UniProtKB - Q9BWG4 (SSBP4_HUMAN)
Protein
Single-stranded DNA-binding protein 4
Gene
SSBP4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- single-stranded DNA binding Source: InterPro
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BWG4 |
Names & Taxonomyi
Protein namesi | Recommended name: Single-stranded DNA-binding protein 4 |
Gene namesi | Name:SSBP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15676, SSBP4 |
MIMi | 607391, gene |
neXtProti | NX_Q9BWG4 |
VEuPathDBi | HostDB:ENSG00000130511.15 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 170463 |
OpenTargetsi | ENSG00000130511 |
PharmGKBi | PA38018 |
Miscellaneous databases
Pharosi | Q9BWG4, Tdark |
Genetic variation databases
BioMutai | SSBP4 |
DMDMi | 27734580 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123832 | 1 – 385 | Single-stranded DNA-binding protein 4Add BLAST | 385 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 341 | PhosphoserineCombined sources | 1 | |
Modified residuei | 355 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BWG4 |
jPOSTi | Q9BWG4 |
MassIVEi | Q9BWG4 |
MaxQBi | Q9BWG4 |
PaxDbi | Q9BWG4 |
PeptideAtlasi | Q9BWG4 |
PRIDEi | Q9BWG4 |
ProteomicsDBi | 79275 [Q9BWG4-1] 79333 |
PTM databases
GlyConnecti | 2076, 1 N-Linked glycan (1 site) |
GlyGeni | Q9BWG4, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | Q9BWG4 |
PhosphoSitePlusi | Q9BWG4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130511, Expressed in right uterine tube and 204 other tissues |
ExpressionAtlasi | Q9BWG4, baseline and differential |
Genevisiblei | Q9BWG4, HS |
Organism-specific databases
HPAi | ENSG00000130511, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9BWG4
Protein-protein interaction databases
BioGRIDi | 128006, 30 interactors |
IntActi | Q9BWG4, 23 interactors |
MINTi | Q9BWG4 |
STRINGi | 9606.ENSP00000270061 |
Miscellaneous databases
RNActi | Q9BWG4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 49 | LisHPROSITE-ProRule annotationAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 125 – 279 | Pro-richAdd BLAST | 155 |
Phylogenomic databases
eggNOGi | KOG4594, Eukaryota |
GeneTreei | ENSGT00950000183049 |
HOGENOMi | CLU_053914_1_0_1 |
InParanoidi | Q9BWG4 |
OMAi | YTIMNPM |
OrthoDBi | 907486at2759 |
PhylomeDBi | Q9BWG4 |
TreeFami | TF318961 |
Family and domain databases
InterProi | View protein in InterPro IPR006594, LisH IPR008116, SSDP_DNA-bd |
PRINTSi | PR01743, SSDNABINDING |
SMARTi | View protein in SMART SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BWG4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYAKGGKGSA VPSDSQAREK LALYVYEYLL HIGAQKSAQT FLSEIRWEKN
60 70 80 90 100
ITLGEPPGFL HSWWCVFWDL YCAAPDRREA CEHSGEAKAF QDYSAAAAPS
110 120 130 140 150
PVMGSMAPGD TMAAGSMAAG FFQGPPGSQP SPHNPNAPMM GPHGQPFMSP
160 170 180 190 200
RFPGGPRPTL RMPSQPPAGL PGSQPLLPGA MEPSPRAQGH PSMGGPMQRV
210 220 230 240 250
TPPRGMASVG PQSYGGGMRP PPNSLAGPGL PAMNMGPGVR GPWASPSGNS
260 270 280 290 300
IPYSSSSPGS YTGPPGGGGP PGTPIMPSPG DSTNSSENMY TIMNPIGQGA
310 320 330 340 350
GRANFPLGPG PEGPMAAMSA MEPHHVNGSL GSGDMDGLPK SSPGAVAGLS
360 370 380
NAPGTPRDDG EMAAAGTFLH PFPSESYSPG MTMSV
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3KQ46 | U3KQ46_HUMAN | Single-stranded DNA-binding protein... | SSBP4 | 234 | Annotation score: | ||
U3KQP2 | U3KQP2_HUMAN | Single-stranded DNA-binding protein... | SSBP4 | 54 | Annotation score: | ||
U3KPY3 | U3KPY3_HUMAN | Single-stranded DNA-binding protein... | SSBP4 | 206 | Annotation score: | ||
U3KQN6 | U3KQN6_HUMAN | Single-stranded DNA-binding protein... | SSBP4 | 117 | Annotation score: | ||
U3KQ98 | U3KQ98_HUMAN | Single-stranded DNA-binding protein... | SSBP4 | 56 | Annotation score: | ||
V9GYB2 | V9GYB2_HUMAN | Single-stranded DNA-binding protein... | SSBP4 | 71 | Annotation score: | ||
