UniProtKB - Q9BVP2 (GNL3_HUMAN)
Guanine nucleotide-binding protein-like 3
GNL3
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 178 – 181 | GTPSequence analysis | 4 | |
Nucleotide bindingi | 261 – 268 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 305 – 308 | GTPSequence analysis | 4 |
GO - Molecular functioni
- GTP binding Source: UniProtKB
- mRNA 5'-UTR binding Source: CAFA
- RNA binding Source: UniProtKB
GO - Biological processi
- cell population proliferation Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of protein localization to chromosome, telomeric region Source: BHF-UCL
- positive regulation of protein sumoylation Source: BHF-UCL
- positive regulation of telomere maintenance Source: BHF-UCL
- regulation of cell population proliferation Source: UniProtKB
- stem cell division Source: UniProtKB
- stem cell population maintenance Source: UniProtKB
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BVP2 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine nucleotide-binding protein-like 3Alternative name(s): E2-induced gene 3 protein Novel nucleolar protein 47 Short name: NNP47 Nucleolar GTP-binding protein 3 Nucleostemin |
Gene namesi | Name:GNL3 Synonyms:E2IG3, NS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29931, GNL3 |
MIMi | 608011, gene |
neXtProti | NX_Q9BVP2 |
VEuPathDBi | HostDB:ENSG00000163938.16 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- nuclear body Source: HPA
- nucleolus Source: BHF-UCL
- nucleus Source: UniProtKB
Other locations
- chromosome Source: HPA
- membrane Source: UniProtKB
- midbody Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26354 |
OpenTargetsi | ENSG00000163938 |
PharmGKBi | PA134952132 |
Miscellaneous databases
Pharosi | Q9BVP2, Tbio |
Genetic variation databases
BioMutai | GNL3 |
DMDMi | 229462872 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122444 | 1 – 549 | Guanine nucleotide-binding protein-like 3Add BLAST | 549 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 79 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 91 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 99 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 101 | PhosphoserineBy similarity | 1 | |
Cross-linki | 114 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 179 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 196 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 253 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 267 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 275 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 490 | PhosphoserineCombined sources | 1 | |
Modified residuei | 504 | PhosphoserineBy similarity | 1 | |
Modified residuei | 517 | PhosphoserineCombined sources | 1 | |
Modified residuei | 529 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-76 CPTAC-77 |
EPDi | Q9BVP2 |
jPOSTi | Q9BVP2 |
MassIVEi | Q9BVP2 |
MaxQBi | Q9BVP2 |
PaxDbi | Q9BVP2 |
PeptideAtlasi | Q9BVP2 |
PRIDEi | Q9BVP2 |
ProteomicsDBi | 79223 [Q9BVP2-1] 79224 [Q9BVP2-2] |
2D gel databases
SWISS-2DPAGEi | Q9BVP2 |
PTM databases
iPTMneti | Q9BVP2 |
MetOSitei | Q9BVP2 |
PhosphoSitePlusi | Q9BVP2 |
SwissPalmi | Q9BVP2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000163938, Expressed in urinary bladder and 237 other tissues |
ExpressionAtlasi | Q9BVP2, baseline and differential |
Genevisiblei | Q9BVP2, HS |
Organism-specific databases
HPAi | ENSG00000163938, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity).
