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Protein

HIG1 domain family member 2A, mitochondrial

Gene

HIGD2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: MGI
  • oxidation-reduction process Source: UniProtKB-KW

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
HIG1 domain family member 2A, mitochondrial
Alternative name(s):
RCF1 homolog B
Short name:
RCF1b
Gene namesi
Name:HIGD2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146066.2
HGNCiHGNC:28311 HIGD2A
neXtProtiNX_Q9BW72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 67HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei83 – 103HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini104 – 106Mitochondrial matrixSequence analysis3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi192286
PharmGKBiPA142671685

Polymorphism and mutation databases

BioMutaiHIGD2A
DMDMi74733402

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002157772 – 106HIG1 domain family member 2A, mitochondrialAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BW72
MaxQBiQ9BW72
PaxDbiQ9BW72
PeptideAtlasiQ9BW72
PRIDEiQ9BW72
ProteomicsDBi79260
TopDownProteomicsiQ9BW72

PTM databases

iPTMnetiQ9BW72
PhosphoSitePlusiQ9BW72
SwissPalmiQ9BW72

Expressioni

Gene expression databases

BgeeiENSG00000146066
CleanExiHS_HIGD2A
ExpressionAtlasiQ9BW72 baseline and differential
GenevisibleiQ9BW72 HS

Organism-specific databases

HPAiHPA042715

Interactioni

Subunit structurei

Associates with cytochrome c oxidase (COX, complex IV); proposed complex component.1 Publication

Protein-protein interaction databases

BioGridi128172, 8 interactors
IntActiQ9BW72, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9BW72
SMRiQ9BW72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 106HIG1PROSITE-ProRule annotationAdd BLAST87

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4431 Eukaryota
ENOG41121ET LUCA
GeneTreeiENSGT00910000144291
HOGENOMiHOG000234513
HOVERGENiHBG054361
InParanoidiQ9BW72
OMAiHRGQSQR
OrthoDBiEOG091G166Q
PhylomeDBiQ9BW72
TreeFamiTF314628

Family and domain databases

InterProiView protein in InterPro
IPR007667 Hypoxia_induced_domain
PfamiView protein in Pfam
PF04588 HIG_1_N, 1 hit
PROSITEiView protein in PROSITE
PS51503 HIG1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BW72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPGPVIPE VPFEPSKPPV IEGLSPTVYR NPESFKEKFV RKTRENPVVP
60 70 80 90 100
IGCLATAAAL TYGLYSFHRG NSQRSQLMMR TRIAAQGFTV AAILLGLAVT

AMKSRP
Length:106
Mass (Da):11,529
Last modified:June 1, 2001 - v1
Checksum:i205DE0AE39950053
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC000587 mRNA No translation available.
BC007502 mRNA Translation: AAH07502.1
CCDSiCCDS4401.1
RefSeqiNP_620175.1, NM_138820.3
UniGeneiHs.534575
Hs.696283

Genome annotation databases

EnsembliENST00000274787; ENSP00000274787; ENSG00000146066
GeneIDi192286
KEGGihsa:192286
UCSCiuc003meg.4 human

Similar proteinsi

Entry informationi

Entry nameiHIG2A_HUMAN
AccessioniPrimary (citable) accession number: Q9BW72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM

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