UniProtKB - Q9BWV1 (BOC_HUMAN)
Brother of CDO
BOC
Functioni
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
Miscellaneous
GO - Biological processi
- axon guidance Source: GO_Central
- cell-cell adhesion Source: GO_Central
- nervous system development Source: GO_Central
- positive regulation of myoblast differentiation Source: HGNC
- smoothened signaling pathway Source: InterPro
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q9BWV1 |
Reactomei | R-HSA-525793, Myogenesis [Q9BWV1-1] R-HSA-5632681, Ligand-receptor interactions R-HSA-5635838, Activation of SMO |
SignaLinki | Q9BWV1 |
SIGNORi | Q9BWV1 |
Names & Taxonomyi
Protein namesi | Recommended name: Brother of CDOShort name: Protein BOC |
Gene namesi | Name:BOC ORF Names:UNQ604/PRO1190 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17173, BOC |
MIMi | 608708, gene |
neXtProti | NX_Q9BWV1 |
VEuPathDBi | HostDB:ENSG00000144857 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Enriched at sites of cell-cell contact.
Plasma Membrane
- integral component of plasma membrane Source: InterPro
- plasma membrane Source: Reactome
Other locations
- axon Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 855 | ExtracellularSequence analysisAdd BLAST | 825 | |
Transmembranei | 856 – 876 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 877 – 1114 | CytoplasmicSequence analysisAdd BLAST | 238 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 91653 |
OpenTargetsi | ENSG00000144857 |
PharmGKBi | PA143485316 |
Miscellaneous databases
Pharosi | Q9BWV1, Tbio |
Genetic variation databases
BioMutai | BOC |
DMDMi | 74761309 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | 1 PublicationAdd BLAST | 30 | |
ChainiPRO_0000234052 | 31 – 1114 | Brother of CDOAdd BLAST | 1084 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 57 ↔ 106 | PROSITE-ProRule annotation | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 150 ↔ 200 | PROSITE-ProRule annotation | ||
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 252 ↔ 299 | PROSITE-ProRule annotation | ||
Glycosylationi | 275 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 344 ↔ 391 | PROSITE-ProRule annotation | ||
Glycosylationi | 517 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 725 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 759 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q9BWV1 |
PaxDbi | Q9BWV1 |
PeptideAtlasi | Q9BWV1 |
PRIDEi | Q9BWV1 |
ProteomicsDBi | 79319 [Q9BWV1-1] 79320 [Q9BWV1-2] 79321 [Q9BWV1-3] |
PTM databases
GlyGeni | Q9BWV1, 9 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9BWV1 |
PhosphoSitePlusi | Q9BWV1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000144857, Expressed in tendon of biceps brachii and 210 other tissues |
ExpressionAtlasi | Q9BWV1, baseline and differential |
Genevisiblei | Q9BWV1, HS |
Organism-specific databases
HPAi | ENSG00000144857, Low tissue specificity |
Interactioni
Subunit structurei
Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1.
Interacts with NTN3 (By similarity).
Interacts with SHH, DHH and IHH.
Interacts with CDH2 and CTNNB1.
Interacts with CDH15 only during the early stages of myoblast differentiation.
