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Entry version 161 (12 Aug 2020)
Sequence version 2 (17 Oct 2006)
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Protein

Caspase recruitment domain-containing protein 10

Gene

CARD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates NF-kappa-B via BCL10 and IKK.

Caution

Supposed to contain a SH3, a PDZ and a guanylate kinase-like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9BWT7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 10
Alternative name(s):
CARD-containing MAGUK protein 3
Short name:
Carma 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARD10
Synonyms:CARMA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100065.14

Human Gene Nomenclature Database

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HGNCi
HGNC:16422, CARD10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607209, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9BWT7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29775

Open Targets

More...
OpenTargetsi
ENSG00000100065

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134927444

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BWT7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CARD10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241281

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440841 – 1032Caspase recruitment domain-containing protein 10Add BLAST1032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BWT7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BWT7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BWT7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BWT7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BWT7

PeptideAtlas

More...
PeptideAtlasi
Q9BWT7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BWT7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
72861
79315 [Q9BWT7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BWT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BWT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100065, Expressed in parotid gland and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BWT7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BWT7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100065, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BWT7
With#Exp.IntAct
BAHD1 [Q8TBE0]3EBI-3866279,EBI-742750
BCL6B [A8KA13]3EBI-3866279,EBI-10174813
C4orf45 [Q96LM5]3EBI-3866279,EBI-12020542
C8orf48 [Q96LL4]3EBI-3866279,EBI-751596
CARD9 - isoform 2 [Q9H257-2]3EBI-3866279,EBI-11530605
CATSPER1 [Q8NEC5]3EBI-3866279,EBI-744545
CBX8 [Q9HC52]3EBI-3866279,EBI-712912
CCDC116 [Q8IYX3]3EBI-3866279,EBI-744311
CDC37 [Q16543]3EBI-3866279,EBI-295634
CEP95 [Q96GE4]3EBI-3866279,EBI-372775
CHIC2 [Q9UKJ5]3EBI-3866279,EBI-741528
CNNM3 [Q8NE01]3EBI-3866279,EBI-741032
CWF19L2 [Q2TBE0]3EBI-3866279,EBI-5453285
CYSRT1 [A8MQ03]3EBI-3866279,EBI-3867333
DHX57 [Q6P158]3EBI-3866279,EBI-1051531
DOCK2 [Q92608]3EBI-3866279,EBI-448771
DUSP26 [Q9BV47]3EBI-3866279,EBI-2924519
FAM47B [Q8NA70]3EBI-3866279,EBI-9247344
FOXD4L3 [Q6VB84]3EBI-3866279,EBI-11961494
GADD45GIP1 [Q8TAE8]3EBI-3866279,EBI-372506
GAS8 [O95995]3EBI-3866279,EBI-1052570
GFAP [P14136]3EBI-3866279,EBI-744302
GPATCH2L - isoform 2 [Q9NWQ4-1]3EBI-3866279,EBI-11959863
