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UniProtKB - Q9BWG6 (SCNM1_HUMAN)

Entry version 149 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Sodium channel modifier 1

Gene

SCNM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri42 – 74Matrin-typeAdd BLAST33

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BWG6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel modifier 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCNM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23136, SCNM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608095, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BWG6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163156.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79005

Open Targets

More...OpenTargetsi		ENSG00000163156

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134958437

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BWG6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SCNM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74752399

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002596351 – 230Sodium channel modifier 1Add BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei144PhosphoserineCombined sources1
Modified residuei183PhosphoserineBy similarity1
Modified residuei219PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BWG6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BWG6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BWG6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BWG6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BWG6

PeptideAtlas

More...PeptideAtlasi		Q9BWG6

PRoteomics IDEntifications database

More...PRIDEi		Q9BWG6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79276 [Q9BWG6-1]
79277 [Q9BWG6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BWG6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BWG6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163156, Expressed in granulocyte and 228 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BWG6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163156, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with spliceosomal Sm proteins (PubMed:17656373).

Interacts with LUC7L2 and SNRNP70, which suggests a role as a spliceosome component (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BWG6
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-748391,EBI-10173507
AKAP9 [Q6PJH3]3EBI-748391,EBI-11745576
AVPI1 [Q5T686]3EBI-748391,EBI-8640233
AXIN2 [Q9Y2T1]3EBI-748391,EBI-4400025
BACH2 [Q9BYV9]3EBI-748391,EBI-1642333
BEND7 - isoform 2 [Q8N7W2-2]3EBI-748391,EBI-10181188
BHLHB9 [Q6PI77]3EBI-748391,EBI-11519926
BLZF1 [Q9H2G9]6EBI-748391,EBI-2548012
CALCOCO2 [Q13137]3EBI-748391,EBI-739580
CARD10 [Q9BWT7]3EBI-748391,EBI-3866279
CARD9 - isoform 2 [Q9H257-2]3EBI-748391,EBI-11530605
CBY2 [Q8NA61]3EBI-748391,EBI-741724
CBY2 - isoform 2 [Q8NA61-2]5EBI-748391,EBI-11524851
CCDC28B - isoform 2 [Q9BUN5-3]3EBI-748391,EBI-12920646
CCDC74B - isoform 2 [Q96LY2-2]3EBI-748391,EBI-17967022
CDR2 [Q01850]6EBI-748391,EBI-1181367
CDR2L [Q86X02]3EBI-748391,EBI-11063830
