UniProtKB - Q9BW66 (CINP_HUMAN)
Protein
Cyclin-dependent kinase 2-interacting protein
Gene
CINP
Organism
Homo sapiens (Human)
Status
Functioni
Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.2 Publications
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
- DNA replication Source: UniProtKB-KW
Keywordsi
Biological process | Cell cycle, Cell division, DNA damage, DNA repair, DNA replication |
Enzyme and pathway databases
PathwayCommonsi | Q9BW66 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 2-interacting proteinShort name: CDK2-interacting protein |
Gene namesi | Name:CINP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23789, CINP |
MIMi | 613362, gene |
neXtProti | NX_Q9BW66 |
VEuPathDBi | HostDB:ENSG00000100865.14 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51550 |
OpenTargetsi | ENSG00000100865 |
PharmGKBi | PA165478684 |
Miscellaneous databases
Pharosi | Q9BW66, Tbio |
Genetic variation databases
BioMutai | CINP |
DMDMi | 74733401 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000326055 | 1 – 212 | Cyclin-dependent kinase 2-interacting proteinAdd BLAST | 212 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 69 | PhosphoserineCombined sources | 1 | |
Modified residuei | 73 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by CDC7 but not by CDK2.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BW66 |
jPOSTi | Q9BW66 |
MassIVEi | Q9BW66 |
MaxQBi | Q9BW66 |
PaxDbi | Q9BW66 |
PeptideAtlasi | Q9BW66 |
PRIDEi | Q9BW66 |
ProteomicsDBi | 27547 27731 79257 [Q9BW66-1] |
PTM databases
iPTMneti | Q9BW66 |
PhosphoSitePlusi | Q9BW66 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100865, Expressed in testis and 170 other tissues |
ExpressionAtlasi | Q9BW66, baseline and differential |
Genevisiblei | Q9BW66, HS |
Organism-specific databases
HPAi | ENSG00000100865, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with CDK2 and CDC7.
Interacts with the components of the replication complex, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 and with ORC2-containing complexes.
Interacts with ATRIP.
Interacts with CEP152.
3 PublicationsBinary interactionsi
Hide detailsQ9BW66
Protein-protein interaction databases
BioGRIDi | 119604, 53 interactors |
DIPi | DIP-49011N |
IntActi | Q9BW66, 48 interactors |
STRINGi | 9606.ENSP00000216756 |
Miscellaneous databases
RNActi | Q9BW66, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 73 – 107 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the CINP family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502S092, Eukaryota |
GeneTreei | ENSGT00390000015784 |
HOGENOMi | CLU_077982_0_0_1 |
InParanoidi | Q9BW66 |
OMAi | DLMMVYL |
PhylomeDBi | Q9BW66 |
TreeFami | TF329462 |
Family and domain databases
InterProi | View protein in InterPro IPR023250, Cyclin-dep_Kinase_2_interact |
PRINTSi | PR02040, CDK2IP |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BW66-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN
60 70 80 90 100
IANLKISLLN KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD
110 120 130 140 150
GLTKIQVKME KLSSTTKGIC ELENYHYGEE SKRPPLFHTW PTTHFYEVSH
160 170 180 190 200
KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL SYLSMWLHQP YVESDSRLHL
210
ESMLLETGHR AL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YKY0 | H0YKY0_HUMAN | Cyclin-dependent kinase 2-interacti... | CINP | 113 | Annotation score: | ||
H0YN33 | H0YN33_HUMAN | Cyclin-dependent kinase 2-interacti... | CINP | 213 | Annotation score: |
Sequence cautioni
The sequence BU174070 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 157 | R → K in AAF44747 (PubMed:16082200).Curated | 1 | |
Sequence conflicti | 157 | R → K in AAF44748 (PubMed:16082200).Curated | 1 | |
Sequence conflicti | 175 | D → N in AAF44747 (PubMed:16082200).Curated | 1 | |
Sequence conflicti | 175 | D → N in AAF44748 (PubMed:16082200).Curated | 1 | |
Sequence conflicti | 194 – 197 | SDSR → NDNK in AAF44747 (PubMed:16082200).Curated | 4 | |
Sequence conflicti | 194 – 197 | SDSR → NDNK in AAF44748 (PubMed:16082200).Curated | 4 | |
Sequence conflicti | 196 | S → R in BU174070 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 202 | S → N in AAF44747 (PubMed:16082200).Curated | 1 | |
Sequence conflicti | 202 | S → N in AAF44748 (PubMed:16082200).Curated | 1 | |
