UniProtKB - Q9BW61 (DDA1_HUMAN)
DET1- and DDB1-associated protein 1
DDA1
Functioni
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17452440, PubMed:28437394, PubMed:28302793, PubMed:31686031, PubMed:31819272).
In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex (PubMed:31686031, PubMed:31819272).
5 Publications: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.2 PublicationsView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
- protein polyubiquitination Source: UniProtKB
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9BW61 |
Reactomei | R-HSA-8951664, Neddylation |
SignaLinki | Q9BW61 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: DET1- and DDB1-associated protein 11 PublicationAlternative name(s): Placenta cross-immune reaction antigen 11 Publication Short name: PCIA-11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28360, DDA1 |
neXtProti | NX_Q9BW61 |
VEuPathDBi | HostDB:ENSG00000130311 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79016 |
OpenTargetsi | ENSG00000130311 |
PharmGKBi | PA162383418 |
Miscellaneous databases
Pharosi | Q9BW61, Tbio |
Genetic variation databases
BioMutai | DDA1 |
DMDMi | 74733400 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000310270 | 2 – 102 | DET1- and DDB1-associated protein 1Add BLAST | 101 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BW61 |
jPOSTi | Q9BW61 |
MassIVEi | Q9BW61 |
MaxQBi | Q9BW61 |
PaxDbi | Q9BW61 |
PeptideAtlasi | Q9BW61 |
PRIDEi | Q9BW61 |
ProteomicsDBi | 79255 |
TopDownProteomicsi | Q9BW61 |
PTM databases
iPTMneti | Q9BW61 |
PhosphoSitePlusi | Q9BW61 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130311, Expressed in testis and 204 other tissues |
ExpressionAtlasi | Q9BW61, baseline and differential |
Genevisiblei | Q9BW61, HS |
Organism-specific databases
HPAi | ENSG00000130311, Low tissue specificity |
Interactioni
Subunit structurei
Component of numerous DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1 (PubMed:28437394, PubMed:28302793, PubMed:31693891, PubMed:31686031, PubMed:31819272, PubMed:31693911).
Component of the DCX(DCAF15) complex, also named CLR4(DCAF15) complex, composed of DCAF15, DDB1, cullin-4 (CUL4A or CUL4B), DDA1 and RBX1 (PubMed:28437394, PubMed:28302793, PubMed:31693891, PubMed:31686031, PubMed:31819272, PubMed:31693911). Part of the DDD core complex containing DET1, DDA1 and DDB1; the DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes (PubMed:17452440).
7 PublicationsBinary interactionsi
Q9BW61
Protein-protein interaction databases
BioGRIDi | 122485, 152 interactors |
DIPi | DIP-53527N |
IntActi | Q9BW61, 75 interactors |
MINTi | Q9BW61 |
STRINGi | 9606.ENSP00000352928 |
Miscellaneous databases
RNActi | Q9BW61, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9BW61 |
SMRi | Q9BW61 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 66 – 102 | DisorderedSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4816, Eukaryota |
GeneTreei | ENSGT00390000007029 |
HOGENOMi | CLU_144562_1_0_1 |
InParanoidi | Q9BW61 |
OMAi | MARTDSE |
OrthoDBi | 1521756at2759 |
PhylomeDBi | Q9BW61 |
TreeFami | TF323534 |
Family and domain databases
InterProi | View protein in InterPro IPR033575, DDA1 IPR018276, DDA1_N |
PANTHERi | PTHR31879, PTHR31879, 1 hit |
Pfami | View protein in Pfam PF10172, DDA1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE
60 70 80 90 100
KTNILLRYLH QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE
DT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ090952 mRNA Translation: AAZ41375.1 AY563006 mRNA Translation: AAS66629.1 CH471106 Genomic DNA Translation: EAW84593.1 BC000615 mRNA Translation: AAH00615.1 |
