UniProtKB - Q9BVP2 (GNL3_HUMAN)

BLAST

>sp|Q9BVP2|GNL3_HUMAN Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2
MKRPKLKKASKRMTCHKRYKIQKKVREHHRKLRKEAKKRGHKKPRKDPGVPNSAPFKEAL
LREAELRKQRLEELKQQQKLDRQKELEKKRKLETNPDIKPSNVEPMEKEFGLCKTENKAK
SGKQNSKKLYCQELKKVIEASDVVLEVLDARDPLGCRCPQVEEAIVQSGQKKLVLILNKS
DLVPKENLESWLNYLKKELPTVVFRASTKPKDKGKITKRVKAKKNAAPFRSEVCFGKEGL
WKLLGGFQETCSKAIRVGVIGFPNVGKSSIINSLKQEQMCNVGVSMGLTRSMQVVPLDKQ
ITIIDSPSFIVSPLNSSSALALRSPASIEVVKPMEAASAILSQADARQVVLKYTVPGYRN
SLEFFTVLAQRRGMHQKGGIPNVEGAAKLLWSEWTGASLAYYCHPPTSWTPPPYFNESIV
VDMKSGFNLEELEKNNAQSIRAIKGPHLANSILFQSSGLTNGIIEEKDIHEELPKRKERK
QEEREDDKDSDQETVDEEVDENSSGMFAAEETGEALSEETTAGEQSTRSFILDKIIEEDD
AYDFSTDYV

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History
Entry version 164 (07 Nov 2018)
Sequence version 2 (05 May 2009)
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Protein

Guanine nucleotide-binding protein-like 3

Gene

GNL3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	178 – 181	GTPSequence analysis	4
Nucleotide bindingⁱ	261 – 268	GTPSequence analysis	8
Nucleotide bindingⁱ	305 – 308	GTPSequence analysis	4

GO - Molecular functionⁱ

GTP binding Source: UniProtKB
mRNA 5'-UTR binding
Source: CAFA
Inferred from direct assayⁱ
- 16213212
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 25569094
positive regulation of protein localization to chromosome, telomeric region
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22641345
positive regulation of protein sumoylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22641345
positive regulation of telomere maintenance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22641345
regulation of cell proliferation Source: UniProtKB
stem cell division
Source: UniProtKB
Inferred from direct assayⁱ
- 25522312
stem cell population maintenance
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25522312

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanine nucleotide-binding protein-like 3 Alternative name(s): E2-induced gene 3 protein Novel nucleolar protein 47 Short name: NNP47 Nucleolar GTP-binding protein 3 Nucleostemin
Gene namesⁱ	Name:GNL3 Synonyms:E2IG3, NS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163938.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29931 GNL3
MIMⁱ	608011 gene
neXtProtⁱ	NX_Q9BVP2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26354
Open Targets More...OpenTargetsⁱ	ENSG00000163938
PharmGKBⁱ	PA134952132

Polymorphism and mutation databases

BioMutaⁱ	GNL3
DMDMⁱ	229462872

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000122444	1 – 549	Guanine nucleotide-binding protein-like 3Add BLAST		549

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	79	N6-acetyllysineCombined sources	1
Cross-linkⁱ	91	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	99	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	101	PhosphoserineBy similarity	1
Cross-linkⁱ	114	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	179	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	196	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	253	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	267	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	275	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	490	PhosphoserineCombined sources	1
Modified residueⁱ	504	PhosphoserineBy similarity	1
Modified residueⁱ	517	PhosphoserineCombined sources	1
Modified residueⁱ	529	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9BVP2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BVP2
PaxDbⁱ	Q9BVP2
PeptideAtlas More...PeptideAtlasⁱ	Q9BVP2
PRIDEⁱ	Q9BVP2
ProteomicsDBⁱ	79223 79224 [Q9BVP2-2]

2D gel databases

SWISS-2DPAGEⁱ	Q9BVP2

SWISS-2DPAGEⁱ

Q9BVP2

PTM databases

iPTMnetⁱ	Q9BVP2
PhosphoSitePlusⁱ	Q9BVP2
SwissPalmⁱ	Q9BVP2

Expressionⁱ

Tissue specificityⁱ

Increased levels in lung tissue in cancer patients.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163938 Expressed in 228 organ(s), highest expression level in urinary bladder
CleanExⁱ	HS_GNL3
ExpressionAtlasⁱ	Q9BVP2 baseline and differential
Genevisibleⁱ	Q9BVP2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020770 HPA036742 HPA036743

