UniProtKB - Q9BW19 (KIFC1_HUMAN)
Protein
Kinesin-like protein KIFC1
Gene
KIFC1
Organism
Homo sapiens (Human)
Status
Functioni
Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).By similarity1 Publication
Miscellaneous
HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 410 – 417 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: UniProtKB
- microtubule binding Source: GO_Central
- microtubule motor activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- microtubule-based movement Source: GO_Central
- mitotic metaphase plate congression Source: UniProtKB
- mitotic sister chromatid segregation Source: UniProtKB
- mitotic spindle assembly Source: UniProtKB
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | Motor protein |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BW19 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIFC1Alternative name(s): Kinesin-like protein 2 Kinesin-related protein HSET |
Gene namesi | Name:KIFC1 Synonyms:HSET, KNSL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000237649.7 |
HGNCi | HGNC:6389, KIFC1 |
MIMi | 603763, gene |
neXtProti | NX_Q9BW19 |
Subcellular locationi
Cytoskeleton
- centrosome By similarity
- spindle By similarity
Nucleus
- Nucleus By similarity
Endosome
- Early endosome By similarity
Note: Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.By similarity
Cytoskeleton
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
- microtubule organizing center Source: GO_Central
- mitotic spindle Source: GO_Central
Endosome
- early endosome Source: UniProtKB-SubCell
Nucleus
- nucleus Source: GO_Central
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Endosome, Microtubule, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3833 |
OpenTargetsi | ENSG00000237649 |
PharmGKBi | PA30178 |
Miscellaneous databases
Pharosi | Q9BW19, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3351200 |
Polymorphism and mutation databases
BioMutai | KIFC1 |
DMDMi | 20138710 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125428 | 1 – 673 | Kinesin-like protein KIFC1Add BLAST | 673 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 6 | PhosphoserineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BW19 |
jPOSTi | Q9BW19 |
MassIVEi | Q9BW19 |
MaxQBi | Q9BW19 |
PaxDbi | Q9BW19 |
PeptideAtlasi | Q9BW19 |
PRIDEi | Q9BW19 |
ProteomicsDBi | 79250 |
PTM databases
iPTMneti | Q9BW19 |
PhosphoSitePlusi | Q9BW19 |
SwissPalmi | Q9BW19 |
Expressioni
Gene expression databases
Bgeei | ENSG00000237649, Expressed in ventricular zone and 170 other tissues |
ExpressionAtlasi | Q9BW19, baseline and differential |
Genevisiblei | Q9BW19, HS |
Organism-specific databases
HPAi | ENSG00000237649, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Binds NUBP1 and NUBP2.
Interacts with PPP1R42 (By similarity).
By similarityGO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 110031, 27 interactors |
IntActi | Q9BW19, 20 interactors |
MINTi | Q9BW19 |
STRINGi | 9606.ENSP00000393963 |
Chemistry databases
BindingDBi | Q9BW19 |
Miscellaneous databases
RNActi | Q9BW19, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BW19 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BW19 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 310 – 663 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 354 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 142 – 306 | Sequence analysisAdd BLAST | 165 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0239, Eukaryota |
GeneTreei | ENSGT00940000161735 |
HOGENOMi | CLU_001485_12_4_1 |
InParanoidi | Q9BW19 |
OMAi | YNEVLYD |
OrthoDBi | 364605at2759 |
PhylomeDBi | Q9BW19 |
TreeFami | TF105237 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9BW19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK
60 70 80 90 100
KRTRGLGATT KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA
110 120 130 140 150
TGLKNQKPVP AVPVQKSGTS GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL
160 170 180 190 200
KRCRERTQTL DQENQQLQDQ LRDAQQQVKA LGTERTTLEG HLAKVQAQAE
210 220 230 240 250
QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE RRGLMSQLEE
260 270 280 290 300
KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL
310 320 330 340 350
HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL
360 370 380 390 400
SRSDERRGTL SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD
410 420 430 440 450
GYPVCIFAYG QTGSGKTFTM EGGPGGDPQL EGLIPRALRH LFSVAQELSG
460 470 480 490 500
QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGGECEIRRA GPGSEELTVT
510 520 530 540 550
NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS VFQLQISGEH
560 570 580 590 600
SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG
610 620 630 640 650
LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES
660 670
LNSLRFASKV NQCVIGTAQA NRK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X1W5 | A0A087X1W5_HUMAN | Kinesin-like protein KIFC1 | KIFC1 | 154 | Annotation score: | ||