By similarity3 PublicationsBinary interactionsi
Q9BWV1
Protein-protein interaction databases
BioGRIDi | 124859, 22 interactors |
IntActi | Q9BWV1, 14 interactors |
STRINGi | 9606.ENSP00000418663 |
Miscellaneous databases
RNActi | Q9BWV1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9BWV1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BWV1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 123 | Ig-like C2-type 1Add BLAST | 88 | |
Domaini | 129 – 213 | Ig-like C2-type 2Add BLAST | 85 | |
Domaini | 235 – 315 | Ig-like C2-type 3Add BLAST | 81 | |
Domaini | 323 – 409 | Ig-like C2-type 4Add BLAST | 87 | |
Domaini | 474 – 571 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 608 – 703 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 712 – 812 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 101 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 422 – 474 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 577 – 615 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 812 – 833 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 972 – 998 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 584 – 601 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 972 – 992 | Polar residuesSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUNT, Eukaryota |
GeneTreei | ENSGT00940000158810 |
HOGENOMi | CLU_008503_0_0_1 |
InParanoidi | Q9BWV1 |
OMAi | QITRDPE |
OrthoDBi | 102649at2759 |
PhylomeDBi | Q9BWV1 |
TreeFami | TF332268 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR032982, BOC IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
PANTHERi | PTHR44170:SF3, PTHR44170:SF3, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 1 hit PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 4 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 4 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLRGTMTAWR GMRPEVTLAC LLLATAGCFA DLNEVPQVTV QPASTVQKPG
60 70 80 90 100
GTVILGCVVE PPRMNVTWRL NGKELNGSDD ALGVLITHGT LVITALNNHT
110 120 130 140 150
VGRYQCVARM PAGAVASVPA TVTLANLQDF KLDVQHVIEV DEGNTAVIAC
160 170 180 190 200
HLPESHPKAQ VRYSVKQEWL EASRGNYLIM PSGNLQIVNA SQEDEGMYKC
210 220 230 240 250
AAYNPVTQEV KTSGSSDRLR VRRSTAEAAR IIYPPEAQTI IVTKGQSLIL
260 270 280 290 300
ECVASGIPPP RVTWAKDGSS VTGYNKTRFL LSNLLIDTTS EEDSGTYRCM
310 320 330 340 350
ADNGVGQPGA AVILYNVQVF EPPEVTMELS QLVIPWGQSA KLTCEVRGNP
360 370 380 390 400
PPSVLWLRNA VPLISSQRLR LSRRALRVLS MGPEDEGVYQ CMAENEVGSA
410 420 430 440 450
HAVVQLRTSR PSITPRLWQD AELATGTPPV SPSKLGNPEQ MLRGQPALPR
460 470 480 490 500
PPTSVGPASP QCPGEKGQGA PAEAPIILSS PRTSKTDSYE LVWRPRHEGS
510 520 530 540 550
GRAPILYYVV KHRKVTNSSD DWTISGIPAN QHRLTLTRLD PGSLYEVEMA
560 570 580 590 600
AYNCAGEGQT AMVTFRTGRR PKPEIMASKE QQIQRDDPGA SPQSSSQPDH
610 620 630 640 650
GRLSPPEAPD RPTISTASET SVYVTWIPRG NGGFPIQSFR VEYKKLKKVG
660 670 680 690 700
DWILATSAIP PSRLSVEITG LEKGTSYKFR VRALNMLGES EPSAPSRPYV
710 720 730 740 750
VSGYSGRVYE RPVAGPYITF TDAVNETTIM LKWMYIPASN NNTPIHGFYI
760 770 780 790 800
YYRPTDSDND SDYKKDMVEG DKYWHSISHL QPETSYDIKM QCFNEGGESE
810 820 830 840 850
FSNVMICETK ARKSSGQPGR LPPPTLAPPQ PPLPETIERP VGTGAMVARS
860 870 880 890 900
SDLPYLIVGV VLGSIVLIIV TFIPFCLWRA WSKQKHTTDL GFPRSALPPS
910 920 930 940 950
CPYTMVPLGG LPGHQASGQP YLSGISGRAC ANGIHMNRGC PSAAVGYPGM