Sequence conflicti | 210 – 212 | RAL → PSSLTS in BU174070 (PubMed:15489334).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039979 | 164 | R → H. Corresponds to variant dbSNP:rs7011Ensembl. | 1 | |
Natural variantiVAR_039980 | 177 | D → N in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046386 | 1 – 3 | MEA → MNGTIYANECQQIRHPNS in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_045342 | 103 – 118 | TKIQV…STTKG → MRFRISSWRCTGRSCS in isoform 2. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_045343 | 119 – 212 | Missing in isoform 2. 1 PublicationAdd BLAST | 94 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF228148 mRNA Translation: AAF44747.1 AF228149 mRNA Translation: AAF44748.1 AK056112 mRNA Translation: BAB71095.1 DA167716 mRNA No translation available. CR457178 mRNA Translation: CAG33459.1 AL137229 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81785.1 BC000600 mRNA Translation: AAH00600.1 BU174070 mRNA No translation available. |
CCDSi | CCDS53915.1 [Q9BW66-2] CCDS9972.1 [Q9BW66-1] |
RefSeqi | NP_001306975.1, NM_001320046.1 [Q9BW66-2] NP_116019.1, NM_032630.2 [Q9BW66-1] |
Genome annotation databases
Ensembli | ENST00000216756; ENSP00000216756; ENSG00000100865 [Q9BW66-1] ENST00000536961; ENSP00000442057; ENSG00000100865 [Q9BW66-3] ENST00000541568; ENSP00000442377; ENSG00000100865 [Q9BW66-2] ENST00000559514; ENSP00000453839; ENSG00000100865 [Q9BW66-1] |
GeneIDi | 51550 |
KEGGi | hsa:51550 |
UCSCi | uc001ylv.2, human [Q9BW66-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF228148 mRNA Translation: AAF44747.1 AF228149 mRNA Translation: AAF44748.1 AK056112 mRNA Translation: BAB71095.1 DA167716 mRNA No translation available. CR457178 mRNA Translation: CAG33459.1 AL137229 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81785.1 BC000600 mRNA Translation: AAH00600.1 BU174070 mRNA No translation available. |
CCDSi | CCDS53915.1 [Q9BW66-2] CCDS9972.1 [Q9BW66-1] |
RefSeqi | NP_001306975.1, NM_001320046.1 [Q9BW66-2] NP_116019.1, NM_032630.2 [Q9BW66-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119604, 53 interactors |
DIPi | DIP-49011N |
IntActi | Q9BW66, 48 interactors |
STRINGi | 9606.ENSP00000216756 |
PTM databases
iPTMneti | Q9BW66 |
PhosphoSitePlusi | Q9BW66 |
Genetic variation databases
BioMutai | CINP |
DMDMi | 74733401 |
Proteomic databases
EPDi | Q9BW66 |
jPOSTi | Q9BW66 |
MassIVEi | Q9BW66 |
MaxQBi | Q9BW66 |
PaxDbi | Q9BW66 |
PeptideAtlasi | Q9BW66 |
PRIDEi | Q9BW66 |
ProteomicsDBi | 27547 27731 79257 [Q9BW66-1] |
Protocols and materials databases
Antibodypediai | 27836, 120 antibodies |
DNASUi | 51550 |
Genome annotation databases
Ensembli | ENST00000216756; ENSP00000216756; ENSG00000100865 [Q9BW66-1] ENST00000536961; ENSP00000442057; ENSG00000100865 [Q9BW66-3] ENST00000541568; ENSP00000442377; ENSG00000100865 [Q9BW66-2] ENST00000559514; ENSP00000453839; ENSG00000100865 [Q9BW66-1] |
GeneIDi | 51550 |
KEGGi | hsa:51550 |
UCSCi | uc001ylv.2, human [Q9BW66-1] |
Organism-specific databases
CTDi | 51550 |
DisGeNETi | 51550 |
GeneCardsi | CINP |
HGNCi | HGNC:23789, CINP |
HPAi | ENSG00000100865, Low tissue specificity |
MIMi | 613362, gene |
neXtProti | NX_Q9BW66 |
OpenTargetsi | ENSG00000100865 |
PharmGKBi | PA165478684 |
VEuPathDBi | HostDB:ENSG00000100865.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S092, Eukaryota |
GeneTreei | ENSGT00390000015784 |
HOGENOMi | CLU_077982_0_0_1 |
InParanoidi | Q9BW66 |
OMAi | DLMMVYL |
PhylomeDBi | Q9BW66 |
TreeFami | TF329462 |
Enzyme and pathway databases
PathwayCommonsi | Q9BW66 |
Miscellaneous databases
BioGRID-ORCSi | 51550, 677 hits in 1012 CRISPR screens |
GenomeRNAii | 51550 |
Pharosi | Q9BW66, Tbio |
PROi | PR:Q9BW66 |
RNActi | Q9BW66, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100865, Expressed in testis and 170 other tissues |
ExpressionAtlasi | Q9BW66, baseline and differential |
Genevisiblei | Q9BW66, HS |
Family and domain databases
InterProi | View protein in InterPro IPR023250, Cyclin-dep_Kinase_2_interact |
PRINTSi | PR02040, CDK2IP |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CINP_HUMAN | |
Accessioni | Q9BW66Primary (citable) accession number: Q9BW66 Secondary accession number(s): F5H7P3, F5H8A7, Q9NPF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families