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Entry version 126 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Apolipoprotein L5

Gene

APOL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • high-density lipoprotein particle binding Source: UniProtKB
  • lipid binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein L5
Alternative name(s):
Apolipoprotein L-V
Short name:
ApoL-V
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14869 APOL5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607255 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BWW9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80831

Open Targets

More...
OpenTargetsi
ENSG00000128313

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24908

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BWW9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APOL5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17433287

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001376031 – 433Apolipoprotein L5Add BLAST433

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BWW9

PeptideAtlas

More...
PeptideAtlasi
Q9BWW9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BWW9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79336

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9BWW9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BWW9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BWW9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Low level of expression; detected in uterus, testis, skeletal muscle and stomach.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128313 Expressed in 19 organ(s), highest expression level in muscle of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BWW9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040968

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9BWW9, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000249044

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BWW9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWES Eukaryota
ENOG410Y0AF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182782

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202815

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BWW9

KEGG Orthology (KO)

More...
KOi
K14480

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTLAMTN

Database of Orthologous Groups

More...
OrthoDBi
1077462at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BWW9

TreeFam database of animal gene trees

More...
TreeFami
TF334681

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008405 ApoL

The PANTHER Classification System

More...
PANTHERi
PTHR14096 PTHR14096, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05461 ApoL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BWW9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCGKQGNLQ VPGSKVLPGL GEGCKEMWLR KVIYGGEVWG KSPEPEFPSL
60 70 80 90 100
VNLCQSWKIN NLMSTVHSDE AGMLSYFLFE ELMRCDKDSM PDGNLSEEEK
110 120 130 140 150
LFLSYFPLHK FELEQNIKEL NTLADQVDTT HELLTKTSLV ASSSGAVSGV
160 170 180 190 200
MNILGLALAP VTAGGSLMLS ATGTGLGAAA AITNIVTNVL ENRSNSAARD
210 220 230 240 250
KASRLGPLTT SHEAFGGINW SEIEAAGFCV NKCVKAIQGI KDLHAYQMAK
260 270 280 290 300
SNSGFMAMVK NFVAKRHIPF WTARGVQRAF EGTTLAMTNG AWVMGAAGAG
310 320 330 340 350
FLLMKDMSSF LQSWKHLEDG ARTETAEELR ALAKKLEQEL DRLTQHHRHL
360 370 380 390 400
PQKASQTCSS SRGRAVRGSR VVKPEGSRSP LPWPVVEHQP RLGPGVALRT
410 420 430
PKRTVSAPRM LGHQPAPPAP ARKGRQAPGR HRQ
Length:433
Mass (Da):47,044
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF64416DE8FEB7E9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JME4A0A0G2JME4_HUMAN
Apolipoprotein L5
APOL5
433Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05301281E → K. Corresponds to variant dbSNP:rs5999985Ensembl.1
Natural variantiVAR_020355272T → M. Corresponds to variant dbSNP:rs2076671Ensembl.1
Natural variantiVAR_020356323T → M. Corresponds to variant dbSNP:rs2076672Ensembl.1
Natural variantiVAR_020357406S → C. Corresponds to variant dbSNP:rs2076673Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY014878 mRNA Translation: AAK07723.1
AL049748 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13920.1

NCBI Reference Sequences

More...
RefSeqi
NP_085145.1, NM_030642.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000249044; ENSP00000249044; ENSG00000128313

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80831

UCSC genome browser

More...
UCSCi
uc003aof.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014878 mRNA Translation: AAK07723.1
AL049748 Genomic DNA No translation available.
CCDSiCCDS13920.1
RefSeqiNP_085145.1, NM_030642.1

3D structure databases

SMRiQ9BWW9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9BWW9, 7 interactors
STRINGi9606.ENSP00000249044

PTM databases

iPTMnetiQ9BWW9
PhosphoSitePlusiQ9BWW9

Polymorphism and mutation databases

BioMutaiAPOL5
DMDMi17433287

Proteomic databases

PaxDbiQ9BWW9
PeptideAtlasiQ9BWW9
PRIDEiQ9BWW9
ProteomicsDBi79336
TopDownProteomicsiQ9BWW9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80831

Genome annotation databases

EnsembliENST00000249044; ENSP00000249044; ENSG00000128313
GeneIDi80831
KEGGihsa:80831
UCSCiuc003aof.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80831
DisGeNETi80831

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APOL5
HGNCiHGNC:14869 APOL5
HPAiHPA040968
MIMi607255 gene
neXtProtiNX_Q9BWW9
OpenTargetsiENSG00000128313
PharmGKBiPA24908

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00950000182782
HOGENOMiHOG000202815
InParanoidiQ9BWW9
KOiK14480
OMAiTTLAMTN
OrthoDBi1077462at2759
PhylomeDBiQ9BWW9
TreeFamiTF334681

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80831
PharosiQ9BWW9

Protein Ontology

More...
PROi
PR:Q9BWW9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128313 Expressed in 19 organ(s), highest expression level in muscle of leg
GenevisibleiQ9BWW9 HS

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOL5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BWW9
Secondary accession number(s): Q5TFL9, Q9UGW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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