CINP

Functionⁱ

Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.2 Publications

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
DNA replication Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, DNA damage, DNA repair, DNA replication

Biological process

Cell cycle, Cell division, DNA damage, DNA repair, DNA replication

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 2-interacting protein Short name: CDK2-interacting protein
Gene namesⁱ	Name:CINP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100865.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23789 CINP
MIMⁱ	613362 gene
neXtProtⁱ	NX_Q9BW66

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51550
Open Targets More...OpenTargetsⁱ	ENSG00000100865
PharmGKBⁱ	PA165478684

Polymorphism and mutation databases

BioMutaⁱ	CINP
DMDMⁱ	74733401

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000326055	1 – 212	Cyclin-dependent kinase 2-interacting proteinAdd BLAST		212

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	69	PhosphoserineCombined sources	1
Modified residueⁱ	73	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by CDC7 but not by CDK2.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BW66
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BW66
PaxDbⁱ	Q9BW66
PeptideAtlas More...PeptideAtlasⁱ	Q9BW66
PRIDEⁱ	Q9BW66
ProteomicsDBⁱ	79257

PTM databases

iPTMnetⁱ	Q9BW66
PhosphoSitePlusⁱ	Q9BW66

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100865 Expressed in 148 organ(s), highest expression level in testis
ExpressionAtlasⁱ	Q9BW66 baseline and differential
Genevisibleⁱ	Q9BW66 HS

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with CDK2 and CDC7. Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes. Interacts with ATRIP. Interacts with CEP152.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ATR	Q13535	5	EBI-739784,EBI-968983
ATRIP	Q8WXE1	9	EBI-739784,EBI-747353
BLZF1	Q9H2G9	5	EBI-739784,EBI-2548012
C1orf109	Q9NX04	9	EBI-739784,EBI-8643161
CLUAP1	Q96AJ1	3	EBI-739784,EBI-739780
FBF1	Q8TES7-6	3	EBI-739784,EBI-10244131
GOLGA2	Q08379	5	EBI-739784,EBI-618309
REL	Q04864	3	EBI-739784,EBI-307352
SNRPD2	P62316	4	EBI-739784,EBI-297993
SYCE1	Q8N0S2	3	EBI-739784,EBI-6872807

Protein-protein interaction databases

BioGridⁱ	119604, 22 interactors
Database of interacting proteins More...DIPⁱ	DIP-49011N
IntActⁱ	Q9BW66, 40 interactors
STRINGⁱ	9606.ENSP00000442057

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BW66
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	73 – 107	Sequence analysisAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the CINP family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IWVU Eukaryota ENOG4111M0E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015784
HOGENOMⁱ	HOG000035137
HOVERGENⁱ	HBG061504
InParanoidⁱ	Q9BW66
OMAⁱ	RPPLFHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RIF
PhylomeDBⁱ	Q9BW66
TreeFamⁱ	TF329462

Family and domain databases

InterProⁱ	View protein in InterPro IPR023250 Cyclin-dep_Kinase_2_interact
PRINTSⁱ	PR02040 CDK2IP

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9BW66-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN 
        60         70         80         90        100
IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD 
       110        120        130        140        150
GLTKIQVKME KLSSTTKGIC ELENYHYGEE SKRPPLFHTW PTTHFYEVSH 
       160        170        180        190        200
KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL SYLSMWLHQP YVESDSRLHL 
       210 
ESMLLETGHR AL

Length:212

Mass (Da):24,324

Last modified:June 1, 2001 - v1

Checksum:ⁱ3678E123B8C206B1

GO

Isoform 2 (identifier: Q9BW66-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
103-118: TKIQVKMEKLSSTTKG → MRFRISSWRCTGRSCS
119-212: Missing.

« Hide

        10         20         30         40         50
MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN 
        60         70         80         90        100
IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD 
       110 
GLMRFRISSW RCTGRSCS

Note: No experimental confirmation available.

Show »

Length:118

Mass (Da):13,287

Checksum:ⁱEBAB2978717852CE

GO

Isoform 3 (identifier: Q9BW66-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-3: MEA → MNGTIYANECQQIRHPNS

« Hide

        10         20         30         40         50
MNGTIYANEC QQIRHPNSKT LGTVTPRKPV LSVSARKIKD NAADWHNLIL 
        60         70         80         90        100
KWETLNDAGF TTANNIANLK ISLLNKDKIE LDSSSPASKE NEEKVCLEYN 
       110        120        130        140        150
EELEKLCEEL QATLDGLTKI QVKMEKLSST TKGICELENY HYGEESKRPP 
       160        170        180        190        200
LFHTWPTTHF YEVSHKLLEM YRKELLLKRT VAKELAHTGD PDLTLSYLSM 
       210        220 
WLHQPYVESD SRLHLESMLL ETGHRAL

Note: No experimental confirmation available.

