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Protein

Apolipoprotein L6

Gene

APOL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  • lipid binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L6
Alternative name(s):
Apolipoprotein L-VI
Short name:
ApoL-VI
Gene namesi
Name:APOL6
ORF Names:UNQ3095/PRO21341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000221963.5
HGNCiHGNC:14870 APOL6
MIMi607256 gene
neXtProtiNX_Q9BWW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80830
OpenTargetsiENSG00000221963
PharmGKBiPA24909

Polymorphism and mutation databases

BioMutaiAPOL6
DMDMi17433286

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001376041 – 343Apolipoprotein L6Add BLAST343

Proteomic databases

EPDiQ9BWW8
PaxDbiQ9BWW8
PeptideAtlasiQ9BWW8
PRIDEiQ9BWW8
ProteomicsDBi79335

PTM databases

iPTMnetiQ9BWW8
PhosphoSitePlusiQ9BWW8

Expressioni

Tissue specificityi

Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.

Gene expression databases

BgeeiENSG00000221963 Expressed in 205 organ(s), highest expression level in pericardium
CleanExiHS_APOL6
ExpressionAtlasiQ9BWW8 baseline and differential
GenevisibleiQ9BWW8 HS

Organism-specific databases

HPAiCAB028574
HPA029165
HPA029167

Interactioni

Protein-protein interaction databases

BioGridi123323, 6 interactors
IntActiQ9BWW8, 8 interactors
STRINGi9606.ENSP00000386280

Structurei

3D structure databases

ProteinModelPortaliQ9BWW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein L family.Curated

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00510000046700
HOGENOMiHOG000294132
HOVERGENiHBG106550
InParanoidiQ9BWW8
KOiK14480
OMAiTHKKFTK
OrthoDBiEOG091G0SMD
PhylomeDBiQ9BWW8
TreeFamiTF334681

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BWW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK
60 70 80 90 100
EDLKGNIDKL RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP
110 120 130 140 150
ATGGGSLLLS TAGQGLATAA GVTSIVSGTL ERSKNKEAQA RAEDILPTYD
160 170 180 190 200
QEDREDEEEK ADYVTAAGKI IYNLRNTLKY AKKNVRAFWK LRANPRLANA
210 220 230 240 250
TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM SAFSLGYDLA
260 270 280 290 300
TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA
310 320 330 340
RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT
Length:343
Mass (Da):38,128
Last modified:June 1, 2001 - v1
Checksum:i9101D15ABAE71CDE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053013173N → K1 PublicationCorresponds to variant dbSNP:rs5999923Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014879 mRNA Translation: AAK07724.1
AY358210 mRNA Translation: AAQ88577.1
CR456381 mRNA Translation: CAG30267.1
AL834420 mRNA Translation: CAH56356.1
Z79996 Genomic DNA No translation available.
BC038950 mRNA Translation: AAH38950.2
BC047864 mRNA Translation: AAH47864.1
CCDSiCCDS13919.1
RefSeqiNP_085144.1, NM_030641.3
XP_011528694.1, XM_011530392.2
UniGeneiHs.257352

Genome annotation databases

EnsembliENST00000409652; ENSP00000386280; ENSG00000221963
GeneIDi80830
KEGGihsa:80830
UCSCiuc003aoe.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014879 mRNA Translation: AAK07724.1
AY358210 mRNA Translation: AAQ88577.1
CR456381 mRNA Translation: CAG30267.1
AL834420 mRNA Translation: CAH56356.1
Z79996 Genomic DNA No translation available.
BC038950 mRNA Translation: AAH38950.2
BC047864 mRNA Translation: AAH47864.1
CCDSiCCDS13919.1
RefSeqiNP_085144.1, NM_030641.3
XP_011528694.1, XM_011530392.2
UniGeneiHs.257352

3D structure databases

ProteinModelPortaliQ9BWW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123323, 6 interactors
IntActiQ9BWW8, 8 interactors
STRINGi9606.ENSP00000386280

PTM databases

iPTMnetiQ9BWW8
PhosphoSitePlusiQ9BWW8

Polymorphism and mutation databases

BioMutaiAPOL6
DMDMi17433286

Proteomic databases

EPDiQ9BWW8
PaxDbiQ9BWW8
PeptideAtlasiQ9BWW8
PRIDEiQ9BWW8
ProteomicsDBi79335

Protocols and materials databases

DNASUi80830
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409652; ENSP00000386280; ENSG00000221963
GeneIDi80830
KEGGihsa:80830
UCSCiuc003aoe.4 human

Organism-specific databases

CTDi80830
DisGeNETi80830
EuPathDBiHostDB:ENSG00000221963.5
GeneCardsiAPOL6
HGNCiHGNC:14870 APOL6
HPAiCAB028574
HPA029165
HPA029167
MIMi607256 gene
neXtProtiNX_Q9BWW8
OpenTargetsiENSG00000221963
PharmGKBiPA24909
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWES Eukaryota
ENOG410Y0AF LUCA
GeneTreeiENSGT00510000046700
HOGENOMiHOG000294132
HOVERGENiHBG106550
InParanoidiQ9BWW8
KOiK14480
OMAiTHKKFTK
OrthoDBiEOG091G0SMD
PhylomeDBiQ9BWW8
TreeFamiTF334681

Miscellaneous databases

ChiTaRSiAPOL6 human
GeneWikiiAPOL6
GenomeRNAii80830
PROiPR:Q9BWW8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221963 Expressed in 205 organ(s), highest expression level in pericardium
CleanExiHS_APOL6
ExpressionAtlasiQ9BWW8 baseline and differential
GenevisibleiQ9BWW8 HS

Family and domain databases

InterProiView protein in InterPro
IPR008405 ApoL
PANTHERiPTHR14096 PTHR14096, 1 hit
PfamiView protein in Pfam
PF05461 ApoL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPOL6_HUMAN
AccessioniPrimary (citable) accession number: Q9BWW8
Secondary accession number(s): Q5R3S1
, Q658J1, Q8IXX6, Q9UGG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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