CEP44 [Q9C0F1]3EBI-748391,EBI-744115
CEP70 [Q8NHQ1]3EBI-748391,EBI-739624
CEP76 [Q8TAP6]3EBI-748391,EBI-742887
CHIC2 [Q9UKJ5]3EBI-748391,EBI-741528
CIB3 [Q96Q77]6EBI-748391,EBI-10292696
COG6 [Q9Y2V7]5EBI-748391,EBI-3866319
CTDSP1 [Q9GZU7]3EBI-748391,EBI-751587
CYSRT1 [A8MQ03]3EBI-748391,EBI-3867333
CYTIP [O60759]3EBI-748391,EBI-997814
EZHIP [Q86X51]3EBI-748391,EBI-12827735
FAM161A [Q3B820]3EBI-748391,EBI-719941
FAM228A [Q86W67]3EBI-748391,EBI-12958227
FANCL [Q9NW38]3EBI-748391,EBI-2339898
FHL2 [Q14192]3EBI-748391,EBI-701903
FHL5 [Q5TD97]6EBI-748391,EBI-750641
FNDC11 [Q9BVV2]3EBI-748391,EBI-744935
FRS3 [O43559]3EBI-748391,EBI-725515
FSD2 [A1L4K1]3EBI-748391,EBI-5661036
GAS8 [O95995]3EBI-748391,EBI-1052570
GIGYF1 [O75420]3EBI-748391,EBI-947774
GOLGA2 [Q08379]5EBI-748391,EBI-618309
GOLGA6L9 [A6NEM1]5EBI-748391,EBI-5916454
HAP1 [P54257]3EBI-748391,EBI-712814
HMBOX1 [Q6NT76]3EBI-748391,EBI-2549423
HMG20A [Q9NP66]7EBI-748391,EBI-740641
HOMER3 [Q9NSC5]3EBI-748391,EBI-748420
HOOK2 - isoform 2 [Q96ED9-2]3EBI-748391,EBI-10961706
HSF2BP [O75031]3EBI-748391,EBI-7116203
IKZF1 [Q13422]3EBI-748391,EBI-745305
IKZF1 - isoform Ik7 [Q13422-7]3EBI-748391,EBI-11522367
IKZF3 [Q9UKT9]3EBI-748391,EBI-747204
INCA1 [Q0VD86]4EBI-748391,EBI-6509505
IRAK1BP1 [Q5VVH5]3EBI-748391,EBI-9658404
JAKMIP1 [Q96N16]3EBI-748391,EBI-2680803
KANK2 [Q63ZY3]6EBI-748391,EBI-2556193
KATNBL1 [Q9H079]3EBI-748391,EBI-715394
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-748391,EBI-14069005
KLF15 [Q9UIH9]3EBI-748391,EBI-2796400
KRT27 [Q7Z3Y8]3EBI-748391,EBI-3044087
KRT31 [Q15323]6EBI-748391,EBI-948001
KRT33B [Q14525]3EBI-748391,EBI-1049638
KRT34 [O76011]5EBI-748391,EBI-1047093
KRT35 [Q92764]3EBI-748391,EBI-1058674
KRT38 [O76015]9EBI-748391,EBI-1047263
KRT39 [Q6A163]3EBI-748391,EBI-11958242
KRT75 [O95678]3EBI-748391,EBI-2949715
KRTAP1-1 [Q07627]3EBI-748391,EBI-11959885
KRTAP10-5 [P60370]3EBI-748391,EBI-10172150
KRTAP10-7 [P60409]3EBI-748391,EBI-10172290
KRTAP10-8 [P60410]6EBI-748391,EBI-10171774
KRTAP10-9 [P60411]3EBI-748391,EBI-10172052
KRTAP5-9 [P26371]3EBI-748391,EBI-3958099
LCN2 [P80188]3EBI-748391,EBI-11911016
LDOC1 [O95751]3EBI-748391,EBI-740738
LHX1 [P48742]3EBI-748391,EBI-11990598
LHX3 - isoform B [Q9UBR4-2]3EBI-748391,EBI-12039345
LIMS1 - isoform 3 [P48059-3]3EBI-748391,EBI-12864460
LNX1 [Q8TBB1]3EBI-748391,EBI-739832
LRP2BP [Q9P2M1]3EBI-748391,EBI-18273118
LZTS1 [Q9Y250]3EBI-748391,EBI-1216080
LZTS2 [Q9BRK4]3EBI-748391,EBI-741037
MDFI [Q99750]3EBI-748391,EBI-724076
MEOX2 [P50222]3EBI-748391,EBI-748397
MID2 - isoform 2 [Q9UJV3-2]3EBI-748391,EBI-10172526
MIPOL1 [Q8TD10]6EBI-748391,EBI-2548751
MKRN3 [Q13064]8EBI-748391,EBI-2340269
MORN3 [Q6PF18]5EBI-748391,EBI-9675802
MRPL28 [Q13084]3EBI-748391,EBI-723426
MSS51 [Q4VC12]3EBI-748391,EBI-11599933
MTUS2 - isoform 2 [Q5JR59-3]7EBI-748391,EBI-11522433
MYLIP [Q8WY64]3EBI-748391,EBI-6952711
MYO1F [O00160]3EBI-748391,EBI-741792
NAB2 [Q15742]3EBI-748391,EBI-8641936
NAP1L2 [Q9ULW6]3EBI-748391,EBI-3911716
NDUFB7 [P17568]3EBI-748391,EBI-1246238
NFKBID [Q8NI38]3EBI-748391,EBI-10271199
