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UniProtKB - Q9BWU0 (NADAP_HUMAN)
Protein
Kanadaptin
Gene
SLC4A1AP
Organism
Homo sapiens (Human)
Status
Functioni
Caution
PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.Curated
GO - Molecular functioni
- mRNA binding Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9BWU0 |
SignaLinki | Q9BWU0 |
Names & Taxonomyi
Protein namesi | Recommended name: KanadaptinAlternative name(s): Human lung cancer oncogene 3 protein Short name: HLC-3 Kidney anion exchanger adapter protein Solute carrier family 4 anion exchanger member 1 adapter protein |
Gene namesi | Name:SLC4A1AP ORF Names:HLC3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13813, SLC4A1AP |
MIMi | 602655, gene |
neXtProti | NX_Q9BWU0 |
VEuPathDBi | HostDB:ENSG00000163798 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB-SubCell
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 22950 |
OpenTargetsi | ENSG00000163798 |
PharmGKBi | PA37811 |
Miscellaneous databases
Pharosi | Q9BWU0, Tdark |
Genetic variation databases
BioMutai | SLC4A1AP |
DMDMi | 74724887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076268 | 1 – 796 | KanadaptinAdd BLAST | 796 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 82 | PhosphoserineCombined sources | 1 | |
Modified residuei | 144 | PhosphoserineCombined sources | 1 | |
Modified residuei | 312 | PhosphoserineCombined sources | 1 | |
Modified residuei | 466 | PhosphoserineCombined sources | 1 | |
Cross-linki | 495 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 530 | PhosphoserineCombined sources | 1 | |
Modified residuei | 709 | PhosphoserineCombined sources | 1 | |
Modified residuei | 712 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BWU0 |
jPOSTi | Q9BWU0 |
MassIVEi | Q9BWU0 |
MaxQBi | Q9BWU0 |
PaxDbi | Q9BWU0 |
PeptideAtlasi | Q9BWU0 |
PRIDEi | Q9BWU0 |
ProteomicsDBi | 79316 |
PTM databases
GlyGeni | Q9BWU0, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BWU0 |
MetOSitei | Q9BWU0 |
PhosphoSitePlusi | Q9BWU0 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000163798, Expressed in testis and 121 other tissues |
ExpressionAtlasi | Q9BWU0, baseline and differential |
Genevisiblei | Q9BWU0, HS |
Organism-specific databases
HPAi | ENSG00000163798, Low tissue specificity |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 116605, 72 interactors |
IntActi | Q9BWU0, 35 interactors |
MINTi | Q9BWU0 |
STRINGi | 9606.ENSP00000479964 |
Miscellaneous databases
RNActi | Q9BWU0, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9BWU0 |
SMRi | Q9BWU0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 189 – 249 | FHAPROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 66 – 166 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 308 – 336 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 619 – 796 | DisorderedSequence analysisAdd BLAST | 178 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 497 – 530 | Sequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 87 – 115 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 645 – 659 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 660 – 677 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 694 – 721 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 739 – 753 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1881, Eukaryota |
GeneTreei | ENSGT00940000155320 |
InParanoidi | Q9BWU0 |
OrthoDBi | 955935at2759 |
PhylomeDBi | Q9BWU0 |
TreeFami | TF314854 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9BWU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAPLRNAPG REGATSPSPP TDATGSLGEW DVDRNVKTEG WVSKERISKL
60 70 80 90 100
HRLRMADILS QSETLASQDL SGDFKKPALP VSPAARSKAP ASSSSNPEEV
110 120 130 140 150
QKEGPTALQD SNSGEPDIPP PQPDCGDFRS LQEEQSRPPT AVSSPGGPAR
160 170 180 190 200
APPYQEPPWG GPATAPYSLE TLKGGTILGT RSLKGTSYCL FGRLSGCDVC
210 220 230 240 250
LEHPSVSRYH AVLQHRASGP DGECDSNGPG FYLYDLGSTH GTFLNKTRIP
260 270 280 290 300
PRTYCRVHVG HVVRFGGSTR LFILQGPEED REAESELTVT QLKELRKQQQ
310 320 330 340 350
ILLEKKMLGE DSDEEEEMDT SERKINAGSQ DDEMGCTWGM GEDAVEDDAE
360 370 380 390 400
ENPIVLEFQQ EREAFYIKDP KKALQGFFDR EGEELEYEFD EQGHSTWLCR
410 420 430 440 450
VRLPVDDSTG KQLVAEAIHS GKKKEAMIQC SLEACRILDT LGLLRQEAVS
460 470 480 490 500
RKRKAKNWED EDFYDSDDDT FLDRTGLIEK KRLNRMKKAG KIDEKPETFE
510 520 530 540 550
SLVAKLNDAE RELSEISERL KASSQVLSES PSQDSLDAFM SEMKSGSTLD
560 570 580 590 600
GVSRKKLHLR TFELRKEQQR LKGLIKIVKP AEIPELKKTE TQTTGAENKA
610 620 630 640 650
KKLTLPLFGA MKGGSKFKLK TGTVGKLPPK RPELPPTLMR MKDEPEVEEE
660 670 680 690 700
