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Protein

FUN14 domain-containing protein 2

Gene

FUNDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
FUN14 domain-containing protein 2
Alternative name(s):
Cervical cancer proto-oncogene 3 protein
Short name:
HCC-3
Hepatitis C virus core-binding protein 6
Gene namesi
Name:FUNDC2
Synonyms:HCBP6
ORF Names:DC44, HCC3, PD03104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000165775.17
HGNCiHGNC:24925 FUNDC2
neXtProtiNX_Q9BWH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi65991
OpenTargetsiENSG00000165775
PharmGKBiPA134908797

Polymorphism and mutation databases

BioMutaiFUNDC2
DMDMi74752400

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003146151 – 189FUN14 domain-containing protein 2Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei151PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BWH2
MaxQBiQ9BWH2
PaxDbiQ9BWH2
PeptideAtlasiQ9BWH2
PRIDEiQ9BWH2
ProteomicsDBi79278

PTM databases

iPTMnetiQ9BWH2
PhosphoSitePlusiQ9BWH2
SwissPalmiQ9BWH2

Expressioni

Gene expression databases

BgeeiENSG00000165775
CleanExiHS_FUNDC2
ExpressionAtlasiQ9BWH2 baseline and differential
GenevisibleiQ9BWH2 HS

Organism-specific databases

HPAiHPA059129

Interactioni

Protein-protein interaction databases

BioGridi122440, 28 interactors
IntActiQ9BWH2, 42 interactors
MINTiQ9BWH2
STRINGi9606.ENSP00000358510

Structurei

3D structure databases

ProteinModelPortaliQ9BWH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FUN14 family.Curated

Phylogenomic databases

eggNOGiKOG4099 Eukaryota
ENOG41122V1 LUCA
GeneTreeiENSGT00390000003926
HOGENOMiHOG000232100
HOVERGENiHBG054805
InParanoidiQ9BWH2
OMAiTKKQPWW
OrthoDBiEOG091G15SP
PhylomeDBiQ9BWH2
TreeFamiTF300280

Family and domain databases

InterProiView protein in InterPro
IPR007014 FUN14
PANTHERiPTHR21346 PTHR21346, 1 hit
PfamiView protein in Pfam
PF04930 FUN14, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BWH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN
60 70 80 90 100
FESLDLAEFA KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI
110 120 130 140 150
FQKVGKLAAT AVGGGFFLLQ LANHTGYIKV DWQRVEKDMK KAKEQLKIRK
160 170 180
SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF GGFLLGMAS
Length:189
Mass (Da):20,676
Last modified:March 1, 2004 - v2
Checksum:i425CC27F23E240D9
GO

Sequence cautioni

The sequence AAG44731 differs from that shown. Reason: Frameshift at position 69.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032594 mRNA Translation: AAK51136.1
AF267862 mRNA Translation: AAG44731.1 Frameshift.
AJ272054 mRNA Translation: CAC81242.1
AF320778 mRNA Translation: AAN51931.1
AK313143 mRNA Translation: BAG35962.1
BX470111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72643.1
CH471172 Genomic DNA Translation: EAW72644.1
BC000255 mRNA Translation: AAH00255.2
BC072685 mRNA Translation: AAH72685.1
BC108657 mRNA Translation: AAI08658.1
CCDSiCCDS14763.1
RefSeqiNP_076423.2, NM_023934.3
UniGeneiHs.356050

Genome annotation databases

EnsembliENST00000369498; ENSP00000358510; ENSG00000165775
GeneIDi65991
KEGGihsa:65991
UCSCiuc004fmw.4 human

Similar proteinsi

Entry informationi

Entry nameiFUND2_HUMAN
AccessioniPrimary (citable) accession number: Q9BWH2
Secondary accession number(s): B2R7W5
, D3DWY5, Q8NHX8, Q9H2I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2004
Last modified: July 18, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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