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UniProtKB - Q9BVX2 (T106C_HUMAN)

Entry version 143 (25 May 2022)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
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Protein

Transmembrane protein 106C

Gene

TMEM106C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BVX2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BVX2

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.23.1.4, the tmem106 (tmem106) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 106C
Alternative name(s):
Endoplasmic reticulum membrane protein overexpressed in cancer
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM106C
Synonyms:EMOC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28775, TMEM106C

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BVX2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134291

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000134291

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670757

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BVX2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM106C

Domain mapping of disease mutations (DMDM)

More...DMDMi		74733372

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002439002 – 250Transmembrane protein 106CAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BVX2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BVX2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BVX2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BVX2

PeptideAtlas

More...PeptideAtlasi		Q9BVX2

PRoteomics IDEntifications database

More...PRIDEi		Q9BVX2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79242 [Q9BVX2-1]
79243 [Q9BVX2-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9BVX2, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BVX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BVX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134291, Expressed in rectum and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BVX2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BVX2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134291, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9BVX2
With#Exp.IntAct
ADAM33 [Q08AM2]3EBI-2821497,EBI-10225815
AIG1 - isoform 1 [Q9NVV5-2]3EBI-2821497,EBI-11957045
BNIP3 [Q12983]3EBI-2821497,EBI-749464
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-2821497,EBI-12256978
CMTM7 [Q96FZ5]3EBI-2821497,EBI-2807956
CTXN3 [Q4LDR2]3EBI-2821497,EBI-12019274
CXCL9 [Q07325]3EBI-2821497,EBI-3911467
EDDM3B [P56851]3EBI-2821497,EBI-10215665
FAXDC2 [Q96IV6]3EBI-2821497,EBI-12142299
GOSR2 [O14653]3EBI-2821497,EBI-4401517
HACD1 [B0YJ81]4EBI-2821497,EBI-12051643
IGFBP5 [P24593]3EBI-2821497,EBI-720480
JAGN1 [Q8N5M9]3EBI-2821497,EBI-10266796
KRT31 [Q15323]6EBI-2821497,EBI-948001
MAL [P21145]3EBI-2821497,EBI-3932027
MARCHF2 [Q9P0N8]3EBI-2821497,EBI-10317612
MYADM [Q96S97]3EBI-2821497,EBI-13301517
NKG7 [Q16617]3EBI-2821497,EBI-3919611
NRAC [Q8N912]3EBI-2821497,EBI-12051377
NRSN1 [Q8IZ57]3EBI-2821497,EBI-10264528
PGA4 [P0DJD7]3EBI-2821497,EBI-12957629
PLN [P26678]3EBI-2821497,EBI-692836
PLP1 - isoform DM-20 [P60201-2]3EBI-2821497,EBI-12188331
PLPP6 [Q8IY26]3EBI-2821497,EBI-11721828
PTTG1IP [P53801]3EBI-2821497,EBI-3906138
RPRM [Q9NS64]3EBI-2821497,EBI-1052363
SEC22A [Q96IW7]3EBI-2821497,EBI-8652744
SERP2 [Q8N6R1]3EBI-2821497,EBI-749270
SFTPC [P11686]3EBI-2821497,EBI-10197617
SMAGP [Q0VAQ4]3EBI-2821497,EBI-10226799
TMEM106A [Q96A25]3EBI-2821497,EBI-3915978
TMEM106B [Q9NUM4]3EBI-2821497,EBI-10490807
TMEM11 [P17152]3EBI-2821497,EBI-723946
TMEM218 [A2RU14]3EBI-2821497,EBI-10173151
TMEM35A [Q53FP2]3EBI-2821497,EBI-11722971
TMEM97 [Q5BJF2]3EBI-2821497,EBI-12111910
TSPAN33 [Q86UF1]4EBI-2821497,EBI-12045841
UPK2 [O00526]3EBI-2821497,EBI-10179682
VAMP5 [O95183]3EBI-2821497,EBI-10191195
YIPF6 [Q96EC8]3EBI-2821497,EBI-751210
ZFPL1 [O95159]3EBI-2821497,EBI-718439

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122490, 84 interactors

Protein interaction database and analysis system

More...IntActi		Q9BVX2, 50 interactors

Molecular INTeraction database

More...MINTi		Q9BVX2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000400471

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BVX2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9BVX2

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM106 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQ43, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161281

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_089337_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BVX2

Identification of Orthologs from Complete Genome Data

More...OMAi		PYVYAFC

Database of Orthologous Groups

More...OrthoDBi		1175832at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BVX2

TreeFam database of animal gene trees

More...TreeFami		TF328907

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009790, TMEM106

The PANTHER Classification System

More...PANTHERi		PTHR28556, PTHR28556, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07092, DUF1356, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BVX2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT 
        60         70         80         90        100
CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG 
       110        120        130        140        150
LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV 
       160        170        180        190        200
AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR SEQLVNFTGK AEMGGPFSYV 
       210        220        230        240        250
YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY VDCGGNSTAI
Length:250
Mass (Da):27,875
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD54511ADFA0F280
GO
Isoform 2 (identifier: Q9BVX2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     166-184: Missing.

