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Entry version 131 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Fibronectin type III domain-containing protein 11

Gene

FNDC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNDC11
Synonyms:C20orf195
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28764 FNDC11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BVV2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000125531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672215

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FNDC11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002328671 – 318Fibronectin type III domain-containing protein 11Add BLAST318

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BVV2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BVV2

PeptideAtlas

More...
PeptideAtlasi
Q9BVV2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BVV2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79235

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BVV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125531 Expressed in 79 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BVV2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BVV2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041341

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122493, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BVV2, 41 interactors

Molecular INTeraction database

More...
MINTi
Q9BVV2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480914

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BVV2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 307Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST98

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGYC Eukaryota
ENOG410YC0Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231855

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVV2

Identification of Orthologs from Complete Genome Data

More...
OMAi
WFVTVQP

Database of Orthologous Groups

More...
OrthoDBi
1532862at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BVV2

TreeFam database of animal gene trees

More...
TreeFami
TF338188

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR039581 FNDC11

The PANTHER Classification System

More...
PANTHERi
PTHR14537 PTHR14537, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17744 DUF5581, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BVV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTHVAGLGL DKMKLGNPQS FLDQEEADDQ QLLEPEAWKT YTERRNALRE
60 70 80 90 100
FLTSDLSPHL LKRHHARMQL LRKCSYYIEV LPKHLALGDQ NPLVLPSALF
110 120 130 140 150
QLIDPWKFQR MKKVGTAQTK IQLLLLGDLL EQLDHGRAEL DALLRSPDPR
160 170 180 190 200
PFLADWALVE RRLADVSAVM DSFLTMMVPG RLHVKHRLVS DVSATKIPHI
210 220 230 240 250
WLMLSTKMPV VFDRKASAAH QDWARLRWFV TIQPATSEQY ELRFRLLDPR
260 270 280 290 300
TQQECAQCGV IPVAACTFDV RNLLPNRSYK FTIKRAETST LVYEPWRDSL
310
TLHTKPEPLE GPALSHSV
Length:318
Mass (Da):36,526
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FDA08CB588A9699
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0Q0A0A087X0Q0_HUMAN
Fibronectin type III domain-contain...
FNDC11
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL121829 Genomic DNA No translation available.
BC000912 mRNA Translation: AAH00912.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13526.1

NCBI Reference Sequences

More...
RefSeqi
NP_001306081.1, NM_001319152.1
NP_001306082.1, NM_001319153.1
NP_076964.1, NM_024059.3
XP_011527343.1, XM_011529041.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370097; ENSP00000359115; ENSG00000125531
ENST00000370098; ENSP00000359116; ENSG00000125531
ENST00000615526; ENSP00000480914; ENSG00000125531

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79025

UCSC genome browser

More...
UCSCi
uc002yfj.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121829 Genomic DNA No translation available.
BC000912 mRNA Translation: AAH00912.1
CCDSiCCDS13526.1
RefSeqiNP_001306081.1, NM_001319152.1
NP_001306082.1, NM_001319153.1
NP_076964.1, NM_024059.3
XP_011527343.1, XM_011529041.2

3D structure databases

SMRiQ9BVV2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122493, 25 interactors
IntActiQ9BVV2, 41 interactors
MINTiQ9BVV2
STRINGi9606.ENSP00000480914

PTM databases

iPTMnetiQ9BVV2
PhosphoSitePlusiQ9BVV2

Polymorphism and mutation databases

BioMutaiFNDC11
DMDMi74761293

Proteomic databases

jPOSTiQ9BVV2
PaxDbiQ9BVV2
PeptideAtlasiQ9BVV2
PRIDEiQ9BVV2
ProteomicsDBi79235

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370097; ENSP00000359115; ENSG00000125531
ENST00000370098; ENSP00000359116; ENSG00000125531
ENST00000615526; ENSP00000480914; ENSG00000125531
GeneIDi79025
KEGGihsa:79025
UCSCiuc002yfj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79025

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FNDC11
HGNCiHGNC:28764 FNDC11
HPAiHPA041341
neXtProtiNX_Q9BVV2
OpenTargetsiENSG00000125531
PharmGKBiPA142672215

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGYC Eukaryota
ENOG410YC0Q LUCA
GeneTreeiENSGT00390000006008
HOGENOMiHOG000231855
InParanoidiQ9BVV2
OMAiWFVTVQP
OrthoDBi1532862at2759
PhylomeDBiQ9BVV2
TreeFamiTF338188

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79025

Protein Ontology

More...
PROi
PR:Q9BVV2

Gene expression databases

BgeeiENSG00000125531 Expressed in 79 organ(s), highest expression level in right testis
ExpressionAtlasiQ9BVV2 baseline and differential
GenevisibleiQ9BVV2 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR039581 FNDC11
PANTHERiPTHR14537 PTHR14537, 1 hit
PfamiView protein in Pfam
PF17744 DUF5581, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFND11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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