UniProtKB - Q9BWH6 (RPAP1_HUMAN)

BLAST

>sp|Q9BWH6|RPAP1_HUMAN RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3
MLSRPKPGESEVDLLHFQSQFLAAGAAPAVQLVKKGNRGGGDANSDRPPLQDHRDVVMLD
NLPDLPPALVPSPPKRARPSPGHCLPEDEDPEERLRRHDQHITAVLTKIIERDTSSVAVN
LPVPSGVAFPAVFLRSRDTQGKSATSGKRSIFAQEIAARRIAEAKGPSVGEVVPNVGPPE
GAVTCETPTPRNQGCQLPGSSHSFQGPNLVTGKGLRDQEAEQEAQTIHEENIARLQAMAP
EEILQEQQRLLAQLDPSLVAFLRSHSHTQEQTGETASEEQRPGGPSANVTKEEPLMSAFA
SEPRKRDKLEPEAPALALPVTPQKEWLHMDTVELEKLHWTQDLPPVRRQQTQERMQARFS
LQGELLAPDVDLPTHLGLHHHGEEAERAGYSLQELFHLTRSQVSQQRALALHVLAQVISR
AQAGEFGDRLAGSVLSLLLDAGFLFLLRFSLDDRVDGVIATAIRALRALLVAPGDEELLD
STFSWYHGALTFPLMPSQEDKEDEDEDEECPAGKAKRKSPEEESRPPPDLARHDVIKGLL
ATSLLPRLRYVLEVTYPGPAVVLDILAVLIRLARHSLESATRVLECPRLIETIVREFLPT
SWSPVGAGPTPSLYKVPCATAMKLLRVLASAGRNIAARLLSSFDLRSRLCRIIAEAPQEL
ALPPEEAEMLSTEALRLWAVAASYGQGGYLYRELYPVLMRALQVVPRELSTHPPQPLSMQ
RIASLLTLLTQLTLAAGSTPAETISDSAEASLSATPSLVTWTQVSGLQPLVEPCLRQTLK
LLSRPEMWRAVGPVPVACLLFLGAYYQAWSQQPSSCPEDWLQDMQRLSEELLLPLLSQPT
LGSLWDSLRHCSLLCNPLSCVPALEAPPSLVSLGCSGGCPRLSLAGSASPFPFLTALLSL
LNTLAQIHKGLCGQLAAILAAPGLQNYFLQCVAPGAAPHLTPFSAWALRHEYHLQYLALA
LAQKAAALQPLPATHAALYHGMALALLSRLLPGSEYLTHELLLSCVFRLEFLPERTSGGP
EAADFSDQLSLGSSRVPRCGQGTLLAQACQDLPSIRNCYLTHCSPARASLLASQALHRGE
LQRVPTLLLPMPTEPLLPTDWPFLPLIRLYHRASDTPSGLSPTDTMGTAMRVLQWVLVLE
SWRPQALWAVPPAARLARLMCVFLVDSELFRESPVQHLVAALLAQLCQPQVLPNLNLDCR
LPGLTSFPDLYANFLDHFEAVSFGDHLFGALVLLPLQRRFSVTLRLALFGEHVGALRALS
LPLTQLPVSLECYTVPPEDNLALLQLYFRTLVTGALRPRWCPVLYAVAVAHVNSFIFSQD
PQSSDEVKAARRSMLQKTWLLADEGLRQHLLHYKLPNSTLPEGFELYSQLPPLRQHYLQR
LTSTVLQNGVSET

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History
Entry version 127 (12 Sep 2018)
Sequence version 3 (18 May 2010)
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Protein

RNA polymerase II-associated protein 1

Gene

RPAP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3.1 Publication

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription by RNA polymerase II Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Nucleotidyltransferase, Transferase
Biological process	Transcription

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA polymerase II-associated protein 1
Gene namesⁱ	Name:RPAP1 Synonyms:KIAA1403
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103932.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24567 RPAP1
MIMⁱ	611475 gene
neXtProtⁱ	NX_Q9BWH6

Keywords - Cellular componentⁱ

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26015
Open Targets More...OpenTargetsⁱ	ENSG00000103932
PharmGKBⁱ	PA134914340

Polymorphism and mutation databases

BioMutaⁱ	RPAP1
DMDMⁱ	296452978

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000284841	1 – 1393	RNA polymerase II-associated protein 1Add BLAST		1393

