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Protein

Splicing factor 3B subunit 5

Gene

SF3B5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).3 Publications

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 3B subunit 5
Short name:
SF3b5
Alternative name(s):
Pre-mRNA-splicing factor SF3b 10 kDa subunit
Gene namesi
Name:SF3B5
Synonyms:SF3B10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000169976.6
HGNCiHGNC:21083 SF3B5
MIMi617847 gene
neXtProtiNX_Q9BWJ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169976
PharmGKBiPA134951632

Polymorphism and mutation databases

BioMutaiSF3B5
DMDMi20140757

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002207572 – 86Splicing factor 3B subunit 5Add BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei17N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BWJ5
MaxQBiQ9BWJ5
PaxDbiQ9BWJ5
PeptideAtlasiQ9BWJ5
PRIDEiQ9BWJ5
ProteomicsDBi79283
TopDownProteomicsiQ9BWJ5

PTM databases

iPTMnetiQ9BWJ5
PhosphoSitePlusiQ9BWJ5

Expressioni

Gene expression databases

BgeeiENSG00000169976 Expressed in 223 organ(s), highest expression level in left adrenal gland
CleanExiHS_SF3B5
GenevisibleiQ9BWJ5 HS

Organism-specific databases

HPAiHPA054408

Interactioni

Subunit structurei

Component of the spliceosome B complex (PubMed:28781166). Component of splicing factor SF3B complex which is composed of at least eight subunits; SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42 (PubMed:12234937, PubMed:12738865, PubMed:28541300, PubMed:27720643). SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) (PubMed:12234937). Within the SF3B complex interacts directly with SF3B1 (via HEAT domain) and SF3B3 (PubMed:27720643). The SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A interacts with U2AF2 (PubMed:27720643). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Interaction with RNA1 Publication1
Sitei20Interaction with RNA1 Publication1

Protein-protein interaction databases

BioGridi123645, 36 interactors
CORUMiQ9BWJ5
IntActiQ9BWJ5, 10 interactors
MINTiQ9BWJ5
STRINGi9606.ENSP00000356541

Structurei

Secondary structure

186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BWJ5
SMRiQ9BWJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 76Interaction with SF3B1 and SF3B31 PublicationAdd BLAST62

Sequence similaritiesi

Belongs to the SF3B5 family.Curated

Phylogenomic databases

eggNOGiKOG3485 Eukaryota
ENOG4111NTV LUCA
GeneTreeiENSGT00390000013215
HOVERGENiHBG054589
InParanoidiQ9BWJ5
KOiK12832
OMAiQSKYVGT
OrthoDBiEOG091G0ZLI
PhylomeDBiQ9BWJ5
TreeFamiTF300117

Family and domain databases

InterProiView protein in InterPro
IPR009846 SF3b5/RDS3-10
IPR017089 Splicing_factor_3B_subunit_5
PANTHERiPTHR20978 PTHR20978, 1 hit
PfamiView protein in Pfam
PF07189 SF3b10, 1 hit
PIRSFiPIRSF037010 Splicing_factor_3B_subunit_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BWJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDRYTIHSQ LEHLQSKYIG TGHADTTKWE WLVNQHRDSY CSYMGHFDLL
60 70 80
NYFAIAENES KARVRFNLME KMLQPCGPPA DKPEEN
Length:86
Mass (Da):10,135
Last modified:June 1, 2001 - v1
Checksum:iB8A209EA9F548E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312079 mRNA Translation: BAG35015.1
AL031390 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47851.1
BC000198 mRNA Translation: AAH00198.1
BK000562 Genomic DNA Translation: DAA00073.1
CCDSiCCDS5204.1
RefSeqiNP_112577.1, NM_031287.2
UniGeneiHs.110695

Genome annotation databases

EnsembliENST00000367569; ENSP00000356541; ENSG00000169976
GeneIDi83443
KEGGihsa:83443
UCSCiuc003qkr.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312079 mRNA Translation: BAG35015.1
AL031390 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47851.1
BC000198 mRNA Translation: AAH00198.1
BK000562 Genomic DNA Translation: DAA00073.1
CCDSiCCDS5204.1
RefSeqiNP_112577.1, NM_031287.2
UniGeneiHs.110695

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IFEX-ray3.10B1-86[»]
5O9Zelectron microscopy4.50x1-86[»]
5Z56electron microscopy5.1071-86[»]
5Z57electron microscopy6.5071-86[»]
5Z58electron microscopy4.9071-86[»]
5ZYAelectron microscopy3.95B1-86[»]
6EN4X-ray3.08B2-86[»]
6FF4electron microscopy16.00x1-86[»]
ProteinModelPortaliQ9BWJ5
SMRiQ9BWJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123645, 36 interactors
CORUMiQ9BWJ5
IntActiQ9BWJ5, 10 interactors
MINTiQ9BWJ5
STRINGi9606.ENSP00000356541

PTM databases

iPTMnetiQ9BWJ5
PhosphoSitePlusiQ9BWJ5

Polymorphism and mutation databases

BioMutaiSF3B5
DMDMi20140757

Proteomic databases

EPDiQ9BWJ5
MaxQBiQ9BWJ5
PaxDbiQ9BWJ5
PeptideAtlasiQ9BWJ5
PRIDEiQ9BWJ5
ProteomicsDBi79283
TopDownProteomicsiQ9BWJ5

Protocols and materials databases

DNASUi83443
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367569; ENSP00000356541; ENSG00000169976
GeneIDi83443
KEGGihsa:83443
UCSCiuc003qkr.2 human

Organism-specific databases

CTDi83443
EuPathDBiHostDB:ENSG00000169976.6
GeneCardsiSF3B5
HGNCiHGNC:21083 SF3B5
HPAiHPA054408
MIMi617847 gene
neXtProtiNX_Q9BWJ5
OpenTargetsiENSG00000169976
PharmGKBiPA134951632
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3485 Eukaryota
ENOG4111NTV LUCA
GeneTreeiENSGT00390000013215
HOVERGENiHBG054589
InParanoidiQ9BWJ5
KOiK12832
OMAiQSKYVGT
OrthoDBiEOG091G0ZLI
PhylomeDBiQ9BWJ5
TreeFamiTF300117

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

GeneWikiiSF3B5
GenomeRNAii83443
PROiPR:Q9BWJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169976 Expressed in 223 organ(s), highest expression level in left adrenal gland
CleanExiHS_SF3B5
GenevisibleiQ9BWJ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR009846 SF3b5/RDS3-10
IPR017089 Splicing_factor_3B_subunit_5
PANTHERiPTHR20978 PTHR20978, 1 hit
PfamiView protein in Pfam
PF07189 SF3b10, 1 hit
PIRSFiPIRSF037010 Splicing_factor_3B_subunit_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSF3B5_HUMAN
AccessioniPrimary (citable) accession number: Q9BWJ5
Secondary accession number(s): B2R568, Q7RTV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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