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Protein

Kanadaptin

Gene

SLC4A1AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.Curated

GO - Molecular functioni

Protein family/group databases

TCDBi3.A.18.1.2 the nuclear mrna exporter (mrna-e) family

Names & Taxonomyi

Protein namesi
Recommended name:
Kanadaptin
Alternative name(s):
Human lung cancer oncogene 3 protein
Short name:
HLC-3
Kidney anion exchanger adapter protein
Solute carrier family 4 anion exchanger member 1 adapter protein
Gene namesi
ORF Names:HLC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163798.13
HGNCiHGNC:13813 SLC4A1AP
MIMi602655 gene
neXtProtiNX_Q9BWU0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163798
PharmGKBiPA37811

Polymorphism and mutation databases

BioMutaiSLC4A1AP
DMDMi74724887

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762681 – 796KanadaptinAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Cross-linki495Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei530PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei712PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BWU0
MaxQBiQ9BWU0
PaxDbiQ9BWU0
PeptideAtlasiQ9BWU0
PRIDEiQ9BWU0
ProteomicsDBi79316

PTM databases

iPTMnetiQ9BWU0
PhosphoSitePlusiQ9BWU0

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000163798 Expressed in 96 organ(s), highest expression level in testis
CleanExiHS_SLC4A1AP
ExpressionAtlasiQ9BWU0 baseline and differential
GenevisibleiQ9BWU0 HS

Organism-specific databases

HPAiHPA036679

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi116605, 35 interactors
IntActiQ9BWU0, 13 interactors
MINTiQ9BWU0
STRINGi9606.ENSP00000323837

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BWU0
SMRiQ9BWU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini189 – 249FHAPROSITE-ProRule annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili497 – 530Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi644 – 715Glu-richAdd BLAST72

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1881 Eukaryota
ENOG410XR6C LUCA
GeneTreeiENSGT00730000110659
HOGENOMiHOG000008002
HOVERGENiHBG052984
InParanoidiQ9BWU0
OMAiQLPMIGK
OrthoDBiEOG091G05D7
PhylomeDBiQ9BWU0
TreeFamiTF314854

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BWU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAPLRNAPG REGATSPSPP TDATGSLGEW DVDRNVKTEG WVSKERISKL
60 70 80 90 100
HRLRMADILS QSETLASQDL SGDFKKPALP VSPAARSKAP ASSSSNPEEV
110 120 130 140 150
QKEGPTALQD SNSGEPDIPP PQPDCGDFRS LQEEQSRPPT AVSSPGGPAR
160 170 180 190 200
APPYQEPPWG GPATAPYSLE TLKGGTILGT RSLKGTSYCL FGRLSGCDVC
210 220 230 240 250
LEHPSVSRYH AVLQHRASGP DGECDSNGPG FYLYDLGSTH GTFLNKTRIP
260 270 280 290 300
PRTYCRVHVG HVVRFGGSTR LFILQGPEED REAESELTVT QLKELRKQQQ
310 320 330 340 350
ILLEKKMLGE DSDEEEEMDT SERKINAGSQ DDEMGCTWGM GEDAVEDDAE
360 370 380 390 400
ENPIVLEFQQ EREAFYIKDP KKALQGFFDR EGEELEYEFD EQGHSTWLCR
410 420 430 440 450
VRLPVDDSTG KQLVAEAIHS GKKKEAMIQC SLEACRILDT LGLLRQEAVS
460 470 480 490 500
RKRKAKNWED EDFYDSDDDT FLDRTGLIEK KRLNRMKKAG KIDEKPETFE
510 520 530 540 550
SLVAKLNDAE RELSEISERL KASSQVLSES PSQDSLDAFM SEMKSGSTLD
560 570 580 590 600
GVSRKKLHLR TFELRKEQQR LKGLIKIVKP AEIPELKKTE TQTTGAENKA
610 620 630 640 650
KKLTLPLFGA MKGGSKFKLK TGTVGKLPPK RPELPPTLMR MKDEPEVEEE
660 670 680 690 700
EEEEEEEEKE KEEHEKKKLE DGSLSRPQPE IEPEAAVQEM RPPTDLTHFK
710 720 730 740 750
ETQTHENMSQ LSEEEQNKDY QDCSKTTSLC AGPSASKNEY EKSRGELKKK
760 770 780 790
KTPGPGKLPP TLSSKYPEDD PDYCVWVPPE GQSGDGRTHL NDKYGY
Length:796
Mass (Da):88,814
Last modified:June 1, 2001 - v1
Checksum:iEE0F560648DA39EF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0M4A0A087X0M4_HUMAN
Kanadaptin
SLC4A1AP
742Annotation score:
A0A087WWF4A0A087WWF4_HUMAN
Kanadaptin
SLC4A1AP
273Annotation score:
H7C256H7C256_HUMAN
Kanadaptin
SLC4A1AP
157Annotation score:

