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UniProtKB - Q9BVX2 (T106C_HUMAN)
Protein
Transmembrane protein 106C
Gene
TMEM106C
Organism
Homo sapiens (Human)
Status
Functioni
Enzyme and pathway databases
PathwayCommonsi | Q9BVX2 |
SignaLinki | Q9BVX2 |
Protein family/group databases
TCDBi | 9.B.23.1.4, the tmem106 (tmem106) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 106CAlternative name(s): Endoplasmic reticulum membrane protein overexpressed in cancer |
Gene namesi | Name:TMEM106C Synonyms:EMOC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28775, TMEM106C |
neXtProti | NX_Q9BVX2 |
VEuPathDBi | HostDB:ENSG00000134291 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- Membrane Curated; Lipid-anchor Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 217 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000134291 |
PharmGKBi | PA142670757 |
Miscellaneous databases
Pharosi | Q9BVX2, Tdark |
Genetic variation databases
BioMutai | TMEM106C |
DMDMi | 74733372 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000243900 | 2 – 250 | Transmembrane protein 106CAdd BLAST | 249 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, MyristateProteomic databases
jPOSTi | Q9BVX2 |
MassIVEi | Q9BVX2 |
MaxQBi | Q9BVX2 |
PaxDbi | Q9BVX2 |
PeptideAtlasi | Q9BVX2 |
PRIDEi | Q9BVX2 |
ProteomicsDBi | 79242 [Q9BVX2-1] 79243 [Q9BVX2-2] |
PTM databases
GlyGeni | Q9BVX2, 2 sites |
iPTMneti | Q9BVX2 |
PhosphoSitePlusi | Q9BVX2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134291, Expressed in rectum and 226 other tissues |
ExpressionAtlasi | Q9BVX2, baseline and differential |
Genevisiblei | Q9BVX2, HS |
Organism-specific databases
HPAi | ENSG00000134291, Low tissue specificity |
Interactioni
Binary interactionsi
Q9BVX2
Protein-protein interaction databases
BioGRIDi | 122490, 84 interactors |
IntActi | Q9BVX2, 50 interactors |
MINTi | Q9BVX2 |
STRINGi | 9606.ENSP00000400471 |
Miscellaneous databases
RNActi | Q9BVX2, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q9BVX2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the TMEM106 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQ43, Eukaryota |
GeneTreei | ENSGT00940000161281 |
HOGENOMi | CLU_089337_0_0_1 |
InParanoidi | Q9BVX2 |
OMAi | PYVYAFC |
OrthoDBi | 1175832at2759 |
PhylomeDBi | Q9BVX2 |
TreeFami | TF328907 |
Family and domain databases
InterProi | View protein in InterPro IPR009790, TMEM106 |
PANTHERi | PTHR28556, PTHR28556, 1 hit |
Pfami | View protein in Pfam PF07092, DUF1356, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BVX2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT
60 70 80 90 100
CLTCQGTGYI PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG
110 120 130 140 150
LVVFFLFPHS VLVDDDGIKV VKVTFNKQDS LVILTIMATL KIRNSNFYTV
160 170 180 190 200
AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR SEQLVNFTGK AEMGGPFSYV
210 220 230 240 250
YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY VDCGGNSTAI
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VWX5 | F8VWX5_HUMAN | Transmembrane protein 106C | TMEM106C | 70 | Annotation score: | ||
F8W120 | F8W120_HUMAN | Transmembrane protein 106C | TMEM106C | 65 | Annotation score: | ||
H0YIA4 | H0YIA4_HUMAN | Transmembrane protein 106C | TMEM106C | 109 | Annotation score: | ||
A0A087WYD4 | A0A087WYD4_HUMAN | Transmembrane protein 106C | TMEM106C | 181 | Annotation score: | ||
C9JUY7 | C9JUY7_HUMAN | Transmembrane protein 106C | TMEM106C | 179 | Annotation score: | ||
F8W098 | F8W098_HUMAN | Transmembrane protein 106C | TMEM106C | 86 | Annotation score: | ||
F8W001 | F8W001_HUMAN | Transmembrane protein 106C | TMEM106C | 147 | Annotation score: | ||
H0YHU2 | H0YHU2_HUMAN | Transmembrane protein 106C | TMEM106C | 117 | Annotation score: | ||
F8VVN7 | F8VVN7_HUMAN | Transmembrane protein 106C | TMEM106C | 84 | Annotation score: | ||
F8VZW0 | F8VZW0_HUMAN | Transmembrane protein 106C | TMEM106C | 62 | Annotation score: | ||
There is more potential isoformShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052338 | 103 | V → F1 PublicationCorresponds to variant dbSNP:rs35000511Ensembl. | 1 | |
