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UniProtKB - Q9BWG6 (SCNM1_HUMAN)
Protein
Sodium channel modifier 1
Gene
SCNM1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 42 – 74 | Matrin-typeAdd BLAST | 33 |
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- alternative mRNA splicing, via spliceosome Source: UniProtKB
- RNA splicing Source: GO_Central
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BWG6 |
SignaLinki | Q9BWG6 |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel modifier 1 |
Gene namesi | Name:SCNM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23136, SCNM1 |
MIMi | 608095, gene |
neXtProti | NX_Q9BWG6 |
VEuPathDBi | HostDB:ENSG00000163156 |
Subcellular locationi
Nucleus
- nucleoplasm 1 Publication
- Nucleus speckle 1 Publication
Note: Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles.By similarity
Nucleus
- nuclear speck Source: UniProtKB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79005 |
OpenTargetsi | ENSG00000163156 |
PharmGKBi | PA134958437 |
Miscellaneous databases
Pharosi | Q9BWG6, Tbio |
Genetic variation databases
BioMutai | SCNM1 |
DMDMi | 74752399 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000259635 | 1 – 230 | Sodium channel modifier 1Add BLAST | 230 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Cross-linki | 67 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 144 | PhosphoserineCombined sources | 1 | |
Modified residuei | 183 | PhosphoserineBy similarity | 1 | |
Modified residuei | 219 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BWG6 |
jPOSTi | Q9BWG6 |
MassIVEi | Q9BWG6 |
MaxQBi | Q9BWG6 |
PaxDbi | Q9BWG6 |
PeptideAtlasi | Q9BWG6 |
PRIDEi | Q9BWG6 |
ProteomicsDBi | 79276 [Q9BWG6-1] 79277 [Q9BWG6-2] |
PTM databases
iPTMneti | Q9BWG6 |
PhosphoSitePlusi | Q9BWG6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163156, Expressed in granulocyte and 228 other tissues |
Genevisiblei | Q9BWG6, HS |
Organism-specific databases
HPAi | ENSG00000163156, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with spliceosomal Sm proteins (PubMed:17656373).
Interacts with LUC7L2 and SNRNP70, which suggests a role as a spliceosome component (By similarity).
By similarity1 PublicationBinary interactionsi
Q9BWG6
GO - Molecular functioni
- enzyme binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 122476, 192 interactors 1529623, 1 interactor |
IntActi | Q9BWG6, 186 interactors |
MINTi | Q9BWG6 |
STRINGi | 9606.ENSP00000357901 |
Miscellaneous databases
RNActi | Q9BWG6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 106 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 129 – 186 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 188 – 230 | Required for interaction with LUC7L2By similarityAdd BLAST | 43 | |
Regioni | 200 – 230 | DisorderedSequence analysisAdd BLAST | 31 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 4 – 20 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 17 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 79 – 104 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 216 – 230 | Acidic residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 42 – 74 | Matrin-typeAdd BLAST | 33 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QWNV, Eukaryota |
GeneTreei | ENSGT00390000010811 |
HOGENOMi | CLU_059812_0_0_1 |
InParanoidi | Q9BWG6 |
OMAi | NYNSCCR |
OrthoDBi | 1557322at2759 |
PhylomeDBi | Q9BWG6 |
TreeFami | TF332168 |
Family and domain databases
InterProi | View protein in InterPro IPR033570, SCNM1 IPR031625, SCNM1_acidic IPR031622, Znf-SCNM1 |
PANTHERi | PTHR32297, PTHR32297, 1 hit |
Pfami | View protein in Pfam PF15805, SCNM1_acidic, 1 hit PF15803, zf-SCNM1, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9BWG6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR
60 70 80 90 100
PVLDTLAMLT AHRAGKKHLS SLQLFYGKKQ PGKERKQNPK HQNELRREET
110 120 130 140 150
KAEAPLLTQT RLITQSALHR APHYNSCCRR KYRPEAPGPS VSLSPMPPSE
160 170 180 190 200
VKLQSGKISR EPEPAAGPQA EESATVSAPA PMSPTRRRAL DHYLTLRSSG
210 220 230
WIPDGRGRWV KDENVEFDSD EEEPPDLPLD
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021489 | 2 – 36 | Missing in isoform 2. CuratedAdd BLAST | 35 | |
Alternative sequenceiVSP_053982 | 134 – 162 | PEAPG…ISREP → YGTGKPEVGRLRRRQMALKE FSSVYSEEY in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_053983 | 163 – 230 | Missing in isoform 3. 1 PublicationAdd BLAST | 68 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056322 mRNA Translation: BAB71149.1 AK301644 mRNA Translation: BAG63123.1 AL592424 Genomic DNA No translation available. BC000264 mRNA Translation: AAH00264.1 |
CCDSi | CCDS55636.1 [Q9BWG6-2] CCDS987.1 [Q9BWG6-1] |
RefSeqi | NP_001191777.1, NM_001204848.1 [Q9BWG6-2] NP_001191785.1, NM_001204856.1 [Q9BWG6-2] NP_076946.1, NM_024041.3 [Q9BWG6-1] |
Genome annotation databases
Ensembli | ENST00000368902; ENSP00000357898; ENSG00000163156 [Q9BWG6-2] ENST00000368905; ENSP00000357901; ENSG00000163156 ENST00000602841; ENSP00000473282; ENSG00000163156 [Q9BWG6-2] |
GeneIDi | 100534012 79005 |
KEGGi | hsa:100534012 hsa:79005 |
MANE-Selecti | ENST00000368905.9; ENSP00000357901.4; NM_024041.4; NP_076946.1 |
UCSCi | uc001ewz.4, human [Q9BWG6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056322 mRNA Translation: BAB71149.1 AK301644 mRNA Translation: BAG63123.1 AL592424 Genomic DNA No translation available. BC000264 mRNA Translation: AAH00264.1 |
CCDSi | CCDS55636.1 [Q9BWG6-2] CCDS987.1 [Q9BWG6-1] |
RefSeqi | NP_001191777.1, NM_001204848.1 [Q9BWG6-2] NP_001191785.1, NM_001204856.1 [Q9BWG6-2] NP_076946.1, NM_024041.3 [Q9BWG6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7DVQ | electron microscopy | 2.89 | v | 1-230 | [»] | |
SMRi | Q9BWG6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122476, 192 interactors 1529623, 1 interactor |
IntActi | Q9BWG6, 186 interactors |
MINTi | Q9BWG6 |
STRINGi | 9606.ENSP00000357901 |
PTM databases
iPTMneti | Q9BWG6 |
PhosphoSitePlusi | Q9BWG6 |
Genetic variation databases
BioMutai | SCNM1 |
DMDMi | 74752399 |
Proteomic databases
EPDi | Q9BWG6 |
jPOSTi | Q9BWG6 |
MassIVEi | Q9BWG6 |
MaxQBi | Q9BWG6 |
PaxDbi | Q9BWG6 |
PeptideAtlasi | Q9BWG6 |
PRIDEi | Q9BWG6 |
ProteomicsDBi | 79276 [Q9BWG6-1] 79277 [Q9BWG6-2] |
Protocols and materials databases
Antibodypediai | 34055, 106 antibodies from 27 providers |
DNASUi | 79005 |
Genome annotation databases
Ensembli | ENST00000368902; ENSP00000357898; ENSG00000163156 [Q9BWG6-2] ENST00000368905; ENSP00000357901; ENSG00000163156 ENST00000602841; ENSP00000473282; ENSG00000163156 [Q9BWG6-2] |
GeneIDi | 100534012 79005 |
KEGGi | hsa:100534012 hsa:79005 |
MANE-Selecti | ENST00000368905.9; ENSP00000357901.4; NM_024041.4; NP_076946.1 |
UCSCi | uc001ewz.4, human [Q9BWG6-1] |
Organism-specific databases
CTDi | 100534012 79005 |
DisGeNETi | 79005 |
GeneCardsi | SCNM1 |
HGNCi | HGNC:23136, SCNM1 |
HPAi | ENSG00000163156, Low tissue specificity |
MIMi | 608095, gene |
neXtProti | NX_Q9BWG6 |
OpenTargetsi | ENSG00000163156 |
PharmGKBi | PA134958437 |
VEuPathDBi | HostDB:ENSG00000163156 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWNV, Eukaryota |
GeneTreei | ENSGT00390000010811 |
HOGENOMi | CLU_059812_0_0_1 |
InParanoidi | Q9BWG6 |
OMAi | NYNSCCR |
OrthoDBi | 1557322at2759 |
PhylomeDBi | Q9BWG6 |
TreeFami | TF332168 |
Enzyme and pathway databases
PathwayCommonsi | Q9BWG6 |
SignaLinki | Q9BWG6 |
Miscellaneous databases
BioGRID-ORCSi | 100534012, 7 hits in 130 CRISPR screens 79005, 116 hits in 1052 CRISPR screens |
ChiTaRSi | SCNM1, human |
Pharosi | Q9BWG6, Tbio |
PROi | PR:Q9BWG6 |
RNActi | Q9BWG6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163156, Expressed in granulocyte and 228 other tissues |
Genevisiblei | Q9BWG6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033570, SCNM1 IPR031625, SCNM1_acidic IPR031622, Znf-SCNM1 |
PANTHERi | PTHR32297, PTHR32297, 1 hit |
Pfami | View protein in Pfam PF15805, SCNM1_acidic, 1 hit PF15803, zf-SCNM1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCNM1_HUMAN | |
Accessioni | Q9BWG6Primary (citable) accession number: Q9BWG6 Secondary accession number(s): B4DWR1, Q5JR74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references