960 970 980 990 1000
KPQQHCPGEL QQQSDTSSLL RQTHLGNGYD PQSHQITRGP KSSPDEGSFL
1010 1020 1030 1040 1050
YTLPDDSTHQ LLQPHHDCCQ RQEQPAAVGQ SGVRRAPDSP VLEAVWDPPF
1060 1070 1080 1090 1100
HSGPPCCLGL VPVEEVDSPD SCQVSGGDWC PQHPVGAYVG QEPGMQLSPG
1110
PLVRVSFETP PLTI
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96DN7 | Q96DN7_HUMAN | BOC protein | BOC hCG_17534 | 157 | Annotation score: | ||
C9J2L7 | C9J2L7_HUMAN | Brother of CDO | BOC | 84 | Annotation score: | ||
C9JZ38 | C9JZ38_HUMAN | Brother of CDO | BOC | 65 | Annotation score: | ||
H7C4U8 | H7C4U8_HUMAN | Brother of CDO | BOC | 39 | Annotation score: | ||
H7C5J2 | H7C5J2_HUMAN | Brother of CDO | BOC | 84 | Annotation score: | ||
C9J7V2 | C9J7V2_HUMAN | Brother of CDO | BOC | 32 | Annotation score: | ||
C9J9M5 | C9J9M5_HUMAN | Brother of CDO | BOC | 21 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 461 | Q → K in AAQ88694 (PubMed:12975309).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035503 | 713 | V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs367589886Ensembl. | 1 | |
Natural variantiVAR_033600 | 883 | K → N. Corresponds to variant dbSNP:rs35536878Ensembl. | 1 | |
Natural variantiVAR_033601 | 915 | Q → H. Corresponds to variant dbSNP:rs3814405Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037603 | 1 – 183 | Missing in isoform 2. CuratedAdd BLAST | 183 | |
Alternative sequenceiVSP_037604 | 184 – 223 | NLQIV…LRVRR → KTRNGCLIPSPCSLGLPPGH ALQDILVHTPSVLALLAPPG in isoform 2. CuratedAdd BLAST | 40 | |
Alternative sequenceiVSP_034684 | 514 | K → KQ in isoform 3. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY027658 mRNA Translation: AAK14795.1 AY358328 mRNA Translation: AAQ88694.1 AK074556 mRNA Translation: BAC11057.1 Different initiation. AK090455 mRNA Translation: BAC03436.1 AC026329 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79643.1 CH471052 Genomic DNA Translation: EAW79644.1 CH471052 Genomic DNA Translation: EAW79646.1 BC136390 mRNA Translation: AAI36391.1 |
CCDSi | CCDS2971.1 [Q9BWV1-1] CCDS77788.1 [Q9BWV1-3] |
RefSeqi | NP_001288790.1, NM_001301861.1 [Q9BWV1-3] NP_150279.1, NM_033254.3 [Q9BWV1-1] XP_005247948.1, XM_005247891.2 XP_005247949.1, XM_005247892.2 XP_011511607.1, XM_011513305.2 [Q9BWV1-1] XP_016862940.1, XM_017007451.1 |
Genome annotation databases
Ensembli | ENST00000273395; ENSP00000273395; ENSG00000144857 [Q9BWV1-3] ENST00000355385; ENSP00000347546; ENSG00000144857 ENST00000495514; ENSP00000418663; ENSG00000144857 ENST00000682979; ENSP00000507783; ENSG00000144857 [Q9BWV1-3] |
GeneIDi | 91653 |
KEGGi | hsa:91653 |
MANE-Selecti | ENST00000682979.1; ENSP00000507783.1; NM_001378074.1; NP_001365003.1 [Q9BWV1-3] |
UCSCi | uc003dzx.4, human [Q9BWV1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY027658 mRNA Translation: AAK14795.1 AY358328 mRNA Translation: AAQ88694.1 AK074556 mRNA Translation: BAC11057.1 Different initiation. AK090455 mRNA Translation: BAC03436.1 AC026329 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79643.1 CH471052 Genomic DNA Translation: EAW79644.1 CH471052 Genomic DNA Translation: EAW79646.1 BC136390 mRNA Translation: AAI36391.1 |
CCDSi | CCDS2971.1 [Q9BWV1-1] CCDS77788.1 [Q9BWV1-3] |