NOTCH2NLA [Q7Z3S9]3EBI-748391,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-748391,EBI-22310682
PBX4 [Q9BYU1]3EBI-748391,EBI-10302990
PDE4DIP [Q5VU43]3EBI-748391,EBI-1105124
PDE4DIP - isoform 2 [Q5VU43-2]3EBI-748391,EBI-9640281
PDLIM7 [Q9NR12]3EBI-748391,EBI-350517
PFDN5 [Q99471]3EBI-748391,EBI-357275
PIBF1 [Q4G0R1]3EBI-748391,EBI-14066006
PICK1 [Q9NRD5]3EBI-748391,EBI-79165
PIH1D1 [Q9NWS0]3EBI-748391,EBI-357318
PLSCR1 [O15162]4EBI-748391,EBI-740019
PNMA1 [Q8ND90]8EBI-748391,EBI-302345
PNMA2 [Q9UL42]3EBI-748391,EBI-302355
PPP1R16A [Q96I34]3EBI-748391,EBI-710402
PPP1R16B [Q96T49]3EBI-748391,EBI-10293968
PRDM14 [Q9GZV8]5EBI-748391,EBI-3957793
PRR5L [Q6MZQ0]3EBI-748391,EBI-1567866
PSTPIP1 [O43586]3EBI-748391,EBI-1050964
RBAK [Q9NYW8]3EBI-748391,EBI-1210429
RBM11 [P57052]3EBI-748391,EBI-741332
RBM48 [Q5RL73]3EBI-748391,EBI-473821
RDM1 [Q8NG50]5EBI-748391,EBI-10288724
REL - isoform 2 [Q04864-2]3EBI-748391,EBI-10829018
RHOH [Q15669]3EBI-748391,EBI-1244971
RINT1 [Q6NUQ1]5EBI-748391,EBI-726876
RORB - isoform 1 [Q92753-1]3EBI-748391,EBI-18560266
RPGRIP1 [Q96KN7]3EBI-748391,EBI-1050213
RPH3AL [Q9UNE2]3EBI-748391,EBI-2855824
SMARCD1 [Q96GM5]3EBI-748391,EBI-358489
SORBS3 [O60504]3EBI-748391,EBI-741237
SPRED1 [Q7Z699]3EBI-748391,EBI-5235340
SSX2IP [Q9Y2D8]3EBI-748391,EBI-2212028
STX11 [O75558]5EBI-748391,EBI-714135
STX19 [Q8N4C7]3EBI-748391,EBI-8484990
SYCE1 [Q8N0S2]3EBI-748391,EBI-6872807
TAX1BP1 [Q86VP1]3EBI-748391,EBI-529518
TFIP11 [Q9UBB9]5EBI-748391,EBI-1105213
TLE5 [Q08117]3EBI-748391,EBI-717810
TLE5 - isoform 2 [Q08117-2]5EBI-748391,EBI-11741437
TNNI1 [P19237]3EBI-748391,EBI-746692
TP53BP2 [Q05BL1]3EBI-748391,EBI-11952721
TRAF1 [Q13077]8EBI-748391,EBI-359224
TRAF2 [Q12933]3EBI-748391,EBI-355744
TRIB3 [Q96RU7]3EBI-748391,EBI-492476
TRIM10 - isoform Beta [Q9UDY6-2]3EBI-748391,EBI-11981577
TRIM23 [P36406]3EBI-748391,EBI-740098
TRIM27 [P14373]6EBI-748391,EBI-719493
TRIM37 [O94972]3EBI-748391,EBI-741602
TRIM42 [Q8IWZ5]3EBI-748391,EBI-5235829
TRIM54 [Q9BYV2]6EBI-748391,EBI-2130429
TTC23L [Q6PF05]3EBI-748391,EBI-8656864
UBXN11 [Q5T124]4EBI-748391,EBI-746004
USH1G [Q495M9]3EBI-748391,EBI-8601749
USHBP1 [Q8N6Y0]3EBI-748391,EBI-739895
VIM [P08670]3EBI-748391,EBI-353844
VMAC [Q2NL98]3EBI-748391,EBI-2803134
VPS52 [Q8N1B4]3EBI-748391,EBI-2799833
VWC2 [Q2TAL6]3EBI-748391,EBI-11957238
ZBTB1 [Q9Y2K1]3EBI-748391,EBI-2682961
ZBTB14 [O43829]3EBI-748391,EBI-10176632
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-748391,EBI-10183064
ZIM2 [Q9NZV7]3EBI-748391,EBI-11962760
ZMYND12 [Q9H0C1]3EBI-748391,EBI-12030590
ZNF135 [P52742]3EBI-748391,EBI-7101455
ZNF19 [P17023]3EBI-748391,EBI-12884200
ZNF20 [P17024]3EBI-748391,EBI-717634
ZNF202 [O95125]3EBI-748391,EBI-751960
ZNF438 [Q7Z4V0]3EBI-748391,EBI-11962468
ZNF511 [Q8NB15]3EBI-748391,EBI-10269136
ZNF526 [Q8TF50]3EBI-748391,EBI-11035148
ZNF547 [Q8IVP9]3EBI-748391,EBI-12895421
ZNF552 [Q9H707]3EBI-748391,EBI-2555731
ZNF641 - isoform 2 [Q96N77-2]3EBI-748391,EBI-12939666
ZNF688 [P0C7X2]3EBI-748391,EBI-4395732
ZNF76 [P36508]3EBI-748391,EBI-7254550
ZNF774 [Q6NX45]3EBI-748391,EBI-10251462
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-748391,EBI-18036029