HPAⁱ

CAB020770
HPA036742
HPA036743

Interactionⁱ

Subunit structureⁱ

Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AGO2	Q9UKV8	3	EBI-641642,EBI-528269
MDM2	Q00987	3	EBI-641642,EBI-389668
PPP2R5A	Q15172	3	EBI-641642,EBI-641666
STAT3	P40763	2	EBI-641642,EBI-518675
TERT	O14746	3	EBI-641642,EBI-1772203

Protein-protein interaction databases

BioGridⁱ	117690, 137 interactors
CORUMⁱ	Q9BVP2
IntActⁱ	Q9BVP2, 52 interactors
Molecular INTeraction database More...MINTⁱ	Q9BVP2
STRINGⁱ	9606.ENSP00000395772

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BVP2
SMRⁱ	Q9BVP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	131 – 312	CP-type GPROSITE-ProRule annotationAdd BLAST		182

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 46	BasicBy similarityAdd BLAST	45
Regionⁱ	282 – 456	IntermediateBy similarityAdd BLAST	175
Regionⁱ	465 – 543	AcidicBy similarityAdd BLAST	79

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	56 – 95	Sequence analysisAdd BLAST		40

Domainⁱ

The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).By similarity

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesⁱ

Belongs to the TRAFAC class YlqF/YawG GTPase family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2484 Eukaryota COG1161 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125472
HOGENOMⁱ	HOG000207716
HOVERGENⁱ	HBG051747
InParanoidⁱ	Q9BVP2
KEGG Orthology (KO) More...KOⁱ	K14538
OMAⁱ	NPKKLYC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08IZ
PhylomeDBⁱ	Q9BVP2
TreeFamⁱ	TF313085

Family and domain databases

InterProⁱ	View protein in InterPro IPR030378 G_CP_dom IPR014813 Gnl3_N_dom IPR006073 GTP_binding_domain IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08701 GN3L_Grn1, 1 hit PF01926 MMR_HSR1, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51721 G_CP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BVP2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG HKKPRKDPGV 
        60         70         80         90        100
PNSAPFKEAL LREAELRKQR LEELKQQQKL DRQKELEKKR KLETNPDIKP 
       110        120        130        140        150
SNVEPMEKEF GLCKTENKAK SGKQNSKKLY CQELKKVIEA SDVVLEVLDA 
       160        170        180        190        200
RDPLGCRCPQ VEEAIVQSGQ KKLVLILNKS DLVPKENLES WLNYLKKELP 
       210        220        230        240        250
TVVFRASTKP KDKGKITKRV KAKKNAAPFR SEVCFGKEGL WKLLGGFQET 
       260        270        280        290        300
CSKAIRVGVI GFPNVGKSSI INSLKQEQMC NVGVSMGLTR SMQVVPLDKQ 
       310        320        330        340        350
ITIIDSPSFI VSPLNSSSAL ALRSPASIEV VKPMEAASAI LSQADARQVV 
       360        370        380        390        400
LKYTVPGYRN SLEFFTVLAQ RRGMHQKGGI PNVEGAAKLL WSEWTGASLA 
       410        420        430        440        450
YYCHPPTSWT PPPYFNESIV VDMKSGFNLE ELEKNNAQSI RAIKGPHLAN 
       460        470        480        490        500
SILFQSSGLT NGIIEEKDIH EELPKRKERK QEEREDDKDS DQETVDEEVD 
       510        520        530        540 
ENSSGMFAAE ETGEALSEET TAGEQSTRSF ILDKIIEEDD AYDFSTDYV

Length:549

Mass (Da):61,993

Last modified:May 5, 2009 - v2

Checksum:ⁱF3928FE1C77C77F4

Isoform 2 (identifier: Q9BVP2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-12: Missing.

