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Protein

RUN and SH3 domain-containing protein 1

Gene

RUSC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

  • protein polyubiquitination Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RUN and SH3 domain-containing protein 1
Alternative name(s):
New molecule containing SH3 at the carboxy-terminus
Short name:
Nesca
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RUSC1
Synonyms:NESCA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160753.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17153 RUSC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617318 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BVN2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Microtubule, Nucleus, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi531L → A: Abrogates nuclear redistribution. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000160753

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947113

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RUSC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160380712

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975321 – 902RUN and SH3 domain-containing protein 1Add BLAST902

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues following nuclear translocation.
Polyubiquitinated; polyubiquitination involves TRAF6.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BVN2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BVN2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BVN2

PeptideAtlas

More...
PeptideAtlasi
Q9BVN2

PRoteomics IDEntifications database

More...
PRIDEi
Q9BVN2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79221
79222 [Q9BVN2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BVN2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160753 Expressed in 221 organ(s), highest expression level in cerebellar hemisphere

CleanEx database of gene expression profiles

More...
CleanExi
HS_RUSC1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BVN2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BVN2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028510
HPA029922
HPA029923

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IKBKG and TRAF6. Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117155, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BVN2, 99 interactors

Molecular INTeraction database

More...
MINTi
Q9BVN2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357336

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1902
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BVN2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BVN2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini522 – 666RUNPROSITE-ProRule annotationAdd BLAST145
Domaini844 – 902SH3PROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni470 – 605Interaction with TRAF61 PublicationAdd BLAST136
Regioni606 – 672Interaction with IKBKG1 PublicationAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RUN domain is necessary for NGF induced nuclear redistribution.

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0711 Eukaryota
COG0142 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141033

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154229

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058522

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVN2

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKTNTGI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0LEE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BVN2

TreeFam database of animal gene trees

More...
TreeFami
TF332235

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02759 RUN, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00593 RUN, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140741 SSF140741, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50826 RUN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BVN2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSPQRALLC NLNHIHLQHV SLGLHLSRRP ELQEGPLSTP PPPGDTGGKE
60 70 80 90 100
SRGPCSGTLV DANSNSPAVP CRCCQEHGPG LENRQDPSQE EEGAASPSDP
110 120 130 140 150
GCSSSLSSCS DLSPDESPVS VYLRDLPGDE DAHPQPSIIP LEQGSPLASA
160 170 180 190 200
GPGTCSPDSF CCSPDSCSGA SSSPDPGLDS NCNALTTCQD VPSPGLEEED
210 220 230 240 250
ERAEQDLPTS ELLEADDGKI DAGKTEPSWK INPIWKIDTE KTKAEWKTTE
260 270 280 290 300
NNNTGWKNNG NVNSSWKSEP EKFDSGWKTN TRITDSGSKT DAGKIDGGWR
310 320 330 340 350
SDVSEEPVPH RTITSFHELA QKRKRGPGLP LVPQAKKDRS DWLIVFSPDT
360 370 380 390 400
ELPPSGSPGG SSAPPREVTT FKELRSRSRA PAPPVPPRDP PVGWALVPPR
410 420 430 440 450
PPPPPVPPRR KKNRPGLQPI AEGQSEEGRA VSPAAGEEAP AAKEPGAQAG
460 470 480 490 500
LEVRSSWSFA GVPGAQRLWM AEAQSGTGQL QEQKKGLLIA VSVSVDKIIS
510 520 530 540 550
HFGAARNLVQ KAQLGDSRLS PDVGHLVLTT LCPALHALVA DGLKPFRKDL
560 570 580 590 600
ITGQRRSSPW SVVEASVKPG SSTRSLGTLY SQVSRLAPLS SSRSRFHAFI
610 620 630 640 650
LGLLNTKQLE LWFSSLQEDA GLLSLLYLPT GFFSLARGGC PSLSTELLLL
660 670 680 690 700
LQPLSVLTFH LDLLFEHHHH LPLGPPQAPA PPGPPPALQQ TMQAMLHFGG
710 720 730 740 750
RLAQSLRGTS KEAASDPSDS PNLPTPGSWW EQLTQASRVY ASGGTEGFPL
760 770 780 790 800
SRWAPGRHGT AAEEGAQERP LPTDEMAPGR GLWLGRLFGV PGGPAENENG
810 820 830 840 850
ALKSRRPSSW LPPTVSVLAL VKRGAPPEMP SPQELEASAP RMVQTHRAVR
860 870 880 890 900
ALCDHTAARP DQLSFRRGEV LRVITTVDED WLRCGRDGME GLVPVGYTSL

VL
Length:902
Mass (Da):96,444
Last modified:October 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41DB65236E766A82
GO
Isoform 2 (identifier: Q9BVN2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-469: Missing.

