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Protein

Katanin p60 ATPase-containing subunit A-like 1

Gene

KATNAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214).By similarity1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi248 – 255ATPUniRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • microtubule binding Source: InterPro
  • microtubule-severing ATPase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p60 ATPase-containing subunit A-like 1UniRule annotation (EC:3.6.4.3UniRule annotation)
Short name:
Katanin p60 subunit A-like 1UniRule annotation
Alternative name(s):
p60 katanin-like 1UniRule annotation
Gene namesi
Name:KATNAL1UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102781.13
HGNCiHGNC:28361 KATNAL1
MIMi614764 gene
neXtProtiNX_Q9BW62

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102781
PharmGKBiPA134951885

Polymorphism and mutation databases

BioMutaiKATNAL1
DMDMi60390214

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846011 – 490Katanin p60 ATPase-containing subunit A-like 1Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei174PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BW62
MaxQBiQ9BW62
PaxDbiQ9BW62
PeptideAtlasiQ9BW62
PRIDEiQ9BW62
ProteomicsDBi79256

PTM databases

iPTMnetiQ9BW62
PhosphoSitePlusiQ9BW62

Expressioni

Tissue specificityi

Expressed in testis, restricted to Sertoli cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000102781 Expressed in 201 organ(s), highest expression level in secondary oocyte
CleanExiHS_KATNAL1
ExpressionAtlasiQ9BW62 baseline and differential
GenevisibleiQ9BW62 HS

Organism-specific databases

HPAiHPA046205

Interactioni

Subunit structurei

Interacts with KATNB1 and KATNBL1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123851, 18 interactors
IntActiQ9BW62, 46 interactors
STRINGi9606.ENSP00000369989

Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BW62
SMRiQ9BW62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0738 Eukaryota
ENOG410XPN7 LUCA
GeneTreeiENSGT00550000074466
HOGENOMiHOG000225142
HOVERGENiHBG057074
InParanoidiQ9BW62
KOiK07767
OMAiDKGRKNM
OrthoDBiEOG091G0Q8J
PhylomeDBiQ9BW62
TreeFamiTF323170

Family and domain databases

HAMAPiMF_03023 Katanin_p60_A1, 1 hit
MF_03024 Katanin_p60_AL1, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR028596 KATNA1
IPR028594 Katnal1_chordates
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9BW62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLAEICDNA KKGREYALLG NYDSSMVYYQ GVMQQIQRHC QSVRDPAIKG
60 70 80 90 100
KWQQVRQELL EEYEQVKSIV STLESFKIDK PPDFPVSCQD EPFRDPAVWP
110 120 130 140 150
PPVPAEHRAP PQIRRPNREV RPLRKEMAGV GARGPVGRAH PISKSEKPST
160 170 180 190 200
SRDKDYRARG RDDKGRKNMQ DGASDGEMPK FDGAGYDKDL VEALERDIVS
210 220 230 240 250
RNPSIHWDDI ADLEEAKKLL REAVVLPMWM PDFFKGIRRP WKGVLMVGPP
260 270 280 290 300
GTGKTMLAKA VATECGTTFF NVSSSTLTSK YRGESEKLVR LLFEMARFYA
310 320 330 340 350
PTTIFIDEID SICSRRGTSD EHEASRRVKS ELLIQMDGVG GALENDDPSK
360 370 380 390 400
MVMVLAATNF PWDIDEALRR RLEKRIYIPL PTAKGRAELL KINLREVELD
410 420 430 440 450
PDIQLEDIAE KIEGYSGADI TNVCRDASLM AMRRRINGLS PEEIRALSKE
460 470 480 490
ELQMPVTKGD FELALKKIAK SVSAADLEKY EKWMVEFGSA
Length:490
Mass (Da):55,392
Last modified:June 1, 2001 - v1
Checksum:iCB8E51A77E5CB487
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T558Q5T558_HUMAN
Katanin p60 ATPase-containing subun...
KATNAL1
150Annotation score:
A2A3H2A2A3H2_HUMAN
Katanin p60 ATPase-containing subun...
KATNAL1
153Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291439 mRNA Translation: BAF84128.1
AL356750 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08452.1
BC000612 mRNA Translation: AAH00612.1
CCDSiCCDS31956.1
RefSeqiNP_001014402.1, NM_001014380.2
NP_115492.1, NM_032116.4
XP_005266631.1, XM_005266574.2
UniGeneiHs.243596

Genome annotation databases

EnsembliENST00000380615; ENSP00000369989; ENSG00000102781
ENST00000380617; ENSP00000369991; ENSG00000102781
GeneIDi84056
KEGGihsa:84056
UCSCiuc001uss.5 human

Similar proteinsi

Entry informationi

Entry nameiKATL1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW62
Secondary accession number(s): A8K5X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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