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UniProtKB - Q9BW66 (CINP_HUMAN)

Entry version 143 (07 Apr 2021)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Cyclin-dependent kinase 2-interacting protein

Gene

CINP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair, DNA replication

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BW66

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase 2-interacting protein
Short name:
CDK2-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CINP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23789, CINP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613362, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BW66

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100865.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51550

Open Targets

More...OpenTargetsi		ENSG00000100865

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165478684

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BW66, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CINP

Domain mapping of disease mutations (DMDM)

More...DMDMi		74733401

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003260551 – 212Cyclin-dependent kinase 2-interacting proteinAdd BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CDC7 but not by CDK2.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BW66

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BW66

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BW66

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BW66

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BW66

PeptideAtlas

More...PeptideAtlasi		Q9BW66

PRoteomics IDEntifications database

More...PRIDEi		Q9BW66

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27547
27731
79257 [Q9BW66-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BW66

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BW66

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100865, Expressed in testis and 170 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BW66, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BW66, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100865, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with CDK2 and CDC7.

Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes.

Interacts with ATRIP.

Interacts with CEP152.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9BW66
With#Exp.IntAct
AMOTL2 [Q9Y2J4]3EBI-739784,EBI-746752
ATR [Q13535]5EBI-739784,EBI-968983
ATRIP [Q8WXE1]9EBI-739784,EBI-747353
BLZF1 [Q9H2G9]7EBI-739784,EBI-2548012
BTBD2 [Q9BX70]3EBI-739784,EBI-710091
C1orf109 [Q9NX04]9EBI-739784,EBI-8643161
CCDC112 - isoform 2 [Q8NEF3-2]3EBI-739784,EBI-12095166
CFAP161 [Q6P656]3EBI-739784,EBI-11901329
CLUAP1 [Q96AJ1]5EBI-739784,EBI-739780
COG3 - isoform 2 [Q96JB2-2]3EBI-739784,EBI-9091495
FAM161B [Q96MY7]3EBI-739784,EBI-7225287
FBF1 - isoform 6 [Q8TES7-6]3EBI-739784,EBI-10244131
FNDC11 [Q9BVV2]3EBI-739784,EBI-744935
GAS8 [O95995]3EBI-739784,EBI-1052570
GOLGA2 [Q08379]6EBI-739784,EBI-618309
INADL [A5PKX9]3EBI-739784,EBI-12035052
INCA1 [Q0VD86]3EBI-739784,EBI-6509505
KANK2 [Q63ZY3]3EBI-739784,EBI-2556193
MAGEA3 [P43357]3EBI-739784,EBI-5651459
MEOX2 [Q6FHY5]3EBI-739784,EBI-16439278
MINAR1 [Q9UPX6]3EBI-739784,EBI-11977115
MMADHC [Q9H3L0]3EBI-739784,EBI-11111575
MZT1 [Q08AG7]5EBI-739784,EBI-2637198
NDUFB7 [P17568]3EBI-739784,EBI-1246238
PAX6 [P26367]3EBI-739784,EBI-747278
POU6F2 [P78424]3EBI-739784,EBI-12029004
PRC1 [O43663]3EBI-739784,EBI-741137
PRRX1 [P54821]3EBI-739784,EBI-12828023
PSMA1 [P25786]3EBI-739784,EBI-359352
REL [Q04864]3EBI-739784,EBI-307352
REL - isoform 2 [Q04864-2]3EBI-739784,EBI-10829018
SERTAD1 [Q9UHV2]3EBI-739784,EBI-748601
SNRPD2 [P62316]3EBI-739784,EBI-297993
SP2 - isoform 2 [Q02086-2]3EBI-739784,EBI-9088579
SYCE1 [Q8N0S2]3EBI-739784,EBI-6872807
TEPSIN [Q96N21]3EBI-739784,EBI-11139477
TXNRD3NB [Q6F5E7]3EBI-739784,EBI-18122152
ZBTB42 [B2RXF5]3EBI-739784,EBI-12287587
ZNF19 [P17023]3EBI-739784,EBI-12884200
ZNF620 [Q6ZNG0]3EBI-739784,EBI-4395669

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119604, 53 interactors

Database of interacting proteins

More...DIPi		DIP-49011N

Protein interaction database and analysis system

More...IntActi		Q9BW66, 48 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216756

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BW66, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili73 – 107Sequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CINP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S092, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_077982_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BW66

Identification of Orthologs from Complete Genome Data

More...OMAi		DLMMVYL

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BW66

TreeFam database of animal gene trees

More...TreeFami		TF329462

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023250, Cyclin-dep_Kinase_2_interact

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02040, CDK2IP

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BW66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN 
        60         70         80         90        100
IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD 
       110        120        130        140        150
GLTKIQVKME KLSSTTKGIC ELENYHYGEE SKRPPLFHTW PTTHFYEVSH 
       160        170        180        190        200
KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL SYLSMWLHQP YVESDSRLHL 
       210 
ESMLLETGHR AL
Length:212
Mass (Da):24,324
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3678E123B8C206B1
GO
Isoform 2 (identifier: Q9BW66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-118: TKIQVKMEKLSSTTKG → MRFRISSWRCTGRSCS
     119-212: Missing.

