UniProtKB - Q9BWH6 (RPAP1_HUMAN)
RNA polymerase II-associated protein 1
RPAP1
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Nucleotidyltransferase, Transferase |
Biological process | Transcription |
Enzyme and pathway databases
PathwayCommonsi | Q9BWH6 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA polymerase II-associated protein 1 |
Gene namesi | Name:RPAP1 Synonyms:KIAA1403 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24567, RPAP1 |
MIMi | 611475, gene |
neXtProti | NX_Q9BWH6 |
VEuPathDBi | HostDB:ENSG00000103932.11 |
Subcellular locationi
Keywords - Cellular componenti
DNA-directed RNA polymerase, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26015 |
OpenTargetsi | ENSG00000103932 |
PharmGKBi | PA134914340 |
Miscellaneous databases
Pharosi | Q9BWH6, Tdark |
Genetic variation databases
BioMutai | RPAP1 |
DMDMi | 296452978 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284841 | 1 – 1393 | RNA polymerase II-associated protein 1Add BLAST | 1393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 72 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1121 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BWH6 |
jPOSTi | Q9BWH6 |
MassIVEi | Q9BWH6 |
MaxQBi | Q9BWH6 |
PaxDbi | Q9BWH6 |
PeptideAtlasi | Q9BWH6 |
PRIDEi | Q9BWH6 |
ProteomicsDBi | 79279 [Q9BWH6-1] 79280 [Q9BWH6-2] 79281 [Q9BWH6-3] |
PTM databases
iPTMneti | Q9BWH6 |
MetOSitei | Q9BWH6 |
PhosphoSitePlusi | Q9BWH6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103932, Expressed in hindlimb stylopod muscle and 169 other tissues |
ExpressionAtlasi | Q9BWH6, baseline and differential |
Genevisiblei | Q9BWH6, HS |
Organism-specific databases
HPAi | ENSG00000103932, Low tissue specificity |
Interactioni
Subunit structurei
Part of an RNA polymerase II complex that contains POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, RPAP1, FCP1 plus the general transcription factors TFIIB and TFIIF.
2 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 117487, 63 interactors |
CORUMi | Q9BWH6 |
IntActi | Q9BWH6, 16 interactors |
MINTi | Q9BWH6 |
STRINGi | 9606.ENSP00000306123 |
Miscellaneous databases
RNActi | Q9BWH6, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 827 – 1286 | Leu-richAdd BLAST | 460 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1894, Eukaryota KOG4732, Eukaryota |
GeneTreei | ENSGT00390000007594 |
HOGENOMi | CLU_005296_1_0_1 |
InParanoidi | Q9BWH6 |
OMAi | LRPRWCP |
PhylomeDBi | Q9BWH6 |
TreeFami | TF324391 |
Family and domain databases
InterProi | View protein in InterPro IPR013929, RNA_pol_II_AP1_C IPR013930, RNA_pol_II_AP1_N IPR039913, RPAP1/Rba50 |
PANTHERi | PTHR21483, PTHR21483, 1 hit |
Pfami | View protein in Pfam PF08620, RPAP1_C, 1 hit PF08621, RPAP1_N, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSRPKPGES EVDLLHFQSQ FLAAGAAPAV QLVKKGNRGG GDANSDRPPL
60 70 80 90 100
QDHRDVVMLD NLPDLPPALV PSPPKRARPS PGHCLPEDED PEERLRRHDQ
110 120 130 140 150
HITAVLTKII ERDTSSVAVN LPVPSGVAFP AVFLRSRDTQ GKSATSGKRS
160 170 180 190 200
IFAQEIAARR IAEAKGPSVG EVVPNVGPPE GAVTCETPTP RNQGCQLPGS
210 220 230 240 250
SHSFQGPNLV TGKGLRDQEA EQEAQTIHEE NIARLQAMAP EEILQEQQRL
260 270 280 290 300
LAQLDPSLVA FLRSHSHTQE QTGETASEEQ RPGGPSANVT KEEPLMSAFA
310 320 330 340 350
SEPRKRDKLE PEAPALALPV TPQKEWLHMD TVELEKLHWT QDLPPVRRQQ
360 370 380 390 400
TQERMQARFS LQGELLAPDV DLPTHLGLHH HGEEAERAGY SLQELFHLTR
410 420 430 440 450
