UniProtKB - Q9BWG4 (SSBP4_HUMAN)

BLAST

>sp|Q9BWG4|SSBP4_HUMAN Single-stranded DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=SSBP4 PE=1 SV=1
MYAKGGKGSAVPSDSQAREKLALYVYEYLLHIGAQKSAQTFLSEIRWEKNITLGEPPGFL
HSWWCVFWDLYCAAPDRREACEHSGEAKAFQDYSAAAAPSPVMGSMAPGDTMAAGSMAAG
FFQGPPGSQPSPHNPNAPMMGPHGQPFMSPRFPGGPRPTLRMPSQPPAGLPGSQPLLPGA
MEPSPRAQGHPSMGGPMQRVTPPRGMASVGPQSYGGGMRPPPNSLAGPGLPAMNMGPGVR
GPWASPSGNSIPYSSSSPGSYTGPPGGGGPPGTPIMPSPGDSTNSSENMYTIMNPIGQGA
GRANFPLGPGPEGPMAAMSAMEPHHVNGSLGSGDMDGLPKSSPGAVAGLSNAPGTPRDDG
EMAAAGTFLHPFPSESYSPGMTMSV

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History
Entry version 128 (12 Sep 2018)
Sequence version 1 (01 Jun 2001)
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Protein

Single-stranded DNA-binding protein 4

Gene

SSBP4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_Central
single-stranded DNA binding Source: InterPro
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Single-stranded DNA-binding protein 4
Gene namesⁱ	Name:SSBP4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130511.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15676 SSBP4
MIMⁱ	607391 gene
neXtProtⁱ	NX_Q9BWG4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000130511
PharmGKBⁱ	PA38018

Polymorphism and mutation databases

BioMutaⁱ	SSBP4
DMDMⁱ	27734580

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000123832	1 – 385	Single-stranded DNA-binding protein 4Add BLAST		385

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	341	PhosphoserineCombined sources	1
Modified residueⁱ	355	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BWG4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BWG4
PaxDbⁱ	Q9BWG4
PeptideAtlas More...PeptideAtlasⁱ	Q9BWG4
PRIDEⁱ	Q9BWG4
ProteomicsDBⁱ	79275

PTM databases

iPTMnetⁱ	Q9BWG4
PhosphoSitePlusⁱ	Q9BWG4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130511 Expressed in 190 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_SSBP4
ExpressionAtlasⁱ	Q9BWG4 baseline and differential
Genevisibleⁱ	Q9BWG4 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL36RN	Q9UBH0	3	EBI-744719,EBI-465156
PIN1	Q13526	3	EBI-744719,EBI-714158

Protein-protein interaction databases

BioGridⁱ	128006, 24 interactors
IntActⁱ	Q9BWG4, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q9BWG4
STRINGⁱ	9606.ENSP00000270061

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BWG4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 49	LisHPROSITE-ProRule annotationAdd BLAST		33

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	125 – 279	Pro-richAdd BLAST		155

Phylogenomic databases

eggNOGⁱ	KOG4594 Eukaryota ENOG410XPQX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009187
HOGENOMⁱ	HOG000037785
HOVERGENⁱ	HBG068487
InParanoidⁱ	Q9BWG4
OMAⁱ	HSSMGPM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G111C
PhylomeDBⁱ	Q9BWG4
TreeFamⁱ	TF318961

Family and domain databases

InterProⁱ	View protein in InterPro IPR006594 LisH IPR008116 SSDP_DNA-bd
PRINTSⁱ	PR01743 SSDNABINDING
SMARTⁱ	View protein in SMART SM00667 LisH, 1 hit
PROSITEⁱ	View protein in PROSITE PS50896 LISH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9BWG4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYAKGGKGSA VPSDSQAREK LALYVYEYLL HIGAQKSAQT FLSEIRWEKN 
        60         70         80         90        100
ITLGEPPGFL HSWWCVFWDL YCAAPDRREA CEHSGEAKAF QDYSAAAAPS 
       110        120        130        140        150
PVMGSMAPGD TMAAGSMAAG FFQGPPGSQP SPHNPNAPMM GPHGQPFMSP 
       160        170        180        190        200
RFPGGPRPTL RMPSQPPAGL PGSQPLLPGA MEPSPRAQGH PSMGGPMQRV 
       210        220        230        240        250
TPPRGMASVG PQSYGGGMRP PPNSLAGPGL PAMNMGPGVR GPWASPSGNS 
       260        270        280        290        300
IPYSSSSPGS YTGPPGGGGP PGTPIMPSPG DSTNSSENMY TIMNPIGQGA 
       310        320        330        340        350
GRANFPLGPG PEGPMAAMSA MEPHHVNGSL GSGDMDGLPK SSPGAVAGLS 
       360        370        380 
NAPGTPRDDG EMAAAGTFLH PFPSESYSPG MTMSV

Length:385

Mass (Da):39,388

Last modified:June 1, 2001 - v1

Checksum:ⁱF55FD3470B810742

Isoform 2 (identifier: Q9BWG4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
123-144: Missing.

