SCNM1

Functionⁱ

Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	42 – 74	Matrin-typeAdd BLAST		33

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23382074
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

alternative mRNA splicing, via spliceosome Source: UniProtKB
RNA splicing
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium channel modifier 1
Gene namesⁱ	Name:SCNM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163156.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23136 SCNM1
MIMⁱ	608095 gene
neXtProtⁱ	NX_Q9BWG6

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79005
Open Targets More...OpenTargetsⁱ	ENSG00000163156
PharmGKBⁱ	PA134958437

Polymorphism and mutation databases

BioMutaⁱ	SCNM1
DMDMⁱ	74752399

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000259635	1 – 230	Sodium channel modifier 1Add BLAST		230

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	PhosphoserineCombined sources	1
Cross-linkⁱ	67	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	144	PhosphoserineCombined sources	1
Modified residueⁱ	183	PhosphoserineBy similarity	1
Modified residueⁱ	219	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9BWG6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BWG6
PaxDbⁱ	Q9BWG6
PeptideAtlas More...PeptideAtlasⁱ	Q9BWG6
PRIDEⁱ	Q9BWG6
ProteomicsDBⁱ	79276 79277 [Q9BWG6-2]

PTM databases

iPTMnetⁱ	Q9BWG6
PhosphoSitePlusⁱ	Q9BWG6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163156 Expressed in 217 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_SCNM1
Genevisibleⁱ	Q9BWG6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052439 HPA054324

HPAⁱ

HPA052439
HPA054324

Interactionⁱ

Subunit structureⁱ

Interacts with spliceosomal Sm proteins (PubMed:17656373). Interacts with LUC7L2 and SNRNP70, which suggests a role as a spliceosome component (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117	3	EBI-748391,EBI-717810
AES	Q08117-2	4	EBI-748391,EBI-11741437
BLZF1	Q9H2G9	5	EBI-748391,EBI-2548012
CDR2	Q01850	5	EBI-748391,EBI-1181367
CEP44	Q9C0F1	3	EBI-748391,EBI-744115
CIB3	Q96Q77	4	EBI-748391,EBI-10292696
COG6	Q9Y2V7	4	EBI-748391,EBI-3866319
GOLGA2	Q08379	5	EBI-748391,EBI-618309
HMG20A	Q9NP66	5	EBI-748391,EBI-740641
IKZF1	Q13422	3	EBI-748391,EBI-745305
INCA1	Q0VD86	3	EBI-748391,EBI-6509505
KANK2	Q63ZY3	4	EBI-748391,EBI-2556193
KRT31	Q15323	5	EBI-748391,EBI-948001
KRT38	O76015	5	EBI-748391,EBI-1047263
KRTAP10-5	P60370	3	EBI-748391,EBI-10172150
KRTAP10-7	P60409	3	EBI-748391,EBI-10172290
KRTAP10-8	P60410	5	EBI-748391,EBI-10171774
KRTAP10-9	P60411	3	EBI-748391,EBI-10172052
LZTS2	Q9BRK4	3	EBI-748391,EBI-741037
MEOX2	P50222	3	EBI-748391,EBI-748397
MID2	Q9UJV3-2	3	EBI-748391,EBI-10172526
MIPOL1	Q8TD10	5	EBI-748391,EBI-2548751
MKRN3	Q13064	5	EBI-748391,EBI-2340269
MTUS2	Q5JR59-3	4	EBI-748391,EBI-11522433
NAB2	Q15742	3	EBI-748391,EBI-8641936
NOTCH2NL	Q7Z3S9	5	EBI-748391,EBI-945833
PDE4DIP	Q5VU43	3	EBI-748391,EBI-1105124
PLSCR1	O15162	3	EBI-748391,EBI-740019
PNMA1	Q8ND90	7	EBI-748391,EBI-302345
PNMA2	Q9UL42	3	EBI-748391,EBI-302355
RINT1	Q6NUQ1	5	EBI-748391,EBI-726876
RPGRIP1	Q96KN7	3	EBI-748391,EBI-1050213
SPERT	Q8NA61	3	EBI-748391,EBI-741724
SPERT	Q8NA61-2	4	EBI-748391,EBI-11524851
SSX2IP	Q9Y2D8	3	EBI-748391,EBI-2212028
SYCE1	Q8N0S2	3	EBI-748391,EBI-6872807
TFIP11	Q9UBB9	4	EBI-748391,EBI-1105213
TRAF1	Q13077	7	EBI-748391,EBI-359224
TRIM27	P14373	5	EBI-748391,EBI-719493
TRIM37	O94972	3	EBI-748391,EBI-741602
TRIM42	Q8IWZ5	3	EBI-748391,EBI-5235829
TRIM54	Q9BYV2	5	EBI-748391,EBI-2130429
UBXN11	Q5T124	3	EBI-748391,EBI-746004
ZBTB14	O43829	3	EBI-748391,EBI-10176632