Show »
Length:231
Mass (Da):25,789
Checksum:i861C68A4E638DFC9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWX5F8VWX5_HUMAN
Transmembrane protein 106C
TMEM106C
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W120F8W120_HUMAN
Transmembrane protein 106C
TMEM106C
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIA4H0YIA4_HUMAN
Transmembrane protein 106C
TMEM106C
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYD4A0A087WYD4_HUMAN
Transmembrane protein 106C
TMEM106C
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUY7C9JUY7_HUMAN
Transmembrane protein 106C
TMEM106C
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W098F8W098_HUMAN
Transmembrane protein 106C
TMEM106C
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W001F8W001_HUMAN
Transmembrane protein 106C
TMEM106C
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHU2H0YHU2_HUMAN
Transmembrane protein 106C
TMEM106C
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVN7F8VVN7_HUMAN
Transmembrane protein 106C
TMEM106C
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZW0F8VZW0_HUMAN
Transmembrane protein 106C
TMEM106C
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052338103V → F1 PublicationCorresponds to variant dbSNP:rs35000511Ensembl.1
Natural variantiVAR_026868175S → F. Corresponds to variant dbSNP:rs2286025Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019483166 – 184Missing in isoform 2. 2 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ020163 mRNA Translation: AAY84826.1
AK299154 mRNA Translation: BAH12960.1
AK313698 mRNA Translation: BAG36445.1
CH471111 Genomic DNA Translation: EAW57965.1
BC000854 mRNA Translation: AAH00854.1
BC107792 mRNA Translation: AAI07793.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44867.1 [Q9BVX2-2]
CCDS8758.1 [Q9BVX2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001137313.1, NM_001143841.1 [Q9BVX2-2]
NP_001137314.1, NM_001143842.1 [Q9BVX2-1]
NP_001137315.1, NM_001143843.1 [Q9BVX2-2]
NP_076961.1, NM_024056.3 [Q9BVX2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256686.10; ENSP00000256686.6; ENSG00000134291.12 [Q9BVX2-2]
ENST00000429772.7; ENSP00000400471.2; ENSG00000134291.12
ENST00000449758.6; ENSP00000402705.2; ENSG00000134291.12 [Q9BVX2-2]
ENST00000550552.5; ENSP00000449737.1; ENSG00000134291.12 [Q9BVX2-2]
ENST00000552561.5; ENSP00000446657.1; ENSG00000134291.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79022

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000429772.7; ENSP00000400471.2; NM_001143842.2; NP_001137314.1

UCSC genome browser

More...UCSCi		uc001rqo.4, human [Q9BVX2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ020163 mRNA Translation: AAY84826.1
AK299154 mRNA Translation: BAH12960.1
AK313698 mRNA Translation: BAG36445.1
CH471111 Genomic DNA Translation: EAW57965.1
BC000854 mRNA Translation: AAH00854.1
BC107792 mRNA Translation: AAI07793.1
CCDSiCCDS44867.1 [Q9BVX2-2]
CCDS8758.1 [Q9BVX2-1]
RefSeqiNP_001137313.1, NM_001143841.1 [Q9BVX2-2]
NP_001137314.1, NM_001143842.1 [Q9BVX2-1]
NP_001137315.1, NM_001143843.1 [Q9BVX2-2]
NP_076961.1, NM_024056.3 [Q9BVX2-1]

3D structure databases

AlphaFoldDBiQ9BVX2
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi122490, 84 interactors
IntActiQ9BVX2, 50 interactors
MINTiQ9BVX2
STRINGi9606.ENSP00000400471

Protein family/group databases

TCDBi9.B.23.1.4, the tmem106 (tmem106) family

PTM databases

GlyGeniQ9BVX2, 2 sites
iPTMnetiQ9BVX2
PhosphoSitePlusiQ9BVX2

Genetic variation databases

BioMutaiTMEM106C
DMDMi74733372

Proteomic databases

jPOSTiQ9BVX2
MassIVEiQ9BVX2
MaxQBiQ9BVX2
PaxDbiQ9BVX2
PeptideAtlasiQ9BVX2
PRIDEiQ9BVX2
ProteomicsDBi79242 [Q9BVX2-1]
79243 [Q9BVX2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25478, 36 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		79022

Genome annotation databases

EnsembliENST00000256686.10; ENSP00000256686.6; ENSG00000134291.12 [Q9BVX2-2]
ENST00000429772.7; ENSP00000400471.2; ENSG00000134291.12
ENST00000449758.6; ENSP00000402705.2; ENSG00000134291.12 [Q9BVX2-2]
ENST00000550552.5; ENSP00000449737.1; ENSG00000134291.12 [Q9BVX2-2]
ENST00000552561.5; ENSP00000446657.1; ENSG00000134291.12
GeneIDi79022
KEGGihsa:79022
MANE-SelectiENST00000429772.7; ENSP00000400471.2; NM_001143842.2; NP_001137314.1
UCSCiuc001rqo.4, human [Q9BVX2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79022

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM106C
HGNCiHGNC:28775, TMEM106C
HPAiENSG00000134291, Low tissue specificity
neXtProtiNX_Q9BVX2
OpenTargetsiENSG00000134291
PharmGKBiPA142670757
VEuPathDBiHostDB:ENSG00000134291

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQ43, Eukaryota
GeneTreeiENSGT00940000161281
HOGENOMiCLU_089337_0_0_1
InParanoidiQ9BVX2
OMAiPYVYAFC
OrthoDBi1175832at2759
PhylomeDBiQ9BVX2
TreeFamiTF328907

Enzyme and pathway databases

PathwayCommonsiQ9BVX2
SignaLinkiQ9BVX2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79022, 10 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM106C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79022
PharosiQ9BVX2, Tdark

Protein Ontology

More...PROi		PR:Q9BVX2
RNActiQ9BVX2, protein

Gene expression databases

BgeeiENSG00000134291, Expressed in rectum and 226 other tissues
ExpressionAtlasiQ9BVX2, baseline and differential
GenevisibleiQ9BVX2, HS

Family and domain databases

InterProiView protein in InterPro
IPR009790, TMEM106
PANTHERiPTHR28556, PTHR28556, 1 hit
PfamiView protein in Pfam
PF07092, DUF1356, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT106C_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVX2
Secondary accession number(s): B2R998, B7Z5M4, Q3B761
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: May 25, 2022
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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