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Entry version 161 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Threonine--tRNA ligase, mitochondrial

Gene

TARS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 5.8 sec(-1) for the activation reaction of L-threonine. kcat is 1.1 sec(-1) for the activation reaction of L-serine. kcat is 0.061 sec(-1) for the aminoacylation of tRNA(Thr) with L-threonine.1 Publication
  1. KM=2.5 mM for L-threonine1 Publication
  2. KM=1.1 µM for tRNA(Thr)1 Publication
  3. KM=180 mM for L-serine1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    • mitochondrial threonyl-tRNA aminoacylation Source: BHF-UCL
    • threonyl-tRNA aminoacylation Source: GO_Central

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminoacyl-tRNA synthetase, Ligase
    Biological processProtein biosynthesis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-379726 Mitochondrial tRNA aminoacylation

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Threonine--tRNA ligase, mitochondrial (EC:6.1.1.31 Publication)
    Alternative name(s):
    Threonyl-tRNA synthetase
    Short name:
    ThrRS
    Threonyl-tRNA synthetase-like 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:TARS2
    Synonyms:TARSL1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:30740 TARS2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612805 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9BW92

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Combined oxidative phosphorylation deficiency 21 (COXPD21)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA mitochondrial disorder characterized by a lethal encephalomyopathy. Shortly after birth, affected individuals manifest axial hypotonia, limb hypertonia, psychomotor delay, and increased serum lactate. Additional features include subsarcolemmal lipofuscin-positive deposits in muscle, cerebral spongiosis, and hepatic steatosis.
    See also OMIM:615918
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071853282P → L in COXPD21; decreased expression at mRNA and protein levels; decreased threonine-tRNA ligase activity; affects both Thr activation and transfer; decreased aminoacyl-tRNA editing activity; decreased protein stability; loss of homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs587777593EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation, Primary mitochondrial disease

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    80222

    MalaCards human disease database

    More...
    MalaCardsi
    TARS2
    MIMi615918 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000143374

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    420733 Combined oxidative phosphorylation defect type 21

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162405200

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3351186

    Drug and drug target database

    More...
    DrugBanki
    DB00156 L-Threonine

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    TARS2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74752395

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000254586? – 718Threonine--tRNA ligase, mitochondrial
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9BW92

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9BW92

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9BW92

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9BW92

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9BW92

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9BW92

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    79266

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9BW92

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9BW92

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000143374 Expressed in 206 organ(s), highest expression level in cerebellar vermis

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9BW92 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9BW92 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA028626

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    123188, 20 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9BW92, 24 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9BW92

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000358060

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9BW92

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 121TGSPROSITE-ProRule annotationAdd BLAST67

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1637 Eukaryota
    COG0441 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161600

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000003878

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9BW92

    KEGG Orthology (KO)

    More...
    KOi
    K01868

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GELWELG

    Database of Orthologous Groups

    More...
    OrthoDBi
    813937at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9BW92

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300858

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00771 ThrRS_core, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.10.20.30, 1 hit
    3.40.50.800, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00184 Thr_tRNA_synth, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002314 aa-tRNA-synt_IIb
    IPR006195 aa-tRNA-synth_II
    IPR004154 Anticodon-bd
    IPR036621 Anticodon-bd_dom_sf
    IPR012675 Beta-grasp_dom_sf
    IPR004095 TGS
    IPR012676 TGS-like
    IPR002320 Thr-tRNA-ligase_IIa
    IPR018163 Thr/Ala-tRNA-synth_IIc_edit
    IPR033728 ThrRS_core
    IPR012947 tRNA_SAD

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11451 PTHR11451, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03129 HGTP_anticodon, 1 hit
    PF02824 TGS, 1 hit
    PF00587 tRNA-synt_2b, 1 hit
    PF07973 tRNA_SAD, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01047 TRNASYNTHTHR

