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UniProtKB - Q9BVV2 (FND11_HUMAN)

Entry version 143 (02 Jun 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Fibronectin type III domain-containing protein 11

Gene

FNDC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BVV2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin type III domain-containing protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNDC11
Synonyms:C20orf195
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:28764, FNDC11

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BVV2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125531.6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000125531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672215

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BVV2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FNDC11

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002328671 – 318Fibronectin type III domain-containing protein 11Add BLAST318

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BVV2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BVV2

PeptideAtlas

More...PeptideAtlasi		Q9BVV2

PRoteomics IDEntifications database

More...PRIDEi		Q9BVV2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79235

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BVV2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BVV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125531, Expressed in right testis and 105 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BVV2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BVV2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125531, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122493, 48 interactors

Protein interaction database and analysis system

More...IntActi		Q9BVV2, 45 interactors

Molecular INTeraction database

More...MINTi		Q9BVV2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480914

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BVV2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BVV2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 307Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST98

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QW8H, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006008

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_049179_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BVV2

Identification of Orthologs from Complete Genome Data

More...OMAi		VPEQFEL

Database of Orthologous Groups

More...OrthoDBi		1532862at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BVV2

TreeFam database of animal gene trees

More...TreeFami		TF338188

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR039581, FNDC11

The PANTHER Classification System

More...PANTHERi		PTHR14537, PTHR14537, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17744, DUF5581, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BVV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTHVAGLGL DKMKLGNPQS FLDQEEADDQ QLLEPEAWKT YTERRNALRE 
        60         70         80         90        100
FLTSDLSPHL LKRHHARMQL LRKCSYYIEV LPKHLALGDQ NPLVLPSALF 
       110        120        130        140        150
QLIDPWKFQR MKKVGTAQTK IQLLLLGDLL EQLDHGRAEL DALLRSPDPR 
       160        170        180        190        200
PFLADWALVE RRLADVSAVM DSFLTMMVPG RLHVKHRLVS DVSATKIPHI 
       210        220        230        240        250
WLMLSTKMPV VFDRKASAAH QDWARLRWFV TIQPATSEQY ELRFRLLDPR 
       260        270        280        290        300
TQQECAQCGV IPVAACTFDV RNLLPNRSYK FTIKRAETST LVYEPWRDSL 
       310 
TLHTKPEPLE GPALSHSV
Length:318
Mass (Da):36,526
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FDA08CB588A9699
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0Q0A0A087X0Q0_HUMAN
Fibronectin type III domain-contain...
FNDC11
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL121829 Genomic DNA No translation available.
BC000912 mRNA Translation: AAH00912.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13526.1

NCBI Reference Sequences

More...RefSeqi		NP_001306081.1, NM_001319152.1
NP_001306082.1, NM_001319153.1
NP_076964.1, NM_024059.3
XP_011527343.1, XM_011529041.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370097; ENSP00000359115; ENSG00000125531
ENST00000370098; ENSP00000359116; ENSG00000125531
ENST00000615526; ENSP00000480914; ENSG00000125531

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79025

UCSC genome browser

More...UCSCi		uc002yfj.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121829 Genomic DNA No translation available.
BC000912 mRNA Translation: AAH00912.1
CCDSiCCDS13526.1
RefSeqiNP_001306081.1, NM_001319152.1
NP_001306082.1, NM_001319153.1
NP_076964.1, NM_024059.3
XP_011527343.1, XM_011529041.2

3D structure databases

SMRiQ9BVV2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122493, 48 interactors
IntActiQ9BVV2, 45 interactors
MINTiQ9BVV2
STRINGi9606.ENSP00000480914

PTM databases

iPTMnetiQ9BVV2
PhosphoSitePlusiQ9BVV2

Genetic variation databases

BioMutaiFNDC11
DMDMi74761293

Proteomic databases

MassIVEiQ9BVV2
PaxDbiQ9BVV2
PeptideAtlasiQ9BVV2
PRIDEiQ9BVV2
ProteomicsDBi79235

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29791, 106 antibodies

The DNASU plasmid repository

More...DNASUi		79025

Genome annotation databases

EnsembliENST00000370097; ENSP00000359115; ENSG00000125531
ENST00000370098; ENSP00000359116; ENSG00000125531
ENST00000615526; ENSP00000480914; ENSG00000125531
GeneIDi79025
KEGGihsa:79025
UCSCiuc002yfj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79025

GeneCards: human genes, protein and diseases

More...GeneCardsi		FNDC11
HGNCiHGNC:28764, FNDC11
HPAiENSG00000125531, Tissue enriched (testis)
neXtProtiNX_Q9BVV2
OpenTargetsiENSG00000125531
PharmGKBiPA142672215
VEuPathDBiHostDB:ENSG00000125531.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QW8H, Eukaryota
GeneTreeiENSGT00390000006008
HOGENOMiCLU_049179_0_0_1
InParanoidiQ9BVV2
OMAiVPEQFEL
OrthoDBi1532862at2759
PhylomeDBiQ9BVV2
TreeFamiTF338188

Enzyme and pathway databases

PathwayCommonsiQ9BVV2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79025, 8 hits in 988 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79025
PharosiQ9BVV2, Tdark

Protein Ontology

More...PROi		PR:Q9BVV2
RNActiQ9BVV2, protein

Gene expression databases

BgeeiENSG00000125531, Expressed in right testis and 105 other tissues
ExpressionAtlasiQ9BVV2, baseline and differential
GenevisibleiQ9BVV2, HS

Family and domain databases

CDDicd00063, FN3, 1 hit
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR039581, FNDC11
PANTHERiPTHR14537, PTHR14537, 1 hit
PfamiView protein in Pfam
PF17744, DUF5581, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFND11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: June 2, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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