« Hide

        10         20         30         40         50
MTCHKRYKIQ KKVREHHRKL RKEAKKRGHK KPRKDPGVPN SAPFKEALLR 
        60         70         80         90        100
EAELRKQRLE ELKQQQKLDR QKELEKKRKL ETNPDIKPSN VEPMEKEFGL 
       110        120        130        140        150
CKTENKAKSG KQNSKKLYCQ ELKKVIEASD VVLEVLDARD PLGCRCPQVE 
       160        170        180        190        200
EAIVQSGQKK LVLILNKSDL VPKENLESWL NYLKKELPTV VFRASTKPKD 
       210        220        230        240        250
KGKITKRVKA KKNAAPFRSE VCFGKEGLWK LLGGFQETCS KAIRVGVIGF 
       260        270        280        290        300
PNVGKSSIIN SLKQEQMCNV GVSMGLTRSM QVVPLDKQIT IIDSPSFIVS 
       310        320        330        340        350
PLNSSSALAL RSPASIEVVK PMEAASAILS QADARQVVLK YTVPGYRNSL 
       360        370        380        390        400
EFFTVLAQRR GMHQKGGIPN VEGAAKLLWS EWTGASLAYY CHPPTSWTPP 
       410        420        430        440        450
PYFNESIVVD MKSGFNLEEL EKNNAQSIRA IKGPHLANSI LFQSSGLTNG 
       460        470        480        490        500
IIEEKDIHEE LPKRKERKQE EREDDKDSDQ ETVDEEVDEN SSGMFAAEET 
       510        520        530 
GEALSEETTA GEQSTRSFIL DKIIEEDDAY DFSTDYV

Show »

Length:537

Mass (Da):60,540

Checksum:ⁱ342BCB22B4234056

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JZT7	C9JZT7_HUMAN	Guanine nucleotide-binding protein-... Guanine nucleotide-binding protein-like 3	GNL3	134	Annotation score:
C9JYH9	C9JYH9_HUMAN	Guanine nucleotide-binding protein-... Guanine nucleotide-binding protein-like 3	GNL3	96	Annotation score:
B4DMU5	B4DMU5_HUMAN	cDNA FLJ57535, highly similar to Gu... cDNA FLJ57535, highly similar to Guanine nucleotide-binding protein-like 3	GNL3	138	Annotation score:

Sequence cautionⁱ

The sequence AAF09482 differs from that shown. Reason: Frameshift at position 516.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	3	R → K in AAV74413 (PubMed:16012751).Curated	1
Sequence conflictⁱ	86	L → Q in AAV74413 (PubMed:16012751).Curated	1
Sequence conflictⁱ	436	N → D in AAV74413 (PubMed:16012751).Curated	1
Sequence conflictⁱ	463	I → M in BAB55169 (PubMed:14702039).Curated	1
Sequence conflictⁱ	495	V → A in AAV74413 (PubMed:16012751).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_022160	39	R → Q3 PublicationsCorresponds to variant dbSNP:rs11177Ensembl.		1
Natural variantⁱVAR_022161	367	V → MCombined sources3 PublicationsCorresponds to variant dbSNP:rs2289247Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013411	1 – 12	Missing in isoform 2. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF191018 mRNA Translation: AAF09482.1 Frameshift. AY825265 mRNA Translation: AAV74413.1 AK027514 mRNA Translation: BAB55168.1 AK027516 mRNA Translation: BAB55169.1 AK315484 mRNA Translation: BAG37868.1 AC104446 Genomic DNA No translation available. BC001024 mRNA Translation: AAH01024.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2861.1 [Q9BVP2-1] CCDS43100.1 [Q9BVP2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_055181.3, NM_014366.4 [Q9BVP2-1] NP_996561.1, NM_206825.1 [Q9BVP2-2] NP_996562.1, NM_206826.1 [Q9BVP2-2]
UniGeneⁱ	Hs.313544

Genome annotation databases

Ensemblⁱ	ENST00000394799; ENSP00000378278; ENSG00000163938 [Q9BVP2-2] ENST00000418458; ENSP00000395772; ENSG00000163938 [Q9BVP2-1]
GeneIDⁱ	26354
KEGGⁱ	hsa:26354
UCSC genome browser More...UCSCⁱ	uc003dfd.4 human [Q9BVP2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BVP2	Isoform 2 of Guanine nucleotide-binding protein-like 3		HUMAN		537	UniRef90_Q9BVP2
Uncharacterized protein		AOTNA		575
Uncharacterized protein		CHLSB		550
Guanine nucleotide-binding protein-like 3 isoform 1		MACMU		549
G protein nucleolar 3		MACFA		549
+29

