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Entry version 170 (12 Aug 2020)
Sequence version 2 (17 Oct 2006)
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Protein

Poly(A) polymerase gamma

Gene

PAPOLG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium ions. Also active with manganese.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.051 µM for poly(A)(15)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei108ATPBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi112Magnesium 1; catalytic1
    Metal bindingi112Magnesium 2; catalyticBy similarity1
    Metal bindingi114Magnesium 1; catalytic1
    Metal bindingi114Magnesium 2; catalyticBy similarity1
    Metal bindingi166Magnesium 2; catalyticBy similarity1
    Binding sitei166ATPBy similarity1
    Binding sitei227ATP1 Publication1
    Binding sitei236ATP1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi99 – 101ATP1 Publication3
    Nucleotide bindingi112 – 114ATP1 Publication3
    Nucleotide bindingi245 – 246ATP1 Publication2

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionRNA-binding, Transferase
    Biological processmRNA processing
    LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q9BWT3

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9BWT3

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Poly(A) polymerase gamma (EC:2.7.7.19)
    Short name:
    PAP-gamma
    Alternative name(s):
    Neo-poly(A) polymerase
    Short name:
    Neo-PAP
    Polynucleotide adenylyltransferase gamma
    SRP RNA 3'-adenylating enzyme
    Signal recognition particle RNA-adenylating enzyme
    Short name:
    SRP RNA-adenylating enzyme
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PAPOLG
    Synonyms:PAP2, PAPG
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000115421.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:14982, PAPOLG

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    616865, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9BWT3

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    64895

    Open Targets

    More...
    OpenTargetsi
    ENSG00000115421

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA32934

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9BWT3, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PAPOLG

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116242699

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516241 – 736Poly(A) polymerase gammaAdd BLAST736

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N6-acetyllysineCombined sources1
    Modified residuei23PhosphoserineCombined sources1
    Modified residuei29PhosphoserineCombined sources1
    Modified residuei525PhosphoserineCombined sources1
    Modified residuei599PhosphoserineCombined sources1
    Modified residuei648PhosphoserineCombined sources1
    Modified residuei654PhosphothreonineCombined sources1
    Modified residuei684PhosphoserineCombined sources1
    Modified residuei708PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9BWT3

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9BWT3

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9BWT3

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9BWT3

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9BWT3

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9BWT3

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9BWT3

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    62654
    79313 [Q9BWT3-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9BWT3

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9BWT3

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000115421, Expressed in female gonad and 227 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9BWT3, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9BWT3, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000115421, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei152Interaction with RNABy similarity1
    Sitei157Interaction with RNABy similarity1
    Sitei327Interaction with RNABy similarity1
    Sitei398Interaction with RNABy similarity1
    Sitei532Interaction with RNABy similarity1

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    122338, 14 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9BWT3, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000238714

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q9BWT3, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1736
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9BWT3

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the poly(A) polymerase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2245, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156467

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_011511_1_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9BWT3

    KEGG Orthology (KO)

    More...
    KOi
    K14376

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NGSEMDV

    Database of Orthologous Groups

    More...
    OrthoDBi
    326577at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9BWT3