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	72	PhosphoserineCombined sources	1
Modified residueⁱ	321	PhosphothreonineCombined sources	1
Modified residueⁱ	1121	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BWH6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BWH6
PaxDbⁱ	Q9BWH6
PeptideAtlas More...PeptideAtlasⁱ	Q9BWH6
PRIDEⁱ	Q9BWH6
ProteomicsDBⁱ	79279 79280 [Q9BWH6-2] 79281 [Q9BWH6-3]

PTM databases

iPTMnetⁱ	Q9BWH6
PhosphoSitePlusⁱ	Q9BWH6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000103932 Expressed in 157 organ(s), highest expression level in heart left ventricle
CleanExⁱ	HS_RPAP1
ExpressionAtlasⁱ	Q9BWH6 baseline and differential
Genevisibleⁱ	Q9BWH6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041739

HPAⁱ

HPA041739

Interactionⁱ

Subunit structureⁱ

Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
POLR2L	P62875	3	EBI-1048085,EBI-359527
POT1	Q9NUX5	2	EBI-1048085,EBI-752420

Protein-protein interaction databases

BioGridⁱ	117487, 52 interactors
CORUMⁱ	Q9BWH6
IntActⁱ	Q9BWH6, 8 interactors
STRINGⁱ	9606.ENSP00000306123

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BWH6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	827 – 1286	Leu-richAdd BLAST		460

Sequence similaritiesⁱ

Belongs to the RPAP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1894 Eukaryota ENOG410XNVT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007594
HOGENOMⁱ	HOG000154180
HOVERGENⁱ	HBG057248
InParanoidⁱ	Q9BWH6
KEGG Orthology (KO) More...KOⁱ	K20826
OMAⁱ	QWVLVLE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06IW
PhylomeDBⁱ	Q9BWH6
TreeFamⁱ	TF324391

Family and domain databases

InterProⁱ	View protein in InterPro IPR013929 RNA_pol_II_AP1_C IPR013930 RNA_pol_II_AP1_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08620 RPAP1_C, 1 hit PF08621 RPAP1_N, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9BWH6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRPKPGES EVDLLHFQSQ FLAAGAAPAV QLVKKGNRGG GDANSDRPPL 
        60         70         80         90        100
QDHRDVVMLD NLPDLPPALV PSPPKRARPS PGHCLPEDED PEERLRRHDQ 
       110        120        130        140        150
HITAVLTKII ERDTSSVAVN LPVPSGVAFP AVFLRSRDTQ GKSATSGKRS 
       160        170        180        190        200
IFAQEIAARR IAEAKGPSVG EVVPNVGPPE GAVTCETPTP RNQGCQLPGS 
       210        220        230        240        250
SHSFQGPNLV TGKGLRDQEA EQEAQTIHEE NIARLQAMAP EEILQEQQRL 
       260        270        280        290        300
LAQLDPSLVA FLRSHSHTQE QTGETASEEQ RPGGPSANVT KEEPLMSAFA 
       310        320        330        340        350
SEPRKRDKLE PEAPALALPV TPQKEWLHMD TVELEKLHWT QDLPPVRRQQ 
       360        370        380        390        400
TQERMQARFS LQGELLAPDV DLPTHLGLHH HGEEAERAGY SLQELFHLTR 
       410        420        430        440        450
SQVSQQRALA LHVLAQVISR AQAGEFGDRL AGSVLSLLLD AGFLFLLRFS 
       460        470        480        490        500
LDDRVDGVIA TAIRALRALL VAPGDEELLD STFSWYHGAL TFPLMPSQED 
       510        520        530        540        550
KEDEDEDEEC PAGKAKRKSP EEESRPPPDL ARHDVIKGLL ATSLLPRLRY 
       560        570        580        590        600
VLEVTYPGPA VVLDILAVLI RLARHSLESA TRVLECPRLI ETIVREFLPT 
       610        620        630        640        650
SWSPVGAGPT PSLYKVPCAT AMKLLRVLAS AGRNIAARLL SSFDLRSRLC 
       660        670        680        690        700
RIIAEAPQEL ALPPEEAEML STEALRLWAV AASYGQGGYL YRELYPVLMR 
       710        720        730        740        750
ALQVVPRELS THPPQPLSMQ RIASLLTLLT QLTLAAGSTP AETISDSAEA 
       760        770        780        790        800
SLSATPSLVT WTQVSGLQPL VEPCLRQTLK LLSRPEMWRA VGPVPVACLL 
       810        820        830        840        850
FLGAYYQAWS QQPSSCPEDW LQDMQRLSEE LLLPLLSQPT LGSLWDSLRH 
       860        870        880        890        900
CSLLCNPLSC VPALEAPPSL VSLGCSGGCP RLSLAGSASP FPFLTALLSL 
       910        920        930        940        950
LNTLAQIHKG LCGQLAAILA APGLQNYFLQ CVAPGAAPHL TPFSAWALRH 
       960        970        980        990       1000
EYHLQYLALA LAQKAAALQP LPATHAALYH GMALALLSRL LPGSEYLTHE 
      1010       1020       1030       1040       1050
LLLSCVFRLE FLPERTSGGP EAADFSDQLS LGSSRVPRCG QGTLLAQACQ 
      1060       1070       1080       1090       1100
DLPSIRNCYL THCSPARASL LASQALHRGE LQRVPTLLLP MPTEPLLPTD 
      1110       1120       1130       1140       1150
WPFLPLIRLY HRASDTPSGL SPTDTMGTAM RVLQWVLVLE SWRPQALWAV 
      1160       1170       1180       1190       1200
PPAARLARLM CVFLVDSELF RESPVQHLVA ALLAQLCQPQ VLPNLNLDCR 
      1210       1220       1230       1240       1250
LPGLTSFPDL YANFLDHFEA VSFGDHLFGA LVLLPLQRRF SVTLRLALFG 
      1260       1270       1280       1290       1300
EHVGALRALS LPLTQLPVSL ECYTVPPEDN LALLQLYFRT LVTGALRPRW 
      1310       1320       1330       1340       1350
CPVLYAVAVA HVNSFIFSQD PQSSDEVKAA RRSMLQKTWL LADEGLRQHL 
      1360       1370       1380       1390 
LHYKLPNSTL PEGFELYSQL PPLRQHYLQR LTSTVLQNGV SET

Length:1,393

Mass (Da):152,755

Last modified:May 18, 2010 - v3

Checksum:ⁱ0DB7C1B49590172F

Isoform 2 (identifier: Q9BWH6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1266-1306: LPVSLECYTV...RPRWCPVLYA → VLSQPSRTCK...RGLRESMKRA
1307-1393: Missing.

« Hide

        10         20         30         40         50
MLSRPKPGES EVDLLHFQSQ FLAAGAAPAV QLVKKGNRGG GDANSDRPPL 
        60         70         80         90        100
QDHRDVVMLD NLPDLPPALV PSPPKRARPS PGHCLPEDED PEERLRRHDQ 
       110        120        130        140        150
HITAVLTKII ERDTSSVAVN LPVPSGVAFP AVFLRSRDTQ GKSATSGKRS 
       160        170        180        190        200
IFAQEIAARR IAEAKGPSVG EVVPNVGPPE GAVTCETPTP RNQGCQLPGS 
       210        220        230        240        250
SHSFQGPNLV TGKGLRDQEA EQEAQTIHEE NIARLQAMAP EEILQEQQRL 
       260        270        280        290        300
LAQLDPSLVA FLRSHSHTQE QTGETASEEQ RPGGPSANVT KEEPLMSAFA 
       310        320        330        340        350
SEPRKRDKLE PEAPALALPV TPQKEWLHMD TVELEKLHWT QDLPPVRRQQ 
       360        370        380        390        400
TQERMQARFS LQGELLAPDV DLPTHLGLHH HGEEAERAGY SLQELFHLTR 
       410        420        430        440        450
SQVSQQRALA LHVLAQVISR AQAGEFGDRL AGSVLSLLLD AGFLFLLRFS 
       460        470        480        490        500
LDDRVDGVIA TAIRALRALL VAPGDEELLD STFSWYHGAL TFPLMPSQED 
       510        520        530        540        550
KEDEDEDEEC PAGKAKRKSP EEESRPPPDL ARHDVIKGLL ATSLLPRLRY 
       560        570        580        590        600
VLEVTYPGPA VVLDILAVLI RLARHSLESA TRVLECPRLI ETIVREFLPT 
       610        620        630        640        650
SWSPVGAGPT PSLYKVPCAT AMKLLRVLAS AGRNIAARLL SSFDLRSRLC 
       660        670        680        690        700
RIIAEAPQEL ALPPEEAEML STEALRLWAV AASYGQGGYL YRELYPVLMR 
       710        720        730        740        750
ALQVVPRELS THPPQPLSMQ RIASLLTLLT QLTLAAGSTP AETISDSAEA 
       760        770        780        790        800
SLSATPSLVT WTQVSGLQPL VEPCLRQTLK LLSRPEMWRA VGPVPVACLL 
       810        820        830        840        850
FLGAYYQAWS QQPSSCPEDW LQDMQRLSEE LLLPLLSQPT LGSLWDSLRH 
       860        870        880        890        900
CSLLCNPLSC VPALEAPPSL VSLGCSGGCP RLSLAGSASP FPFLTALLSL 
       910        920        930        940        950
LNTLAQIHKG LCGQLAAILA APGLQNYFLQ CVAPGAAPHL TPFSAWALRH 
       960        970        980        990       1000
EYHLQYLALA LAQKAAALQP LPATHAALYH GMALALLSRL LPGSEYLTHE 
      1010       1020       1030       1040       1050
LLLSCVFRLE FLPERTSGGP EAADFSDQLS LGSSRVPRCG QGTLLAQACQ 
      1060       1070       1080       1090       1100
DLPSIRNCYL THCSPARASL LASQALHRGE LQRVPTLLLP MPTEPLLPTD 
      1110       1120       1130       1140       1150
WPFLPLIRLY HRASDTPSGL SPTDTMGTAM RVLQWVLVLE SWRPQALWAV 
      1160       1170       1180       1190       1200
PPAARLARLM CVFLVDSELF RESPVQHLVA ALLAQLCQPQ VLPNLNLDCR 
      1210       1220       1230       1240       1250
LPGLTSFPDL YANFLDHFEA VSFGDHLFGA LVLLPLQRRF SVTLRLALFG 
      1260       1270       1280       1290       1300
EHVGALRALS LPLTQVLSQP SRTCKGTLHW ASGAVLSLEE LWKTSASSSY 
      1310 
LLGALRGLRE SMKRA