Show »
Length:118
Mass (Da):13,287
Checksum:iEBAB2978717852CE
GO
Isoform 3 (identifier: Q9BW66-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MEA → MNGTIYANECQQIRHPNS

Show »
Length:227
Mass (Da):26,051
Checksum:i9245BA7C5767DA0B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKY0H0YKY0_HUMAN
Cyclin-dependent kinase 2-interacti...
CINP
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN33H0YN33_HUMAN
Cyclin-dependent kinase 2-interacti...
CINP
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BU174070 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157R → K in AAF44747 (PubMed:16082200).Curated1
Sequence conflicti157R → K in AAF44748 (PubMed:16082200).Curated1
Sequence conflicti175D → N in AAF44747 (PubMed:16082200).Curated1
Sequence conflicti175D → N in AAF44748 (PubMed:16082200).Curated1
Sequence conflicti194 – 197SDSR → NDNK in AAF44747 (PubMed:16082200).Curated4
Sequence conflicti194 – 197SDSR → NDNK in AAF44748 (PubMed:16082200).Curated4
Sequence conflicti196S → R in BU174070 (PubMed:15489334).Curated1
Sequence conflicti202S → N in AAF44747 (PubMed:16082200).Curated1
Sequence conflicti202S → N in AAF44748 (PubMed:16082200).Curated1
Sequence conflicti210 – 212RAL → PSSLTS in BU174070 (PubMed:15489334).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039979164R → H. Corresponds to variant dbSNP:rs7011Ensembl.1
Natural variantiVAR_039980177D → N in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0463861 – 3MEA → MNGTIYANECQQIRHPNS in isoform 3. 1 Publication3
Alternative sequenceiVSP_045342103 – 118TKIQV…STTKG → MRFRISSWRCTGRSCS in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_045343119 – 212Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF228148 mRNA Translation: AAF44747.1
AF228149 mRNA Translation: AAF44748.1
AK056112 mRNA Translation: BAB71095.1
DA167716 mRNA No translation available.
CR457178 mRNA Translation: CAG33459.1
AL137229 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81785.1
BC000600 mRNA Translation: AAH00600.1
BU174070 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53915.1 [Q9BW66-2]
CCDS9972.1 [Q9BW66-1]

NCBI Reference Sequences

More...RefSeqi		NP_001306975.1, NM_001320046.1 [Q9BW66-2]
NP_116019.1, NM_032630.2 [Q9BW66-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216756; ENSP00000216756; ENSG00000100865 [Q9BW66-1]
ENST00000536961; ENSP00000442057; ENSG00000100865 [Q9BW66-3]
ENST00000541568; ENSP00000442377; ENSG00000100865 [Q9BW66-2]
ENST00000559514; ENSP00000453839; ENSG00000100865 [Q9BW66-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51550

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51550

UCSC genome browser

More...UCSCi		uc001ylv.2, human [Q9BW66-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228148 mRNA Translation: AAF44747.1
AF228149 mRNA Translation: AAF44748.1
AK056112 mRNA Translation: BAB71095.1
DA167716 mRNA No translation available.
CR457178 mRNA Translation: CAG33459.1
AL137229 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81785.1
BC000600 mRNA Translation: AAH00600.1
BU174070 mRNA No translation available.
CCDSiCCDS53915.1 [Q9BW66-2]
CCDS9972.1 [Q9BW66-1]
RefSeqiNP_001306975.1, NM_001320046.1 [Q9BW66-2]
NP_116019.1, NM_032630.2 [Q9BW66-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119604, 53 interactors
DIPiDIP-49011N
IntActiQ9BW66, 48 interactors
STRINGi9606.ENSP00000216756

PTM databases

iPTMnetiQ9BW66
PhosphoSitePlusiQ9BW66

Genetic variation databases

BioMutaiCINP
DMDMi74733401

Proteomic databases

EPDiQ9BW66
jPOSTiQ9BW66
MassIVEiQ9BW66
MaxQBiQ9BW66
PaxDbiQ9BW66
PeptideAtlasiQ9BW66
PRIDEiQ9BW66
ProteomicsDBi27547
27731
79257 [Q9BW66-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27836, 120 antibodies

The DNASU plasmid repository

More...DNASUi		51550

Genome annotation databases

EnsembliENST00000216756; ENSP00000216756; ENSG00000100865 [Q9BW66-1]
ENST00000536961; ENSP00000442057; ENSG00000100865 [Q9BW66-3]
ENST00000541568; ENSP00000442377; ENSG00000100865 [Q9BW66-2]
ENST00000559514; ENSP00000453839; ENSG00000100865 [Q9BW66-1]
GeneIDi51550
KEGGihsa:51550
UCSCiuc001ylv.2, human [Q9BW66-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51550
DisGeNETi51550

GeneCards: human genes, protein and diseases

More...GeneCardsi		CINP
HGNCiHGNC:23789, CINP
HPAiENSG00000100865, Low tissue specificity
MIMi613362, gene
neXtProtiNX_Q9BW66
OpenTargetsiENSG00000100865
PharmGKBiPA165478684
VEuPathDBiHostDB:ENSG00000100865.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S092, Eukaryota
GeneTreeiENSGT00390000015784
HOGENOMiCLU_077982_0_0_1
InParanoidiQ9BW66
OMAiDLMMVYL
PhylomeDBiQ9BW66
TreeFamiTF329462

Enzyme and pathway databases

PathwayCommonsiQ9BW66

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51550, 677 hits in 1012 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51550
PharosiQ9BW66, Tbio

Protein Ontology

More...PROi		PR:Q9BW66
RNActiQ9BW66, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100865, Expressed in testis and 170 other tissues
ExpressionAtlasiQ9BW66, baseline and differential
GenevisibleiQ9BW66, HS

Family and domain databases

InterProiView protein in InterPro
IPR023250, Cyclin-dep_Kinase_2_interact
PRINTSiPR02040, CDK2IP

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCINP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BW66
Secondary accession number(s): F5H7P3, F5H8A7, Q9NPF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: April 7, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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