Show »
Length:433
Mass (Da):46,592
Checksum:i6A1D519CA4291A94
GO
Isoform 3 (identifier: Q9BVN2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-452: MLSPQRALLC...KEPGAQAGLE → MPPTCSPGLR...ALQALAGQAG

Show »
Length:492
Mass (Da):52,751
Checksum:i8F398A6E086099DF
GO
Isoform 4 (identifier: Q9BVN2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     621-726: Missing.

Note: No experimental confirmation available.
Show »
Length:796
Mass (Da):85,216
Checksum:iD5772D1B94B5ABC2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q68CX2Q68CX2_HUMAN
RUN and SH3 domain-containing prote...
RUSC1 DKFZp761A1822
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ68A0A087WZ68_HUMAN
RUN and SH3 domain containing 1, is...
RUSC1 hCG_2039583
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVK5A0A087WVK5_HUMAN
RUN and SH3 domain-containing prote...
RUSC1
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX95A0A087WX95_HUMAN
RUN and SH3 domain-containing prote...
RUSC1
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW20A0A087WW20_HUMAN
RUN and SH3 domain-containing prote...
RUSC1
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYB2A0A087WYB2_HUMAN
RUN and SH3 domain-containing prote...
RUSC1
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYU8A0A087WYU8_HUMAN
RUN and SH3 domain-containing prote...
RUSC1
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52277 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG54191 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36P → S in BC025680 (PubMed:15489334).Curated1
Sequence conflicti539V → L in BAA77507 (PubMed:10760598).Curated1
Sequence conflicti770P → T in BAA77507 (PubMed:10760598).Curated1
Sequence conflicti788F → L in CAB45702 (PubMed:17974005).Curated1
Sequence conflicti793 – 795GPA → APP in BAA77507 (PubMed:10760598).Curated3
Sequence conflicti852L → F in CAB45702 (PubMed:17974005).Curated1
Sequence conflicti865F → Y in CAB45702 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036803362S → F. Corresponds to variant dbSNP:rs12061020Ensembl.1
Natural variantiVAR_051329493V → A. Corresponds to variant dbSNP:rs35826120Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0108551 – 469Missing in isoform 2. 5 PublicationsAdd BLAST469
Alternative sequenceiVSP_0540521 – 452MLSPQ…QAGLE → MPPTCSPGLRRQDWAPGRCA GLHLPPRAPSSPALQALAGQ AG in isoform 3. 1 PublicationAdd BLAST452
Alternative sequenceiVSP_054053621 – 726Missing in isoform 4. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB026894 mRNA Translation: BAA77507.2
AL080083 mRNA Translation: CAB45702.1
AK314559 mRNA Translation: BAG37144.1
AK074982 mRNA Translation: BAG52045.1
AK055451 mRNA No translation available.
AK125378 mRNA Translation: BAG54191.1 Different initiation.
BX640612 mRNA Translation: CAE45718.1
AL139410 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53069.1
CH471121 Genomic DNA Translation: EAW53071.1
CH471121 Genomic DNA Translation: EAW53072.1
BC001045 mRNA Translation: AAH01045.1
BC025680 mRNA No translation available.
BC052277 mRNA Translation: AAH52277.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS1112.1 [Q9BVN2-2]
CCDS41410.1 [Q9BVN2-1]
CCDS41411.1 [Q9BVN2-4]
CCDS41412.1 [Q9BVN2-3]

Protein sequence database of the Protein Information Resource

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PIRi
T12473

NCBI Reference Sequences

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RefSeqi
NP_001098673.1, NM_001105203.1 [Q9BVN2-1]
NP_001098674.1, NM_001105204.1 [Q9BVN2-4]
NP_001098675.1, NM_001105205.1 [Q9BVN2-3]
NP_001265156.1, NM_001278227.1
NP_001265157.1, NM_001278228.1
NP_001265158.1, NM_001278229.1
NP_001265159.1, NM_001278230.1 [Q9BVN2-2]
NP_055143.2, NM_014328.4 [Q9BVN2-2]
XP_006711320.1, XM_006711257.1 [Q9BVN2-2]
XP_016856381.1, XM_017000892.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.226499

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000292254; ENSP00000292254; ENSG00000160753 [Q9BVN2-2]
ENST00000368347; ENSP00000357331; ENSG00000160753 [Q9BVN2-3]
ENST00000368349; ENSP00000357333; ENSG00000160753 [Q9BVN2-2]
ENST00000368352; ENSP00000357336; ENSG00000160753 [Q9BVN2-1]
ENST00000368354; ENSP00000357338; ENSG00000160753 [Q9BVN2-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23623

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23623

UCSC genome browser

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UCSCi
uc001fkj.3 human [Q9BVN2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026894 mRNA Translation: BAA77507.2
AL080083 mRNA Translation: CAB45702.1
AK314559 mRNA Translation: BAG37144.1
AK074982 mRNA Translation: BAG52045.1
AK055451 mRNA No translation available.
AK125378 mRNA Translation: BAG54191.1 Different initiation.
BX640612 mRNA Translation: CAE45718.1
AL139410 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53069.1
CH471121 Genomic DNA Translation: EAW53071.1
CH471121 Genomic DNA Translation: EAW53072.1
BC001045 mRNA Translation: AAH01045.1
BC025680 mRNA No translation available.
BC052277 mRNA Translation: AAH52277.1 Different initiation.
CCDSiCCDS1112.1 [Q9BVN2-2]
CCDS41410.1 [Q9BVN2-1]
CCDS41411.1 [Q9BVN2-4]
CCDS41412.1 [Q9BVN2-3]
PIRiT12473
RefSeqiNP_001098673.1, NM_001105203.1 [Q9BVN2-1]
NP_001098674.1, NM_001105204.1 [Q9BVN2-4]
NP_001098675.1, NM_001105205.1 [Q9BVN2-3]
NP_001265156.1, NM_001278227.1
NP_001265157.1, NM_001278228.1
NP_001265158.1, NM_001278229.1
NP_001265159.1, NM_001278230.1 [Q9BVN2-2]
NP_055143.2, NM_014328.4 [Q9BVN2-2]
XP_006711320.1, XM_006711257.1 [Q9BVN2-2]
XP_016856381.1, XM_017000892.1
UniGeneiHs.226499

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GIWX-ray2.00A/B477-666[»]
ProteinModelPortaliQ9BVN2
SMRiQ9BVN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117155, 14 interactors
IntActiQ9BVN2, 99 interactors
MINTiQ9BVN2
STRINGi9606.ENSP00000357336

PTM databases

iPTMnetiQ9BVN2
PhosphoSitePlusiQ9BVN2

Polymorphism and mutation databases

BioMutaiRUSC1
DMDMi160380712

Proteomic databases

EPDiQ9BVN2
MaxQBiQ9BVN2
PaxDbiQ9BVN2
PeptideAtlasiQ9BVN2
PRIDEiQ9BVN2
ProteomicsDBi79221
79222 [Q9BVN2-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23623
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292254; ENSP00000292254; ENSG00000160753 [Q9BVN2-2]
ENST00000368347; ENSP00000357331; ENSG00000160753 [Q9BVN2-3]
ENST00000368349; ENSP00000357333; ENSG00000160753 [Q9BVN2-2]
ENST00000368352; ENSP00000357336; ENSG00000160753 [Q9BVN2-1]
ENST00000368354; ENSP00000357338; ENSG00000160753 [Q9BVN2-4]
GeneIDi23623
KEGGihsa:23623
UCSCiuc001fkj.3 human [Q9BVN2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23623
EuPathDBiHostDB:ENSG00000160753.15

GeneCards: human genes, protein and diseases

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GeneCardsi
RUSC1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0116321
HGNCiHGNC:17153 RUSC1
HPAiHPA028510
HPA029922
HPA029923
MIMi617318 gene
neXtProtiNX_Q9BVN2
OpenTargetsiENSG00000160753
PharmGKBiPA134947113

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0711 Eukaryota
COG0142 LUCA
GeneTreeiENSGT00900000141033
HOGENOMiHOG000154229
HOVERGENiHBG058522
InParanoidiQ9BVN2
OMAiWKTNTGI
OrthoDBiEOG091G0LEE
PhylomeDBiQ9BVN2
TreeFamiTF332235

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RUSC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23623

Protein Ontology

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PROi
PR:Q9BVN2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160753 Expressed in 221 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_RUSC1
ExpressionAtlasiQ9BVN2 baseline and differential
GenevisibleiQ9BVN2 HS

Family and domain databases

InterProiView protein in InterPro
IPR004012 Run_dom
IPR037213 Run_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF02759 RUN, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00593 RUN, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF140741 SSF140741, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50826 RUN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRUSC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVN2
Secondary accession number(s): B3KWM9
, Q5T9U9, Q5T9V0, Q5T9V1, Q5T9V2, Q9UPY4, Q9Y4T5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 23, 2007
Last modified: October 10, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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