GSE1 [Q14687]3EBI-3866279,EBI-372619
GSTP1 [P09211]3EBI-3866279,EBI-353467
HBZ [P02008]3EBI-3866279,EBI-719843
HOXB9 [P17482]3EBI-3866279,EBI-745290
IL16 - isoform 2 [Q14005-2]3EBI-3866279,EBI-17178971
JOSD1 [Q15040]3EBI-3866279,EBI-2510602
KANK2 [Q63ZY3]3EBI-3866279,EBI-2556193
KDM1A [O60341]3EBI-3866279,EBI-710124
KEAP1 [Q14145]3EBI-3866279,EBI-751001
KRT75 [O95678]3EBI-3866279,EBI-2949715
KRTAP10-8 [P60410]3EBI-3866279,EBI-10171774
KRTAP12-3 [P60328]3EBI-3866279,EBI-11953334
KRTAP26-1 [Q6PEX3]3EBI-3866279,EBI-3957672
KRTAP9-2 [Q9BYQ4]3EBI-3866279,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-3866279,EBI-1043191
LENG1 [Q96BZ8]3EBI-3866279,EBI-726510
MAGOHB [Q96A72]3EBI-3866279,EBI-746778
METTL17 - isoform 2 [Q9H7H0-2]3EBI-3866279,EBI-11098807
MGC50722 [Q8IVT4]3EBI-3866279,EBI-14086479
MITD1 [Q8WV92]3EBI-3866279,EBI-2691489
MYPOP [Q86VE0]3EBI-3866279,EBI-2858213
NME7 [Q9Y5B8]3EBI-3866279,EBI-744782
OLIG3 [Q7RTU3]3EBI-3866279,EBI-10225049
PIBF1 [Q4G0R1]3EBI-3866279,EBI-14066006
PKP1 - isoform 1 [Q13835-2]3EBI-3866279,EBI-9087684
PNKP [Q96T60]3EBI-3866279,EBI-1045072
PRDM14 [Q9GZV8]3EBI-3866279,EBI-3957793
PRPF18 [Q99633]3EBI-3866279,EBI-2798416
PRPF3 [O43395]3EBI-3866279,EBI-744322
PRR35 [P0CG20]3EBI-3866279,EBI-11986293
PTCD1 [O75127]3EBI-3866279,EBI-2560233
PTGDS [P41222]3EBI-3866279,EBI-948821
RIN1 [Q13671]3EBI-3866279,EBI-366017
SCNM1 [Q9BWG6]3EBI-3866279,EBI-748391
SEMA3B - isoform 2 [Q13214-2]3EBI-3866279,EBI-11017428
SPATA18 [Q8TC71]3EBI-3866279,EBI-11334239
TBC1D22B [Q9NU19]3EBI-3866279,EBI-8787464
TFAP2D [Q7Z6R9]3EBI-3866279,EBI-11952651
TRIM27 [P14373]3EBI-3866279,EBI-719493
TRIM41 [Q8WV44]3EBI-3866279,EBI-725997
USP54 - isoform 6 [Q70EL1-9]3EBI-3866279,EBI-11975223
UTP14C [Q5TAP6]3EBI-3866279,EBI-11737646
ZBTB26 [Q9HCK0]3EBI-3866279,EBI-3918996
ZFP1 [Q6P2D0]3EBI-3866279,EBI-2555749
ZNF10 [P21506]3EBI-3866279,EBI-1105324
ZNF12 [P17014]3EBI-3866279,EBI-11278550
ZNF165 [P49910]3EBI-3866279,EBI-741694
ZNF180 - isoform 4 [Q9UJW8-4]3EBI-3866279,EBI-12055755
ZNF202 [O95125]3EBI-3866279,EBI-751960
ZNF223 [Q9UK11]3EBI-3866279,EBI-10322867
ZNF239 [Q16600]3EBI-3866279,EBI-8787052
ZNF250 - isoform 3 [P15622-3]3EBI-3866279,EBI-10177272
ZNF285 [Q96NJ3]3EBI-3866279,EBI-18064466
ZNF286A [Q9HBT8]3EBI-3866279,EBI-10754950
ZNF32 [P17041]3EBI-3866279,EBI-1965483
ZNF329 [Q86UD4]3EBI-3866279,EBI-7233259
ZNF366 [Q8N895]3EBI-3866279,EBI-2813661
ZNF414 [Q96IQ9]3EBI-3866279,EBI-744257
ZNF415 - isoform 4 [Q09FC8-4]3EBI-3866279,EBI-12273744
ZNF439 [Q8NDP4]3EBI-3866279,EBI-747580
ZNF440 [Q8IYI8]3EBI-3866279,EBI-726439
ZNF524 [Q96C55]3EBI-3866279,EBI-10283126
ZNF552 [Q9H707]3EBI-3866279,EBI-2555731
ZNF559 [Q9BR84]3EBI-3866279,EBI-746605
ZNF564 [Q8TBZ8]3EBI-3866279,EBI-10273713
ZNF575 [Q86XF7]3EBI-3866279,EBI-14069183
ZNF581 [Q9P0T4]3EBI-3866279,EBI-745520
ZNF587 [Q96SQ5]3EBI-3866279,EBI-6427977
ZNF613 [Q6PF04]3EBI-3866279,EBI-12062855
ZNF670 [Q9BS34]3EBI-3866279,EBI-745276
ZNF775 [Q96BV0]3EBI-3866279,EBI-7149881
ZNF80 [P51504]3EBI-3866279,EBI-12013828
ZNF837 [Q96EG3]3EBI-3866279,EBI-11962574
ZSCAN25 - isoform 2 [Q6NSZ9-2]3EBI-3866279,EBI-14650477

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
118908, 23 interactors

Protein interaction database and analysis system

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IntActi
Q9BWT7, 111 interactors