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122476, 190 interactors
1529623, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q9BWG6, 185 interactors

Molecular INTeraction database

More...MINTi		Q9BWG6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357901

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BWG6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni76 – 106DisorderedSequence analysisAdd BLAST31
Regioni129 – 186DisorderedSequence analysisAdd BLAST58
Regioni188 – 230Required for interaction with LUC7L2By similarityAdd BLAST43
Regioni200 – 230DisorderedSequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi4 – 20Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 104Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi216 – 230Acidic residuesSequence analysisAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 74Matrin-typeAdd BLAST33

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWNV, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059812_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BWG6

Identification of Orthologs from Complete Genome Data

More...OMAi		QWVKDEN

Database of Orthologous Groups

More...OrthoDBi		1557322at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BWG6

TreeFam database of animal gene trees

More...TreeFami		TF332168

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033570, SCNM1
IPR031625, SCNM1_acidic
IPR031622, Znf-SCNM1

The PANTHER Classification System

More...PANTHERi		PTHR32297, PTHR32297, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15805, SCNM1_acidic, 1 hit
PF15803, zf-SCNM1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BWG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR 
        60         70         80         90        100
PVLDTLAMLT AHRAGKKHLS SLQLFYGKKQ PGKERKQNPK HQNELRREET 
       110        120        130        140        150
KAEAPLLTQT RLITQSALHR APHYNSCCRR KYRPEAPGPS VSLSPMPPSE 
       160        170        180        190        200
VKLQSGKISR EPEPAAGPQA EESATVSAPA PMSPTRRRAL DHYLTLRSSG 
       210        220        230
WIPDGRGRWV KDENVEFDSD EEEPPDLPLD
Length:230
Mass (Da):25,949
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i001576EA78C61C85
GO
Isoform 2 (identifier: Q9BWG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-36: Missing.

Show »
Length:195
Mass (Da):21,887
Checksum:i010E51E98394DA83
GO
Isoform 3 (identifier: Q9BWG6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-162: PEAPGPSVSLSPMPPSEVKLQSGKISREP → YGTGKPEVGRLRRRQMALKEFSSVYSEEY
     163-230: Missing.