« Hide

        10         20         30         40         50
MYAKGGKGSA VPSDSQAREK LALYVYEYLL HIGAQKSAQT FLSEIRWEKN 
        60         70         80         90        100
ITLGEPPGFL HSWWCVFWDL YCAAPDRREA CEHSGEAKAF QDYSAAAAPS 
       110        120        130        140        150
PVMGSMAPGD TMAAGSMAAG FFQPFMSPRF PGGPRPTLRM PSQPPAGLPG 
       160        170        180        190        200
SQPLLPGAME PSPRAQGHPS MGGPMQRVTP PRGMASVGPQ SYGGGMRPPP 
       210        220        230        240        250
NSLAGPGLPA MNMGPGVRGP WASPSGNSIP YSSSSPGSYT GPPGGGGPPG 
       260        270        280        290        300
TPIMPSPGDS TNSSENMYTI MNPIGQGAGR ANFPLGPGPE GPMAAMSAME 
       310        320        330        340        350
PHHVNGSLGS GDMDGLPKSS PGAVAGLSNA PGTPRDDGEM AAAGTFLHPF 
       360 
PSESYSPGMT MSV

Show »

Length:363

Mass (Da):37,214

Checksum:ⁱ001C3AACC1A38F1F

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
U3KQ46	U3KQ46_HUMAN	Single-stranded DNA-binding protein... Single-stranded DNA-binding protein 4	SSBP4	234	Annotation score:
U3KQP2	U3KQP2_HUMAN	Single-stranded DNA-binding protein... Single-stranded DNA-binding protein 4	SSBP4	54	Annotation score:
U3KPY3	U3KPY3_HUMAN	Single-stranded DNA-binding protein... Single-stranded DNA-binding protein 4	SSBP4	206	Annotation score:
V9GYB2	V9GYB2_HUMAN	Single-stranded DNA-binding protein... Single-stranded DNA-binding protein 4	SSBP4	71	Annotation score:
U3KQN6	U3KQN6_HUMAN	Single-stranded DNA-binding protein... Single-stranded DNA-binding protein 4	SSBP4	117	Annotation score:
M0R338	M0R338_HUMAN	Single-stranded DNA-binding protein... Single-stranded DNA-binding protein 4	SSBP4	53	Annotation score:
U3KQ98	U3KQ98_HUMAN	Single-stranded DNA-binding protein... Single-stranded DNA-binding protein 4	SSBP4	56	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054113	123 – 144	Missing in isoform 2. CuratedAdd BLAST		22

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY026292 AY026291 Genomic DNA Translation: AAK20020.1 AC008397 Genomic DNA No translation available. BC000274 mRNA Translation: AAH00274.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12378.1 [Q9BWG4-1] CCDS32960.1 [Q9BWG4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001009998.1, NM_001009998.3 [Q9BWG4-2] NP_116016.1, NM_032627.4 [Q9BWG4-1]
UniGeneⁱ	Hs.515259

Genome annotation databases

Ensemblⁱ	ENST00000270061; ENSP00000270061; ENSG00000130511 [Q9BWG4-1] ENST00000348495; ENSP00000252807; ENSG00000130511 [Q9BWG4-2]
GeneIDⁱ	170463
KEGGⁱ	hsa:170463
UCSC genome browser More...UCSCⁱ	uc002niy.4 human [Q9BWG4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BWG4	SSBP4 isoform 3		PANTR		385	UniRef90_Q9BWG4
Single stranded DNA binding protein 4		CERAT		385
Single stranded DNA binding protein 4		GORGO		385
Single-stranded DNA-binding protein 4 isoform a		MACMU		385
Single stranded DNA binding protein 4		MACFA		385
+20
Q9BWG4-2	Single stranded DNA binding protein 4		GORGO		363	UniRef90_Q9BWG4-2
Single-stranded DNA-binding protein 4 isoform b		MACMU		363
Single stranded DNA binding protein 4		MACFA		363
Single stranded DNA binding protein 4		MACNE		363
Single stranded DNA binding protein 4		CHLSB		363
+21

Protein	Similar proteins		Species	Score	Length	Source
Q9BWG4	Single-stranded DNA-binding protein 3		HUMAN		388	UniRef50_Q9BWW4
Single-stranded DNA-binding protein 3		MOUSE		388
SSBP3 isoform 4		PANTR		388
Single-stranded DNA-binding protein 3 isoform a		MACMU		388
Single stranded DNA binding protein 3		PROCO		388
+323

Entry informationⁱ

Entry nameⁱ	SSBP4_HUMAN
Accessionⁱ	Q9BWG4Primary (citable) accession number: Q9BWG4 Secondary accession number(s): Q9BWW5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BWG4 (SSBP4_HUMAN)

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Single-stranded DNA-binding protein 4

SSBP4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