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Protein

Transmembrane protein 106C

Gene

TMEM106C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 106C
Alternative name(s):
Endoplasmic reticulum membrane protein overexpressed in cancer
Gene namesi
Name:TMEM106C
Synonyms:EMOC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134291.11
HGNCiHGNC:28775 TMEM106C
neXtProtiNX_Q9BVX2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134291
PharmGKBiPA142670757

Polymorphism and mutation databases

BioMutaiTMEM106C
DMDMi74733372

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002439002 – 250Transmembrane protein 106CAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate

Proteomic databases

EPDiQ9BVX2
MaxQBiQ9BVX2
PaxDbiQ9BVX2
PeptideAtlasiQ9BVX2
PRIDEiQ9BVX2
ProteomicsDBi79242
79243 [Q9BVX2-2]

PTM databases

iPTMnetiQ9BVX2
PhosphoSitePlusiQ9BVX2

Expressioni

Gene expression databases

BgeeiENSG00000134291 Expressed in 213 organ(s), highest expression level in thoracic aorta
CleanExiHS_TMEM106C
ExpressionAtlasiQ9BVX2 baseline and differential
GenevisibleiQ9BVX2 HS

Organism-specific databases

HPAiHPA047204

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153235EBI-2821497,EBI-948001

Protein-protein interaction databases

BioGridi122490, 5 interactors
IntActiQ9BVX2, 44 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9BVX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM106 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEC7 Eukaryota
ENOG410ZX7B LUCA
GeneTreeiENSGT00390000013076
HOGENOMiHOG000230966
HOVERGENiHBG055025
InParanoidiQ9BVX2
OMAiYIGHVTQ
OrthoDBiEOG091G0KDT
PhylomeDBiQ9BVX2
TreeFamiTF328907

Family and domain databases

InterProiView protein in InterPro
IPR009790 DUF1356_TMEM106
PANTHERiPTHR28556 PTHR28556, 1 hit
PfamiView protein in Pfam
PF07092 DUF1356, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9BVX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT
60 70 80 90 100
CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG
110 120 130 140 150
LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV
160 170 180 190 200
AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR SEQLVNFTGK AEMGGPFSYV
210 220 230 240 250
YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY VDCGGNSTAI
Length:250
Mass (Da):27,875
Last modified:June 1, 2001 - v1
Checksum:iDD54511ADFA0F280
GO
Isoform 2 (identifier: Q9BVX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-184: Missing.

Show »
Length:231
Mass (Da):25,789
Checksum:i861C68A4E638DFC9
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUY7C9JUY7_HUMAN
Transmembrane protein 106C
TMEM106C
179Annotation score:
A0A087WYD4A0A087WYD4_HUMAN
Transmembrane protein 106C
TMEM106C
181Annotation score:
H0YHU2H0YHU2_HUMAN
Transmembrane protein 106C
TMEM106C
117Annotation score:
F8W001F8W001_HUMAN
Transmembrane protein 106C
TMEM106C
147Annotation score:
H0YIA4H0YIA4_HUMAN
Transmembrane protein 106C
TMEM106C
109Annotation score:
F8W120F8W120_HUMAN
Transmembrane protein 106C
TMEM106C
65Annotation score:
F8W098F8W098_HUMAN
Transmembrane protein 106C
TMEM106C
86Annotation score:
F8VVN7F8VVN7_HUMAN
Transmembrane protein 106C
TMEM106C
84Annotation score:
A0A087WTK1A0A087WTK1_HUMAN
Transmembrane protein 106C
TMEM106C
75Annotation score:
F8VZW0F8VZW0_HUMAN
Transmembrane protein 106C
TMEM106C
62Annotation score:
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052338103V → F1 PublicationCorresponds to variant dbSNP:rs35000511Ensembl.1
Natural variantiVAR_026868175S → F. Corresponds to variant dbSNP:rs2286025Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019483166 – 184Missing in isoform 2. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ020163 mRNA Translation: AAY84826.1
AK299154 mRNA Translation: BAH12960.1
AK313698 mRNA Translation: BAG36445.1
CH471111 Genomic DNA Translation: EAW57965.1
BC000854 mRNA Translation: AAH00854.1
BC107792 mRNA Translation: AAI07793.1
CCDSiCCDS44867.1 [Q9BVX2-2]
CCDS8758.1 [Q9BVX2-1]
RefSeqiNP_001137313.1, NM_001143841.1 [Q9BVX2-2]
NP_001137314.1, NM_001143842.1 [Q9BVX2-1]
NP_001137315.1, NM_001143843.1 [Q9BVX2-2]
NP_076961.1, NM_024056.3 [Q9BVX2-1]
UniGeneiHs.596726

Genome annotation databases

EnsembliENST00000256686; ENSP00000256686; ENSG00000134291 [Q9BVX2-2]
ENST00000429772; ENSP00000400471; ENSG00000134291 [Q9BVX2-1]
ENST00000449758; ENSP00000402705; ENSG00000134291 [Q9BVX2-2]
ENST00000550552; ENSP00000449737; ENSG00000134291 [Q9BVX2-2]
ENST00000552561; ENSP00000446657; ENSG00000134291 [Q9BVX2-1]
GeneIDi79022
KEGGihsa:79022
UCSCiuc001rqo.4 human [Q9BVX2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT106C_HUMAN
AccessioniPrimary (citable) accession number: Q9BVX2
Secondary accession number(s): B2R998, B7Z5M4, Q3B761
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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