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00863 tRNA_SAD, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55186 SSF55186, 1 hit
    SSF81271 SSF81271, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00418 thrS, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50862 AA_TRNA_LIGASE_II, 1 hit
    PS51880 TGS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9BW92-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MALYQRWRCL RLQGLQACRL HTAVVSTPPR WLAERLGLFE ELWAAQVKRL
    60 70 80 90 100
    ASMAQKEPRT IKISLPGGQK IDAVAWNTTP YQLARQISST LADTAVAAQV
    110 120 130 140 150
    NGEPYDLERP LETDSDLRFL TFDSPEGKAV FWHSSTHVLG AAAEQFLGAV
    160 170 180 190 200
    LCRGPSTEYG FYHDFFLGKE RTIRGSELPV LERICQELTA AARPFRRLEA
    210 220 230 240 250
    SRDQLRQLFK DNPFKLHLIE EKVTGPTATV YGCGTLVDLC QGPHLRHTGQ
    260 270 280 290 300
    IGGLKLLSNS SSLWRSSGAP ETLQRVSGIS FPTTELLRVW EAWREEAELR
    310 320 330 340 350
    DHRRIGKEQE LFFFHELSPG SCFFLPRGTR VYNALVAFIR AEYAHRGFSE
    360 370 380 390 400
    VKTPTLFSTK LWEQSGHWEH YQEDMFAVQP PGSDRPPSSQ SDDSTRHITD
    410 420 430 440 450
    TLALKPMNCP AHCLMFAHRP RSWRELPLRL ADFGALHRAE ASGGLGGLTR
    460 470 480 490 500
    LRCFQQDDAH IFCTTDQLEA EIQSCLDFLR SVYAVLGFSF RLALSTRPSG
    510 520 530 540 550
    FLGDPCLWDQ AEQVLKQALK EFGEPWDLNS GDGAFYGPKI DVHLHDALGR
    560 570 580 590 600
    PHQCGTIQLD FQLPLRFDLQ YKGQAGALER PVLIHRAVLG SVERLLGVLA
    610 620 630 640 650
    ESCGGKWPLW LSPFQVVVIP VGSEQEEYAK EAQQSLRAAG LVSDLDADSG
    660 670 680 690 700
    LTLSRRIRRA QLAHYNFQFV VGQKEQSKRT VNIRTRDNRR LGEWDLPEAV
    710
    QRLVELQNTR VPNAEEIF
    Length:718
    Mass (Da):81,036
    Last modified:June 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2F793A60483E7F9
    GO
    Isoform 2 (identifier: Q9BW92-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-340: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:588
    Mass (Da):66,372
    Checksum:i19A2BD2A6BB8C400
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    U3KQG0U3KQG0_HUMAN
    Threonine--tRNA ligase, mitochondri...
    TARS2
    636Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F6S7Q7F6S7Q7_HUMAN
    Threonine--tRNA ligase, mitochondri...
    TARS2
    443Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    U3KQ50U3KQ50_HUMAN
    Threonine--tRNA ligase, mitochondri...
    TARS2
    143Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q5T5E9Q5T5E9_HUMAN
    Threonine--tRNA ligase, mitochondri...
    TARS2
    135Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti269A → P in BAD96534 (Ref. 2) Curated1
    Sequence conflicti579E → G in BAD96534 (Ref. 2) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_071853282P → L in COXPD21; decreased expression at mRNA and protein levels; decreased threonine-tRNA ligase activity; affects both Thr activation and transfer; decreased aminoacyl-tRNA editing activity; decreased protein stability; loss of homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs587777593EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054537211 – 340Missing in isoform 2. 1 PublicationAdd BLAST130

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

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    EMBLi

    GenBank nucleotide sequence database

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    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK022590 mRNA Translation: BAB14117.1
    AK222814 mRNA Translation: BAD96534.1
    AL356356 Genomic DNA No translation available.
    CH471121 Genomic DNA Translation: EAW53549.1
    BC000541 mRNA Translation: AAH00541.1
    BC007824 mRNA Translation: AAH07824.2
    BC009997 mRNA Translation: AAH09997.1

    The Consensus CDS (CCDS) project

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    CCDSi
    CCDS60252.1 [Q9BW92-2]
    CCDS952.1 [Q9BW92-1]

    NCBI Reference Sequences

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    RefSeqi
    NP_001258825.1, NM_001271896.1 [Q9BW92-2]
    NP_079426.2, NM_025150.4 [Q9BW92-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

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    Ensembli
    ENST00000369054; ENSP00000358050; ENSG00000143374 [Q9BW92-2]
    ENST00000369064; ENSP00000358060; ENSG00000143374 [Q9BW92-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    80222