M0R338 | M0R338_HUMAN | Single-stranded DNA-binding protein... | SSBP4 | 53 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054113 | 123 – 144 | Missing in isoform 2. CuratedAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY026292 , AY026276, AY026277, AY026278, AY026279, AY026280, AY026281, AY026282, AY026283, AY026284, AY026285, AY026286, AY026287, AY026288, AY026289, AY026290, AY026291 Genomic DNA Translation: AAK20020.1 AC008397 Genomic DNA No translation available. BC000274 mRNA Translation: AAH00274.1 |
CCDSi | CCDS12378.1 [Q9BWG4-1] CCDS32960.1 [Q9BWG4-2] |
RefSeqi | NP_001009998.1, NM_001009998.3 [Q9BWG4-2] NP_116016.1, NM_032627.4 [Q9BWG4-1] |
Genome annotation databases
Ensembli | ENST00000270061; ENSP00000270061; ENSG00000130511 [Q9BWG4-1] ENST00000348495; ENSP00000252807; ENSG00000130511 [Q9BWG4-2] |
GeneIDi | 170463 |
KEGGi | hsa:170463 |
UCSCi | uc002niy.4, human [Q9BWG4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY026292 , AY026276, AY026277, AY026278, AY026279, AY026280, AY026281, AY026282, AY026283, AY026284, AY026285, AY026286, AY026287, AY026288, AY026289, AY026290, AY026291 Genomic DNA Translation: AAK20020.1 AC008397 Genomic DNA No translation available. BC000274 mRNA Translation: AAH00274.1 |
CCDSi | CCDS12378.1 [Q9BWG4-1] CCDS32960.1 [Q9BWG4-2] |
RefSeqi | NP_001009998.1, NM_001009998.3 [Q9BWG4-2] NP_116016.1, NM_032627.4 [Q9BWG4-1] |
3D structure databases
SMRi | Q9BWG4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128006, 30 interactors |
IntActi | Q9BWG4, 23 interactors |
MINTi | Q9BWG4 |
STRINGi | 9606.ENSP00000270061 |
PTM databases
GlyConnecti | 2076, 1 N-Linked glycan (1 site) |
GlyGeni | Q9BWG4, 1 site, 1 N-linked glycan (1 site) |
iPTMneti | Q9BWG4 |
PhosphoSitePlusi | Q9BWG4 |
Genetic variation databases
BioMutai | SSBP4 |
DMDMi | 27734580 |
Proteomic databases
EPDi | Q9BWG4 |
jPOSTi | Q9BWG4 |
MassIVEi | Q9BWG4 |
MaxQBi | Q9BWG4 |
PaxDbi | Q9BWG4 |
PeptideAtlasi | Q9BWG4 |
PRIDEi | Q9BWG4 |
ProteomicsDBi | 79275 [Q9BWG4-1] 79333 |
Protocols and materials databases
Antibodypediai | 28035, 77 antibodies |
DNASUi | 170463 |
Genome annotation databases
Ensembli | ENST00000270061; ENSP00000270061; ENSG00000130511 [Q9BWG4-1] ENST00000348495; ENSP00000252807; ENSG00000130511 [Q9BWG4-2] |
GeneIDi | 170463 |
KEGGi | hsa:170463 |
UCSCi | uc002niy.4, human [Q9BWG4-1] |
Organism-specific databases
CTDi | 170463 |
DisGeNETi | 170463 |
GeneCardsi | SSBP4 |
HGNCi | HGNC:15676, SSBP4 |
HPAi | ENSG00000130511, Low tissue specificity |
MIMi | 607391, gene |
neXtProti | NX_Q9BWG4 |
OpenTargetsi | ENSG00000130511 |
PharmGKBi | PA38018 |
VEuPathDBi | HostDB:ENSG00000130511.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4594, Eukaryota |
GeneTreei | ENSGT00950000183049 |
HOGENOMi | CLU_053914_1_0_1 |
InParanoidi | Q9BWG4 |
OMAi | YTIMNPM |
OrthoDBi | 907486at2759 |
PhylomeDBi | Q9BWG4 |
TreeFami | TF318961 |
Enzyme and pathway databases
PathwayCommonsi | Q9BWG4 |
Miscellaneous databases
BioGRID-ORCSi | 170463, 29 hits in 996 CRISPR screens |
ChiTaRSi | SSBP4, human |
GenomeRNAii | 170463 |
Pharosi | Q9BWG4, Tdark |
PROi | PR:Q9BWG4 |
RNActi | Q9BWG4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130511, Expressed in right uterine tube and 204 other tissues |
ExpressionAtlasi | Q9BWG4, baseline and differential |
Genevisiblei | Q9BWG4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006594, LisH IPR008116, SSDP_DNA-bd |
PRINTSi | PR01743, SSDNABINDING |
SMARTi | View protein in SMART SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50896, LISH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SSBP4_HUMAN | |
Accessioni | Q9BWG4Primary (citable) accession number: Q9BWG4 Secondary accession number(s): Q9BWW5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot