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Protein

Caspase recruitment domain-containing protein 10

Gene

CARD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates NF-kappa-B via BCL10 and IKK.

Caution

Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.Curated

GO - Molecular functioni

  • receptor signaling complex scaffold activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 10
Alternative name(s):
CARD-containing MAGUK protein 3
Short name:
Carma 3
Gene namesi
Name:CARD10
Synonyms:CARMA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100065.14
HGNCiHGNC:16422 CARD10
MIMi607209 gene
neXtProtiNX_Q9BWT7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi29775
OpenTargetsiENSG00000100065
PharmGKBiPA134927444

Polymorphism and mutation databases

BioMutaiCARD10
DMDMi116241281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440841 – 1032Caspase recruitment domain-containing protein 10Add BLAST1032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWT7
MaxQBiQ9BWT7
PaxDbiQ9BWT7
PeptideAtlasiQ9BWT7
PRIDEiQ9BWT7
ProteomicsDBi79315

PTM databases

iPTMnetiQ9BWT7
PhosphoSitePlusiQ9BWT7

Expressioni

Tissue specificityi

Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Gene expression databases

BgeeiENSG00000100065 Expressed in 193 organ(s), highest expression level in parotid gland
CleanExiHS_CARD10
ExpressionAtlasiQ9BWT7 baseline and differential
GenevisibleiQ9BWT7 HS

Organism-specific databases

HPAiHPA029359
HPA055612

Interactioni

Subunit structurei

CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118908, 17 interactors
IntActiQ9BWT7, 111 interactors
MINTiQ9BWT7
STRINGi9606.ENSP00000251973

Structurei

3D structure databases

ProteinModelPortaliQ9BWT7
SMRiQ9BWT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 115CARDPROSITE-ProRule annotationAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 456Sequence analysisAdd BLAST319

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi567 – 574Poly-Ser8

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00530000063108
HOGENOMiHOG000111299
HOVERGENiHBG050791
InParanoidiQ9BWT7
KOiK20912
OMAiGPCLKAC
OrthoDBiEOG091G0T58
PhylomeDBiQ9BWT7
TreeFamiTF351139

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BWT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGRAEAGEA EEEAGAGSGS EAEEDALWER IEGVRHRLAR ALNPAKLTPY
60 70 80 90 100
LRQCRVIDEQ DEEEVLSTYR FPCRVNRTGR LMDILRCRGK RGYEAFLEAL
110 120 130 140 150
EFYYPEHFTL LTGQEPAQRC SMILDEEGPE GLTQFLMTEV RRLREARKSQ
160 170 180 190 200
LQREQQLQAR GRVLEEERAG LEQRLRDQQQ AQERCQRLRE DWEAGSLELL
210 220 230 240 250
RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK VSRLEEECAL
260 270 280 290 300
LRRARGPPPG AEEKEKEKEK EKEPDNVDLV SELRAENQRL TASLRELQEG
310 320 330 340 350
LQQEASRPGA PGSERILLDI LEHDWREAQD SRQELCQKLH AVQGELQWAE
360 370 380 390 400
ELRDQYLQEM EDLRLKHRTL QKDCDLYKHR MATVLAQLEE IEKERDQAIQ
410 420 430 440 450
SRDRIQLQYS QSLIEKDQYR KQVRGLEAER DELLTTLTSL EGTKALLEVQ
460 470 480 490 500
LQRAQGGTCL KACASSHSLC SNLSSTWSLS EFPSPLGGPE ATGEAAVMGG
510 520 530 540 550
PEPHNSEEAT DSEKEINRLS ILPFPPSAGS ILRRQREEDP APPKRSFSSM
560 570 580 590 600
SDITGSVTLK PWSPGLSSSS SSDSVWPLGK PEGLLARGCG LDFLNRSLAI
610 620 630 640 650
RVSGRSPPGG PEPQDKGPDG LSFYGDRWSG AVVRRVLSGP GSARMEPREQ
660 670 680 690 700
RVEAAGLEGA CLEAEAQQRT LLWNQGSTLP SLMDSKACQS FHEALEAWAK
710 720 730 740 750
GPGAEPFYIR ANLTLPERAD PHALCVKAQE ILRLVDSAYK RRQEWFCTRV
760 770 780 790 800
DPLTLRDLDR GTVPNYQRAQ QLLEVQEKCL PSSRHRGPRS NLKKRALDQL
810 820 830 840 850
RLVRPKPVGA PAGDSPDQLL LEPCAEPERS LRPYSLVRPL LVSALRPVVL
860 870 880 890 900
LPECLAPRLI RNLLDLPSSR LDFQVCPAES LSGEELCPSS APGAPKAQPA
910 920 930 940 950
TPGLGSRIRA IQESVGKKHC LLELGARGVR ELVQNEIYPI VIHVEVTEKN
960 970 980 990 1000
VREVRGLLGR PGWRDSELLR QCRGSEQVLW GLPCSWVQVP AHEWGHAEEL
1010 1020 1030
AKVVRGRILQ EQARLVWVEC GSSRGCPSSS EA
Length:1,032
Mass (Da):115,931
Last modified:October 17, 2006 - v2
Checksum:i298AAC132778376A
GO
Isoform 2 (identifier: Q9BWT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MPGRAEAGEAEEEAGAG → MGVGVGLGNGLRLLPWM
     18-303: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):82,541
Checksum:iFDDA94D32E670CD9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYC4B0QYC4_HUMAN
Caspase recruitment domain-containi...
CARD10
480Annotation score:
B0QYC3B0QYC3_HUMAN
Caspase recruitment domain-containi...
CARD10
192Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti932L → R in AAK26165 (PubMed:11259443).Curated1
Sequence conflicti932L → R in AAK54454 (PubMed:11356195).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028116289R → Q2 PublicationsCorresponds to variant dbSNP:rs9610775Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555231 – 17MPGRA…EAGAG → MGVGVGLGNGLRLLPWM in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05552418 – 303Missing in isoform 2. 1 PublicationAdd BLAST286

