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Protein

Retrotransposon Gag-like protein 8A

Gene

RTL8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

RTL8A is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon Gag-like protein 8AImported
Alternative name(s):
Mammalian retrotransposon derived protein 8A
Gene namesi
Name:RTL8AImported
Synonyms:CXX1B, FAM127BCurated, MAR8A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000203950.6
HGNCiHGNC:24514 RTL8A
neXtProtiNX_Q9BWD3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203950
PharmGKBiPA162385915

Polymorphism and mutation databases

BioMutaiFAM127B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003116931 – 113Retrotransposon Gag-like protein 8AAdd BLAST113

Proteomic databases

EPDiQ9BWD3
MaxQBiQ9BWD3
PaxDbiQ9BWD3
PeptideAtlasiQ9BWD3
PRIDEiQ9BWD3
ProteomicsDBi79269
TopDownProteomicsiQ9BWD3

PTM databases

iPTMnetiQ9BWD3
PhosphoSitePlusiQ9BWD3

Expressioni

Gene expression databases

BgeeiENSG00000203950 Expressed in 174 organ(s), highest expression level in lower esophagus
CleanExiHS_FAM127B
GenevisibleiQ9BWD3 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi117530, 5 interactors
IntActiQ9BWD3, 4 interactors
STRINGi9606.ENSP00000375267

Structurei

3D structure databases

ProteinModelPortaliQ9BWD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM127 family.Curated

Phylogenomic databases

eggNOGiENOG410IXM4 Eukaryota
ENOG41113F5 LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000049195
HOVERGENiHBG052318
InParanoidiQ9BWD3
OMAiTEEHRWR
OrthoDBiEOG091G02TH
PhylomeDBiQ9BWD3
TreeFamiTF337843

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BWD3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGRVQLMKA LLAGPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY
60 70 80 90 100
MFVDENTFSN DALKVTFLIT RLTGPALQWV IPYIRKESPL LNDYRGFLAE
110
MKRVFGWEED EDF
Length:113
Mass (Da):13,188
Last modified:December 4, 2007 - v3
Checksum:i65227B6D28946B9F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06016248S → C1 PublicationCorresponds to variant dbSNP:rs2498776Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA No translation available.
BC000393 mRNA Translation: AAH00393.2
BC019300 mRNA Translation: AAH19300.1
CCDSiCCDS43998.1
RefSeqiNP_001071640.1, NM_001078172.1
NP_001127793.1, NM_001134321.1
UniGeneiHs.460924

Genome annotation databases

EnsembliENST00000370775; ENSP00000375267; ENSG00000203950
GeneIDi26071
KEGGihsa:26071
UCSCiuc004eyf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136169 Genomic DNA No translation available.
BC000393 mRNA Translation: AAH00393.2
BC019300 mRNA Translation: AAH19300.1
CCDSiCCDS43998.1
RefSeqiNP_001071640.1, NM_001078172.1
NP_001127793.1, NM_001134321.1
UniGeneiHs.460924

3D structure databases

ProteinModelPortaliQ9BWD3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117530, 5 interactors
IntActiQ9BWD3, 4 interactors
STRINGi9606.ENSP00000375267

PTM databases

iPTMnetiQ9BWD3
PhosphoSitePlusiQ9BWD3

Polymorphism and mutation databases

BioMutaiFAM127B

Proteomic databases

EPDiQ9BWD3
MaxQBiQ9BWD3
PaxDbiQ9BWD3
PeptideAtlasiQ9BWD3
PRIDEiQ9BWD3
ProteomicsDBi79269
TopDownProteomicsiQ9BWD3

Protocols and materials databases

DNASUi26071
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370775; ENSP00000375267; ENSG00000203950
GeneIDi26071
KEGGihsa:26071
UCSCiuc004eyf.4 human

Organism-specific databases

CTDi26071
EuPathDBiHostDB:ENSG00000203950.6
GeneCardsiRTL8A
H-InvDBiHIX0014311
HGNCiHGNC:24514 RTL8A
neXtProtiNX_Q9BWD3
OpenTargetsiENSG00000203950
PharmGKBiPA162385915
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXM4 Eukaryota
ENOG41113F5 LUCA
GeneTreeiENSGT00510000047956
HOGENOMiHOG000049195
HOVERGENiHBG052318
InParanoidiQ9BWD3
OMAiTEEHRWR
OrthoDBiEOG091G02TH
PhylomeDBiQ9BWD3
TreeFamiTF337843

Miscellaneous databases

ChiTaRSiFAM127B human
GenomeRNAii26071
PROiPR:Q9BWD3

Gene expression databases

BgeeiENSG00000203950 Expressed in 174 organ(s), highest expression level in lower esophagus
CleanExiHS_FAM127B
GenevisibleiQ9BWD3 HS

Family and domain databases

InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTL8A_HUMAN
AccessioniPrimary (citable) accession number: Q9BWD3
Secondary accession number(s): A2A2V9, Q8TBU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 12, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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Main funding by: National Institutes of Health

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