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:1,315

Mass (Da):143,582

Checksum:ⁱ3D9EC009EA2CE308

Isoform 3 (identifier: Q9BWH6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-621: Missing.

« Hide

        10         20         30         40         50
MKLLRVLASA GRNIAARLLS SFDLRSRLCR IIAEAPQELA LPPEEAEMLS 
        60         70         80         90        100
TEALRLWAVA ASYGQGGYLY RELYPVLMRA LQVVPRELST HPPQPLSMQR 
       110        120        130        140        150
IASLLTLLTQ LTLAAGSTPA ETISDSAEAS LSATPSLVTW TQVSGLQPLV 
       160        170        180        190        200
EPCLRQTLKL LSRPEMWRAV GPVPVACLLF LGAYYQAWSQ QPSSCPEDWL 
       210        220        230        240        250
QDMQRLSEEL LLPLLSQPTL GSLWDSLRHC SLLCNPLSCV PALEAPPSLV 
       260        270        280        290        300
SLGCSGGCPR LSLAGSASPF PFLTALLSLL NTLAQIHKGL CGQLAAILAA 
       310        320        330        340        350
PGLQNYFLQC VAPGAAPHLT PFSAWALRHE YHLQYLALAL AQKAAALQPL 
       360        370        380        390        400
PATHAALYHG MALALLSRLL PGSEYLTHEL LLSCVFRLEF LPERTSGGPE 
       410        420        430        440        450
AADFSDQLSL GSSRVPRCGQ GTLLAQACQD LPSIRNCYLT HCSPARASLL 
       460        470        480        490        500
ASQALHRGEL QRVPTLLLPM PTEPLLPTDW PFLPLIRLYH RASDTPSGLS 
       510        520        530        540        550
PTDTMGTAMR VLQWVLVLES WRPQALWAVP PAARLARLMC VFLVDSELFR 
       560        570        580        590        600
ESPVQHLVAA LLAQLCQPQV LPNLNLDCRL PGLTSFPDLY ANFLDHFEAV 
       610        620        630        640        650
SFGDHLFGAL VLLPLQRRFS VTLRLALFGE HVGALRALSL PLTQLPVSLE 
       660        670        680        690        700
CYTVPPEDNL ALLQLYFRTL VTGALRPRWC PVLYAVAVAH VNSFIFSQDP 
       710        720        730        740        750
QSSDEVKAAR RSMLQKTWLL ADEGLRQHLL HYKLPNSTLP EGFELYSQLP 
       760        770 
PLRQHYLQRL TSTVLQNGVS ET

Show »