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028896 mRNA Translation: AAK26165.1
AY032928 mRNA Translation: AAK54454.1
AK074906 mRNA Translation: BAC11282.1
AL022315 Genomic DNA No translation available.
FP325335 Genomic DNA No translation available.
BC113659 mRNA Translation: AAI13660.1
CCDSiCCDS13948.1 [Q9BWT7-1]
RefSeqiNP_055365.2, NM_014550.3 [Q9BWT7-1]
UniGeneiHs.57973

Genome annotation databases

EnsembliENST00000251973; ENSP00000251973; ENSG00000100065 [Q9BWT7-1]
ENST00000403299; ENSP00000384570; ENSG00000100065 [Q9BWT7-1]
ENST00000406271; ENSP00000385799; ENSG00000100065 [Q9BWT7-2]
GeneIDi29775
KEGGihsa:29775
UCSCiuc003asw.2 human [Q9BWT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028896 mRNA Translation: AAK26165.1
AY032928 mRNA Translation: AAK54454.1
AK074906 mRNA Translation: BAC11282.1
AL022315 Genomic DNA No translation available.
FP325335 Genomic DNA No translation available.
BC113659 mRNA Translation: AAI13660.1
CCDSiCCDS13948.1 [Q9BWT7-1]
RefSeqiNP_055365.2, NM_014550.3 [Q9BWT7-1]
UniGeneiHs.57973

3D structure databases

ProteinModelPortaliQ9BWT7
SMRiQ9BWT7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118908, 17 interactors
IntActiQ9BWT7, 111 interactors
MINTiQ9BWT7
STRINGi9606.ENSP00000251973

PTM databases

iPTMnetiQ9BWT7
PhosphoSitePlusiQ9BWT7

Polymorphism and mutation databases

BioMutaiCARD10
DMDMi116241281

Proteomic databases

EPDiQ9BWT7
MaxQBiQ9BWT7
PaxDbiQ9BWT7
PeptideAtlasiQ9BWT7
PRIDEiQ9BWT7
ProteomicsDBi79315

Protocols and materials databases

DNASUi29775
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251973; ENSP00000251973; ENSG00000100065 [Q9BWT7-1]
ENST00000403299; ENSP00000384570; ENSG00000100065 [Q9BWT7-1]
ENST00000406271; ENSP00000385799; ENSG00000100065 [Q9BWT7-2]
GeneIDi29775
KEGGihsa:29775
UCSCiuc003asw.2 human [Q9BWT7-1]

Organism-specific databases

CTDi29775
DisGeNETi29775
EuPathDBiHostDB:ENSG00000100065.14
GeneCardsiCARD10
HGNCiHGNC:16422 CARD10
HPAiHPA029359
HPA055612
MIMi607209 gene
neXtProtiNX_Q9BWT7
OpenTargetsiENSG00000100065
PharmGKBiPA134927444
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00530000063108
HOGENOMiHOG000111299
HOVERGENiHBG050791
InParanoidiQ9BWT7
KOiK20912
OMAiGPCLKAC
OrthoDBiEOG091G0T58
PhylomeDBiQ9BWT7
TreeFamiTF351139

Miscellaneous databases

ChiTaRSiCARD10 human
GeneWikiiCARD10
GenomeRNAii29775
PROiPR:Q9BWT7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100065 Expressed in 193 organ(s), highest expression level in parotid gland
CleanExiHS_CARD10
ExpressionAtlasiQ9BWT7 baseline and differential
GenevisibleiQ9BWT7 HS

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
PfamiView protein in Pfam
PF00619 CARD, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAR10_HUMAN
AccessioniPrimary (citable) accession number: Q9BWT7
Secondary accession number(s): Q14CQ8
, Q5TFG6, Q8NC81, Q9UGR5, Q9UGR6, Q9Y3H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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