Molecular INTeraction database

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MINTi
Q9BWT7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384570

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BWT7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BWT7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 115CARDPROSITE-ProRule annotationAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili138 – 456Sequence analysisAdd BLAST319

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi567 – 574Poly-Ser8

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0708, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157763

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009760_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BWT7

KEGG Orthology (KO)

More...
KOi
K20912

Identification of Orthologs from Complete Genome Data

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OMAi
RTLPWSQ

Database of Orthologous Groups

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OrthoDBi
115953at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BWT7

TreeFam database of animal gene trees

More...
TreeFami
TF351139

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08807, CARD_CARD10_CARMA3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR042140, CARD_CARD10
IPR011029, DEATH-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BWT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGRAEAGEA EEEAGAGSGS EAEEDALWER IEGVRHRLAR ALNPAKLTPY
60 70 80 90 100
LRQCRVIDEQ DEEEVLSTYR FPCRVNRTGR LMDILRCRGK RGYEAFLEAL
110 120 130 140 150
EFYYPEHFTL LTGQEPAQRC SMILDEEGPE GLTQFLMTEV RRLREARKSQ
160 170 180 190 200
LQREQQLQAR GRVLEEERAG LEQRLRDQQQ AQERCQRLRE DWEAGSLELL
210 220 230 240 250
RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK VSRLEEECAL
260 270 280 290 300
LRRARGPPPG AEEKEKEKEK EKEPDNVDLV SELRAENQRL TASLRELQEG
310 320 330 340 350
LQQEASRPGA PGSERILLDI LEHDWREAQD SRQELCQKLH AVQGELQWAE
360 370 380 390 400
ELRDQYLQEM EDLRLKHRTL QKDCDLYKHR MATVLAQLEE IEKERDQAIQ
410 420 430 440 450
SRDRIQLQYS QSLIEKDQYR KQVRGLEAER DELLTTLTSL EGTKALLEVQ
460 470 480 490 500
LQRAQGGTCL KACASSHSLC SNLSSTWSLS EFPSPLGGPE ATGEAAVMGG
510 520 530 540 550
PEPHNSEEAT DSEKEINRLS ILPFPPSAGS ILRRQREEDP APPKRSFSSM
560 570 580 590 600
SDITGSVTLK PWSPGLSSSS SSDSVWPLGK PEGLLARGCG LDFLNRSLAI
610 620 630 640 650
RVSGRSPPGG PEPQDKGPDG LSFYGDRWSG AVVRRVLSGP GSARMEPREQ
660 670 680 690 700
RVEAAGLEGA CLEAEAQQRT LLWNQGSTLP SLMDSKACQS FHEALEAWAK
710 720 730 740 750
GPGAEPFYIR ANLTLPERAD PHALCVKAQE ILRLVDSAYK RRQEWFCTRV
760 770 780 790 800
DPLTLRDLDR GTVPNYQRAQ QLLEVQEKCL PSSRHRGPRS NLKKRALDQL
810 820 830 840 850
RLVRPKPVGA PAGDSPDQLL LEPCAEPERS LRPYSLVRPL LVSALRPVVL
860 870 880 890 900
LPECLAPRLI RNLLDLPSSR LDFQVCPAES LSGEELCPSS APGAPKAQPA
910 920 930 940 950
TPGLGSRIRA IQESVGKKHC LLELGARGVR ELVQNEIYPI VIHVEVTEKN
960 970 980 990 1000
VREVRGLLGR PGWRDSELLR QCRGSEQVLW GLPCSWVQVP AHEWGHAEEL
1010 1020 1030
AKVVRGRILQ EQARLVWVEC GSSRGCPSSS EA
Length:1,032
Mass (Da):115,931
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i298AAC132778376A
GO
Isoform 2 (identifier: Q9BWT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MPGRAEAGEAEEEAGAG → MGVGVGLGNGLRLLPWM
     18-303: Missing.

