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Protein

FUN14 domain-containing protein 2

Gene

FUNDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • autophagy of mitochondrion Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FUN14 domain-containing protein 2
Alternative name(s):
Cervical cancer proto-oncogene 3 protein
Short name:
HCC-3
Hepatitis C virus core-binding protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FUNDC2
Synonyms:HCBP6
ORF Names:DC44, HCC3, PD03104
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165775.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24925 FUNDC2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BWH2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
65991

Open Targets

More...
OpenTargetsi
ENSG00000165775

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134908797

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FUNDC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752400

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003146151 – 189FUN14 domain-containing protein 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BWH2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BWH2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BWH2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BWH2

PeptideAtlas

More...
PeptideAtlasi
Q9BWH2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BWH2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79278

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BWH2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BWH2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BWH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165775 Expressed in 148 organ(s), highest expression level in heart left ventricle

CleanEx database of gene expression profiles

More...
CleanExi
HS_FUNDC2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BWH2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BWH2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059129

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122440, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BWH2, 44 interactors

Molecular INTeraction database

More...
MINTi
Q9BWH2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358510

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BWH2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FUN14 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4099 Eukaryota
ENOG41122V1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154783

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232100

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054805

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BWH2

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKKQPWW

Database of Orthologous Groups

More...
OrthoDBi
1431148at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BWH2

TreeFam database of animal gene trees

More...
TreeFami
TF300280

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007014 FUN14

The PANTHER Classification System

More...
PANTHERi
PTHR21346 PTHR21346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04930 FUN14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BWH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN
60 70 80 90 100
FESLDLAEFA KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI
110 120 130 140 150
FQKVGKLAAT AVGGGFFLLQ LANHTGYIKV DWQRVEKDMK KAKEQLKIRK
160 170 180
SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF GGFLLGMAS
Length:189
Mass (Da):20,676
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i425CC27F23E240D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0K8H7C0K8_HUMAN
FUN14 domain-containing protein 2
FUNDC2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG44731 differs from that shown. Reason: Frameshift at position 69.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY032594 mRNA Translation: AAK51136.1
AF267862 mRNA Translation: AAG44731.1 Frameshift.
AJ272054 mRNA Translation: CAC81242.1
AF320778 mRNA Translation: AAN51931.1
AK313143 mRNA Translation: BAG35962.1
BX470111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72643.1
CH471172 Genomic DNA Translation: EAW72644.1
BC000255 mRNA Translation: AAH00255.2
BC072685 mRNA Translation: AAH72685.1
BC108657 mRNA Translation: AAI08658.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14763.1

NCBI Reference Sequences

More...
RefSeqi
NP_076423.2, NM_023934.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.356050

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369498; ENSP00000358510; ENSG00000165775

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65991

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65991

UCSC genome browser

More...
UCSCi
uc004fmw.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032594 mRNA Translation: AAK51136.1
AF267862 mRNA Translation: AAG44731.1 Frameshift.
AJ272054 mRNA Translation: CAC81242.1
AF320778 mRNA Translation: AAN51931.1
AK313143 mRNA Translation: BAG35962.1
BX470111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72643.1
CH471172 Genomic DNA Translation: EAW72644.1
BC000255 mRNA Translation: AAH00255.2
BC072685 mRNA Translation: AAH72685.1
BC108657 mRNA Translation: AAI08658.1
CCDSiCCDS14763.1
RefSeqiNP_076423.2, NM_023934.3
UniGeneiHs.356050

3D structure databases

ProteinModelPortaliQ9BWH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122440, 30 interactors
IntActiQ9BWH2, 44 interactors
MINTiQ9BWH2
STRINGi9606.ENSP00000358510

PTM databases

iPTMnetiQ9BWH2
PhosphoSitePlusiQ9BWH2
SwissPalmiQ9BWH2

Polymorphism and mutation databases

BioMutaiFUNDC2
DMDMi74752400

Proteomic databases

EPDiQ9BWH2
jPOSTiQ9BWH2
MaxQBiQ9BWH2
PaxDbiQ9BWH2
PeptideAtlasiQ9BWH2
PRIDEiQ9BWH2
ProteomicsDBi79278

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
65991
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369498; ENSP00000358510; ENSG00000165775
GeneIDi65991
KEGGihsa:65991
UCSCiuc004fmw.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65991
DisGeNETi65991
EuPathDBiHostDB:ENSG00000165775.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FUNDC2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0029974
HGNCiHGNC:24925 FUNDC2
HPAiHPA059129
neXtProtiNX_Q9BWH2
OpenTargetsiENSG00000165775
PharmGKBiPA134908797

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4099 Eukaryota
ENOG41122V1 LUCA
GeneTreeiENSGT00940000154783
HOGENOMiHOG000232100
HOVERGENiHBG054805
InParanoidiQ9BWH2
OMAiTKKQPWW
OrthoDBi1431148at2759
PhylomeDBiQ9BWH2
TreeFamiTF300280

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FUNDC2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FUNDC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65991

Protein Ontology

More...
PROi
PR:Q9BWH2

Gene expression databases

BgeeiENSG00000165775 Expressed in 148 organ(s), highest expression level in heart left ventricle
CleanExiHS_FUNDC2
ExpressionAtlasiQ9BWH2 baseline and differential
GenevisibleiQ9BWH2 HS

Family and domain databases

InterProiView protein in InterPro
IPR007014 FUN14
PANTHERiPTHR21346 PTHR21346, 1 hit
PfamiView protein in Pfam
PF04930 FUN14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUND2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BWH2
Secondary accession number(s): B2R7W5
, D3DWY5, Q8NHX8, Q9H2I6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2004
Last modified: January 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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