UniProtKB - Q9BW19 (KIFC1_HUMAN)

BLAST

>sp|Q9BW19|KIFC1_HUMAN Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2
MDPQRSPLLEVKGNIELKRPLIKAPSQLPLSGSRLKRRPDQMEDGLEPEKKRTRGLGATT
KITTSHPRVPSLTTVPQTQGQTTAQKVSKKTGPRCSTAIATGLKNQKPVPAVPVQKSGTS
GVPPMAGGKKPSKRPAWDLKGQLCDLNAELKRCRERTQTLDQENQQLQDQLRDAQQQVKA
LGTERTTLEGHLAKVQAQAEQGQQELKNLRACVLELEERLSTQEGLVQELQKKQVELQEE
RRGLMSQLEEKERRLQTSEAALSSSQAEVASLRQETVAQAALLTEREERLHGLEMERRRL
HNQLQELKGNIRVFCRVRPVLPGEPTPPPGLLLFPSGPGGPSDPPTRLSLSRSDERRGTL
SGAPAPPTRHDFSFDRVFPPGSGQDEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTM
EGGPGGDPQLEGLIPRALRHLFSVAQELSGQGWTYSFVASYVEIYNETVRDLLATGTRKG
QGGECEIRRAGPGSEELTVTNARYVPVSCEKEVDALLHLARQNRAVARTAQNERSSRSHS
VFQLQISGEHSSRGLQCGAPLSLVDLAGSERLDPGLALGPGERERLRETQAINSSLSTLG
LVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKV
NQCVIGTAQANRK

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History
Entry version 166 (07 Nov 2018)
Sequence version 2 (23 Jan 2002)
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Protein

Kinesin-like protein KIFC1

Gene

KIFC1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).By similarity1 Publication

Miscellaneous

HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	410 – 417	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ATP binding
Source: UniProtKB
Non-traceable author statementⁱ
- 8276466
microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
microtubule motor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
microtubule-based movement
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitotic metaphase plate congression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15843429
mitotic sister chromatid segregation
Source: UniProtKB
Non-traceable author statementⁱ
- 8276466
mitotic spindle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15843429
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Motor protein
Biological process	Cell cycle, Cell division, Mitosis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189 Kinesins

Reactomeⁱ

R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinesin-like protein KIFC1 Alternative name(s): Kinesin-like protein 2 Kinesin-related protein HSET
Gene namesⁱ	Name:KIFC1 Synonyms:HSET, KNSL2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000237649.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6389 KIFC1
MIMⁱ	603763 gene
neXtProtⁱ	NX_Q9BW19

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3833
Open Targets More...OpenTargetsⁱ	ENSG00000237649
PharmGKBⁱ	PA30178

Chemistry databases

ChEMBLⁱ	CHEMBL3351200

ChEMBLⁱ

CHEMBL3351200

Polymorphism and mutation databases

BioMutaⁱ	KIFC1
DMDMⁱ	20138710

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000125428	1 – 673	Kinesin-like protein KIFC1Add BLAST		673

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	6	PhosphoserineCombined sources	1
Modified residueⁱ	26	PhosphoserineCombined sources	1
Modified residueⁱ	31	PhosphoserineCombined sources	1
Modified residueⁱ	33	PhosphoserineCombined sources	1
Modified residueⁱ	359	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BW19
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BW19
PaxDbⁱ	Q9BW19
PeptideAtlas More...PeptideAtlasⁱ	Q9BW19
PRIDEⁱ	Q9BW19
ProteomicsDBⁱ	79250

PTM databases

iPTMnetⁱ	Q9BW19
PhosphoSitePlusⁱ	Q9BW19

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000237649 Expressed in 147 organ(s), highest expression level in embryo
CleanExⁱ	HS_KIFC1
ExpressionAtlasⁱ	Q9BW19 baseline and differential
Genevisibleⁱ	Q9BW19 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA055997 HPA062674

HPAⁱ

HPA055997
HPA062674

Interactionⁱ

Subunit structureⁱ

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).By similarity

GO - Molecular functionⁱ

microtubule binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110031, 20 interactors
IntActⁱ	Q9BW19, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q9BW19
STRINGⁱ	9606.ENSP00000393963