SQVSQQRALA LHVLAQVISR AQAGEFGDRL AGSVLSLLLD AGFLFLLRFS
460 470 480 490 500
LDDRVDGVIA TAIRALRALL VAPGDEELLD STFSWYHGAL TFPLMPSQED
510 520 530 540 550
KEDEDEDEEC PAGKAKRKSP EEESRPPPDL ARHDVIKGLL ATSLLPRLRY
560 570 580 590 600
VLEVTYPGPA VVLDILAVLI RLARHSLESA TRVLECPRLI ETIVREFLPT
610 620 630 640 650
SWSPVGAGPT PSLYKVPCAT AMKLLRVLAS AGRNIAARLL SSFDLRSRLC
660 670 680 690 700
RIIAEAPQEL ALPPEEAEML STEALRLWAV AASYGQGGYL YRELYPVLMR
710 720 730 740 750
ALQVVPRELS THPPQPLSMQ RIASLLTLLT QLTLAAGSTP AETISDSAEA
760 770 780 790 800
SLSATPSLVT WTQVSGLQPL VEPCLRQTLK LLSRPEMWRA VGPVPVACLL
810 820 830 840 850
FLGAYYQAWS QQPSSCPEDW LQDMQRLSEE LLLPLLSQPT LGSLWDSLRH
860 870 880 890 900
CSLLCNPLSC VPALEAPPSL VSLGCSGGCP RLSLAGSASP FPFLTALLSL
910 920 930 940 950
LNTLAQIHKG LCGQLAAILA APGLQNYFLQ CVAPGAAPHL TPFSAWALRH
960 970 980 990 1000
EYHLQYLALA LAQKAAALQP LPATHAALYH GMALALLSRL LPGSEYLTHE
1010 1020 1030 1040 1050
LLLSCVFRLE FLPERTSGGP EAADFSDQLS LGSSRVPRCG QGTLLAQACQ
1060 1070 1080 1090 1100
DLPSIRNCYL THCSPARASL LASQALHRGE LQRVPTLLLP MPTEPLLPTD
1110 1120 1130 1140 1150
WPFLPLIRLY HRASDTPSGL SPTDTMGTAM RVLQWVLVLE SWRPQALWAV
1160 1170 1180 1190 1200
PPAARLARLM CVFLVDSELF RESPVQHLVA ALLAQLCQPQ VLPNLNLDCR
1210 1220 1230 1240 1250
LPGLTSFPDL YANFLDHFEA VSFGDHLFGA LVLLPLQRRF SVTLRLALFG
1260 1270 1280 1290 1300
EHVGALRALS LPLTQLPVSL ECYTVPPEDN LALLQLYFRT LVTGALRPRW
1310 1320 1330 1340 1350
CPVLYAVAVA HVNSFIFSQD PQSSDEVKAA RRSMLQKTWL LADEGLRQHL
1360 1370 1380 1390
LHYKLPNSTL PEGFELYSQL PPLRQHYLQR LTSTVLQNGV SET
The sequence of this isoform differs from the canonical sequence as follows:
1266-1306: LPVSLECYTV...RPRWCPVLYA → VLSQPSRTCK...RGLRESMKRA
1307-1393: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRE8 | H3BRE8_HUMAN | RNA polymerase II-associated protei... | RPAP1 | 1,128 | Annotation score: | ||
H3BPY8 | H3BPY8_HUMAN | RNA polymerase II-associated protei... | RPAP1 | 128 | Annotation score: | ||
H3BPM3 | H3BPM3_HUMAN | RNA polymerase II-associated protei... | RPAP1 | 180 | Annotation score: | ||
H3BTJ6 | H3BTJ6_HUMAN | RNA polymerase II-associated protei... | RPAP1 | 200 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 760 | T → A in BAB14247 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057738 | 165 | K → M. Corresponds to variant dbSNP:rs2297382Ensembl. | 1 | |
Natural variantiVAR_057739 | 429 | R → Q. Corresponds to variant dbSNP:rs2289741Ensembl. | 1 | |
Natural variantiVAR_060348 | 506 | E → K2 PublicationsCorresponds to variant dbSNP:rs1200345Ensembl. | 1 | |
Natural variantiVAR_036469 | 525 | R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs372712659Ensembl. | 1 | |
Natural variantiVAR_057740 | 582 | R → G. Corresponds to variant dbSNP:rs11630901Ensembl. | 1 | |
Natural variantiVAR_060349 | 825 | Q → E4 PublicationsCorresponds to variant dbSNP:rs8027526Ensembl. | 1 | |
Natural variantiVAR_060350 | 1108 | R → G. Corresponds to variant dbSNP:rs7170898EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024679 | 1 – 621 | Missing in isoform 3. 1 PublicationAdd BLAST | 621 | |
Alternative sequenceiVSP_024680 | 1266 – 1306 | LPVSL…PVLYA → VLSQPSRTCKGTLHWASGAV LSLEELWKTSASSSYLLGAL RGLRESMKRA in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_024681 | 1307 – 1393 | Missing in isoform 2. 1 PublicationAdd BLAST | 87 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037824 mRNA Translation: BAA92641.1 Different initiation. AK022794 mRNA Translation: BAB14247.1 AC016134 Genomic DNA No translation available. BC000246 mRNA Translation: AAH00246.2 AL117479 mRNA Translation: CAB55952.1 AL157487 mRNA Translation: CAB75675.2 |
