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Protein

TIMELESS-interacting protein

Gene

TIPIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.3 Publications

GO - Molecular functioni

GO - Biological processi

  • cell cycle phase transition Source: BHF-UCL
  • cell division Source: UniProtKB-KW
  • DNA replication checkpoint Source: HGNC
  • intra-S DNA damage checkpoint Source: HGNC
  • positive regulation of cell proliferation Source: HGNC
  • regulation of nuclear cell cycle DNA replication Source: HGNC
  • replication fork arrest Source: GO_Central
  • replication fork protection Source: GO_Central
  • response to UV Source: Ensembl

Keywordsi

Biological processCell cycle, Cell division, DNA damage, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-5693607 Processing of DNA double-strand break ends

Names & Taxonomyi

Protein namesi
Recommended name:
TIMELESS-interacting protein
Gene namesi
Name:TIPIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000075131.9
HGNCiHGNC:30750 TIPIN
MIMi610716 gene
neXtProtiNX_Q9BVW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54962
OpenTargetsiENSG00000075131
PharmGKBiPA147357269

Polymorphism and mutation databases

BioMutaiTIPIN
DMDMi296452932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052531 – 301TIMELESS-interacting proteinAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei233PhosphothreonineCombined sources1
Modified residuei244PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BVW5
MaxQBiQ9BVW5
PaxDbiQ9BVW5
PeptideAtlasiQ9BVW5
PRIDEiQ9BVW5
ProteomicsDBi79240

PTM databases

iPTMnetiQ9BVW5
PhosphoSitePlusiQ9BVW5

Expressioni

Gene expression databases

BgeeiENSG00000075131
CleanExiHS_TIPIN
ExpressionAtlasiQ9BVW5 baseline and differential
GenevisibleiQ9BVW5 HS

Organism-specific databases

HPAiHPA039704
HPA058799

Interactioni

Subunit structurei

Interacts with TIMELESS, which impairs TIMELESS self-association. Interacts with RPA2, PRDX2, MCM6 and MCM7.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120300, 18 interactors
DIPiDIP-53658N
ELMiQ9BVW5
IntActiQ9BVW5, 22 interactors
MINTiQ9BVW5
STRINGi9606.ENSP00000261881

Structurei

3D structure databases

ProteinModelPortaliQ9BVW5
SMRiQ9BVW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 143Interaction with TIMELESSAdd BLAST77

Sequence similaritiesi

Belongs to the CSM3 family.Curated

Phylogenomic databases

eggNOGiKOG3004 Eukaryota
ENOG4111VXN LUCA
GeneTreeiENSGT00390000005764
HOGENOMiHOG000154594
HOVERGENiHBG061130
InParanoidiQ9BVW5
KOiK10904
OMAiMLEPQEN
OrthoDBiEOG091G0H5F
PhylomeDBiQ9BVW5
TreeFamiTF313290

Family and domain databases

InterProiView protein in InterPro
IPR012923 Csm3
PfamiView protein in Pfam
PF07962 Swi3, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD089639 Swi3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BVW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEPQENGVI DLPDYEHVED ETFPPFPPPA SPERQDGEGT EPDEESGNGA
60 70 80 90 100
PVRVPPKRTV KRNIPKLDAQ RLISERGLPA LRHVFDKAKF KGKGHEAEDL
110 120 130 140 150
KMLIRHMEHW AHRLFPKLQF EDFIDRVEYL GSKKEVQTCL KRIRLDLPIL
160 170 180 190 200
HEDFVSNNDE VAENNEHDVT STELDPFLTN LSESEMFASE LSRSLTEEQQ
210 220 230 240 250
QRIERNKQLA LERRQAKLLS NSQTLGNDML MNTPRAHTVE EVNTDEDQKE
260 270 280 290 300
ESNGLNEDIL DNPCNDAIAN TLNEEETLLD QSFKNVQQQL DATSRNITEA

R
Length:301
Mass (Da):34,555
Last modified:May 18, 2010 - v2
Checksum:iB0C69117A636CE3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201Q → R in BAA91229 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03519453R → P4 PublicationsCorresponds to variant dbSNP:rs9806123Ensembl.1
Natural variantiVAR_035195111A → G1 PublicationCorresponds to variant dbSNP:rs2063690Ensembl.1
Natural variantiVAR_053952260L → P. Corresponds to variant dbSNP:rs3759787Ensembl.1
Natural variantiVAR_035196267A → S1 PublicationCorresponds to variant dbSNP:rs3759786Ensembl.1
Natural variantiVAR_062207270N → D. Corresponds to variant dbSNP:rs34848112Ensembl.1
Natural variantiVAR_054483270N → S1 PublicationCorresponds to variant dbSNP:rs780014564Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000523 mRNA Translation: BAA91229.1
EU551725 Genomic DNA Translation: ACB21044.1
AC055855 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77762.1
BC000870 mRNA Translation: AAH00870.1
BK001386 mRNA Translation: DAA01365.1
CCDSiCCDS10215.1
RefSeqiNP_001276915.1, NM_001289986.1
NP_060328.2, NM_017858.2
XP_005254578.1, XM_005254521.2
XP_005254579.1, XM_005254522.4
XP_006720657.1, XM_006720594.3
XP_011520045.1, XM_011521743.1
XP_016877879.1, XM_017022390.1
UniGeneiHs.744308

Genome annotation databases

EnsembliENST00000261881; ENSP00000261881; ENSG00000075131
GeneIDi54962
KEGGihsa:54962
UCSCiuc002apr.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTIPIN_HUMAN
AccessioniPrimary (citable) accession number: Q9BVW5
Secondary accession number(s): B2CW64, Q9NWZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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