A2AB20 | A2AB20_HUMAN | Kinesin-like protein KIFC1 | KIFC1 | 203 | Annotation score: | ||
A0A140T9E6 | A0A140T9E6_HUMAN | Kinesin-like protein KIFC1 | KIFC1 | 203 | Annotation score: |
Sequence cautioni
The sequence AAH00712 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH63567 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH73878 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH98438 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA03509 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 368 | T → P in AAH00712 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012650 | 219 | R → Q1 PublicationCorresponds to variant dbSNP:rs61736175Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ010479 mRNA Translation: CAA09217.1 AL021366 Genomic DNA Translation: CAA16157.1 AL050332 Genomic DNA Translation: CAB63782.1 AL662799 Genomic DNA No translation available. BX088650 Genomic DNA No translation available. BX248088 Genomic DNA No translation available. BC000712 mRNA Translation: AAH00712.2 Different initiation. BC063567 mRNA Translation: AAH63567.1 Different initiation. BC073878 mRNA Translation: AAH73878.1 Different initiation. BC098438 mRNA Translation: AAH98438.1 Different initiation. BC121041 mRNA Translation: AAI21042.1 BC121042 mRNA Translation: AAI21043.1 D14678 mRNA Translation: BAA03509.1 Frameshift. |
CCDSi | CCDS34430.1 |
PIRi | I54523 |
RefSeqi | NP_002254.2, NM_002263.3 |
Genome annotation databases
Ensembli | ENST00000374523; ENSP00000363647; ENSG00000204197 ENST00000428849; ENSP00000393963; ENSG00000237649 ENST00000448818; ENSP00000407885; ENSG00000233450 |
GeneIDi | 3833 |
KEGGi | hsa:3833 |
UCSCi | uc003oef.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ010479 mRNA Translation: CAA09217.1 AL021366 Genomic DNA Translation: CAA16157.1 AL050332 Genomic DNA Translation: CAB63782.1 AL662799 Genomic DNA No translation available. BX088650 Genomic DNA No translation available. BX248088 Genomic DNA No translation available. BC000712 mRNA Translation: AAH00712.2 Different initiation. BC063567 mRNA Translation: AAH63567.1 Different initiation. BC073878 mRNA Translation: AAH73878.1 Different initiation. BC098438 mRNA Translation: AAH98438.1 Different initiation. BC121041 mRNA Translation: AAI21042.1 BC121042 mRNA Translation: AAI21043.1 D14678 mRNA Translation: BAA03509.1 Frameshift. |
CCDSi | CCDS34430.1 |
PIRi | I54523 |
RefSeqi | NP_002254.2, NM_002263.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5WDH | X-ray | 2.25 | A | 307-663 | [»] | |
SMRi | Q9BW19 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110031, 27 interactors |
IntActi | Q9BW19, 20 interactors |
MINTi | Q9BW19 |
STRINGi | 9606.ENSP00000393963 |
Chemistry databases
BindingDBi | Q9BW19 |
ChEMBLi | CHEMBL3351200 |
PTM databases
iPTMneti | Q9BW19 |
PhosphoSitePlusi | Q9BW19 |
SwissPalmi | Q9BW19 |
Polymorphism and mutation databases
BioMutai | KIFC1 |
DMDMi | 20138710 |
Proteomic databases
EPDi | Q9BW19 |
jPOSTi | Q9BW19 |
MassIVEi | Q9BW19 |
MaxQBi | Q9BW19 |
PaxDbi | Q9BW19 |
PeptideAtlasi | Q9BW19 |
PRIDEi | Q9BW19 |
ProteomicsDBi | 79250 |
Protocols and materials databases
Antibodypediai | 29133, 135 antibodies |
Genome annotation databases
Ensembli | ENST00000374523; ENSP00000363647; ENSG00000204197 ENST00000428849; ENSP00000393963; ENSG00000237649 ENST00000448818; ENSP00000407885; ENSG00000233450 |
GeneIDi | 3833 |
KEGGi | hsa:3833 |
UCSCi | uc003oef.5, human |
Organism-specific databases
CTDi | 3833 |
DisGeNETi | 3833 |
EuPathDBi | HostDB:ENSG00000237649.7 |
GeneCardsi | KIFC1 |
HGNCi | HGNC:6389, KIFC1 |
HPAi | ENSG00000237649, Tissue enriched (lymphoid) |
MIMi | 603763, gene |
neXtProti | NX_Q9BW19 |
OpenTargetsi | ENSG00000237649 |
PharmGKBi | PA30178 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0239, Eukaryota |
GeneTreei | ENSGT00940000161735 |
HOGENOMi | CLU_001485_12_4_1 |
InParanoidi | Q9BW19 |
OMAi | YNEVLYD |
OrthoDBi | 364605at2759 |
PhylomeDBi | Q9BW19 |
TreeFami | TF105237 |
Enzyme and pathway databases
PathwayCommonsi | Q9BW19 |
Reactomei | R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983189, Kinesins |
Miscellaneous databases
BioGRID-ORCSi | 3833, 31 hits in 843 CRISPR screens |
ChiTaRSi | KIFC1, human |
EvolutionaryTracei | Q9BW19 |
GeneWikii | KIFC1 |
GenomeRNAii | 3833 |
Pharosi | Q9BW19, Tchem |
PROi | PR:Q9BW19 |
RNActi | Q9BW19, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000237649, Expressed in ventricular zone and 170 other tissues |
ExpressionAtlasi | Q9BW19, baseline and differential |
Genevisiblei | Q9BW19, HS |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIFC1_HUMAN | |
Accessioni | Q9BW19Primary (citable) accession number: Q9BW19 Secondary accession number(s): O60887 Q9UQP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | January 23, 2002 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations