SLC4A1AP

Functionⁱ

Caution

PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.Curated

GO - Molecular functionⁱ

mRNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein family/group databases

TCDBⁱ	3.A.18.1.2 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.2 the nuclear mrna exporter (mrna-e) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kanadaptin Alternative name(s): Human lung cancer oncogene 3 protein Short name: HLC-3 Kidney anion exchanger adapter protein Solute carrier family 4 anion exchanger member 1 adapter protein
Gene namesⁱ	Name:SLC4A1AP ORF Names:HLC3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163798.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13813 SLC4A1AP
MIMⁱ	602655 gene
neXtProtⁱ	NX_Q9BWU0

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000163798
PharmGKBⁱ	PA37811

Polymorphism and mutation databases

BioMutaⁱ	SLC4A1AP
DMDMⁱ	74724887

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076268	1 – 796	KanadaptinAdd BLAST		796

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	144	PhosphoserineCombined sources	1
Modified residueⁱ	312	PhosphoserineCombined sources	1
Modified residueⁱ	466	PhosphoserineCombined sources	1
Cross-linkⁱ	495	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	530	PhosphoserineCombined sources	1
Modified residueⁱ	709	PhosphoserineCombined sources	1
Modified residueⁱ	712	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9BWU0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BWU0
PaxDbⁱ	Q9BWU0
PeptideAtlas More...PeptideAtlasⁱ	Q9BWU0
PRIDEⁱ	Q9BWU0
ProteomicsDBⁱ	79316

PTM databases

iPTMnetⁱ	Q9BWU0
PhosphoSitePlusⁱ	Q9BWU0

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163798
CleanExⁱ	HS_SLC4A1AP
ExpressionAtlasⁱ	Q9BWU0 baseline and differential
Genevisibleⁱ	Q9BWU0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036679

HPAⁱ

HPA036679

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ILK	Q13418	8	EBI-1999704,EBI-747644
TCF4	P15884	3	EBI-1999704,EBI-533224

Show more details

Protein-protein interaction databases

BioGridⁱ	116605, 35 interactors
IntActⁱ	Q9BWU0, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q9BWU0
STRINGⁱ	9606.ENSP00000323837

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	168 – 173	Combined sources	6
Beta strandⁱ	176 – 182	Combined sources	7
Beta strandⁱ	187 – 194	Combined sources	8
Beta strandⁱ	197 – 200	Combined sources	4
Beta strandⁱ	211 – 216	Combined sources	6
Beta strandⁱ	231 – 235	Combined sources	5
Beta strandⁱ	242 – 244	Combined sources	3
Beta strandⁱ	262 – 265	Combined sources	4
Beta strandⁱ	269 – 275	Combined sources	7

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4H87	X-ray	1.55	A/B	149-276	[»]
ProteinModelPortalⁱ	Q9BWU0
SMRⁱ	Q9BWU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	189 – 249	FHAPROSITE-ProRule annotationAdd BLAST		61

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	497 – 530	Sequence analysisAdd BLAST		34

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	644 – 715	Glu-richAdd BLAST		72

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1881 Eukaryota ENOG410XR6C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110659
HOGENOMⁱ	HOG000008002
HOVERGENⁱ	HBG052984
InParanoidⁱ	Q9BWU0
OMAⁱ	QLPMIGK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05D7
PhylomeDBⁱ	Q9BWU0
TreeFamⁱ	TF314854