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23382074

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122476, 55 interactors
IntActⁱ	Q9BWG6, 181 interactors
Molecular INTeraction database More...MINTⁱ	Q9BWG6
STRINGⁱ	9606.ENSP00000357901

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BWG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	188 – 230	Required for interaction with LUC7L2By similarityAdd BLAST		43

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	4 – 20	Bipartite nuclear localization signalSequence analysisAdd BLAST		17

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	42 – 74	Matrin-typeAdd BLAST		33

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IW6J Eukaryota ENOG4112DAT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010811
HOGENOMⁱ	HOG000033694
HOVERGENⁱ	HBG093936
InParanoidⁱ	Q9BWG6
OMAⁱ	QWVKDEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y5A
PhylomeDBⁱ	Q9BWG6
TreeFamⁱ	TF332168

Family and domain databases

InterProⁱ	View protein in InterPro IPR033570 SCNM1 IPR031625 SCNM1_acidic IPR031622 Znf-SCNM1
PANTHERⁱ	PTHR32297 PTHR32297, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15805 SCNM1_acidic, 1 hit PF15803 zf-SCNM1, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BWG6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR 
        60         70         80         90        100
PVLDTLAMLT AHRAGKKHLS SLQLFYGKKQ PGKERKQNPK HQNELRREET 
       110        120        130        140        150
KAEAPLLTQT RLITQSALHR APHYNSCCRR KYRPEAPGPS VSLSPMPPSE 
       160        170        180        190        200
VKLQSGKISR EPEPAAGPQA EESATVSAPA PMSPTRRRAL DHYLTLRSSG 
       210        220        230
WIPDGRGRWV KDENVEFDSD EEEPPDLPLD

Length:230

Mass (Da):25,949

Last modified:June 1, 2001 - v1

Checksum:ⁱ001576EA78C61C85

GO

Isoform 2 (identifier: Q9BWG6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
2-36: Missing.

« Hide

        10         20         30         40         50
MLRDGRFACA ICPHRPVLDT LAMLTAHRAG KKHLSSLQLF YGKKQPGKER 
        60         70         80         90        100
KQNPKHQNEL RREETKAEAP LLTQTRLITQ SALHRAPHYN SCCRRKYRPE 
       110        120        130        140        150
APGPSVSLSP MPPSEVKLQS GKISREPEPA AGPQAEESAT VSAPAPMSPT 
       160        170        180        190 
RRRALDHYLT LRSSGWIPDG RGRWVKDENV EFDSDEEEPP DLPLD

Show »

Length:195

Mass (Da):21,887

Checksum:ⁱ010E51E98394DA83

GO

Isoform 3 (identifier: Q9BWG6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
134-162: PEAPGPSVSLSPMPPSEVKLQSGKISREP → YGTGKPEVGRLRRRQMALKEFSSVYSEEY
163-230: Missing.

« Hide

        10         20         30         40         50
MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR 
        60         70         80         90        100
PVLDTLAMLT AHRAGKKHLS SLQLFYGKKQ PGKERKQNPK HQNELRREET 
       110        120        130        140        150
KAEAPLLTQT RLITQSALHR APHYNSCCRR KYRYGTGKPE VGRLRRRQMA 
       160 
LKEFSSVYSE EY

Note: No experimental confirmation available.

Show »

Length:162

Mass (Da):18,886

Checksum:ⁱ93C4D90FF7F664D6

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_021489	2 – 36	Missing in isoform 2. CuratedAdd BLAST	35
Alternative sequenceⁱVSP_053982	134 – 162	PEAPG…ISREP → YGTGKPEVGRLRRRQMALKE FSSVYSEEY in isoform 3. 1 PublicationAdd BLAST	29
Alternative sequenceⁱVSP_053983	163 – 230	Missing in isoform 3. 1 PublicationAdd BLAST	68

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056322 mRNA Translation: BAB71149.1 AK301644 mRNA Translation: BAG63123.1 AL592424 Genomic DNA No translation available. BC000264 mRNA Translation: AAH00264.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55636.1 [Q9BWG6-2] CCDS987.1 [Q9BWG6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001191777.1, NM_001204848.1 [Q9BWG6-2] NP_001191785.1, NM_001204856.1 [Q9BWG6-2] NP_076946.1, NM_024041.3 [Q9BWG6-1]
UniGeneⁱ	Hs.732060