Protein	Similar proteins		Species	Score	Length	Source
Q9BVP2	Isoform 2 of Guanine nucleotide-binding protein-like 3		HUMAN		537	UniRef50_Q9BVP2
Uncharacterized protein		AOTNA		575
Uncharacterized protein		CHLSB		550
Uncharacterized protein		CERAT		549
G protein nucleolar 3		PANTR		549
+114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF191018 mRNA Translation: AAF09482.1 Frameshift. AY825265 mRNA Translation: AAV74413.1 AK027514 mRNA Translation: BAB55168.1 AK027516 mRNA Translation: BAB55169.1 AK315484 mRNA Translation: BAG37868.1 AC104446 Genomic DNA No translation available. BC001024 mRNA Translation: AAH01024.1
CCDSⁱ	CCDS2861.1 [Q9BVP2-1] CCDS43100.1 [Q9BVP2-2]
RefSeqⁱ	NP_055181.3, NM_014366.4 [Q9BVP2-1] NP_996561.1, NM_206825.1 [Q9BVP2-2] NP_996562.1, NM_206826.1 [Q9BVP2-2]
UniGeneⁱ	Hs.313544

3D structure databases

ProteinModelPortalⁱ	Q9BVP2
SMRⁱ	Q9BVP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117690, 137 interactors
CORUMⁱ	Q9BVP2
IntActⁱ	Q9BVP2, 52 interactors
MINTⁱ	Q9BVP2
STRINGⁱ	9606.ENSP00000395772

PTM databases

iPTMnetⁱ	Q9BVP2
PhosphoSitePlusⁱ	Q9BVP2
SwissPalmⁱ	Q9BVP2

Polymorphism and mutation databases

BioMutaⁱ	GNL3
DMDMⁱ	229462872

2D gel databases

SWISS-2DPAGEⁱ	Q9BVP2

SWISS-2DPAGEⁱ

Q9BVP2

Proteomic databases

EPDⁱ	Q9BVP2
MaxQBⁱ	Q9BVP2
PaxDbⁱ	Q9BVP2
PeptideAtlasⁱ	Q9BVP2
PRIDEⁱ	Q9BVP2
ProteomicsDBⁱ	79223 79224 [Q9BVP2-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26354
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000394799; ENSP00000378278; ENSG00000163938 [Q9BVP2-2] ENST00000418458; ENSP00000395772; ENSG00000163938 [Q9BVP2-1]
GeneIDⁱ	26354
KEGGⁱ	hsa:26354
UCSCⁱ	uc003dfd.4 human [Q9BVP2-1]

Organism-specific databases

CTDⁱ	26354
DisGeNETⁱ	26354
EuPathDBⁱ	HostDB:ENSG00000163938.16
GeneCardsⁱ	GNL3
H-InvDBⁱ	HIX0003367
HGNCⁱ	HGNC:29931 GNL3
HPAⁱ	CAB020770 HPA036742 HPA036743
MIMⁱ	608011 gene
neXtProtⁱ	NX_Q9BVP2
OpenTargetsⁱ	ENSG00000163938
PharmGKBⁱ	PA134952132
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2484 Eukaryota COG1161 LUCA
GeneTreeⁱ	ENSGT00810000125472
HOGENOMⁱ	HOG000207716
HOVERGENⁱ	HBG051747
InParanoidⁱ	Q9BVP2
KOⁱ	K14538
OMAⁱ	NPKKLYC
OrthoDBⁱ	EOG091G08IZ
PhylomeDBⁱ	Q9BVP2
TreeFamⁱ	TF313085

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	GNL3 human
GeneWikiⁱ	GNL3
GenomeRNAiⁱ	26354
Protein Ontology More...PROⁱ	PR:Q9BVP2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163938 Expressed in 228 organ(s), highest expression level in urinary bladder
CleanExⁱ	HS_GNL3
ExpressionAtlasⁱ	Q9BVP2 baseline and differential
Genevisibleⁱ	Q9BVP2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR030378 G_CP_dom IPR014813 Gnl3_N_dom IPR006073 GTP_binding_domain IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF08701 GN3L_Grn1, 1 hit PF01926 MMR_HSR1, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51721 G_CP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GNL3_HUMAN
Accessionⁱ	Q9BVP2Primary (citable) accession number: Q9BVP2 Secondary accession number(s): B2RDC1 , Q5PU80, Q96SV6, Q96SV7, Q9UJY0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
	Last sequence update:	May 5, 2009
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BVP2 (GNL3_HUMAN)

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Guanine nucleotide-binding protein-like 3

GNL3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