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00060 FHA, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR008984 SMAD_FHA_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit
SMARTⁱ	View protein in SMART SM00240 FHA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BWU0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLAPLRNAPG REGATSPSPP TDATGSLGEW DVDRNVKTEG WVSKERISKL 
        60         70         80         90        100
HRLRMADILS QSETLASQDL SGDFKKPALP VSPAARSKAP ASSSSNPEEV 
       110        120        130        140        150
QKEGPTALQD SNSGEPDIPP PQPDCGDFRS LQEEQSRPPT AVSSPGGPAR 
       160        170        180        190        200
APPYQEPPWG GPATAPYSLE TLKGGTILGT RSLKGTSYCL FGRLSGCDVC 
       210        220        230        240        250
LEHPSVSRYH AVLQHRASGP DGECDSNGPG FYLYDLGSTH GTFLNKTRIP 
       260        270        280        290        300
PRTYCRVHVG HVVRFGGSTR LFILQGPEED REAESELTVT QLKELRKQQQ 
       310        320        330        340        350
ILLEKKMLGE DSDEEEEMDT SERKINAGSQ DDEMGCTWGM GEDAVEDDAE 
       360        370        380        390        400
ENPIVLEFQQ EREAFYIKDP KKALQGFFDR EGEELEYEFD EQGHSTWLCR 
       410        420        430        440        450
VRLPVDDSTG KQLVAEAIHS GKKKEAMIQC SLEACRILDT LGLLRQEAVS 
       460        470        480        490        500
RKRKAKNWED EDFYDSDDDT FLDRTGLIEK KRLNRMKKAG KIDEKPETFE 
       510        520        530        540        550
SLVAKLNDAE RELSEISERL KASSQVLSES PSQDSLDAFM SEMKSGSTLD 
       560        570        580        590        600
GVSRKKLHLR TFELRKEQQR LKGLIKIVKP AEIPELKKTE TQTTGAENKA 
       610        620        630        640        650
KKLTLPLFGA MKGGSKFKLK TGTVGKLPPK RPELPPTLMR MKDEPEVEEE 
       660        670        680        690        700
EEEEEEEEKE KEEHEKKKLE DGSLSRPQPE IEPEAAVQEM RPPTDLTHFK 
       710        720        730        740        750
ETQTHENMSQ LSEEEQNKDY QDCSKTTSLC AGPSASKNEY EKSRGELKKK 
       760        770        780        790 
KTPGPGKLPP TLSSKYPEDD PDYCVWVPPE GQSGDGRTHL NDKYGY

Length:796

Mass (Da):88,814

Last modified:June 1, 2001 - v1

Checksum:ⁱEE0F560648DA39EF

GO

Sequence cautionⁱ

The sequence AAN12269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	111 – 115	SNSGE → PIAKP in AAN12269 (Ref. 6) Curated	5
Sequence conflictⁱ	309	G → R in AAK29177 (PubMed:14702039).Curated	1
Sequence conflictⁱ	359	Q → R in AAH98358 (PubMed:15489334).Curated	1
Sequence conflictⁱ	373	A → V in AAK29177 (PubMed:14702039).Curated	1
Sequence conflictⁱ	444	L → I in AAN12269 (Ref. 6) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024748	139	P → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs9678851Ensembl.		1
Natural variantⁱVAR_051219	181	R → C. Corresponds to variant dbSNP:rs9679004Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028435 mRNA Translation: AAK29177.1 AK001486 mRNA Translation: BAA91718.1 AC074091 Genomic DNA Translation: AAX93203.1 CH471053 Genomic DNA Translation: EAX00555.1 BC098302 mRNA Translation: AAH98302.1 BC098358 mRNA Translation: AAH98358.1 BC099711 mRNA Translation: AAH99711.1 BC099739 mRNA Translation: AAH99739.1 AY117688 mRNA Translation: AAN12269.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33166.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060628.2, NM_018158.2
UniGeneⁱ	Hs.306000

Genome annotation databases

Ensemblⁱ	ENST00000326019; ENSP00000323837; ENSG00000163798 ENST00000613058; ENSP00000479964; ENSG00000163798
GeneIDⁱ	22950
KEGGⁱ	hsa:22950
UCSC genome browser More...UCSCⁱ	uc002rlk.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9BWU0	Kanadaptin		HUMAN		742
SLC4A1AP isoform 2		PANTR		796
Solute carrier family 4 member 1 adaptor protein		PANPA		796
Solute carrier family 4 member 1 adaptor protein		GORGO		796
Solute carrier family 4 member 1 adaptor protein		CERAT		786
+34