Chemistry databases

BindingDBⁱ

Q9BW19

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	311 – 317	Combined sources	7
Beta strandⁱ	331 – 333	Combined sources	3
Beta strandⁱ	347 – 350	Combined sources	4
Beta strandⁱ	371 – 373	Combined sources	3
Beta strandⁱ	375 – 378	Combined sources	4
Helixⁱ	384 – 389	Combined sources	6
Helixⁱ	392 – 396	Combined sources	5
Helixⁱ	397 – 400	Combined sources	4
Beta strandⁱ	404 – 411	Combined sources	8
Helixⁱ	416 – 420	Combined sources	5
Helixⁱ	428 – 430	Combined sources	3
Helixⁱ	433 – 449	Combined sources	17
Turnⁱ	450 – 452	Combined sources	3
Beta strandⁱ	453 – 465	Combined sources	13
Beta strandⁱ	468 – 471	Combined sources	4
Beta strandⁱ	487 – 489	Combined sources	3
Beta strandⁱ	497 – 499	Combined sources	3
Helixⁱ	510 – 526	Combined sources	17
Helixⁱ	535 – 537	Combined sources	3
Beta strandⁱ	538 – 554	Combined sources	17
Beta strandⁱ	556 – 565	Combined sources	10
Helixⁱ	596 – 607	Combined sources	12
Helixⁱ	615 – 617	Combined sources	3
Helixⁱ	619 – 624	Combined sources	6
Helixⁱ	625 – 627	Combined sources	3
Beta strandⁱ	633 – 640	Combined sources	8
Helixⁱ	644 – 646	Combined sources	3
Helixⁱ	647 – 662	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BW19
SMRⁱ	Q9BW19
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BW19

EvolutionaryTraceⁱ

Q9BW19

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	310 – 663	Kinesin motorPROSITE-ProRule annotationAdd BLAST		354

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	142 – 306	Sequence analysisAdd BLAST		165

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0239 Eukaryota COG5059 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149025
HOVERGENⁱ	HBG001080
InParanoidⁱ	Q9BW19
KEGG Orthology (KO) More...KOⁱ	K10405
OMAⁱ	YNEVLYD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DJX
PhylomeDBⁱ	Q9BW19
TreeFamⁱ	TF105237

Family and domain databases

Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR027640 Kinesin-like_fam IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00225 Kinesin, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00129 KISc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9BW19-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK 
        60         70         80         90        100
KRTRGLGATT KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA 
       110        120        130        140        150
TGLKNQKPVP AVPVQKSGTS GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL 
       160        170        180        190        200
KRCRERTQTL DQENQQLQDQ LRDAQQQVKA LGTERTTLEG HLAKVQAQAE 
       210        220        230        240        250
QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE RRGLMSQLEE 
       260        270        280        290        300
KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL 
       310        320        330        340        350
HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL 
       360        370        380        390        400
SRSDERRGTL SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD 
       410        420        430        440        450
GYPVCIFAYG QTGSGKTFTM EGGPGGDPQL EGLIPRALRH LFSVAQELSG 
       460        470        480        490        500
QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGGECEIRRA GPGSEELTVT 
       510        520        530        540        550
NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS VFQLQISGEH 
       560        570        580        590        600
SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG 
       610        620        630        640        650
LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES 
       660        670 
LNSLRFASKV NQCVIGTAQA NRK

Length:673

Mass (Da):73,748

Last modified:January 23, 2002 - v2

Checksum:ⁱ9E99737665BF1E92

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087X1W5	A0A087X1W5_HUMAN	Kinesin-like protein KIFC1 Kinesin-like protein KIFC1	KIFC1	154	Annotation score:
A2AB20	A2AB20_HUMAN	Kinesin-like protein KIFC1 Kinesin-like protein KIFC1	KIFC1	203	Annotation score:
A0A140T9E6	A0A140T9E6_HUMAN	Kinesin-like protein KIFC1 Kinesin-like protein KIFC1	KIFC1	203	Annotation score:

Sequence cautionⁱ

The sequence AAH00712 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH63567 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH73878 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH98438 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA03509 differs from that shown. Reason: Frameshift at positions 223 and 256.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	368	T → P in AAH00712 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_012650	219	R → Q1 PublicationCorresponds to variant dbSNP:rs61736175Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ010479 mRNA Translation: CAA09217.1 AL021366 Genomic DNA Translation: CAA16157.1 AL050332 Genomic DNA Translation: CAB63782.1 AL662799 Genomic DNA No translation available. BX088650 Genomic DNA No translation available. BX248088 Genomic DNA No translation available. BC000712 mRNA Translation: AAH00712.2 Different initiation. BC063567 mRNA Translation: AAH63567.1 Different initiation. BC073878 mRNA Translation: AAH73878.1 Different initiation. BC098438 mRNA Translation: AAH98438.1 Different initiation. BC121041 mRNA Translation: AAI21042.1 BC121042 mRNA Translation: AAI21043.1 D14678 mRNA Translation: BAA03509.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34430.1
PIRⁱ	I54523
NCBI Reference Sequences More...RefSeqⁱ	NP_002254.2, NM_002263.3
UniGeneⁱ	Hs.436912

Genome annotation databases

Ensemblⁱ	ENST00000374523; ENSP00000363647; ENSG00000204197 ENST00000428849; ENSP00000393963; ENSG00000237649 ENST00000448818; ENSP00000407885; ENSG00000233450
GeneIDⁱ	3833
KEGGⁱ	hsa:3833
UCSC genome browser More...UCSCⁱ	uc003oef.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BW19	Kinesin-like protein		HUMAN		673	UniRef100_Q9BW19

Protein	Similar proteins		Species	Score	Length	Source
Q9BW19	Kinesin-like protein		HUMAN		673	UniRef90_Q9BW19
Kinesin-like protein		PANTR		688
Kinesin-like protein		PANPA		688
Kinesin-like protein		CALJA		673
Kinesin-like protein		MACMU		673
+52