CCDSi | CCDS10079.1 [Q9BWH6-1] |
PIRi | T17262 T46928 |
RefSeqi | NP_056355.2, NM_015540.3 [Q9BWH6-1] XP_005254354.1, XM_005254297.1 [Q9BWH6-1] |
Genome annotation databases
Ensembli | ENST00000304330; ENSP00000306123; ENSG00000103932 [Q9BWH6-1] ENST00000562303; ENSP00000455363; ENSG00000103932 [Q9BWH6-2] |
GeneIDi | 26015 |
KEGGi | hsa:26015 |
UCSCi | uc001zod.5, human [Q9BWH6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037824 mRNA Translation: BAA92641.1 Different initiation. AK022794 mRNA Translation: BAB14247.1 AC016134 Genomic DNA No translation available. BC000246 mRNA Translation: AAH00246.2 AL117479 mRNA Translation: CAB55952.1 AL157487 mRNA Translation: CAB75675.2 |
CCDSi | CCDS10079.1 [Q9BWH6-1] |
PIRi | T17262 T46928 |
RefSeqi | NP_056355.2, NM_015540.3 [Q9BWH6-1] XP_005254354.1, XM_005254297.1 [Q9BWH6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117487, 63 interactors |
CORUMi | Q9BWH6 |
IntActi | Q9BWH6, 16 interactors |
MINTi | Q9BWH6 |
STRINGi | 9606.ENSP00000306123 |
PTM databases
iPTMneti | Q9BWH6 |
MetOSitei | Q9BWH6 |
PhosphoSitePlusi | Q9BWH6 |
Genetic variation databases
BioMutai | RPAP1 |
DMDMi | 296452978 |
Proteomic databases
EPDi | Q9BWH6 |
jPOSTi | Q9BWH6 |
MassIVEi | Q9BWH6 |
MaxQBi | Q9BWH6 |
PaxDbi | Q9BWH6 |
PeptideAtlasi | Q9BWH6 |
PRIDEi | Q9BWH6 |
ProteomicsDBi | 79279 [Q9BWH6-1] 79280 [Q9BWH6-2] 79281 [Q9BWH6-3] |
Protocols and materials databases
Antibodypediai | 42079, 118 antibodies |
DNASUi | 26015 |
Genome annotation databases
Ensembli | ENST00000304330; ENSP00000306123; ENSG00000103932 [Q9BWH6-1] ENST00000562303; ENSP00000455363; ENSG00000103932 [Q9BWH6-2] |
GeneIDi | 26015 |
KEGGi | hsa:26015 |
UCSCi | uc001zod.5, human [Q9BWH6-1] |
Organism-specific databases
CTDi | 26015 |
DisGeNETi | 26015 |
GeneCardsi | RPAP1 |
HGNCi | HGNC:24567, RPAP1 |
HPAi | ENSG00000103932, Low tissue specificity |
MIMi | 611475, gene |
neXtProti | NX_Q9BWH6 |
OpenTargetsi | ENSG00000103932 |
PharmGKBi | PA134914340 |
VEuPathDBi | HostDB:ENSG00000103932.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1894, Eukaryota KOG4732, Eukaryota |
GeneTreei | ENSGT00390000007594 |
HOGENOMi | CLU_005296_1_0_1 |
InParanoidi | Q9BWH6 |
OMAi | LRPRWCP |
PhylomeDBi | Q9BWH6 |
TreeFami | TF324391 |
Enzyme and pathway databases
PathwayCommonsi | Q9BWH6 |
Miscellaneous databases
BioGRID-ORCSi | 26015, 712 hits in 886 CRISPR screens |
ChiTaRSi | RPAP1, human |
GenomeRNAii | 26015 |
Pharosi | Q9BWH6, Tdark |
PROi | PR:Q9BWH6 |
RNActi | Q9BWH6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103932, Expressed in hindlimb stylopod muscle and 169 other tissues |
ExpressionAtlasi | Q9BWH6, baseline and differential |
Genevisiblei | Q9BWH6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013929, RNA_pol_II_AP1_C IPR013930, RNA_pol_II_AP1_N IPR039913, RPAP1/Rba50 |
PANTHERi | PTHR21483, PTHR21483, 1 hit |
Pfami | View protein in Pfam PF08620, RPAP1_C, 1 hit PF08621, RPAP1_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPAP1_HUMAN | |
Accessioni | Q9BWH6Primary (citable) accession number: Q9BWH6 Secondary accession number(s): Q9H9I2 Q9UFS7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants