrthoDBiEOG091G0Q24
PhylomeDBiQ9BWX1
TreeFamiTF325426

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BWX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTVKEKKEC QRLRKSAKTR RVTQRKPSSG PVCWLCLREP GDPEKLGEFL
60 70 80 90 100
QKDNISVHYF CLILSSKLPQ RGQSNRGFHG FLPEDIKKEA ARASRKICFV
110 120 130 140 150
CKKKGAAINC QKDQCLRNFH LPCGQERGCL SQFFGEYKSF CDKHRPTQNI
160 170 180 190 200
QHGHVGEESC ILCCEDLSQQ SVENIQSPCC SQAIYHRKCI QKYAHTSAKH
210 220 230 240 250
FFKCPQCNNR KEFPQEMLRM GIHIPDRDAA WELEPGAFSD LYQRYQHCDA
260 270 280 290 300
PICLYEQGRD SFEDEGRWCL ILCATCGSHG THRDCSSLRS NSKKWECEEC
310 320 330 340 350
SPAAATDYIP ENSGDIPCCS STFHPEEHFC RDNTLEENPG LSWTDWPEPS
360 370 380
LLEKPESSRG RRSYSWRSKG VRITNSCKKS K
Length:381
Mass (Da):43,767
Last modified:June 1, 2001 - v1
Checksum:i5219D262D8135B8D
GO
Isoform 2 (identifier: Q9BWX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-266: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:342
Mass (Da):39,259
Checksum:i760DEF8BFABB5CAD
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4N0H7C4N0_HUMAN
PHD finger protein 7
PHF7
326Annotation score:
H7C5Q8H7C5Q8_HUMAN
PHD finger protein 7
PHF7
63Annotation score:
A0A087X0X8A0A087X0X8_HUMAN
PHD finger protein 7
PHF7
213Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035957369K → N in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046255228 – 266Missing in isoform 2. CuratedAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014283 mRNA Translation: AAK27308.1
AC006208 Genomic DNA No translation available.
AC092045 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65224.1
BC022002 mRNA Translation: AAH22002.1
CCDSiCCDS2854.1 [Q9BWX1-1]
CCDS2855.1 [Q9BWX1-2]
RefSeqiNP_001265150.1, NM_001278221.2 [Q9BWX1-2]
NP_001308055.1, NM_001321126.1 [Q9BWX1-1]
NP_001308056.1, NM_001321127.1 [Q9BWX1-1]
NP_057567.3, NM_016483.6 [Q9BWX1-1]
UniGeneiHs.372719

Genome annotation databases

EnsembliENST00000327906; ENSP00000333024; ENSG00000010318 [Q9BWX1-1]
ENST00000347025; ENSP00000246282; ENSG00000010318 [Q9BWX1-2]
ENST00000614886; ENSP00000480003; ENSG00000010318 [Q9BWX1-2]
GeneIDi51533
KEGGihsa:51533
UCSCiuc003ddy.5 human [Q9BWX1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014283 mRNA Translation: AAK27308.1
AC006208 Genomic DNA No translation available.
AC092045 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65224.1
BC022002 mRNA Translation: AAH22002.1
CCDSiCCDS2854.1 [Q9BWX1-1]
CCDS2855.1 [Q9BWX1-2]
RefSeqiNP_001265150.1, NM_001278221.2 [Q9BWX1-2]
NP_001308055.1, NM_001321126.1 [Q9BWX1-1]
NP_001308056.1, NM_001321127.1 [Q9BWX1-1]
NP_057567.3, NM_016483.6 [Q9BWX1-1]
UniGeneiHs.372719

3D structure databases

ProteinModelPortaliQ9BWX1
SMRiQ9BWX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119594, 23 interactors
IntActiQ9BWX1, 12 interactors
STRINGi9606.ENSP00000333024

PTM databases

iPTMnetiQ9BWX1
PhosphoSitePlusiQ9BWX1

Polymorphism and mutation databases

DMDMi62900704

Proteomic databases

PaxDbiQ9BWX1
PeptideAtlasiQ9BWX1
PRIDEiQ9BWX1
ProteomicsDBi79337

Protocols and materials databases

DNASUi51533
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327906; ENSP00000333024; ENSG00000010318 [Q9BWX1-1]
ENST00000347025; ENSP00000246282; ENSG00000010318 [Q9BWX1-2]
ENST00000614886; ENSP00000480003; ENSG00000010318 [Q9BWX1-2]
GeneIDi51533
KEGGihsa:51533
UCSCiuc003ddy.5 human [Q9BWX1-1]

Organism-specific databases

CTDi51533
EuPathDBiHostDB:ENSG00000010318.19
GeneCardsiPHF7
HGNCiHGNC:18458 PHF7
HPAiHPA036283
HPA070305
neXtProtiNX_Q9BWX1
OpenTargetsiENSG00000010318
PharmGKBiPA38541
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1084 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00390000005246
HOGENOMiHOG000236336
HOVERGENiHBG053588
InParanoidiQ9BWX1
OMAiFFGEYKS
OrthoDBiEOG091G0Q24
PhylomeDBiQ9BWX1
TreeFamiTF325426

Miscellaneous databases

ChiTaRSiPHF7 human
GenomeRNAii51533
PROiPR:Q9BWX1

Gene expression databases

BgeeiENSG00000010318 Expressed in 176 organ(s), highest expression level in testis
CleanExiHS_PHF7
ExpressionAtlasiQ9BWX1 baseline and differential
GenevisibleiQ9BWX1 HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR034732 EPHD
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHF7_HUMAN
AccessioniPrimary (citable) accession number: Q9BWX1
Secondary accession number(s): K4DI82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again