Sequence cautioni

The sequence AAN12269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111 – 115SNSGE → PIAKP in AAN12269 (Ref. 6) Curated5
Sequence conflicti309G → R in AAK29177 (PubMed:14702039).Curated1
Sequence conflicti359Q → R in AAH98358 (PubMed:15489334).Curated1
Sequence conflicti373A → V in AAK29177 (PubMed:14702039).Curated1
Sequence conflicti444L → I in AAN12269 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024748139P → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs9678851Ensembl.1
Natural variantiVAR_051219181R → C. Corresponds to variant dbSNP:rs9679004Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028435 mRNA Translation: AAK29177.1
AK001486 mRNA Translation: BAA91718.1
AC074091 Genomic DNA Translation: AAX93203.1
CH471053 Genomic DNA Translation: EAX00555.1
BC098302 mRNA Translation: AAH98302.1
BC098358 mRNA Translation: AAH98358.1
BC099711 mRNA Translation: AAH99711.1
BC099739 mRNA Translation: AAH99739.1
AY117688 mRNA Translation: AAN12269.1 Different initiation.
CCDSiCCDS33166.1
RefSeqiNP_060628.2, NM_018158.2
UniGeneiHs.306000

Genome annotation databases

EnsembliENST00000326019; ENSP00000323837; ENSG00000163798
ENST00000613058; ENSP00000479964; ENSG00000163798
GeneIDi22950
KEGGihsa:22950
UCSCiuc002rlk.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Band 3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028435 mRNA Translation: AAK29177.1
AK001486 mRNA Translation: BAA91718.1
AC074091 Genomic DNA Translation: AAX93203.1
CH471053 Genomic DNA Translation: EAX00555.1
BC098302 mRNA Translation: AAH98302.1
BC098358 mRNA Translation: AAH98358.1
BC099711 mRNA Translation: AAH99711.1
BC099739 mRNA Translation: AAH99739.1
AY117688 mRNA Translation: AAN12269.1 Different initiation.
CCDSiCCDS33166.1
RefSeqiNP_060628.2, NM_018158.2
UniGeneiHs.306000

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H87X-ray1.55A/B149-276[»]
ProteinModelPortaliQ9BWU0
SMRiQ9BWU0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116605, 35 interactors
IntActiQ9BWU0, 13 interactors
MINTiQ9BWU0
STRINGi9606.ENSP00000323837

Protein family/group databases

TCDBi3.A.18.1.2 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetiQ9BWU0
PhosphoSitePlusiQ9BWU0

Polymorphism and mutation databases

BioMutaiSLC4A1AP
DMDMi74724887

Proteomic databases

EPDiQ9BWU0
MaxQBiQ9BWU0
PaxDbiQ9BWU0
PeptideAtlasiQ9BWU0
PRIDEiQ9BWU0
ProteomicsDBi79316

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326019; ENSP00000323837; ENSG00000163798
ENST00000613058; ENSP00000479964; ENSG00000163798
GeneIDi22950
KEGGihsa:22950
UCSCiuc002rlk.5 human

Organism-specific databases

CTDi22950
EuPathDBiHostDB:ENSG00000163798.13
GeneCardsiSLC4A1AP
H-InvDBiHIX0001931
HGNCiHGNC:13813 SLC4A1AP
HPAiHPA036679
MIMi602655 gene
neXtProtiNX_Q9BWU0
OpenTargetsiENSG00000163798
PharmGKBiPA37811
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1881 Eukaryota
ENOG410XR6C LUCA
GeneTreeiENSGT00730000110659
HOGENOMiHOG000008002
HOVERGENiHBG052984
InParanoidiQ9BWU0
OMAiQLPMIGK
OrthoDBiEOG091G05D7
PhylomeDBiQ9BWU0
TreeFamiTF314854

Miscellaneous databases

ChiTaRSiSLC4A1AP human
GenomeRNAii22950
PROiPR:Q9BWU0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163798 Expressed in 96 organ(s), highest expression level in testis
CleanExiHS_SLC4A1AP
ExpressionAtlasiQ9BWU0 baseline and differential
GenevisibleiQ9BWU0 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNADAP_HUMAN
AccessioniPrimary (citable) accession number: Q9BWU0
Secondary accession number(s): A6NJ39
, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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