By similarityBinary interactionsi
Hide detailsQ9BVP2
Protein-protein interaction databases
BioGRIDi | 117690, 212 interactors |
CORUMi | Q9BVP2 |
IntActi | Q9BVP2, 69 interactors |
MINTi | Q9BVP2 |
STRINGi | 9606.ENSP00000395772 |
Miscellaneous databases
RNActi | Q9BVP2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 131 – 312 | CP-type GPROSITE-ProRule annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 46 | BasicBy similarityAdd BLAST | 45 | |
Regioni | 282 – 456 | IntermediateBy similarityAdd BLAST | 175 | |
Regioni | 465 – 543 | AcidicBy similarityAdd BLAST | 79 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 56 – 95 | Sequence analysisAdd BLAST | 40 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2484, Eukaryota |
GeneTreei | ENSGT00940000158320 |
HOGENOMi | CLU_011106_5_6_1 |
InParanoidi | Q9BVP2 |
OMAi | QKRGMLK |
OrthoDBi | 1210675at2759 |
PhylomeDBi | Q9BVP2 |
TreeFami | TF313085 |
Family and domain databases
InterProi | View protein in InterPro IPR030378, G_CP_dom IPR014813, Gnl3_N_dom IPR006073, GTP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF08701, GN3L_Grn1, 1 hit PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51721, G_CP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG HKKPRKDPGV
60 70 80 90 100
PNSAPFKEAL LREAELRKQR LEELKQQQKL DRQKELEKKR KLETNPDIKP
110 120 130 140 150
SNVEPMEKEF GLCKTENKAK SGKQNSKKLY CQELKKVIEA SDVVLEVLDA
160 170 180 190 200
RDPLGCRCPQ VEEAIVQSGQ KKLVLILNKS DLVPKENLES WLNYLKKELP
210 220 230 240 250
TVVFRASTKP KDKGKITKRV KAKKNAAPFR SEVCFGKEGL WKLLGGFQET
260 270 280 290 300
CSKAIRVGVI GFPNVGKSSI INSLKQEQMC NVGVSMGLTR SMQVVPLDKQ
310 320 330 340 350
ITIIDSPSFI VSPLNSSSAL ALRSPASIEV VKPMEAASAI LSQADARQVV
360 370 380 390 400
LKYTVPGYRN SLEFFTVLAQ RRGMHQKGGI PNVEGAAKLL WSEWTGASLA
410 420 430 440 450
YYCHPPTSWT PPPYFNESIV VDMKSGFNLE ELEKNNAQSI RAIKGPHLAN
460 470 480 490 500
SILFQSSGLT NGIIEEKDIH EELPKRKERK QEEREDDKDS DQETVDEEVD
510 520 530 540
ENSSGMFAAE ETGEALSEET TAGEQSTRSF ILDKIIEEDD AYDFSTDYV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DMU5 | B4DMU5_HUMAN | Guanine nucleotide-binding protein-... | GNL3 | 138 | Annotation score: | ||
C9JYH9 | C9JYH9_HUMAN | Guanine nucleotide-binding protein-... | GNL3 | 96 | Annotation score: | ||
C9JZT7 | C9JZT7_HUMAN | Guanine nucleotide-binding protein-... | GNL3 | 134 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | R → K in AAV74413 (PubMed:16012751).Curated | 1 | |
Sequence conflicti | 86 | L → Q in AAV74413 (PubMed:16012751).Curated | 1 | |
Sequence conflicti | 436 | N → D in AAV74413 (PubMed:16012751).Curated | 1 | |
Sequence conflicti | 463 | I → M in BAB55169 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 495 | V → A in AAV74413 (PubMed:16012751).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022160 | 39 | R → Q3 PublicationsCorresponds to variant dbSNP:rs11177Ensembl. | 1 | |
Natural variantiVAR_022161 | 367 | V → MCombined sources3 PublicationsCorresponds to variant dbSNP:rs2289247Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013411 | 1 – 12 | Missing in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191018 mRNA Translation: AAF09482.1 Frameshift. AY825265 mRNA Translation: AAV74413.1 AK027514 mRNA Translation: BAB55168.1 AK027516 mRNA Translation: BAB55169.1 AK315484 mRNA Translation: BAG37868.1 AC104446 Genomic DNA No translation available. BC001024 mRNA Translation: AAH01024.1 |
CCDSi | CCDS2861.1 [Q9BVP2-1] CCDS43100.1 [Q9BVP2-2] |
RefSeqi | NP_055181.3, NM_014366.4 [Q9BVP2-1] NP_996561.1, NM_206825.1 [Q9BVP2-2] NP_996562.1, NM_206826.1 [Q9BVP2-2] |
Genome annotation databases
Ensembli | ENST00000394799; ENSP00000378278; ENSG00000163938 [Q9BVP2-2] ENST00000418458; ENSP00000395772; ENSG00000163938 [Q9BVP2-1] |
GeneIDi | 26354 |
KEGGi | hsa:26354 |
UCSCi | uc003dfd.4, human [Q9BVP2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF191018 mRNA Translation: AAF09482.1 Frameshift. AY825265 mRNA Translation: AAV74413.1 AK027514 mRNA Translation: BAB55168.1 AK027516 mRNA Translation: BAB55169.1 AK315484 mRNA Translation: BAG37868.1 AC104446 Genomic DNA No translation available. BC001024 mRNA Translation: AAH01024.1 |
CCDSi | CCDS2861.1 [Q9BVP2-1] CCDS43100.1 [Q9BVP2-2] |
RefSeqi | NP_055181.3, NM_014366.4 [Q9BVP2-1] NP_996561.1, NM_206825.1 [Q9BVP2-2] NP_996562.1, NM_206826.1 [Q9BVP2-2] |
3D structure databases
SMRi | Q9BVP2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117690, 212 interactors |
CORUMi | Q9BVP2 |
IntActi | Q9BVP2, 69 interactors |
MINTi | Q9BVP2 |
STRINGi | 9606.ENSP00000395772 |
PTM databases
iPTMneti | Q9BVP2 |
MetOSitei | Q9BVP2 |
PhosphoSitePlusi | Q9BVP2 |
SwissPalmi | Q9BVP2 |
Genetic variation databases
BioMutai | GNL3 |
DMDMi | 229462872 |
2D gel databases
SWISS-2DPAGEi | Q9BVP2 |
Proteomic databases
CPTACi | CPTAC-76 CPTAC-77 |
EPDi | Q9BVP2 |
jPOSTi | Q9BVP2 |
MassIVEi | Q9BVP2 |
MaxQBi | Q9BVP2 |
PaxDbi | Q9BVP2 |
PeptideAtlasi | Q9BVP2 |
PRIDEi | Q9BVP2 |
ProteomicsDBi | 79223 [Q9BVP2-1] 79224 [Q9BVP2-2] |
Protocols and materials databases
Antibodypediai | 31298, 517 antibodies |
DNASUi | 26354 |
Genome annotation databases
Ensembli | ENST00000394799; ENSP00000378278; ENSG00000163938 [Q9BVP2-2] ENST00000418458; ENSP00000395772; ENSG00000163938 [Q9BVP2-1] |
GeneIDi | 26354 |
KEGGi | hsa:26354 |
UCSCi | uc003dfd.4, human [Q9BVP2-1] |
Organism-specific databases
CTDi | 26354 |
DisGeNETi | 26354 |
GeneCardsi | GNL3 |
HGNCi | HGNC:29931, GNL3 |
HPAi | ENSG00000163938, Low tissue specificity |
MIMi | 608011, gene |
neXtProti | NX_Q9BVP2 |
OpenTargetsi | ENSG00000163938 |
PharmGKBi | PA134952132 |
VEuPathDBi | HostDB:ENSG00000163938.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2484, Eukaryota |
GeneTreei | ENSGT00940000158320 |
HOGENOMi | CLU_011106_5_6_1 |
InParanoidi | Q9BVP2 |
OMAi | QKRGMLK |
OrthoDBi | 1210675at2759 |
PhylomeDBi | Q9BVP2 |
TreeFami | TF313085 |
Enzyme and pathway databases
PathwayCommonsi | Q9BVP2 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 26354, 750 hits in 1001 CRISPR screens |
ChiTaRSi | GNL3, human |
GeneWikii | GNL3 |
GenomeRNAii | 26354 |
Pharosi | Q9BVP2, Tbio |
PROi | PR:Q9BVP2 |
RNActi | Q9BVP2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163938, Expressed in urinary bladder and 237 other tissues |
ExpressionAtlasi | Q9BVP2, baseline and differential |
Genevisiblei | Q9BVP2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030378, G_CP_dom IPR014813, Gnl3_N_dom IPR006073, GTP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF08701, GN3L_Grn1, 1 hit PF01926, MMR_HSR1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51721, G_CP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNL3_HUMAN | |
Accessioni | Q9BVP2Primary (citable) accession number: Q9BVP2 Secondary accession number(s): B2RDC1 Q9UJY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | May 5, 2009 | |
Last modified: | April 7, 2021 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families