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300842

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.460.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR043519, NT_sf
    IPR011068, NuclTrfase_I-like_C
    IPR007012, PolA_pol_cen_dom
    IPR007010, PolA_pol_RNA-bd_dom
    IPR002934, Polymerase_NTP_transf_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01909, NTP_transf_2, 1 hit
    PF04928, PAP_central, 1 hit
    PF04926, PAP_RNA-bind, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55003, SSF55003, 1 hit
    SSF81301, SSF81301, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9BWT3-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKEMSANTVL DSQRQQKHYG ITSPISLASP KEIDHIYTQK LIDAMKPFGV
    60 70 80 90 100
    FEDEEELNHR LVVLGKLNNL VKEWISDVSE SKNLPPSVVA TVGGKIFTFG
    110 120 130 140 150
    SYRLGVHTKG ADIDALCVAP RHVERSDFFQ SFFEKLKHQD GIRNLRAVED
    160 170 180 190 200
    AFVPVIKFEF DGIEIDLVFA RLAIQTISDN LDLRDDSRLR SLDIRCIRSL
    210 220 230 240 250
    NGCRVTDEIL HLVPNKETFR LTLRAVKLWA KRRGIYSNML GFLGGVSWAM
    260 270 280 290 300
    LVARTCQLYP NAAASTLVHK FFLVFSKWEW PNPVLLKQPE ESNLNLPVWD
    310 320 330 340 350
    PRVNPSDRYH LMPIITPAYP QQNSTYNVST STRTVMVEEF KQGLAVTDEI
    360 370 380 390 400
    LQGKSDWSKL LEPPNFFQKY RHYIVLTASA STEENHLEWV GLVESKIRVL
    410 420 430 440 450
    VGNLERNEFI TLAHVNPQSF PGNKEHHKDN NYVSMWFLGI IFRRVENAES
    460 470 480 490 500
    VNIDLTYDIQ SFTDTVYRQA NNINMLKEGM KIEATHVKKK QLHHYLPAEI
    510 520 530 540 550
    LQKKKKQSLS DVNRSSGGLQ SKRLSLDSSC LDSSRDTDNG TPFNSPASKS
    560 570 580 590 600
    DSPSVGETER NSAEPAAVIV EKPLSVPPAQ GLSIPVIGAK VDSTVKTVSP
    610 620 630 640 650
    PTVCTIPTVV GRNVIPRITT PHNPAQGQPH LNGMSNITKT VTPKRSHSPS
    660 670 680 690 700
    IDGTPKRLKD VEKFIRLEST FKDPRTAEER KRKSVDAIGG ESMPIPTIDT
    710 720 730
    SRKKRLPSKE LPDSSSPVPA NNIRVIKNSI RLTLNR
    Length:736
    Mass (Da):82,803
    Last modified:October 17, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0F6F217AA36E552
    GO
    Isoform 2 (identifier: Q9BWT3-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         664-685: Missing.

    Show »
    Length:714
    Mass (Da):80,127
    Checksum:i0467FCF53C3CE806
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0C4DH56A0A0C4DH56_HUMAN
    Poly(A) polymerase gamma
    PAPOLG
    382Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WAT4F8WAT4_HUMAN
    Polynucleotide adenylyltransferase
    PAPOLG
    234Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C3W0H7C3W0_HUMAN
    Polynucleotide adenylyltransferase
    PAPOLG
    168Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAB14604 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31K → E in AAK31791 (PubMed:11287430).Curated1
    Sequence conflicti289P → S in AAK31791 (PubMed:11287430).Curated1
    Sequence conflicti619T → I in AAK31791 (PubMed:11287430).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054379664 – 685Missing in isoform 2. 1 PublicationAdd BLAST22

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY029162 mRNA Translation: AAK31791.1
    AF312211 mRNA Translation: AAK83701.1
    AJ308101 mRNA Translation: CAC59751.1
    AK021867 mRNA Translation: BAB13919.1
    AK023544 mRNA Translation: BAB14604.1 Different initiation.
    AK314663 mRNA Translation: BAG37221.1
    AC011245 Genomic DNA No translation available.
    AC012498 Genomic DNA No translation available.
    CH471053 Genomic DNA Translation: EAX00034.1
    BC111701 mRNA Translation: AAI11702.1
    BC113747 mRNA Translation: AAI13748.1
    AB209304 mRNA Translation: BAD92541.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1863.1 [Q9BWT3-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_075045.2, NM_022894.3 [Q9BWT3-1]
    XP_005264557.1, XM_005264500.3 [Q9BWT3-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000238714; ENSP00000238714; ENSG00000115421 [Q9BWT3-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    64895

