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Protein

Brother of CDO

Gene

BOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

Miscellaneous

The C-terminal cytoplasmic domain is not required for the stimulation of myogenesis.

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-375170 CDO in myogenesis
R-HSA-5632681 Ligand-receptor interactions
R-HSA-5635838 Activation of SMO
SignaLinkiQ9BWV1
SIGNORiQ9BWV1

Names & Taxonomyi

Protein namesi
Recommended name:
Brother of CDO
Short name:
Protein BOC
Gene namesi
Name:BOC
ORF Names:UNQ604/PRO1190
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144857.14
HGNCiHGNC:17173 BOC
MIMi608708 gene
neXtProtiNX_Q9BWV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 855ExtracellularSequence analysisAdd BLAST825
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Topological domaini877 – 1114CytoplasmicSequence analysisAdd BLAST238

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi91653
OpenTargetsiENSG00000144857
PharmGKBiPA143485316

Polymorphism and mutation databases

BioMutaiBOC
DMDMi74761309

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000023405231 – 1114Brother of CDOAdd BLAST1084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 106PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi150 ↔ 200PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 299PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi344 ↔ 391PROSITE-ProRule annotation
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi725N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi759N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9BWV1
PeptideAtlasiQ9BWV1
PRIDEiQ9BWV1
ProteomicsDBi79319
79320 [Q9BWV1-2]
79321 [Q9BWV1-3]

PTM databases

iPTMnetiQ9BWV1
PhosphoSitePlusiQ9BWV1

Expressioni

Tissue specificityi

Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.1 Publication

Gene expression databases

BgeeiENSG00000144857
CleanExiHS_BOC
ExpressionAtlasiQ9BWV1 baseline and differential
GenevisibleiQ9BWV1 HS

Organism-specific databases

HPAiCAB025806
HPA060778
HPA061787

Interactioni

Subunit structurei

Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with SHH, DHH and IHH. Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation.By similarity3 Publications

Protein-protein interaction databases

BioGridi124859, 12 interactors
IntActiQ9BWV1, 3 interactors
STRINGi9606.ENSP00000347546

Structurei

Secondary structure

11114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi717 – 725Combined sources9
Beta strandi728 – 734Combined sources7
Helixi737 – 740Combined sources4
Beta strandi746 – 754Combined sources9
Helixi760 – 762Combined sources3
Beta strandi764 – 769Combined sources6
Beta strandi774 – 777Combined sources4
Beta strandi785 – 794Combined sources10
Beta strandi805 – 808Combined sources4

3D structure databases

ProteinModelPortaliQ9BWV1
SMRiQ9BWV1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BWV1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 123Ig-like C2-type 1Add BLAST88
Domaini129 – 213Ig-like C2-type 2Add BLAST85
Domaini235 – 315Ig-like C2-type 3Add BLAST81
Domaini323 – 409Ig-like C2-type 4Add BLAST87
Domaini474 – 571Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini608 – 703Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini712 – 812Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHIH Eukaryota
ENOG410XSVT LUCA
GeneTreeiENSGT00910000144011
HOVERGENiHBG061102
InParanoidiQ9BWV1
KOiK20020
OMAiYTMVPLG
OrthoDBiEOG091G00TB
PhylomeDBiQ9BWV1
TreeFamiTF332268

