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Protein

Cyclin-dependent kinase 19

Gene

CDK19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 35ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiQ9BWU1
SIGNORiQ9BWU1

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 19 (EC:2.7.11.22)
Alternative name(s):
CDC2-related protein kinase 6
Cell division cycle 2-like protein kinase 6
Cell division protein kinase 19
Cyclin-dependent kinase 11
Death-preventing kinase
Gene namesi
Name:CDK19
Synonyms:CDC2L6, CDK11, KIAA1028
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000155111.14
HGNCiHGNC:19338 CDK19
MIMi614720 gene
neXtProtiNX_Q9BWU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23097
OpenTargetsiENSG00000155111
PharmGKBiPA165617767

Chemistry databases

ChEMBLiCHEMBL6002
GuidetoPHARMACOLOGYi1972

Polymorphism and mutation databases

BioMutaiCDK19
DMDMi60391917

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857131 – 502Cyclin-dependent kinase 19Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei449PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BWU1
MaxQBiQ9BWU1
PaxDbiQ9BWU1
PeptideAtlasiQ9BWU1
PRIDEiQ9BWU1
ProteomicsDBi79317
79318 [Q9BWU1-2]

PTM databases

iPTMnetiQ9BWU1
PhosphoSitePlusiQ9BWU1

Expressioni

Gene expression databases

BgeeiENSG00000155111 Expressed in 226 organ(s), highest expression level in substantia nigra
CleanExiHS_CDC2L6
ExpressionAtlasiQ9BWU1 baseline and differential
GenevisibleiQ9BWU1 HS

Organism-specific databases

HPAiHPA007053

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116725, 64 interactors
ComplexPortaliCPX-3263 CKM complex variant 2
CORUMiQ9BWU1
DIPiDIP-29013N
IntActiQ9BWU1, 40 interactors
STRINGi9606.ENSP00000357907

Chemistry databases

BindingDBiQ9BWU1

Structurei

3D structure databases

ProteinModelPortaliQ9BWU1
SMRiQ9BWU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 335Protein kinasePROSITE-ProRule annotationAdd BLAST315

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi372 – 404Gln-richAdd BLAST33
Compositional biasi461 – 491Ser-richAdd BLAST31

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0666 Eukaryota
ENOG410XPPA LUCA
GeneTreeiENSGT00530000064012
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ9BWU1
KOiK02208
OMAiNKKPRIG
OrthoDBiEOG091G0812
PhylomeDBiQ9BWU1
TreeFamiTF101025

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BWU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDYDFKAKLA AERERVEDLF EYEGCKVGRG TYGHVYKARR KDGKDEKEYA
60 70 80 90 100
LKQIEGTGIS MSACREIALL RELKHPNVIA LQKVFLSHSD RKVWLLFDYA
110 120 130 140 150
EHDLWHIIKF HRASKANKKP MQLPRSMVKS LLYQILDGIH YLHANWVLHR
160 170 180 190 200
DLKPANILVM GEGPERGRVK IADMGFARLF NSPLKPLADL DPVVVTFWYR
210 220 230 240 250
APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED IKTSNPFHHD
260 270 280 290 300
QLDRIFSVMG FPADKDWEDI RKMPEYPTLQ KDFRRTTYAN SSLIKYMEKH
310 320 330 340 350
KVKPDSKVFL LLQKLLTMDP TKRITSEQAL QDPYFQEDPL PTLDVFAGCQ
360 370 380 390 400
IPYPKREFLN EDDPEEKGDK NQQQQQNQHQ QPTAPPQQAA APPQAPPPQQ
410 420 430 440 450
NSTQTNGTAG GAGAGVGGTG AGLQHSQDSS LNQVPPNKKP RLGPSGANSG
460 470 480 490 500
GPVMPSDYQH SSSRLNYQSS VQGSSQSQST LGYSSSSQQS SQYHPSHQAH

RY
Length:502
Mass (Da):56,802
Last modified:June 1, 2001 - v1
Checksum:iD9EED1BBB582EABA
GO
Isoform 2 (identifier: Q9BWU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):49,870
Checksum:i102214DB403B5C59
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JQZ9Q5JQZ9_HUMAN
Cyclin-dependent kinase 19
CDK19
251Annotation score:
H0YDW9H0YDW9_HUMAN
Cyclin-dependent kinase 19
CDK19
122Annotation score:
F6QTA4F6QTA4_HUMAN
Cyclin-dependent kinase 19
CDK19
398Annotation score:

