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Protein

Nucleoporin p58/p45

Gene

NUP58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

Miscellaneous

In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • structural constituent of nuclear pore Source: GO_Central

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin p58/p45Curated
Alternative name(s):
58 kDa nucleoporinImported
Nucleoporin-like protein 1
Gene namesi
Name:NUP58Imported
Synonyms:KIAA0410, NUPL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139496.15
HGNCiHGNC:20261 NUP58
MIMi607615 gene
neXtProtiNX_Q9BVL2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139496
PharmGKBiPA134981903

Polymorphism and mutation databases

BioMutaiNUPL1
DMDMi44888845

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048921 – 599Nucleoporin p58/p45Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei331PhosphothreonineCombined sources1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BVL2
MaxQBiQ9BVL2
PaxDbiQ9BVL2
PeptideAtlasiQ9BVL2
PRIDEiQ9BVL2
ProteomicsDBi79216
79217 [Q9BVL2-2]

PTM databases

iPTMnetiQ9BVL2
PhosphoSitePlusiQ9BVL2

Expressioni

Gene expression databases

BgeeiENSG00000139496 Expressed in 215 organ(s), highest expression level in intestine
CleanExiHS_NUPL1
ExpressionAtlasiQ9BVL2 baseline and differential
GenevisibleiQ9BVL2 HS

Organism-specific databases

HPAiHPA039360

Interactioni

Subunit structurei

Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi115157, 51 interactors
IntActiQ9BVL2, 40 interactors
MINTiQ9BVL2
STRINGi9606.ENSP00000371155

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BVL2
SMRiQ9BVL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 812
Repeati30 – 3122
Repeati44 – 4532
Repeati63 – 6442
Repeati68 – 6952
Repeati488 – 48962
Repeati492 – 49372
Repeati513 – 51482
Repeati519 – 52092
Repeati529 – 530102
Repeati531 – 532112
Repeati545 – 546122
Repeati568 – 569132
Repeati578 – 579142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 57914 X 2 AA repeats of F-GAdd BLAST573

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili256 – 276Sequence analysisAdd BLAST21
Coiled coili314 – 381Sequence analysisAdd BLAST68

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IIR3 Eukaryota
ENOG410ZJAM LUCA
GeneTreeiENSGT00730000111111
HOGENOMiHOG000273874
HOVERGENiHBG052703
InParanoidiQ9BVL2
KOiK14307
OMAiHIQGRVQ
OrthoDBiEOG091G0KUR
PhylomeDBiQ9BVL2
TreeFamiTF106502

Family and domain databases

InterProiView protein in InterPro
IPR024882 Nucleoporin_p58/p45
PANTHERiPTHR13437 PTHR13437, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BVL2-1) [UniParc]FASTAAdd to basket
Also known as: p58

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST
60 70 80 90 100
STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT
110 120 130 140 150
TSAATTGFSL GFNKPAASAT PFALPITSTS ASGLTLSSAL TSTPAASTGF
160 170 180 190 200
TLNNLGGTTA TTTTASTGLS LGGALAGLGG SLFQSTNTGT SGLGQNALGL
210 220 230 240 250
TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK ALKDENLPPV
260 270 280 290 300
ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG
310 320 330 340 350
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV
360 370 380 390 400
QQFEVQLQQY RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA
410 420 430 440 450
AQLQSIHENV KVLKEQYLGY RKMFLGDAVD VFETRRAEAK KWQNTPRVTT
460 470 480 490 500
GPTPFSTMPN AAAVAMAATL TQQQQPATGP QPSLGVSFGT PFGSGIGTGL
510 520 530 540 550
QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS LSAGFGSSST
560 570 580 590
SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
Length:599
Mass (Da):60,897
Last modified:June 1, 2001 - v1
Checksum:i2CC32E2A1B9E5132
GO
Isoform 2 (identifier: Q9BVL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-485: PQPSLG → LNAFKL
     486-599: Missing.