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:80222

    UCSC genome browser

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    UCSCi
    uc001euq.5 human [Q9BW92-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK022590 mRNA Translation: BAB14117.1
    AK222814 mRNA Translation: BAD96534.1
    AL356356 Genomic DNA No translation available.
    CH471121 Genomic DNA Translation: EAW53549.1
    BC000541 mRNA Translation: AAH00541.1
    BC007824 mRNA Translation: AAH07824.2
    BC009997 mRNA Translation: AAH09997.1
    CCDSiCCDS60252.1 [Q9BW92-2]
    CCDS952.1 [Q9BW92-1]
    RefSeqiNP_001258825.1, NM_001271896.1 [Q9BW92-2]
    NP_079426.2, NM_025150.4 [Q9BW92-1]

    3D structure databases

    SMRiQ9BW92
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi123188, 20 interactors
    IntActiQ9BW92, 24 interactors
    MINTiQ9BW92
    STRINGi9606.ENSP00000358060

    Chemistry databases

    ChEMBLiCHEMBL3351186
    DrugBankiDB00156 L-Threonine

    PTM databases

    iPTMnetiQ9BW92
    PhosphoSitePlusiQ9BW92

    Polymorphism and mutation databases

    BioMutaiTARS2
    DMDMi74752395

    Proteomic databases

    EPDiQ9BW92
    jPOSTiQ9BW92
    MaxQBiQ9BW92
    PaxDbiQ9BW92
    PeptideAtlasiQ9BW92
    PRIDEiQ9BW92
    ProteomicsDBi79266

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000369054; ENSP00000358050; ENSG00000143374 [Q9BW92-2]
    ENST00000369064; ENSP00000358060; ENSG00000143374 [Q9BW92-1]
    GeneIDi80222
    KEGGihsa:80222
    UCSCiuc001euq.5 human [Q9BW92-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    80222
    DisGeNETi80222

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    TARS2
    HGNCiHGNC:30740 TARS2
    HPAiHPA028626
    MalaCardsiTARS2
    MIMi612805 gene
    615918 phenotype
    neXtProtiNX_Q9BW92
    OpenTargetsiENSG00000143374
    Orphaneti420733 Combined oxidative phosphorylation defect type 21
    PharmGKBiPA162405200

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1637 Eukaryota
    COG0441 LUCA
    GeneTreeiENSGT00940000161600
    HOGENOMiHOG000003878
    InParanoidiQ9BW92
    KOiK01868
    OMAiGELWELG
    OrthoDBi813937at2759
    PhylomeDBiQ9BW92
    TreeFamiTF300858

    Enzyme and pathway databases

    ReactomeiR-HSA-379726 Mitochondrial tRNA aminoacylation

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    TARS2 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    80222

    Protein Ontology

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    PROi
    PR:Q9BW92

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000143374 Expressed in 206 organ(s), highest expression level in cerebellar vermis
    ExpressionAtlasiQ9BW92 baseline and differential
    GenevisibleiQ9BW92 HS

    Family and domain databases

    CDDicd00771 ThrRS_core, 1 hit
    Gene3Di3.10.20.30, 1 hit
    3.40.50.800, 1 hit
    HAMAPiMF_00184 Thr_tRNA_synth, 1 hit
    InterProiView protein in InterPro
    IPR002314 aa-tRNA-synt_IIb
    IPR006195 aa-tRNA-synth_II
    IPR004154 Anticodon-bd
    IPR036621 Anticodon-bd_dom_sf
    IPR012675 Beta-grasp_dom_sf
    IPR004095 TGS
    IPR012676 TGS-like
    IPR002320 Thr-tRNA-ligase_IIa
    IPR018163 Thr/Ala-tRNA-synth_IIc_edit
    IPR033728 ThrRS_core
    IPR012947 tRNA_SAD
    PANTHERiPTHR11451 PTHR11451, 1 hit
    PfamiView protein in Pfam
    PF03129 HGTP_anticodon, 1 hit
    PF02824 TGS, 1 hit
    PF00587 tRNA-synt_2b, 1 hit
    PF07973 tRNA_SAD, 1 hit
    PRINTSiPR01047 TRNASYNTHTHR
    SMARTiView protein in SMART
    SM00863 tRNA_SAD, 1 hit
    SUPFAMiSSF55186 SSF55186, 1 hit
    SSF81271 SSF81271, 1 hit
    TIGRFAMsiTIGR00418 thrS, 1 hit
    PROSITEiView protein in PROSITE
    PS50862 AA_TRNA_LIGASE_II, 1 hit
    PS51880 TGS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYTM_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BW92
    Secondary accession number(s): Q53GW7, Q96I50, Q9H9V2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 1, 2001
    Last modified: May 8, 2019
    This is version 161 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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