Show »
Length:162
Mass (Da):18,886
Checksum:i93C4D90FF7F664D6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0214892 – 36Missing in isoform 2. CuratedAdd BLAST35
Alternative sequenceiVSP_053982134 – 162PEAPG…ISREP → YGTGKPEVGRLRRRQMALKE FSSVYSEEY in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_053983163 – 230Missing in isoform 3. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK056322 mRNA Translation: BAB71149.1
AK301644 mRNA Translation: BAG63123.1
AL592424 Genomic DNA No translation available.
BC000264 mRNA Translation: AAH00264.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55636.1 [Q9BWG6-2]
CCDS987.1 [Q9BWG6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001191777.1, NM_001204848.1 [Q9BWG6-2]
NP_001191785.1, NM_001204856.1 [Q9BWG6-2]
NP_076946.1, NM_024041.3 [Q9BWG6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368902; ENSP00000357898; ENSG00000163156 [Q9BWG6-2]
ENST00000368905; ENSP00000357901; ENSG00000163156 [Q9BWG6-1]
ENST00000602841; ENSP00000473282; ENSG00000163156 [Q9BWG6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100534012
79005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100534012
hsa:79005

UCSC genome browser

More...UCSCi		uc001ewz.4, human [Q9BWG6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056322 mRNA Translation: BAB71149.1
AK301644 mRNA Translation: BAG63123.1
AL592424 Genomic DNA No translation available.
BC000264 mRNA Translation: AAH00264.1
CCDSiCCDS55636.1 [Q9BWG6-2]
CCDS987.1 [Q9BWG6-1]
RefSeqiNP_001191777.1, NM_001204848.1 [Q9BWG6-2]
NP_001191785.1, NM_001204856.1 [Q9BWG6-2]
NP_076946.1, NM_024041.3 [Q9BWG6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122476, 190 interactors
1529623, 1 interactor
IntActiQ9BWG6, 185 interactors
MINTiQ9BWG6
STRINGi9606.ENSP00000357901

PTM databases

iPTMnetiQ9BWG6
PhosphoSitePlusiQ9BWG6

Genetic variation databases

BioMutaiSCNM1
DMDMi74752399

Proteomic databases

EPDiQ9BWG6
jPOSTiQ9BWG6
MassIVEiQ9BWG6
MaxQBiQ9BWG6
PaxDbiQ9BWG6
PeptideAtlasiQ9BWG6
PRIDEiQ9BWG6
ProteomicsDBi79276 [Q9BWG6-1]
79277 [Q9BWG6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34055, 100 antibodies

The DNASU plasmid repository

More...DNASUi		79005

Genome annotation databases

EnsembliENST00000368902; ENSP00000357898; ENSG00000163156 [Q9BWG6-2]
ENST00000368905; ENSP00000357901; ENSG00000163156 [Q9BWG6-1]
ENST00000602841; ENSP00000473282; ENSG00000163156 [Q9BWG6-2]
GeneIDi100534012
79005
KEGGihsa:100534012
hsa:79005
UCSCiuc001ewz.4, human [Q9BWG6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100534012
79005
DisGeNETi79005

GeneCards: human genes, protein and diseases

More...GeneCardsi		SCNM1
HGNCiHGNC:23136, SCNM1
HPAiENSG00000163156, Low tissue specificity
MIMi608095, gene
neXtProtiNX_Q9BWG6
OpenTargetsiENSG00000163156
PharmGKBiPA134958437
VEuPathDBiHostDB:ENSG00000163156.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWNV, Eukaryota
GeneTreeiENSGT00390000010811
HOGENOMiCLU_059812_0_0_1
InParanoidiQ9BWG6
OMAiQWVKDEN
OrthoDBi1557322at2759
PhylomeDBiQ9BWG6
TreeFamiTF332168

Enzyme and pathway databases

PathwayCommonsiQ9BWG6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100534012, 7 hits in 100 CRISPR screens
79005, 115 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SCNM1, human
PharosiQ9BWG6, Tdark

Protein Ontology

More...PROi		PR:Q9BWG6
RNActiQ9BWG6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163156, Expressed in granulocyte and 228 other tissues
GenevisibleiQ9BWG6, HS

Family and domain databases

InterProiView protein in InterPro
IPR033570, SCNM1
IPR031625, SCNM1_acidic
IPR031622, Znf-SCNM1
PANTHERiPTHR32297, PTHR32297, 1 hit
PfamiView protein in Pfam
PF15805, SCNM1_acidic, 1 hit
PF15803, zf-SCNM1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCNM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BWG6
Secondary accession number(s): B4DWR1, Q5JR74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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