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Protein

Kinesin-like protein KIFC1

Gene

KIFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).By similarity1 Publication

Miscellaneous

HeLa cells lacking KIFC1 show multipolar mitotic spindles and a defect in chromosome congression and chromosome alignment during mitosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi410 – 417ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule-based movement Source: GO_Central
  • mitotic metaphase plate congression Source: UniProtKB
  • mitotic sister chromatid segregation Source: UniProtKB
  • mitotic spindle assembly Source: UniProtKB
  • spermatogenesis Source: Ensembl

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC1
Alternative name(s):
Kinesin-like protein 2
Kinesin-related protein HSET
Gene namesi
Name:KIFC1
Synonyms:HSET, KNSL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000237649.7
HGNCiHGNC:6389 KIFC1
MIMi603763 gene
neXtProtiNX_Q9BW19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3833
OpenTargetsiENSG00000237649
PharmGKBiPA30178

Chemistry databases

ChEMBLiCHEMBL3351200

Polymorphism and mutation databases

BioMutaiKIFC1
DMDMi20138710

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254281 – 673Kinesin-like protein KIFC1Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei359PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BW19
MaxQBiQ9BW19
PaxDbiQ9BW19
PeptideAtlasiQ9BW19
PRIDEiQ9BW19
ProteomicsDBi79250

PTM databases

iPTMnetiQ9BW19
PhosphoSitePlusiQ9BW19

Expressioni

Gene expression databases

BgeeiENSG00000237649
CleanExiHS_KIFC1
ExpressionAtlasiQ9BW19 baseline and differential
GenevisibleiQ9BW19 HS

Organism-specific databases

HPAiHPA055997
HPA062674

Interactioni

Subunit structurei

Binds NUBP1 and NUBP2. Interacts with PPP1R42 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110031, 20 interactors
IntActiQ9BW19, 13 interactors
MINTiQ9BW19
STRINGi9606.ENSP00000393963

Chemistry databases

BindingDBiQ9BW19

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi311 – 317Combined sources7
Beta strandi331 – 333Combined sources3
Beta strandi347 – 350Combined sources4
Beta strandi371 – 373Combined sources3
Beta strandi375 – 378Combined sources4
Helixi384 – 389Combined sources6
Helixi392 – 396Combined sources5
Helixi397 – 400Combined sources4
Beta strandi404 – 411Combined sources8
Helixi416 – 420Combined sources5
Helixi428 – 430Combined sources3
Helixi433 – 449Combined sources17
Turni450 – 452Combined sources3
Beta strandi453 – 465Combined sources13
Beta strandi468 – 471Combined sources4
Beta strandi487 – 489Combined sources3
Beta strandi497 – 499Combined sources3
Helixi510 – 526Combined sources17
Helixi535 – 537Combined sources3
Beta strandi538 – 554Combined sources17
Beta strandi556 – 565Combined sources10
Helixi596 – 607Combined sources12
Helixi615 – 617Combined sources3
Helixi619 – 624Combined sources6
Helixi625 – 627Combined sources3
Beta strandi633 – 640Combined sources8
Helixi644 – 646Combined sources3
Helixi647 – 662Combined sources16

3D structure databases

ProteinModelPortaliQ9BW19
SMRiQ9BW19
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BW19

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 663Kinesin motorPROSITE-ProRule annotationAdd BLAST354

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili142 – 306Sequence analysisAdd BLAST165

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00920000149025
HOVERGENiHBG001080
InParanoidiQ9BW19
KOiK10405
OMAiYNEVLYD
OrthoDBiEOG091G0DJX
PhylomeDBiQ9BW19
TreeFamiTF105237

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BW19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQRSPLLE VKGNIELKRP LIKAPSQLPL SGSRLKRRPD QMEDGLEPEK
60 70 80 90 100
KRTRGLGATT KITTSHPRVP SLTTVPQTQG QTTAQKVSKK TGPRCSTAIA
110 120 130 140 150
TGLKNQKPVP AVPVQKSGTS GVPPMAGGKK PSKRPAWDLK GQLCDLNAEL
160 170 180 190 200
KRCRERTQTL DQENQQLQDQ LRDAQQQVKA LGTERTTLEG HLAKVQAQAE
210 220 230 240 250
QGQQELKNLR ACVLELEERL STQEGLVQEL QKKQVELQEE RRGLMSQLEE
260 270 280 290 300
KERRLQTSEA ALSSSQAEVA SLRQETVAQA ALLTEREERL HGLEMERRRL
310 320 330 340 350
HNQLQELKGN IRVFCRVRPV LPGEPTPPPG LLLFPSGPGG PSDPPTRLSL
360 370 380 390 400
SRSDERRGTL SGAPAPPTRH DFSFDRVFPP GSGQDEVFEE IAMLVQSALD
410 420 430 440 450
GYPVCIFAYG QTGSGKTFTM EGGPGGDPQL EGLIPRALRH LFSVAQELSG
460 470 480 490 500
QGWTYSFVAS YVEIYNETVR DLLATGTRKG QGGECEIRRA GPGSEELTVT
510 520 530 540 550
NARYVPVSCE KEVDALLHLA RQNRAVARTA QNERSSRSHS VFQLQISGEH
560 570 580 590 600
SSRGLQCGAP LSLVDLAGSE RLDPGLALGP GERERLRETQ AINSSLSTLG
610 620 630 640 650
LVIMALSNKE SHVPYRNSKL TYLLQNSLGG SAKMLMFVNI SPLEENVSES
660 670
LNSLRFASKV NQCVIGTAQA NRK
Length:673
Mass (Da):73,748
Last modified:January 23, 2002 - v2
Checksum:i9E99737665BF1E92
GO

Sequence cautioni

The sequence AAH00712 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH63567 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH73878 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH98438 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA03509 differs from that shown. Reason: Frameshift at positions 223 and 256.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368T → P in AAH00712 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012650219R → Q1 PublicationCorresponds to variant dbSNP:rs61736175Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010479 mRNA Translation: CAA09217.1
AL021366 Genomic DNA Translation: CAA16157.1
AL050332 Genomic DNA Translation: CAB63782.1
AL662799 Genomic DNA No translation available.
BX088650 Genomic DNA No translation available.
BX248088 Genomic DNA No translation available.
BC000712 mRNA Translation: AAH00712.2 Different initiation.
BC063567 mRNA Translation: AAH63567.1 Different initiation.
BC073878 mRNA Translation: AAH73878.1 Different initiation.
BC098438 mRNA Translation: AAH98438.1 Different initiation.
BC121041 mRNA Translation: AAI21042.1
BC121042 mRNA Translation: AAI21043.1
D14678 mRNA Translation: BAA03509.1 Frameshift.
CCDSiCCDS34430.1
PIRiI54523
RefSeqiNP_002254.2, NM_002263.3
UniGeneiHs.436912

Genome annotation databases

EnsembliENST00000374523; ENSP00000363647; ENSG00000204197
ENST00000428849; ENSP00000393963; ENSG00000237649
ENST00000448818; ENSP00000407885; ENSG00000233450
GeneIDi3833
KEGGihsa:3833
UCSCiuc003oef.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKIFC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BW19
Secondary accession number(s): O60887
, Q14834, Q4KMP0, Q5SU09, Q6GMS7, Q6P4A5, Q9UQP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 20, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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