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UniProtKB - Q9BWU0 (NADAP_HUMAN)

Entry version 164 (25 May 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Kanadaptin

Gene

SLC4A1AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

PubMed:15764369 initially suggested a role in targeting SLC4A1 (kidney anion exchanger 1) to the plasma membrane; it does not seem to do so as it does not interact with SLC4A1 and has no effect on SLC4A1 trafficking.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central
Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BWU0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BWU0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kanadaptin
Alternative name(s):
Human lung cancer oncogene 3 protein
Short name:
HLC-3
Kidney anion exchanger adapter protein
Solute carrier family 4 anion exchanger member 1 adapter protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A1AP
ORF Names:HLC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13813, SLC4A1AP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602655, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BWU0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163798

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22950

Open Targets

More...OpenTargetsi		ENSG00000163798

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37811

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BWU0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC4A1AP

Domain mapping of disease mutations (DMDM)

More...DMDMi		74724887

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762681 – 796KanadaptinAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei82PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki495Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei530PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei712PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BWU0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BWU0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BWU0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BWU0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BWU0

PeptideAtlas

More...PeptideAtlasi		Q9BWU0

PRoteomics IDEntifications database

More...PRIDEi		Q9BWU0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79316

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BWU0, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BWU0

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9BWU0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BWU0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163798, Expressed in testis and 121 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BWU0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BWU0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163798, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116605, 72 interactors

Protein interaction database and analysis system

More...IntActi		Q9BWU0, 35 interactors

Molecular INTeraction database

More...MINTi		Q9BWU0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000479964

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BWU0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9BWU0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BWU0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini189 – 249FHAPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 43DisorderedSequence analysisAdd BLAST43
Regioni66 – 166DisorderedSequence analysisAdd BLAST101
Regioni308 – 336DisorderedSequence analysisAdd BLAST29
Regioni619 – 796DisorderedSequence analysisAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili497 – 530Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 115Polar residuesSequence analysisAdd BLAST29
Compositional biasi645 – 659Acidic residuesSequence analysisAdd BLAST15
Compositional biasi660 – 677Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi694 – 721Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi739 – 753Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1881, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155320

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BWU0

Database of Orthologous Groups

More...OrthoDBi		955935at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BWU0

TreeFam database of animal gene trees

More...TreeFami		TF314854

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000253, FHA_dom
IPR008984, SMAD_FHA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00498, FHA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00240, FHA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BWU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAPLRNAPG REGATSPSPP TDATGSLGEW DVDRNVKTEG WVSKERISKL 
        60         70         80         90        100
HRLRMADILS QSETLASQDL SGDFKKPALP VSPAARSKAP ASSSSNPEEV 
       110        120        130        140        150
QKEGPTALQD SNSGEPDIPP PQPDCGDFRS LQEEQSRPPT AVSSPGGPAR 
       160        170        180        190        200
APPYQEPPWG GPATAPYSLE TLKGGTILGT RSLKGTSYCL FGRLSGCDVC 
       210        220        230        240        250
LEHPSVSRYH AVLQHRASGP DGECDSNGPG FYLYDLGSTH GTFLNKTRIP 
       260        270        280        290        300
PRTYCRVHVG HVVRFGGSTR LFILQGPEED REAESELTVT QLKELRKQQQ 
       310        320        330        340        350
ILLEKKMLGE DSDEEEEMDT SERKINAGSQ DDEMGCTWGM GEDAVEDDAE 
       360        370        380        390        400
ENPIVLEFQQ EREAFYIKDP KKALQGFFDR EGEELEYEFD EQGHSTWLCR 
       410        420        430        440        450
VRLPVDDSTG KQLVAEAIHS GKKKEAMIQC SLEACRILDT LGLLRQEAVS 
       460        470        480        490        500
RKRKAKNWED EDFYDSDDDT FLDRTGLIEK KRLNRMKKAG KIDEKPETFE 
       510        520        530        540        550
SLVAKLNDAE RELSEISERL KASSQVLSES PSQDSLDAFM SEMKSGSTLD 
       560        570        580        590        600
GVSRKKLHLR TFELRKEQQR LKGLIKIVKP AEIPELKKTE TQTTGAENKA 
       610        620        630        640        650
KKLTLPLFGA MKGGSKFKLK TGTVGKLPPK RPELPPTLMR MKDEPEVEEE 
       660        670        680        690        700
EEEEEEEEKE KEEHEKKKLE DGSLSRPQPE IEPEAAVQEM RPPTDLTHFK 
       710        720        730        740        750
ETQTHENMSQ LSEEEQNKDY QDCSKTTSLC AGPSASKNEY EKSRGELKKK 
       760        770        780        790 
KTPGPGKLPP TLSSKYPEDD PDYCVWVPPE GQSGDGRTHL NDKYGY
Length:796
Mass (Da):88,814
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE0F560648DA39EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0M4A0A087X0M4_HUMAN
Kanadaptin
SLC4A1AP
742Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWF4A0A087WWF4_HUMAN
Kanadaptin
SLC4A1AP
273Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C256H7C256_HUMAN
Kanadaptin
SLC4A1AP
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN12269 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111 – 115SNSGE → PIAKP in AAN12269 (Ref. 6) Curated5
Sequence conflicti309G → R in AAK29177 (PubMed:14702039).Curated1
Sequence conflicti359Q → R in AAH98358 (PubMed:15489334).Curated1
Sequence conflicti373A → V in AAK29177 (PubMed:14702039).Curated1
Sequence conflicti444L → I in AAN12269 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024748139P → TCombined sources2 PublicationsCorresponds to variant dbSNP:rs9678851Ensembl.1
Natural variantiVAR_051219181R → C. Corresponds to variant dbSNP:rs9679004Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY028435 mRNA Translation: AAK29177.1
AK001486 mRNA Translation: BAA91718.1
AC074091 Genomic DNA Translation: AAX93203.1
CH471053 Genomic DNA Translation: EAX00555.1
BC098302 mRNA Translation: AAH98302.1
BC098358 mRNA Translation: AAH98358.1
BC099711 mRNA Translation: AAH99711.1
BC099739 mRNA Translation: AAH99739.1
AY117688 mRNA Translation: AAN12269.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_060628.2, NM_018158.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000326019.10; ENSP00000323837.6; ENSG00000163798.13
ENST00000613058.4; ENSP00000479964.1; ENSG00000163798.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22950

