UniProtKB - Q9BVX2 (T106C_HUMAN)

BLAST

>sp|Q9BVX2|T106C_HUMAN Transmembrane protein 106C OS=Homo sapiens OX=9606 GN=TMEM106C PE=1 SV=1
MGSQHSAAARPSSCRRKQEDDRDGLLAEREQEEAIAQFPYVEFTGRDSITCLTCQGTGYI
PTEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKV
VKVTFNKQDSLVILTIMATLKIRNSNFYTVAVTSLSSQIQYMNTVVSTYVTTNVSLIPPR
SEQLVNFTGKAEMGGPFSYVYFFCTVPEILVHNIVIFMRTSVKISYIGLMTQSSLETHHY
VDCGGNSTAI

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History
Entry version 120 (12 Sep 2018)
Sequence version 1 (01 Jun 2001)
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Protein

Transmembrane protein 106C

Gene

TMEM106C

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 106C Alternative name(s): Endoplasmic reticulum membrane protein overexpressed in cancer
Gene namesⁱ	Name:TMEM106C Synonyms:EMOC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134291.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28775 TMEM106C
neXtProtⁱ	NX_Q9BVX2

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	87 – 107	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	197 – 217	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000134291
PharmGKBⁱ	PA142670757

Polymorphism and mutation databases

BioMutaⁱ	TMEM106C
DMDMⁱ	74733372

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000243900	2 – 250	Transmembrane protein 106CAdd BLAST		249

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication	1
Glycosylationⁱ	173	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	186	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Lipoprotein, Myristate

Proteomic databases

EPDⁱ	Q9BVX2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BVX2
PaxDbⁱ	Q9BVX2
PeptideAtlas More...PeptideAtlasⁱ	Q9BVX2
PRIDEⁱ	Q9BVX2
ProteomicsDBⁱ	79242 79243 [Q9BVX2-2]

PTM databases

iPTMnetⁱ	Q9BVX2
PhosphoSitePlusⁱ	Q9BVX2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134291 Expressed in 213 organ(s), highest expression level in thoracic aorta
CleanExⁱ	HS_TMEM106C
ExpressionAtlasⁱ	Q9BVX2 baseline and differential
Genevisibleⁱ	Q9BVX2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047204

HPAⁱ

HPA047204

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KRT31	Q15323	5	EBI-2821497,EBI-948001

With

Entry

#Exp.

IntAct

Notes

KRT31

Q15323

EBI-2821497,EBI-948001

Protein-protein interaction databases

BioGridⁱ	122490, 5 interactors
IntActⁱ	Q9BVX2, 44 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BVX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMEM106 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEC7 Eukaryota ENOG410ZX7B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013076
HOGENOMⁱ	HOG000230966
HOVERGENⁱ	HBG055025
InParanoidⁱ	Q9BVX2
OMAⁱ	YIGHVTQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KDT
PhylomeDBⁱ	Q9BVX2
TreeFamⁱ	TF328907

Family and domain databases

InterProⁱ	View protein in InterPro IPR009790 DUF1356_TMEM106
PANTHERⁱ	PTHR28556 PTHR28556, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07092 DUF1356, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9BVX2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT 
        60         70         80         90        100
CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG 
       110        120        130        140        150
LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV 
       160        170        180        190        200
AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR SEQLVNFTGK AEMGGPFSYV 
       210        220        230        240        250
YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY VDCGGNSTAI

Length:250

Mass (Da):27,875

Last modified:June 1, 2001 - v1

Checksum:ⁱDD54511ADFA0F280

Isoform 2 (identifier: Q9BVX2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
166-184: Missing.