CCDSi | CCDS12357.1 |
RefSeqi | NP_076955.1, NM_024050.5 |
Genome annotation databases
Ensembli | ENST00000359866.9; ENSP00000352928.3; ENSG00000130311.11 ENST00000593466.5; ENSP00000473086.1; ENSG00000130311.11 ENST00000596582.1; ENSP00000472171.1; ENSG00000130311.11 |
GeneIDi | 79016 |
KEGGi | hsa:79016 |
MANE-Selecti | ENST00000359866.9; ENSP00000352928.3; NM_024050.6; NP_076955.1 |
UCSCi | uc002ngd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ090952 mRNA Translation: AAZ41375.1 AY563006 mRNA Translation: AAS66629.1 CH471106 Genomic DNA Translation: EAW84593.1 BC000615 mRNA Translation: AAH00615.1 |
CCDSi | CCDS12357.1 |
RefSeqi | NP_076955.1, NM_024050.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6DSZ | X-ray | 3.09 | C/D | 1-19 | [»] | |
6PAI | X-ray | 2.90 | E | 1-102 | [»] | |
6Q0R | X-ray | 2.90 | E | 1-102 | [»] | |
6Q0V | X-ray | 2.90 | E | 1-102 | [»] | |
6Q0W | X-ray | 2.90 | E | 1-102 | [»] | |
6SJ7 | electron microscopy | 3.54 | D | 2-102 | [»] | |
6UD7 | X-ray | 2.30 | D | 2-102 | [»] | |
6UE5 | X-ray | 2.61 | D | 2-102 | [»] | |
AlphaFoldDBi | Q9BW61 | |||||
SMRi | Q9BW61 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122485, 152 interactors |
DIPi | DIP-53527N |
IntActi | Q9BW61, 75 interactors |
MINTi | Q9BW61 |
STRINGi | 9606.ENSP00000352928 |
PTM databases
iPTMneti | Q9BW61 |
PhosphoSitePlusi | Q9BW61 |
Genetic variation databases
BioMutai | DDA1 |
DMDMi | 74733400 |
Proteomic databases
EPDi | Q9BW61 |
jPOSTi | Q9BW61 |
MassIVEi | Q9BW61 |
MaxQBi | Q9BW61 |
PaxDbi | Q9BW61 |
PeptideAtlasi | Q9BW61 |
PRIDEi | Q9BW61 |
ProteomicsDBi | 79255 |
TopDownProteomicsi | Q9BW61 |
Protocols and materials databases
Antibodypediai | 43757, 177 antibodies from 27 providers |
DNASUi | 79016 |
Genome annotation databases
Ensembli | ENST00000359866.9; ENSP00000352928.3; ENSG00000130311.11 ENST00000593466.5; ENSP00000473086.1; ENSG00000130311.11 ENST00000596582.1; ENSP00000472171.1; ENSG00000130311.11 |
GeneIDi | 79016 |
KEGGi | hsa:79016 |
MANE-Selecti | ENST00000359866.9; ENSP00000352928.3; NM_024050.6; NP_076955.1 |
UCSCi | uc002ngd.4, human |
Organism-specific databases
CTDi | 79016 |
DisGeNETi | 79016 |
GeneCardsi | DDA1 |
HGNCi | HGNC:28360, DDA1 |
HPAi | ENSG00000130311, Low tissue specificity |
neXtProti | NX_Q9BW61 |
OpenTargetsi | ENSG00000130311 |
PharmGKBi | PA162383418 |
VEuPathDBi | HostDB:ENSG00000130311 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4816, Eukaryota |
GeneTreei | ENSGT00390000007029 |
HOGENOMi | CLU_144562_1_0_1 |
InParanoidi | Q9BW61 |
OMAi | MARTDSE |
OrthoDBi | 1521756at2759 |
PhylomeDBi | Q9BW61 |
TreeFami | TF323534 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9BW61 |
Reactomei | R-HSA-8951664, Neddylation |
SignaLinki | Q9BW61 |
Miscellaneous databases
BioGRID-ORCSi | 79016, 182 hits in 1086 CRISPR screens |
ChiTaRSi | DDA1, human |
GenomeRNAii | 79016 |
Pharosi | Q9BW61, Tbio |
PROi | PR:Q9BW61 |
RNActi | Q9BW61, protein |
Gene expression databases
Bgeei | ENSG00000130311, Expressed in testis and 204 other tissues |
ExpressionAtlasi | Q9BW61, baseline and differential |
Genevisiblei | Q9BW61, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033575, DDA1 IPR018276, DDA1_N |
PANTHERi | PTHR31879, PTHR31879, 1 hit |
Pfami | View protein in Pfam PF10172, DDA1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DDA1_HUMAN | |
Accessioni | Q9BW61Primary (citable) accession number: Q9BW61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families