Genome annotation databases

Ensemblⁱ	ENST00000368902; ENSP00000357898; ENSG00000163156 [Q9BWG6-2] ENST00000368905; ENSP00000357901; ENSG00000163156 [Q9BWG6-1] ENST00000602841; ENSP00000473282; ENSG00000163156 [Q9BWG6-2]
GeneIDⁱ	100534012 79005
KEGGⁱ	hsa:100534012 hsa:79005
UCSC genome browser More...UCSCⁱ	uc001ewz.4 human [Q9BWG6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BWG6	Sodium channel modifier 1		BOVIN		230	UniRef90_Q9BWG6
Isoform 2 of Sodium channel modifier 1		HUMAN		195
Uncharacterized protein		RHIRO		230
Uncharacterized protein		RHIBE		230
Uncharacterized protein		COLAP		195
+34

Protein	Similar proteins		Species	Score	Length	Source
Q9BWG6	Sodium channel modifier 1		BOVIN		230	UniRef50_Q9BWG6
Isoform 2 of Sodium channel modifier 1		HUMAN		195
Sodium channel modifier 1		HORSE		230
SCNM1 isoform 3		PONAB		230
sodium channel modifier 1		PHYCD		230
+91
Q9BWG6-3	Sodium channel modifier 1 (Predicted)		RHIFE		192	UniRef50_Q9BWG6-3
UPI00062A7171		OCTDE		165

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056322 mRNA Translation: BAB71149.1 AK301644 mRNA Translation: BAG63123.1 AL592424 Genomic DNA No translation available. BC000264 mRNA Translation: AAH00264.1
CCDSⁱ	CCDS55636.1 [Q9BWG6-2] CCDS987.1 [Q9BWG6-1]
RefSeqⁱ	NP_001191777.1, NM_001204848.1 [Q9BWG6-2] NP_001191785.1, NM_001204856.1 [Q9BWG6-2] NP_076946.1, NM_024041.3 [Q9BWG6-1]
UniGeneⁱ	Hs.732060

3D structure databases

ProteinModelPortalⁱ	Q9BWG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122476, 55 interactors
IntActⁱ	Q9BWG6, 181 interactors
MINTⁱ	Q9BWG6
STRINGⁱ	9606.ENSP00000357901

PTM databases

iPTMnetⁱ	Q9BWG6
PhosphoSitePlusⁱ	Q9BWG6

Polymorphism and mutation databases

BioMutaⁱ	SCNM1
DMDMⁱ	74752399

Proteomic databases

EPDⁱ	Q9BWG6
MaxQBⁱ	Q9BWG6
PaxDbⁱ	Q9BWG6
PeptideAtlasⁱ	Q9BWG6
PRIDEⁱ	Q9BWG6
ProteomicsDBⁱ	79276 79277 [Q9BWG6-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79005
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368902; ENSP00000357898; ENSG00000163156 [Q9BWG6-2] ENST00000368905; ENSP00000357901; ENSG00000163156 [Q9BWG6-1] ENST00000602841; ENSP00000473282; ENSG00000163156 [Q9BWG6-2]
GeneIDⁱ	100534012 79005
KEGGⁱ	hsa:100534012 hsa:79005
UCSCⁱ	uc001ewz.4 human [Q9BWG6-1]

Organism-specific databases

CTDⁱ	100534012 79005
DisGeNETⁱ	79005
EuPathDBⁱ	HostDB:ENSG00000163156.11
GeneCardsⁱ	SCNM1
HGNCⁱ	HGNC:23136 SCNM1
HPAⁱ	HPA052439 HPA054324
MIMⁱ	608095 gene
neXtProtⁱ	NX_Q9BWG6
OpenTargetsⁱ	ENSG00000163156
PharmGKBⁱ	PA134958437
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW6J Eukaryota ENOG4112DAT LUCA
GeneTreeⁱ	ENSGT00390000010811
HOGENOMⁱ	HOG000033694
HOVERGENⁱ	HBG093936
InParanoidⁱ	Q9BWG6
OMAⁱ	QWVKDEN
OrthoDBⁱ	EOG091G0Y5A
PhylomeDBⁱ	Q9BWG6
TreeFamⁱ	TF332168

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9BWG6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163156 Expressed in 217 organ(s), highest expression level in mononuclear cell
CleanExⁱ	HS_SCNM1
Genevisibleⁱ	Q9BWG6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033570 SCNM1 IPR031625 SCNM1_acidic IPR031622 Znf-SCNM1
PANTHERⁱ	PTHR32297 PTHR32297, 1 hit
Pfamⁱ	View protein in Pfam PF15805 SCNM1_acidic, 1 hit PF15803 zf-SCNM1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SCNM1_HUMAN
Accessionⁱ	Q9BWG6Primary (citable) accession number: Q9BWG6 Secondary accession number(s): B4DWR1, Q5JR74
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BWG6 (SCNM1_HUMAN)

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Sodium channel modifier 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