« Hide

        10         20         30         40         50
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT 
        60         70         80         90        100
CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG 
       110        120        130        140        150
LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV 
       160        170        180        190        200
AVTSLSSQIQ YMNTVVNFTG KAEMGGPFSY VYFFCTVPEI LVHNIVIFMR 
       210        220        230 
TSVKISYIGL MTQSSLETHH YVDCGGNSTA I

Show »

Length:231

Mass (Da):25,789

Checksum:ⁱ861C68A4E638DFC9

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation
	C9JUY7	C9JUY7_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	179	Annotation score:
	A0A087WYD4	A0A087WYD4_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	181	Annotation score:
	H0YHU2	H0YHU2_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	117	Annotation score:
	F8W001	F8W001_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	147	Annotation score:
	H0YIA4	H0YIA4_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	109	Annotation score:
	F8W120	F8W120_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	65	Annotation score:
	F8W098	F8W098_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	86	Annotation score:
	F8VVN7	F8VVN7_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	84	Annotation score:
	A0A087WTK1	A0A087WTK1_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	75	Annotation score:
	F8VZW0	F8VZW0_HUMAN	Transmembrane protein 106C Transmembrane protein 106C	TMEM106C	62	Annotation score:
There is more potential isoformShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052338	103	V → F1 PublicationCorresponds to variant dbSNP:rs35000511Ensembl.		1
Natural variantⁱVAR_026868	175	S → F. Corresponds to variant dbSNP:rs2286025Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019483	166 – 184	Missing in isoform 2. 2 PublicationsAdd BLAST		19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ020163 mRNA Translation: AAY84826.1 AK299154 mRNA Translation: BAH12960.1 AK313698 mRNA Translation: BAG36445.1 CH471111 Genomic DNA Translation: EAW57965.1 BC000854 mRNA Translation: AAH00854.1 BC107792 mRNA Translation: AAI07793.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44867.1 [Q9BVX2-2] CCDS8758.1 [Q9BVX2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001137313.1, NM_001143841.1 [Q9BVX2-2] NP_001137314.1, NM_001143842.1 [Q9BVX2-1] NP_001137315.1, NM_001143843.1 [Q9BVX2-2] NP_076961.1, NM_024056.3 [Q9BVX2-1]
UniGeneⁱ	Hs.596726

Genome annotation databases

Ensemblⁱ	ENST00000256686; ENSP00000256686; ENSG00000134291 [Q9BVX2-2] ENST00000429772; ENSP00000400471; ENSG00000134291 [Q9BVX2-1] ENST00000449758; ENSP00000402705; ENSG00000134291 [Q9BVX2-2] ENST00000550552; ENSP00000449737; ENSG00000134291 [Q9BVX2-2] ENST00000552561; ENSP00000446657; ENSG00000134291 [Q9BVX2-1]
GeneIDⁱ	79022
KEGGⁱ	hsa:79022
UCSC genome browser More...UCSCⁱ	uc001rqo.4 human [Q9BVX2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BVX2-2	Transmembrane protein 106C		HUMAN		181	UniRef100_A0A087WYD4
TMEM106C isoform 10		PANTR		231
TMEM106C isoform 17		PANTR		181

Protein	Similar proteins		Species	Score	Length	Source
Q9BVX2	Transmembrane protein 106C (Fragment)		HUMAN		62	UniRef90_Q9BVX2
Transmembrane protein 106C		PANTR		250
Transmembrane protein 106C isoform a		CALJA		250
Transmembrane protein 106C		SAIBB		250
Transmembrane protein 106C		Cebus capucinus imitator		250
+13

Protein	Similar proteins		Species	Score	Length	Source
Q9BVX2	Transmembrane protein 106C		BOVIN		249	UniRef50_Q9BVX2
Transmembrane protein 106C (Fragment)		HUMAN		62
Transmembrane protein 106C		GORGO		250
Transmembrane protein 106C		Cebus capucinus imitator		250
Transmembrane protein 106C		AOTNA		250
+89

Entry informationⁱ

Entry nameⁱ	T106C_HUMAN
Accessionⁱ	Q9BVX2Primary (citable) accession number: Q9BVX2 Secondary accession number(s): B2R998, B7Z5M4, Q3B761
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BVX2 (T106C_HUMAN)

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Transmembrane protein 106C

TMEM106C

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