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22950

UCSC genome browser

More...UCSCi		uc002rlk.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Band 3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028435 mRNA Translation: AAK29177.1
AK001486 mRNA Translation: BAA91718.1
AC074091 Genomic DNA Translation: AAX93203.1
CH471053 Genomic DNA Translation: EAX00555.1
BC098302 mRNA Translation: AAH98302.1
BC098358 mRNA Translation: AAH98358.1
BC099711 mRNA Translation: AAH99711.1
BC099739 mRNA Translation: AAH99739.1
AY117688 mRNA Translation: AAN12269.1 Different initiation.
RefSeqiNP_060628.2, NM_018158.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H87X-ray1.55A/B149-276[»]
AlphaFoldDBiQ9BWU0
SMRiQ9BWU0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116605, 72 interactors
IntActiQ9BWU0, 35 interactors
MINTiQ9BWU0
STRINGi9606.ENSP00000479964

PTM databases

GlyGeniQ9BWU0, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9BWU0
MetOSiteiQ9BWU0
PhosphoSitePlusiQ9BWU0

Genetic variation databases

BioMutaiSLC4A1AP
DMDMi74724887

Proteomic databases

EPDiQ9BWU0
jPOSTiQ9BWU0
MassIVEiQ9BWU0
MaxQBiQ9BWU0
PaxDbiQ9BWU0
PeptideAtlasiQ9BWU0
PRIDEiQ9BWU0
ProteomicsDBi79316

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28720, 119 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		22950

Genome annotation databases

EnsembliENST00000326019.10; ENSP00000323837.6; ENSG00000163798.13
ENST00000613058.4; ENSP00000479964.1; ENSG00000163798.13
GeneIDi22950
KEGGihsa:22950
UCSCiuc002rlk.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22950
DisGeNETi22950

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC4A1AP
HGNCiHGNC:13813, SLC4A1AP
HPAiENSG00000163798, Low tissue specificity
MIMi602655, gene
neXtProtiNX_Q9BWU0
OpenTargetsiENSG00000163798
PharmGKBiPA37811
VEuPathDBiHostDB:ENSG00000163798

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1881, Eukaryota
GeneTreeiENSGT00940000155320
InParanoidiQ9BWU0
OrthoDBi955935at2759
PhylomeDBiQ9BWU0
TreeFamiTF314854

Enzyme and pathway databases

PathwayCommonsiQ9BWU0
SignaLinkiQ9BWU0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22950, 16 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC4A1AP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22950
PharosiQ9BWU0, Tdark

Protein Ontology

More...PROi		PR:Q9BWU0
RNActiQ9BWU0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163798, Expressed in testis and 121 other tissues
ExpressionAtlasiQ9BWU0, baseline and differential
GenevisibleiQ9BWU0, HS

Family and domain databases

CDDicd00060, FHA, 1 hit
InterProiView protein in InterPro
IPR000253, FHA_dom
IPR008984, SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF00498, FHA, 1 hit
SMARTiView protein in SMART
SM00240, FHA, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNADAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BWU0
Secondary accession number(s): A6NJ39
, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: May 25, 2022
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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