EEEEEEEEKE KEEHEKKKLE DGSLSRPQPE IEPEAAVQEM RPPTDLTHFK
710 720 730 740 750
ETQTHENMSQ LSEEEQNKDY QDCSKTTSLC AGPSASKNEY EKSRGELKKK
760 770 780 790
KTPGPGKLPP TLSSKYPEDD PDYCVWVPPE GQSGDGRTHL NDKYGY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X0M4 | A0A087X0M4_HUMAN | Kanadaptin | SLC4A1AP | 742 | Annotation score: | ||
A0A087WWF4 | A0A087WWF4_HUMAN | Kanadaptin | SLC4A1AP | 273 | Annotation score: | ||
H7C256 | H7C256_HUMAN | Kanadaptin | SLC4A1AP | 157 | Annotation score: |
Sequence cautioni
The sequence AAN12269 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 111 – 115 | SNSGE → PIAKP in AAN12269 (Ref. 6) Curated | 5 | |
Sequence conflicti | 309 | G → R in AAK29177 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 359 | Q → R in AAH98358 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 373 | A → V in AAK29177 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 444 | L → I in AAN12269 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024748 | 139 | P → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs9678851Ensembl. | 1 | |
Natural variantiVAR_051219 | 181 | R → C. Corresponds to variant dbSNP:rs9679004Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028435 mRNA Translation: AAK29177.1 AK001486 mRNA Translation: BAA91718.1 AC074091 Genomic DNA Translation: AAX93203.1 CH471053 Genomic DNA Translation: EAX00555.1 BC098302 mRNA Translation: AAH98302.1 BC098358 mRNA Translation: AAH98358.1 BC099711 mRNA Translation: AAH99711.1 BC099739 mRNA Translation: AAH99739.1 AY117688 mRNA Translation: AAN12269.1 Different initiation. |
RefSeqi | NP_060628.2, NM_018158.2 |
Genome annotation databases
Ensembli | ENST00000326019.10; ENSP00000323837.6; ENSG00000163798.13 ENST00000613058.4; ENSP00000479964.1; ENSG00000163798.13 |
GeneIDi | 22950 |
KEGGi | hsa:22950 |
UCSCi | uc002rlk.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Band 3 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028435 mRNA Translation: AAK29177.1 AK001486 mRNA Translation: BAA91718.1 AC074091 Genomic DNA Translation: AAX93203.1 CH471053 Genomic DNA Translation: EAX00555.1 BC098302 mRNA Translation: AAH98302.1 BC098358 mRNA Translation: AAH98358.1 BC099711 mRNA Translation: AAH99711.1 BC099739 mRNA Translation: AAH99739.1 AY117688 mRNA Translation: AAN12269.1 Different initiation. |
RefSeqi | NP_060628.2, NM_018158.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4H87 | X-ray | 1.55 | A/B | 149-276 | [»] | |
AlphaFoldDBi | Q9BWU0 | |||||
SMRi | Q9BWU0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116605, 72 interactors |
IntActi | Q9BWU0, 35 interactors |
MINTi | Q9BWU0 |
STRINGi | 9606.ENSP00000479964 |
PTM databases
GlyGeni | Q9BWU0, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9BWU0 |
MetOSitei | Q9BWU0 |
PhosphoSitePlusi | Q9BWU0 |
Genetic variation databases
BioMutai | SLC4A1AP |
DMDMi | 74724887 |
Proteomic databases
EPDi | Q9BWU0 |
jPOSTi | Q9BWU0 |
MassIVEi | Q9BWU0 |
MaxQBi | Q9BWU0 |
PaxDbi | Q9BWU0 |
PeptideAtlasi | Q9BWU0 |
PRIDEi | Q9BWU0 |
ProteomicsDBi | 79316 |
Protocols and materials databases
Antibodypediai | 28720, 119 antibodies from 25 providers |
DNASUi | 22950 |
Genome annotation databases
Ensembli | ENST00000326019.10; ENSP00000323837.6; ENSG00000163798.13 ENST00000613058.4; ENSP00000479964.1; ENSG00000163798.13 |
GeneIDi | 22950 |
KEGGi | hsa:22950 |
UCSCi | uc002rlk.5, human |
Organism-specific databases
CTDi | 22950 |
DisGeNETi | 22950 |
GeneCardsi | SLC4A1AP |
HGNCi | HGNC:13813, SLC4A1AP |
HPAi | ENSG00000163798, Low tissue specificity |
MIMi | 602655, gene |
neXtProti | NX_Q9BWU0 |
OpenTargetsi | ENSG00000163798 |
PharmGKBi | PA37811 |
VEuPathDBi | HostDB:ENSG00000163798 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1881, Eukaryota |
GeneTreei | ENSGT00940000155320 |
InParanoidi | Q9BWU0 |
OrthoDBi | 955935at2759 |
PhylomeDBi | Q9BWU0 |
TreeFami | TF314854 |
Enzyme and pathway databases
PathwayCommonsi | Q9BWU0 |
SignaLinki | Q9BWU0 |
Miscellaneous databases
BioGRID-ORCSi | 22950, 16 hits in 1079 CRISPR screens |
ChiTaRSi | SLC4A1AP, human |
GenomeRNAii | 22950 |
Pharosi | Q9BWU0, Tdark |
PROi | PR:Q9BWU0 |
RNActi | Q9BWU0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163798, Expressed in testis and 121 other tissues |
ExpressionAtlasi | Q9BWU0, baseline and differential |
Genevisiblei | Q9BWU0, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NADAP_HUMAN | |
Accessioni | Q9BWU0Primary (citable) accession number: Q9BWU0 Secondary accession number(s): A6NJ39 Q9NVN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references