Show »

Length:227

Mass (Da):26,051

Checksum:ⁱ9245BA7C5767DA0B

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	H0YKY0	H0YKY0_HUMAN		Cyclin-dependent kinase 2-interacti... Cyclin-dependent kinase 2-interacting protein	CINP	113	Annotation score:
	H0YN33	H0YN33_HUMAN		Cyclin-dependent kinase 2-interacti... Cyclin-dependent kinase 2-interacting protein	CINP	213	Annotation score:

Sequence cautionⁱ

The sequence BU174070 differs from that shown. Reason: Frameshift at positions 183 and 197.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	157	R → K in AAF44747 (PubMed:16082200).Curated	1
Sequence conflictⁱ	157	R → K in AAF44748 (PubMed:16082200).Curated	1
Sequence conflictⁱ	175	D → N in AAF44747 (PubMed:16082200).Curated	1
Sequence conflictⁱ	175	D → N in AAF44748 (PubMed:16082200).Curated	1
Sequence conflictⁱ	194 – 197	SDSR → NDNK in AAF44747 (PubMed:16082200).Curated	4
Sequence conflictⁱ	194 – 197	SDSR → NDNK in AAF44748 (PubMed:16082200).Curated	4
Sequence conflictⁱ	196	S → R in BU174070 (PubMed:15489334).Curated	1
Sequence conflictⁱ	202	S → N in AAF44747 (PubMed:16082200).Curated	1
Sequence conflictⁱ	202	S → N in AAF44748 (PubMed:16082200).Curated	1
Sequence conflictⁱ	210 – 212	RAL → PSSLTS in BU174070 (PubMed:15489334).Curated	3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039979	164	R → H. Corresponds to variant dbSNP:rs7011Ensembl.		1
Natural variantⁱVAR_039980	177	D → N in a colorectal cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046386	1 – 3	MEA → MNGTIYANECQQIRHPNS in isoform 3. 1 Publication	3
Alternative sequenceⁱVSP_045342	103 – 118	TKIQV…STTKG → MRFRISSWRCTGRSCS in isoform 2. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_045343	119 – 212	Missing in isoform 2. 1 PublicationAdd BLAST	94

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF228148 mRNA Translation: AAF44747.1 AF228149 mRNA Translation: AAF44748.1 AK056112 mRNA Translation: BAB71095.1 DA167716 mRNA No translation available. CR457178 mRNA Translation: CAG33459.1 AL137229 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81785.1 BC000600 mRNA Translation: AAH00600.1 BU174070 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53915.1 [Q9BW66-2] CCDS9972.1 [Q9BW66-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001306975.1, NM_001320046.1 [Q9BW66-2] NP_116019.1, NM_032630.2 [Q9BW66-1]
UniGeneⁱ	Hs.129634

Genome annotation databases

Ensemblⁱ	ENST00000216756; ENSP00000216756; ENSG00000100865 [Q9BW66-1] ENST00000536961; ENSP00000442057; ENSG00000100865 [Q9BW66-3] ENST00000541568; ENSP00000442377; ENSG00000100865 [Q9BW66-2] ENST00000559514; ENSP00000453839; ENSG00000100865 [Q9BW66-1]
GeneIDⁱ	51550
KEGGⁱ	hsa:51550
UCSC genome browser More...UCSCⁱ	uc001ylv.2 human [Q9BW66-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9BW66	Cyclin-dependent kinase 2-interacting protein, isoform CRA_a		HUMAN		212	UniRef90_Q9BW66
CINP isoform 7		PANTR		227
Cyclin dependent kinase 2 interacting protein		PANPA		227
Cyclin dependent kinase 2 interacting protein		MACMU		227
Cyclin dependent kinase 2 interacting protein		MACFA		227
+46
Q9BW66-2	CINP isoform 7		PONAB		118	UniRef90_Q9BW66-2
Cyclin dependent kinase 2 interacting protein		PAPAN		118
Cyclin dependent kinase 2 interacting protein		RHIRO		118
Cyclin dependent kinase 2 interacting protein		MACNE		118
Cyclin dependent kinase 2 interacting protein		NOMLE		118
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9BW66	Cyclin-dependent kinase 2-interacting protein		MOUSE		212	UniRef50_Q9BW66
Cyclin-dependent kinase 2-interacting protein, isoform CRA_a		HUMAN		212
CINP isoform 7		PANTR		227
Cyclin dependent kinase 2 interacting protein		PANPA		227
Cyclin dependent kinase 2 interacting protein		PAPAN		227
+97
Q9BW66-2	Cyclin dependent kinase 2 interacting protein		MANLE		118	UniRef50_Q9BW66-2
Cyclin dependent kinase 2 interacting protein		GORGO		118
Cyclin dependent kinase 2 interacting protein		MACNE		118
Cyclin dependent kinase 2 interacting protein		NOMLE		118
Cyclin dependent kinase 2 interacting protein		COLAP		118
+13

Entry informationⁱ

Entry nameⁱ	CINP_HUMAN
Accessionⁱ	Q9BW66Primary (citable) accession number: Q9BW66 Secondary accession number(s): F5H7P3, F5H8A7, Q9NPF9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BW66 (CINP_HUMAN)

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Cyclin-dependent kinase 2-interacting protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