Length:772

Mass (Da):84,735

Checksum:ⁱ74075BBA34A7FBAA

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H3BRE8	H3BRE8_HUMAN	RNA polymerase II-associated protei... RNA polymerase II-associated protein 1	RPAP1	1,128	Annotation score:
H3BPY8	H3BPY8_HUMAN	RNA polymerase II-associated protei... RNA polymerase II-associated protein 1	RPAP1	128	Annotation score:
H3BPM3	H3BPM3_HUMAN	RNA polymerase II-associated protei... RNA polymerase II-associated protein 1	RPAP1	180	Annotation score:
H3BTJ6	H3BTJ6_HUMAN	RNA polymerase II-associated protei... RNA polymerase II-associated protein 1	RPAP1	200	Annotation score:

Sequence cautionⁱ

The sequence BAA92641 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	760	T → A in BAB14247 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057738	165	K → M. Corresponds to variant dbSNP:rs2297382Ensembl.	1
Natural variantⁱVAR_057739	429	R → Q. Corresponds to variant dbSNP:rs2289741Ensembl.	1
Natural variantⁱVAR_060348	506	E → K2 PublicationsCorresponds to variant dbSNP:rs1200345Ensembl.	1
Natural variantⁱVAR_036469	525	R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs372712659Ensembl.	1
Natural variantⁱVAR_057740	582	R → G. Corresponds to variant dbSNP:rs11630901Ensembl.	1
Natural variantⁱVAR_060349	825	Q → E4 PublicationsCorresponds to variant dbSNP:rs8027526Ensembl.	1
Natural variantⁱVAR_060350	1108	R → G. Corresponds to variant dbSNP:rs7170898Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_024679	1 – 621	Missing in isoform 3. 1 PublicationAdd BLAST	621
Alternative sequenceⁱVSP_024680	1266 – 1306	LPVSL…PVLYA → VLSQPSRTCKGTLHWASGAV LSLEELWKTSASSSYLLGAL RGLRESMKRA in isoform 2. 1 PublicationAdd BLAST	41
Alternative sequenceⁱVSP_024681	1307 – 1393	Missing in isoform 2. 1 PublicationAdd BLAST	87

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB037824 mRNA Translation: BAA92641.1 Different initiation. AK022794 mRNA Translation: BAB14247.1 AC016134 Genomic DNA No translation available. BC000246 mRNA Translation: AAH00246.2 AL117479 mRNA Translation: CAB55952.1 AL157487 mRNA Translation: CAB75675.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10079.1 [Q9BWH6-1]
PIRⁱ	T17262 T46928
NCBI Reference Sequences More...RefSeqⁱ	NP_056355.2, NM_015540.3 [Q9BWH6-1] XP_005254354.1, XM_005254297.1 [Q9BWH6-1]
UniGeneⁱ	Hs.371045

Genome annotation databases

Ensemblⁱ	ENST00000304330; ENSP00000306123; ENSG00000103932 [Q9BWH6-1] ENST00000562303; ENSP00000455363; ENSG00000103932 [Q9BWH6-2]
GeneIDⁱ	26015
KEGGⁱ	hsa:26015
UCSC genome browser More...UCSCⁱ	uc001zod.5 human [Q9BWH6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BWH6	RNA polymerase II-associated protein 1 (Fragment)		HUMAN		128	UniRef100_Q9BWH6
RPAP1 isoform 11 (Fragment)		PANTR		128
Isoform 3 of RNA polymerase II-associated protein 1		HUMAN		772
RNA polymerase II-associated protein 1 (Fragment)		HUMAN		180
RPAP1 isoform 10 (Fragment)		PANTR		180

Protein	Similar proteins		Species	Score	Length	Source
Q9BWH6	RNA polymerase II-associated protein 1 (Fragment)		HUMAN		128	UniRef90_Q9BWH6
RPAP1 isoform 11 (Fragment)		PANTR		128
RNA polymerase II-associated protein 1		MACMU		1393
Uncharacterized protein		MACFA		301
RNA polymerase II associated protein 1		RHIRO		1393
+46

Protein	Similar proteins		Species	Score	Length	Source
Q9BWH6	RNA polymerase II-associated protein 1 (Fragment)		HUMAN		128	UniRef50_Q9BWH6
RPAP1 isoform 11 (Fragment)		PANTR		128
RNA polymerase II associated protein 1		MACFA		1393
RNA polymerase II associated protein 1		MACNE		1393
RNA polymerase II associated protein 1		RHIBE		1393
+88

Entry informationⁱ

Entry nameⁱ	RPAP1_HUMAN
Accessionⁱ	Q9BWH6Primary (citable) accession number: Q9BWH6 Secondary accession number(s): Q9H9I2 , Q9NSQ5, Q9P2E4, Q9UFS7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BWH6 (RPAP1_HUMAN)

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RNA polymerase II-associated protein 1

RPAP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