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:64895

    UCSC genome browser

    More...
    UCSCi
    uc002sai.4, human [Q9BWT3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY029162 mRNA Translation: AAK31791.1
    AF312211 mRNA Translation: AAK83701.1
    AJ308101 mRNA Translation: CAC59751.1
    AK021867 mRNA Translation: BAB13919.1
    AK023544 mRNA Translation: BAB14604.1 Different initiation.
    AK314663 mRNA Translation: BAG37221.1
    AC011245 Genomic DNA No translation available.
    AC012498 Genomic DNA No translation available.
    CH471053 Genomic DNA Translation: EAX00034.1
    BC111701 mRNA Translation: AAI11702.1
    BC113747 mRNA Translation: AAI13748.1
    AB209304 mRNA Translation: BAD92541.1
    CCDSiCCDS1863.1 [Q9BWT3-1]
    RefSeqiNP_075045.2, NM_022894.3 [Q9BWT3-1]
    XP_005264557.1, XM_005264500.3 [Q9BWT3-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4LT6X-ray2.79A/B1-508[»]
    SMRiQ9BWT3
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi122338, 14 interactors
    IntActiQ9BWT3, 3 interactors
    STRINGi9606.ENSP00000238714

    PTM databases

    iPTMnetiQ9BWT3
    PhosphoSitePlusiQ9BWT3

    Polymorphism and mutation databases

    BioMutaiPAPOLG
    DMDMi116242699

    Proteomic databases

    EPDiQ9BWT3
    jPOSTiQ9BWT3
    MassIVEiQ9BWT3
    MaxQBiQ9BWT3
    PaxDbiQ9BWT3
    PeptideAtlasiQ9BWT3
    PRIDEiQ9BWT3
    ProteomicsDBi62654
    79313 [Q9BWT3-1]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    30527, 125 antibodies

    Genome annotation databases

    EnsembliENST00000238714; ENSP00000238714; ENSG00000115421 [Q9BWT3-1]
    GeneIDi64895
    KEGGihsa:64895
    UCSCiuc002sai.4, human [Q9BWT3-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    64895
    DisGeNETi64895
    EuPathDBiHostDB:ENSG00000115421.12

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PAPOLG
    HGNCiHGNC:14982, PAPOLG
    HPAiENSG00000115421, Low tissue specificity
    MIMi616865, gene
    neXtProtiNX_Q9BWT3
    OpenTargetsiENSG00000115421
    PharmGKBiPA32934

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2245, Eukaryota
    GeneTreeiENSGT00940000156467
    HOGENOMiCLU_011511_1_2_1
    InParanoidiQ9BWT3
    KOiK14376
    OMAiNGSEMDV
    OrthoDBi326577at2759
    PhylomeDBiQ9BWT3
    TreeFamiTF300842

    Enzyme and pathway databases

    PathwayCommonsiQ9BWT3
    SABIO-RKiQ9BWT3

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    64895, 5 hits in 874 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PAPOLG, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PAPOLG

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    64895
    PharosiQ9BWT3, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q9BWT3
    RNActiQ9BWT3, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000115421, Expressed in female gonad and 227 other tissues
    ExpressionAtlasiQ9BWT3, baseline and differential
    GenevisibleiQ9BWT3, HS

    Family and domain databases

    Gene3Di3.30.460.10, 1 hit
    InterProiView protein in InterPro
    IPR043519, NT_sf
    IPR011068, NuclTrfase_I-like_C
    IPR007012, PolA_pol_cen_dom
    IPR007010, PolA_pol_RNA-bd_dom
    IPR002934, Polymerase_NTP_transf_dom
    PfamiView protein in Pfam
    PF01909, NTP_transf_2, 1 hit
    PF04928, PAP_central, 1 hit
    PF04926, PAP_RNA-bind, 2 hits
    SUPFAMiSSF55003, SSF55003, 1 hit
    SSF81301, SSF81301, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAPOG_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BWT3
    Secondary accession number(s): B2RBH4
    , Q59G05, Q969N1, Q9H8L2, Q9HAD0
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: October 17, 2006
    Last modified: August 12, 2020
    This is version 170 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
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