Sequence cautioni

The sequence AAH24247 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0158571 – 60Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028424 mRNA Translation: AAK27731.1
Z84480 Genomic DNA No translation available.
AL512430 Genomic DNA No translation available.
AL603914 Genomic DNA No translation available.
BC024247 mRNA Translation: AAH24247.1 Different initiation.
BC037289 mRNA Translation: AAH37289.1
AB028951 mRNA Translation: BAA82980.2
CCDSiCCDS5085.1 [Q9BWU1-1]
CCDS75503.1 [Q9BWU1-2]
RefSeqiNP_001287889.1, NM_001300960.1
NP_001287892.1, NM_001300963.1 [Q9BWU1-2]
NP_001287893.1, NM_001300964.1 [Q9BWU1-2]
NP_055891.1, NM_015076.4 [Q9BWU1-1]
UniGeneiHs.744895

Genome annotation databases

EnsembliENST00000323817; ENSP00000317665; ENSG00000155111 [Q9BWU1-2]
ENST00000368911; ENSP00000357907; ENSG00000155111 [Q9BWU1-1]
GeneIDi23097
KEGGihsa:23097
UCSCiuc003puh.2 human [Q9BWU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028424 mRNA Translation: AAK27731.1
Z84480 Genomic DNA No translation available.
AL512430 Genomic DNA No translation available.
AL603914 Genomic DNA No translation available.
BC024247 mRNA Translation: AAH24247.1 Different initiation.
BC037289 mRNA Translation: AAH37289.1
AB028951 mRNA Translation: BAA82980.2
CCDSiCCDS5085.1 [Q9BWU1-1]
CCDS75503.1 [Q9BWU1-2]
RefSeqiNP_001287889.1, NM_001300960.1
NP_001287892.1, NM_001300963.1 [Q9BWU1-2]
NP_001287893.1, NM_001300964.1 [Q9BWU1-2]
NP_055891.1, NM_015076.4 [Q9BWU1-1]
UniGeneiHs.744895

3D structure databases

ProteinModelPortaliQ9BWU1
SMRiQ9BWU1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116725, 64 interactors
ComplexPortaliCPX-3263 CKM complex variant 2
CORUMiQ9BWU1
DIPiDIP-29013N
IntActiQ9BWU1, 40 interactors
STRINGi9606.ENSP00000357907

Chemistry databases

BindingDBiQ9BWU1
ChEMBLiCHEMBL6002
GuidetoPHARMACOLOGYi1972

PTM databases

iPTMnetiQ9BWU1
PhosphoSitePlusiQ9BWU1

Polymorphism and mutation databases

BioMutaiCDK19
DMDMi60391917

Proteomic databases

EPDiQ9BWU1
MaxQBiQ9BWU1
PaxDbiQ9BWU1
PeptideAtlasiQ9BWU1
PRIDEiQ9BWU1
ProteomicsDBi79317
79318 [Q9BWU1-2]

Protocols and materials databases

DNASUi23097
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323817; ENSP00000317665; ENSG00000155111 [Q9BWU1-2]
ENST00000368911; ENSP00000357907; ENSG00000155111 [Q9BWU1-1]
GeneIDi23097
KEGGihsa:23097
UCSCiuc003puh.2 human [Q9BWU1-1]

Organism-specific databases

CTDi23097
DisGeNETi23097
EuPathDBiHostDB:ENSG00000155111.14
GeneCardsiCDK19
HGNCiHGNC:19338 CDK19
HPAiHPA007053
MIMi614720 gene
neXtProtiNX_Q9BWU1
OpenTargetsiENSG00000155111
PharmGKBiPA165617767
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0666 Eukaryota
ENOG410XPPA LUCA
GeneTreeiENSGT00530000064012
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ9BWU1
KOiK02208
OMAiNKKPRIG
OrthoDBiEOG091G0812
PhylomeDBiQ9BWU1
TreeFamiTF101025

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
SignaLinkiQ9BWU1
SIGNORiQ9BWU1

Miscellaneous databases

ChiTaRSiCDK19 human
GenomeRNAii23097
PROiPR:Q9BWU1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155111 Expressed in 226 organ(s), highest expression level in substantia nigra
CleanExiHS_CDC2L6
ExpressionAtlasiQ9BWU1 baseline and differential
GenevisibleiQ9BWU1 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK19_HUMAN
AccessioniPrimary (citable) accession number: Q9BWU1
Secondary accession number(s): Q5JQZ7
, Q5JR00, Q8TC78, Q9UPX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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