Show »
Length:746
Mass (Da):82,541
Checksum:iFDDA94D32E670CD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QYC4B0QYC4_HUMAN
Caspase recruitment domain-containi...
CARD10
480Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QYC3B0QYC3_HUMAN
Caspase recruitment domain-containi...
CARD10
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti932L → R in AAK26165 (PubMed:11259443).Curated1
Sequence conflicti932L → R in AAK54454 (PubMed:11356195).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028116289R → Q2 PublicationsCorresponds to variant dbSNP:rs9610775Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0555231 – 17MPGRA…EAGAG → MGVGVGLGNGLRLLPWM in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05552418 – 303Missing in isoform 2. 1 PublicationAdd BLAST286

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY028896 mRNA Translation: AAK26165.1
AY032928 mRNA Translation: AAK54454.1
AK074906 mRNA Translation: BAC11282.1
AL022315 Genomic DNA No translation available.
FP325335 Genomic DNA No translation available.
BC113659 mRNA Translation: AAI13660.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13948.1 [Q9BWT7-1]

NCBI Reference Sequences

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RefSeqi
NP_055365.2, NM_014550.3 [Q9BWT7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251973; ENSP00000251973; ENSG00000100065 [Q9BWT7-1]
ENST00000403299; ENSP00000384570; ENSG00000100065 [Q9BWT7-1]
ENST00000406271; ENSP00000385799; ENSG00000100065 [Q9BWT7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29775

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29775

UCSC genome browser

More...
UCSCi
uc003asw.2, human [Q9BWT7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028896 mRNA Translation: AAK26165.1
AY032928 mRNA Translation: AAK54454.1
AK074906 mRNA Translation: BAC11282.1
AL022315 Genomic DNA No translation available.
FP325335 Genomic DNA No translation available.
BC113659 mRNA Translation: AAI13660.1
CCDSiCCDS13948.1 [Q9BWT7-1]
RefSeqiNP_055365.2, NM_014550.3 [Q9BWT7-1]

3D structure databases

SMRiQ9BWT7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118908, 23 interactors
IntActiQ9BWT7, 111 interactors
MINTiQ9BWT7
STRINGi9606.ENSP00000384570

PTM databases

iPTMnetiQ9BWT7
PhosphoSitePlusiQ9BWT7

Polymorphism and mutation databases

BioMutaiCARD10
DMDMi116241281

Proteomic databases

EPDiQ9BWT7
jPOSTiQ9BWT7
MassIVEiQ9BWT7
MaxQBiQ9BWT7
PaxDbiQ9BWT7
PeptideAtlasiQ9BWT7
PRIDEiQ9BWT7
ProteomicsDBi72861
79315 [Q9BWT7-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25967, 227 antibodies

The DNASU plasmid repository

More...
DNASUi
29775

Genome annotation databases

EnsembliENST00000251973; ENSP00000251973; ENSG00000100065 [Q9BWT7-1]
ENST00000403299; ENSP00000384570; ENSG00000100065 [Q9BWT7-1]
ENST00000406271; ENSP00000385799; ENSG00000100065 [Q9BWT7-2]
GeneIDi29775
KEGGihsa:29775
UCSCiuc003asw.2, human [Q9BWT7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29775
DisGeNETi29775
EuPathDBiHostDB:ENSG00000100065.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CARD10
HGNCiHGNC:16422, CARD10
HPAiENSG00000100065, Tissue enhanced (intestine)
MIMi607209, gene
neXtProtiNX_Q9BWT7
OpenTargetsiENSG00000100065
PharmGKBiPA134927444

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0708, Eukaryota
GeneTreeiENSGT00940000157763
HOGENOMiCLU_009760_1_0_1
InParanoidiQ9BWT7
KOiK20912
OMAiRTLPWSQ
OrthoDBi115953at2759
PhylomeDBiQ9BWT7
TreeFamiTF351139

Enzyme and pathway databases

PathwayCommonsiQ9BWT7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
29775, 21 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CARD10, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CARD10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
29775
PharosiQ9BWT7, Tbio

Protein Ontology

More...
PROi
PR:Q9BWT7
RNActiQ9BWT7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100065, Expressed in parotid gland and 205 other tissues
ExpressionAtlasiQ9BWT7, baseline and differential
GenevisibleiQ9BWT7, HS

Family and domain databases

CDDicd08807, CARD_CARD10_CARMA3, 1 hit
InterProiView protein in InterPro
IPR001315, CARD
IPR042140, CARD_CARD10
IPR011029, DEATH-like_dom_sf
PfamiView protein in Pfam
PF00619, CARD, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAR10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BWT7
Secondary accession number(s): Q14CQ8
, Q5TFG6, Q8NC81, Q9UGR5, Q9UGR6, Q9Y3H0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 17, 2006
Last modified: August 12, 2020
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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