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR032982 BOC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PANTHERiPTHR44170:SF3 PTHR44170:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 4 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BWV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRGTMTAWR GMRPEVTLAC LLLATAGCFA DLNEVPQVTV QPASTVQKPG
60 70 80 90 100
GTVILGCVVE PPRMNVTWRL NGKELNGSDD ALGVLITHGT LVITALNNHT
110 120 130 140 150
VGRYQCVARM PAGAVASVPA TVTLANLQDF KLDVQHVIEV DEGNTAVIAC
160 170 180 190 200
HLPESHPKAQ VRYSVKQEWL EASRGNYLIM PSGNLQIVNA SQEDEGMYKC
210 220 230 240 250
AAYNPVTQEV KTSGSSDRLR VRRSTAEAAR IIYPPEAQTI IVTKGQSLIL
260 270 280 290 300
ECVASGIPPP RVTWAKDGSS VTGYNKTRFL LSNLLIDTTS EEDSGTYRCM
310 320 330 340 350
ADNGVGQPGA AVILYNVQVF EPPEVTMELS QLVIPWGQSA KLTCEVRGNP
360 370 380 390 400
PPSVLWLRNA VPLISSQRLR LSRRALRVLS MGPEDEGVYQ CMAENEVGSA
410 420 430 440 450
HAVVQLRTSR PSITPRLWQD AELATGTPPV SPSKLGNPEQ MLRGQPALPR
460 470 480 490 500
PPTSVGPASP QCPGEKGQGA PAEAPIILSS PRTSKTDSYE LVWRPRHEGS
510 520 530 540 550
GRAPILYYVV KHRKVTNSSD DWTISGIPAN QHRLTLTRLD PGSLYEVEMA
560 570 580 590 600
AYNCAGEGQT AMVTFRTGRR PKPEIMASKE QQIQRDDPGA SPQSSSQPDH
610 620 630 640 650
GRLSPPEAPD RPTISTASET SVYVTWIPRG NGGFPIQSFR VEYKKLKKVG
660 670 680 690 700
DWILATSAIP PSRLSVEITG LEKGTSYKFR VRALNMLGES EPSAPSRPYV
710 720 730 740 750
VSGYSGRVYE RPVAGPYITF TDAVNETTIM LKWMYIPASN NNTPIHGFYI
760 770 780 790 800
YYRPTDSDND SDYKKDMVEG DKYWHSISHL QPETSYDIKM QCFNEGGESE
810 820 830 840 850
FSNVMICETK ARKSSGQPGR LPPPTLAPPQ PPLPETIERP VGTGAMVARS
860 870 880 890 900
SDLPYLIVGV VLGSIVLIIV TFIPFCLWRA WSKQKHTTDL GFPRSALPPS
910 920 930 940 950
CPYTMVPLGG LPGHQASGQP YLSGISGRAC ANGIHMNRGC PSAAVGYPGM
960 970 980 990 1000
KPQQHCPGEL QQQSDTSSLL RQTHLGNGYD PQSHQITRGP KSSPDEGSFL
1010 1020 1030 1040 1050
YTLPDDSTHQ LLQPHHDCCQ RQEQPAAVGQ SGVRRAPDSP VLEAVWDPPF
1060 1070 1080 1090 1100
HSGPPCCLGL VPVEEVDSPD SCQVSGGDWC PQHPVGAYVG QEPGMQLSPG
1110
PLVRVSFETP PLTI
Length:1,114
Mass (Da):121,059
Last modified:June 1, 2001 - v1
Checksum:iBDA9021D39CFE3BC
GO
Isoform 2 (identifier: Q9BWV1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.
     184-223: NLQIVNASQE...GSSDRLRVRR → KTRNGCLIPS...SVLALLAPPG

Note: No experimental confirmation available. Incomplete sequence.
Show »
Length:931
Mass (Da):100,978
Checksum:iCA65A54A8B86F63E
GO
Isoform 3 (identifier: Q9BWV1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     514-514: K → KQ

Show »
Length:1,115
Mass (Da):121,188
Checksum:iA46602F71E323561
GO

Sequence cautioni

The sequence BAC11057 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti461Q → K in AAQ88694 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035503713V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs367589886Ensembl.1
Natural variantiVAR_033600883K → N. Corresponds to variant dbSNP:rs35536878Ensembl.1
Natural variantiVAR_033601915Q → H. Corresponds to variant dbSNP:rs3814405Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0376031 – 183Missing in isoform 2. CuratedAdd BLAST183
Alternative sequenceiVSP_037604184 – 223NLQIV…LRVRR → KTRNGCLIPSPCSLGLPPGH ALQDILVHTPSVLALLAPPG in isoform 2. CuratedAdd BLAST40
Alternative sequenceiVSP_034684514K → KQ in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY027658 mRNA Translation: AAK14795.1
AY358328 mRNA Translation: AAQ88694.1
AK074556 mRNA Translation: BAC11057.1 Different initiation.
AK090455 mRNA Translation: BAC03436.1
AC026329 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79643.1
CH471052 Genomic DNA Translation: EAW79644.1
CH471052 Genomic DNA Translation: EAW79646.1
BC136390 mRNA Translation: AAI36391.1
CCDSiCCDS2971.1 [Q9BWV1-1]
CCDS77788.1 [Q9BWV1-3]
RefSeqiNP_001288790.1, NM_001301861.1 [Q9BWV1-3]
NP_150279.1, NM_033254.3 [Q9BWV1-1]
XP_005247948.1, XM_005247891.2 [Q9BWV1-3]
XP_005247949.1, XM_005247892.2 [Q9BWV1-3]
XP_011511607.1, XM_011513305.2 [Q9BWV1-1]
XP_016862940.1, XM_017007451.1 [Q9BWV1-1]
UniGeneiHs.591318

Genome annotation databases

EnsembliENST00000273395; ENSP00000273395; ENSG00000144857 [Q9BWV1-3]
ENST00000355385; ENSP00000347546; ENSG00000144857 [Q9BWV1-1]
ENST00000495514; ENSP00000418663; ENSG00000144857 [Q9BWV1-1]
GeneIDi91653
KEGGihsa:91653
UCSCiuc003dzx.4 human [Q9BWV1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBOC_HUMAN
AccessioniPrimary (citable) accession number: Q9BWV1
Secondary accession number(s): A6NJ30
, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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