Protein	Similar proteins		Species	Score	Length	Source
Q9BW19	Kinesin-like protein KIFC1		MOUSE		674	UniRef50_Q9QWT9
Kinesin-like protein KIFC1		RAT		693
Kinesin-like protein KIFC1		CRIGR		622
Kinesin-like protein		FUKDA		705
Kinesin-like protein		CHEMY		627
+210

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ010479 mRNA Translation: CAA09217.1 AL021366 Genomic DNA Translation: CAA16157.1 AL050332 Genomic DNA Translation: CAB63782.1 AL662799 Genomic DNA No translation available. BX088650 Genomic DNA No translation available. BX248088 Genomic DNA No translation available. BC000712 mRNA Translation: AAH00712.2 Different initiation. BC063567 mRNA Translation: AAH63567.1 Different initiation. BC073878 mRNA Translation: AAH73878.1 Different initiation. BC098438 mRNA Translation: AAH98438.1 Different initiation. BC121041 mRNA Translation: AAI21042.1 BC121042 mRNA Translation: AAI21043.1 D14678 mRNA Translation: BAA03509.1 Frameshift.
CCDSⁱ	CCDS34430.1
PIRⁱ	I54523
RefSeqⁱ	NP_002254.2, NM_002263.3
UniGeneⁱ	Hs.436912

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5WDH	X-ray	2.25	A	307-663	[»]
ProteinModelPortalⁱ	Q9BW19
SMRⁱ	Q9BW19
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110031, 20 interactors
IntActⁱ	Q9BW19, 14 interactors
MINTⁱ	Q9BW19
STRINGⁱ	9606.ENSP00000393963

Chemistry databases

BindingDBⁱ	Q9BW19
ChEMBLⁱ	CHEMBL3351200

PTM databases

iPTMnetⁱ	Q9BW19
PhosphoSitePlusⁱ	Q9BW19

Polymorphism and mutation databases

BioMutaⁱ	KIFC1
DMDMⁱ	20138710

Proteomic databases

EPDⁱ	Q9BW19
MaxQBⁱ	Q9BW19
PaxDbⁱ	Q9BW19
PeptideAtlasⁱ	Q9BW19
PRIDEⁱ	Q9BW19
ProteomicsDBⁱ	79250

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000374523; ENSP00000363647; ENSG00000204197 ENST00000428849; ENSP00000393963; ENSG00000237649 ENST00000448818; ENSP00000407885; ENSG00000233450
GeneIDⁱ	3833
KEGGⁱ	hsa:3833
UCSCⁱ	uc003oef.5 human

Organism-specific databases

CTDⁱ	3833
DisGeNETⁱ	3833
EuPathDBⁱ	HostDB:ENSG00000237649.7
GeneCardsⁱ	KIFC1
HGNCⁱ	HGNC:6389 KIFC1
HPAⁱ	HPA055997 HPA062674
MIMⁱ	603763 gene
neXtProtⁱ	NX_Q9BW19
OpenTargetsⁱ	ENSG00000237649
PharmGKBⁱ	PA30178
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0239 Eukaryota COG5059 LUCA
GeneTreeⁱ	ENSGT00920000149025
HOVERGENⁱ	HBG001080
InParanoidⁱ	Q9BW19
KOⁱ	K10405
OMAⁱ	YNEVLYD
OrthoDBⁱ	EOG091G0DJX
PhylomeDBⁱ	Q9BW19
TreeFamⁱ	TF105237

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189 Kinesins

Reactomeⁱ

R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Miscellaneous databases

ChiTaRSⁱ	KIFC1 human
EvolutionaryTraceⁱ	Q9BW19
GeneWikiⁱ	KIFC1
GenomeRNAiⁱ	3833
Protein Ontology More...PROⁱ	PR:Q9BW19
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000237649 Expressed in 147 organ(s), highest expression level in embryo
CleanExⁱ	HS_KIFC1
ExpressionAtlasⁱ	Q9BW19 baseline and differential
Genevisibleⁱ	Q9BW19 HS

Family and domain databases

Gene3Dⁱ	3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR027640 Kinesin-like_fam IPR019821 Kinesin_motor_CS IPR001752 Kinesin_motor_dom IPR036961 Kinesin_motor_dom_sf IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR24115 PTHR24115, 1 hit
Pfamⁱ	View protein in Pfam PF00225 Kinesin, 1 hit
PRINTSⁱ	PR00380 KINESINHEAVY
SMARTⁱ	View protein in SMART SM00129 KISc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00411 KINESIN_MOTOR_1, 1 hit PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KIFC1_HUMAN
Accessionⁱ	Q9BW19Primary (citable) accession number: Q9BW19 Secondary accession number(s): O60887 Q9UQP7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	January 23, 2002
	Last modified:	November 7, 2018
	This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q9BW19 (KIFC1_HUMAN)

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Kinesin-like protein KIFC1

KIFC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Cytoskeleton

Nucleus

Cytoskeleton

Endosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