Natural variantiVAR_026868 | 175 | S → F. Corresponds to variant dbSNP:rs2286025Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019483 | 166 – 184 | Missing in isoform 2. 2 PublicationsAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ020163 mRNA Translation: AAY84826.1 AK299154 mRNA Translation: BAH12960.1 AK313698 mRNA Translation: BAG36445.1 CH471111 Genomic DNA Translation: EAW57965.1 BC000854 mRNA Translation: AAH00854.1 BC107792 mRNA Translation: AAI07793.1 |
CCDSi | CCDS44867.1 [Q9BVX2-2] CCDS8758.1 [Q9BVX2-1] |
RefSeqi | NP_001137313.1, NM_001143841.1 [Q9BVX2-2] NP_001137314.1, NM_001143842.1 [Q9BVX2-1] NP_001137315.1, NM_001143843.1 [Q9BVX2-2] NP_076961.1, NM_024056.3 [Q9BVX2-1] |
Genome annotation databases
Ensembli | ENST00000256686.10; ENSP00000256686.6; ENSG00000134291.12 [Q9BVX2-2] ENST00000429772.7; ENSP00000400471.2; ENSG00000134291.12 ENST00000449758.6; ENSP00000402705.2; ENSG00000134291.12 [Q9BVX2-2] ENST00000550552.5; ENSP00000449737.1; ENSG00000134291.12 [Q9BVX2-2] ENST00000552561.5; ENSP00000446657.1; ENSG00000134291.12 |
GeneIDi | 79022 |
KEGGi | hsa:79022 |
MANE-Selecti | ENST00000429772.7; ENSP00000400471.2; NM_001143842.2; NP_001137314.1 |
UCSCi | uc001rqo.4, human [Q9BVX2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ020163 mRNA Translation: AAY84826.1 AK299154 mRNA Translation: BAH12960.1 AK313698 mRNA Translation: BAG36445.1 CH471111 Genomic DNA Translation: EAW57965.1 BC000854 mRNA Translation: AAH00854.1 BC107792 mRNA Translation: AAI07793.1 |
CCDSi | CCDS44867.1 [Q9BVX2-2] CCDS8758.1 [Q9BVX2-1] |
RefSeqi | NP_001137313.1, NM_001143841.1 [Q9BVX2-2] NP_001137314.1, NM_001143842.1 [Q9BVX2-1] NP_001137315.1, NM_001143843.1 [Q9BVX2-2] NP_076961.1, NM_024056.3 [Q9BVX2-1] |
3D structure databases
AlphaFoldDBi | Q9BVX2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122490, 84 interactors |
IntActi | Q9BVX2, 50 interactors |
MINTi | Q9BVX2 |
STRINGi | 9606.ENSP00000400471 |
Protein family/group databases
TCDBi | 9.B.23.1.4, the tmem106 (tmem106) family |
PTM databases
GlyGeni | Q9BVX2, 2 sites |
iPTMneti | Q9BVX2 |
PhosphoSitePlusi | Q9BVX2 |
Genetic variation databases
BioMutai | TMEM106C |
DMDMi | 74733372 |
Proteomic databases
jPOSTi | Q9BVX2 |
MassIVEi | Q9BVX2 |
MaxQBi | Q9BVX2 |
PaxDbi | Q9BVX2 |
PeptideAtlasi | Q9BVX2 |
PRIDEi | Q9BVX2 |
ProteomicsDBi | 79242 [Q9BVX2-1] 79243 [Q9BVX2-2] |
Protocols and materials databases
Antibodypediai | 25478, 36 antibodies from 18 providers |
DNASUi | 79022 |
Genome annotation databases
Ensembli | ENST00000256686.10; ENSP00000256686.6; ENSG00000134291.12 [Q9BVX2-2] ENST00000429772.7; ENSP00000400471.2; ENSG00000134291.12 ENST00000449758.6; ENSP00000402705.2; ENSG00000134291.12 [Q9BVX2-2] ENST00000550552.5; ENSP00000449737.1; ENSG00000134291.12 [Q9BVX2-2] ENST00000552561.5; ENSP00000446657.1; ENSG00000134291.12 |
GeneIDi | 79022 |
KEGGi | hsa:79022 |
MANE-Selecti | ENST00000429772.7; ENSP00000400471.2; NM_001143842.2; NP_001137314.1 |
UCSCi | uc001rqo.4, human [Q9BVX2-1] |
Organism-specific databases
CTDi | 79022 |
GeneCardsi | TMEM106C |
HGNCi | HGNC:28775, TMEM106C |
HPAi | ENSG00000134291, Low tissue specificity |
neXtProti | NX_Q9BVX2 |
OpenTargetsi | ENSG00000134291 |
PharmGKBi | PA142670757 |
VEuPathDBi | HostDB:ENSG00000134291 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ43, Eukaryota |
GeneTreei | ENSGT00940000161281 |
HOGENOMi | CLU_089337_0_0_1 |
InParanoidi | Q9BVX2 |
OMAi | PYVYAFC |
OrthoDBi | 1175832at2759 |
PhylomeDBi | Q9BVX2 |
TreeFami | TF328907 |
Enzyme and pathway databases
PathwayCommonsi | Q9BVX2 |
SignaLinki | Q9BVX2 |
Miscellaneous databases
BioGRID-ORCSi | 79022, 10 hits in 1081 CRISPR screens |
ChiTaRSi | TMEM106C, human |
GenomeRNAii | 79022 |
Pharosi | Q9BVX2, Tdark |
PROi | PR:Q9BVX2 |
RNActi | Q9BVX2, protein |
Gene expression databases
Bgeei | ENSG00000134291, Expressed in rectum and 226 other tissues |
ExpressionAtlasi | Q9BVX2, baseline and differential |
Genevisiblei | Q9BVX2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009790, TMEM106 |
PANTHERi | PTHR28556, PTHR28556, 1 hit |
Pfami | View protein in Pfam PF07092, DUF1356, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | T106C_HUMAN | |
Accessioni | Q9BVX2Primary (citable) accession number: Q9BVX2 Secondary accession number(s): B2R998, B7Z5M4, Q3B761 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families