Protein	Similar proteins		Species	Score	Length
Q9BWU0	Kanadaptin		HUMAN		742
SLC4A1AP isoform 2		PANTR		796
Solute carrier family 4 member 1 adaptor protein		PANPA		796
Solute carrier family 4 member 1 adaptor protein		GORGO		796
Solute carrier family 4 member 1 adaptor protein		CERAT		786
+161

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Band 3 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028435 mRNA Translation: AAK29177.1 AK001486 mRNA Translation: BAA91718.1 AC074091 Genomic DNA Translation: AAX93203.1 CH471053 Genomic DNA Translation: EAX00555.1 BC098302 mRNA Translation: AAH98302.1 BC098358 mRNA Translation: AAH98358.1 BC099711 mRNA Translation: AAH99711.1 BC099739 mRNA Translation: AAH99739.1 AY117688 mRNA Translation: AAN12269.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33166.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060628.2, NM_018158.2
UniGeneⁱ	Hs.306000

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4H87	X-ray	1.55	A/B	149-276	[»]
ProteinModelPortalⁱ	Q9BWU0
SMRⁱ	Q9BWU0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116605, 35 interactors
IntActⁱ	Q9BWU0, 11 interactors
Molecular INTeraction database More...MINTⁱ	Q9BWU0
STRINGⁱ	9606.ENSP00000323837

Protein family/group databases

TCDBⁱ	3.A.18.1.2 the nuclear mrna exporter (mrna-e) family

TCDBⁱ

3.A.18.1.2 the nuclear mrna exporter (mrna-e) family

PTM databases

iPTMnetⁱ	Q9BWU0
PhosphoSitePlusⁱ	Q9BWU0

Polymorphism and mutation databases

BioMutaⁱ	SLC4A1AP
DMDMⁱ	74724887

Proteomic databases

EPDⁱ	Q9BWU0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BWU0
PaxDbⁱ	Q9BWU0
PeptideAtlas More...PeptideAtlasⁱ	Q9BWU0
PRIDEⁱ	Q9BWU0
ProteomicsDBⁱ	79316

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000326019; ENSP00000323837; ENSG00000163798 ENST00000613058; ENSP00000479964; ENSG00000163798
GeneIDⁱ	22950
KEGGⁱ	hsa:22950
UCSC genome browser More...UCSCⁱ	uc002rlk.5 human

Organism-specific databases

CTDⁱ	22950
EuPathDBⁱ	HostDB:ENSG00000163798.13
GeneCardsⁱ	SLC4A1AP
H-InvDBⁱ	HIX0001931
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13813 SLC4A1AP
Human Protein Atlas More...HPAⁱ	HPA036679
MIMⁱ	602655 gene
neXtProtⁱ	NX_Q9BWU0
Open Targets More...OpenTargetsⁱ	ENSG00000163798
PharmGKBⁱ	PA37811
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1881 Eukaryota ENOG410XR6C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110659
HOGENOMⁱ	HOG000008002
HOVERGENⁱ	HBG052984
InParanoidⁱ	Q9BWU0
OMAⁱ	QLPMIGK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05D7
PhylomeDBⁱ	Q9BWU0
TreeFamⁱ	TF314854

Miscellaneous databases

ChiTaRSⁱ	SLC4A1AP human
GenomeRNAiⁱ	22950
Protein Ontology More...PROⁱ	PR:Q9BWU0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163798
CleanExⁱ	HS_SLC4A1AP
ExpressionAtlasⁱ	Q9BWU0 baseline and differential
Genevisibleⁱ	Q9BWU0 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00060 FHA, 1 hit
InterProⁱ	View protein in InterPro IPR000253 FHA_dom IPR008984 SMAD_FHA_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00498 FHA, 1 hit
SMARTⁱ	View protein in SMART SM00240 FHA, 1 hit
SUPFAMⁱ	SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS50006 FHA_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NADAP_HUMAN
Accessionⁱ	Q9BWU0Primary (citable) accession number: Q9BWU0 Secondary accession number(s): A6NJ39 , Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	June 1, 2001
	Last modified:	June 20, 2018
	This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q9BWU0 (NADAP_HUMAN)

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Kanadaptin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