RefSeqi | NP_001288790.1, NM_001301861.1 [Q9BWV1-3] NP_150279.1, NM_033254.3 [Q9BWV1-1] XP_005247948.1, XM_005247891.2 XP_005247949.1, XM_005247892.2 XP_011511607.1, XM_011513305.2 [Q9BWV1-1] XP_016862940.1, XM_017007451.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3N1G | X-ray | 1.90 | C/D | 710-817 | [»] | |
3N1M | X-ray | 1.69 | C | 710-817 | [»] | |
3N1P | X-ray | 2.70 | C | 710-817 | [»] | |
SMRi | Q9BWV1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124859, 22 interactors |
IntActi | Q9BWV1, 14 interactors |
STRINGi | 9606.ENSP00000418663 |
PTM databases
GlyGeni | Q9BWV1, 9 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9BWV1 |
PhosphoSitePlusi | Q9BWV1 |
Genetic variation databases
BioMutai | BOC |
DMDMi | 74761309 |
Proteomic databases
MassIVEi | Q9BWV1 |
PaxDbi | Q9BWV1 |
PeptideAtlasi | Q9BWV1 |
PRIDEi | Q9BWV1 |
ProteomicsDBi | 79319 [Q9BWV1-1] 79320 [Q9BWV1-2] 79321 [Q9BWV1-3] |
Protocols and materials databases
Antibodypediai | 32560, 168 antibodies from 31 providers |
DNASUi | 91653 |
Genome annotation databases
Ensembli | ENST00000273395; ENSP00000273395; ENSG00000144857 [Q9BWV1-3] ENST00000355385; ENSP00000347546; ENSG00000144857 ENST00000495514; ENSP00000418663; ENSG00000144857 ENST00000682979; ENSP00000507783; ENSG00000144857 [Q9BWV1-3] |
GeneIDi | 91653 |
KEGGi | hsa:91653 |
MANE-Selecti | ENST00000682979.1; ENSP00000507783.1; NM_001378074.1; NP_001365003.1 [Q9BWV1-3] |
UCSCi | uc003dzx.4, human [Q9BWV1-1] |
Organism-specific databases
CTDi | 91653 |
DisGeNETi | 91653 |
GeneCardsi | BOC |
HGNCi | HGNC:17173, BOC |
HPAi | ENSG00000144857, Low tissue specificity |
MIMi | 608708, gene |
neXtProti | NX_Q9BWV1 |
OpenTargetsi | ENSG00000144857 |
PharmGKBi | PA143485316 |
VEuPathDBi | HostDB:ENSG00000144857 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUNT, Eukaryota |
GeneTreei | ENSGT00940000158810 |
HOGENOMi | CLU_008503_0_0_1 |
InParanoidi | Q9BWV1 |
OMAi | QITRDPE |
OrthoDBi | 102649at2759 |
PhylomeDBi | Q9BWV1 |
TreeFami | TF332268 |
Enzyme and pathway databases
PathwayCommonsi | Q9BWV1 |
Reactomei | R-HSA-525793, Myogenesis [Q9BWV1-1] R-HSA-5632681, Ligand-receptor interactions R-HSA-5635838, Activation of SMO |
SignaLinki | Q9BWV1 |
SIGNORi | Q9BWV1 |
Miscellaneous databases
BioGRID-ORCSi | 91653, 9 hits in 1031 CRISPR screens |
ChiTaRSi | BOC, human |
EvolutionaryTracei | Q9BWV1 |
GeneWikii | BOC_(gene) |
GenomeRNAii | 91653 |
Pharosi | Q9BWV1, Tbio |
PROi | PR:Q9BWV1 |
RNActi | Q9BWV1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144857, Expressed in tendon of biceps brachii and 210 other tissues |
ExpressionAtlasi | Q9BWV1, baseline and differential |
Genevisiblei | Q9BWV1, HS |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR032982, BOC IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
PANTHERi | PTHR44170:SF3, PTHR44170:SF3, 1 hit |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 1 hit PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 3 hits SM00409, IG, 4 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 3 hits PS50835, IG_LIKE, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BOC_HUMAN | |
Accessioni | Q9BWV1Primary (citable) accession number: Q9BWV1 Secondary accession number(s): A6NJ30 Q8NF26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references