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Protein

DET1- and DDB1-associated protein 1

Gene

DDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.1 Publication

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
DET1- and DDB1-associated protein 1
Alternative name(s):
Placenta cross-immune reaction antigen 1
Short name:
PCIA-1
Gene namesi
Name:DDA1
Synonyms:C19orf58, PCIA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130311.10
HGNCiHGNC:28360 DDA1
neXtProtiNX_Q9BW61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130311
PharmGKBiPA162383418

Polymorphism and mutation databases

BioMutaiDDA1
DMDMi74733400

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003102702 – 102DET1- and DDB1-associated protein 1Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BW61
MaxQBiQ9BW61
PaxDbiQ9BW61
PeptideAtlasiQ9BW61
PRIDEiQ9BW61
ProteomicsDBi79255
TopDownProteomicsiQ9BW61

PTM databases

iPTMnetiQ9BW61
PhosphoSitePlusiQ9BW61

Expressioni

Gene expression databases

BgeeiENSG00000130311 Expressed in 187 organ(s), highest expression level in testis
CleanExiHS_DDA1
ExpressionAtlasiQ9BW61 baseline and differential
GenevisibleiQ9BW61 HS

Organism-specific databases

HPAiHPA042134
HPA055272

Interactioni

Subunit structurei

Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi122485, 91 interactors
DIPiDIP-53527N
IntActiQ9BW61, 59 interactors
MINTiQ9BW61
STRINGi9606.ENSP00000352928

Structurei

3D structure databases

ProteinModelPortaliQ9BW61
SMRiQ9BW61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDA1 family.Curated

Phylogenomic databases

eggNOGiKOG4816 Eukaryota
ENOG41120QM LUCA
GeneTreeiENSGT00390000007029
HOGENOMiHOG000006384
HOVERGENiHBG055081
InParanoidiQ9BW61
KOiK11792
OMAiRTDSQDM
OrthoDBiEOG091G129W
PhylomeDBiQ9BW61
TreeFamiTF323534

Family and domain databases

InterProiView protein in InterPro
IPR033575 DDA1
IPR018276 DDA1_N
PANTHERiPTHR31879 PTHR31879, 1 hit
PfamiView protein in Pfam
PF10172 DDA1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BW61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE
60 70 80 90 100
KTNILLRYLH QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE

DT
Length:102
Mass (Da):11,835
Last modified:June 1, 2001 - v1
Checksum:i94E43C3528589F01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ090952 mRNA Translation: AAZ41375.1
AY563006 mRNA Translation: AAS66629.1
CH471106 Genomic DNA Translation: EAW84593.1
BC000615 mRNA Translation: AAH00615.1
CCDSiCCDS12357.1
RefSeqiNP_076955.1, NM_024050.5
UniGeneiHs.466154

Genome annotation databases

EnsembliENST00000359866; ENSP00000352928; ENSG00000130311
ENST00000593466; ENSP00000473086; ENSG00000130311
ENST00000596582; ENSP00000472171; ENSG00000130311
GeneIDi79016
KEGGihsa:79016
UCSCiuc002ngd.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ090952 mRNA Translation: AAZ41375.1
AY563006 mRNA Translation: AAS66629.1
CH471106 Genomic DNA Translation: EAW84593.1
BC000615 mRNA Translation: AAH00615.1
CCDSiCCDS12357.1
RefSeqiNP_076955.1, NM_024050.5
UniGeneiHs.466154

3D structure databases

ProteinModelPortaliQ9BW61
SMRiQ9BW61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122485, 91 interactors
DIPiDIP-53527N
IntActiQ9BW61, 59 interactors
MINTiQ9BW61
STRINGi9606.ENSP00000352928

PTM databases

iPTMnetiQ9BW61
PhosphoSitePlusiQ9BW61

Polymorphism and mutation databases

BioMutaiDDA1
DMDMi74733400

Proteomic databases

EPDiQ9BW61
MaxQBiQ9BW61
PaxDbiQ9BW61
PeptideAtlasiQ9BW61
PRIDEiQ9BW61
ProteomicsDBi79255
TopDownProteomicsiQ9BW61

Protocols and materials databases

DNASUi79016
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359866; ENSP00000352928; ENSG00000130311
ENST00000593466; ENSP00000473086; ENSG00000130311
ENST00000596582; ENSP00000472171; ENSG00000130311
GeneIDi79016
KEGGihsa:79016
UCSCiuc002ngd.4 human

Organism-specific databases

CTDi79016
EuPathDBiHostDB:ENSG00000130311.10
GeneCardsiDDA1
H-InvDBiHIX0137478
HGNCiHGNC:28360 DDA1
HPAiHPA042134
HPA055272
neXtProtiNX_Q9BW61
OpenTargetsiENSG00000130311
PharmGKBiPA162383418
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4816 Eukaryota
ENOG41120QM LUCA
GeneTreeiENSGT00390000007029
HOGENOMiHOG000006384
HOVERGENiHBG055081
InParanoidiQ9BW61
KOiK11792
OMAiRTDSQDM
OrthoDBiEOG091G129W
PhylomeDBiQ9BW61
TreeFamiTF323534

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSiDDA1 human
GenomeRNAii79016
PROiPR:Q9BW61

Gene expression databases

BgeeiENSG00000130311 Expressed in 187 organ(s), highest expression level in testis
CleanExiHS_DDA1
ExpressionAtlasiQ9BW61 baseline and differential
GenevisibleiQ9BW61 HS

Family and domain databases

InterProiView protein in InterPro
IPR033575 DDA1
IPR018276 DDA1_N
PANTHERiPTHR31879 PTHR31879, 1 hit
PfamiView protein in Pfam
PF10172 DDA1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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