Show »
Length:485
Mass (Da):50,210
Checksum:iFC22003B927D904F
GO
Isoform 3 (identifier: Q9BVL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-95: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):59,754
Checksum:i741B3A6CA2FAE06A
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JRG1Q5JRG1_HUMAN
Nucleoporin p58/p45
NUP58
463Annotation score:
H7BYF2H7BYF2_HUMAN
Nucleoporin p58/p45
NUP58
510Annotation score:
F8WC35F8WC35_HUMAN
Nucleoporin p58/p45
NUP58
128Annotation score:
F8WBZ1F8WBZ1_HUMAN
Nucleoporin p58/p45
NUP58
36Annotation score:
F8WCJ8F8WCJ8_HUMAN
Nucleoporin p58/p45
NUP58
62Annotation score:

Sequence cautioni

The sequence BAA23706 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05057034A → T1 PublicationCorresponds to variant dbSNP:rs11556093Ensembl.1
Natural variantiVAR_050571166S → P. Corresponds to variant dbSNP:rs12871608Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04565884 – 95Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_007946480 – 485PQPSLG → LNAFKL in isoform 2. 1 Publication6
Alternative sequenceiVSP_007947486 – 599Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007870 mRNA Translation: BAA23706.2 Different initiation.
AK302946 mRNA Translation: BAG64103.1
AL138958 Genomic DNA No translation available.
AL590787 Genomic DNA No translation available.
AL646102 Genomic DNA No translation available.
BC001104 mRNA Translation: AAH01104.1
CCDSiCCDS31949.1 [Q9BVL2-3]
CCDS9314.1 [Q9BVL2-1]
RefSeqiNP_001008564.1, NM_001008564.1 [Q9BVL2-3]
NP_054808.1, NM_014089.3 [Q9BVL2-1]
UniGeneiHs.507537
Hs.718943
Hs.732064

Genome annotation databases

EnsembliENST00000381718; ENSP00000371137; ENSG00000139496 [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496 [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496 [Q9BVL2-2]
GeneIDi9818
KEGGihsa:9818
UCSCiuc001uqg.2 human [Q9BVL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007870 mRNA Translation: BAA23706.2 Different initiation.
AK302946 mRNA Translation: BAG64103.1
AL138958 Genomic DNA No translation available.
AL590787 Genomic DNA No translation available.
AL646102 Genomic DNA No translation available.
BC001104 mRNA Translation: AAH01104.1
CCDSiCCDS31949.1 [Q9BVL2-3]
CCDS9314.1 [Q9BVL2-1]
RefSeqiNP_001008564.1, NM_001008564.1 [Q9BVL2-3]
NP_054808.1, NM_014089.3 [Q9BVL2-1]
UniGeneiHs.507537
Hs.718943
Hs.732064

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JO7X-ray1.75A/C/E/G341-428[»]
4JO9X-ray2.50B341-426[»]
4JQ5X-ray2.20A/B/C/D/E/F/G/H/I/J/K/L341-425[»]
5IJNelectron microscopy21.40G/M/S/Y1-599[»]
5IJOelectron microscopy21.40G/M/S/Y1-599[»]
ProteinModelPortaliQ9BVL2
SMRiQ9BVL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115157, 51 interactors
IntActiQ9BVL2, 40 interactors
MINTiQ9BVL2
STRINGi9606.ENSP00000371155

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ9BVL2
PhosphoSitePlusiQ9BVL2

Polymorphism and mutation databases

BioMutaiNUPL1
DMDMi44888845

Proteomic databases

EPDiQ9BVL2
MaxQBiQ9BVL2
PaxDbiQ9BVL2
PeptideAtlasiQ9BVL2
PRIDEiQ9BVL2
ProteomicsDBi79216
79217 [Q9BVL2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381718; ENSP00000371137; ENSG00000139496 [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496 [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496 [Q9BVL2-2]
GeneIDi9818
KEGGihsa:9818
UCSCiuc001uqg.2 human [Q9BVL2-1]

Organism-specific databases

CTDi9818
EuPathDBiHostDB:ENSG00000139496.15
GeneCardsiNUP58
HGNCiHGNC:20261 NUP58
HPAiHPA039360
MIMi607615 gene
neXtProtiNX_Q9BVL2
OpenTargetsiENSG00000139496
PharmGKBiPA134981903
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIR3 Eukaryota
ENOG410ZJAM LUCA
GeneTreeiENSGT00730000111111
HOGENOMiHOG000273874
HOVERGENiHBG052703
InParanoidiQ9BVL2
KOiK14307
OMAiHIQGRVQ
OrthoDBiEOG091G0KUR
PhylomeDBiQ9BVL2
TreeFamiTF106502

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

Miscellaneous databases

ChiTaRSiNUP58 human
GeneWikiiNUPL1
GenomeRNAii9818
PROiPR:Q9BVL2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139496 Expressed in 215 organ(s), highest expression level in intestine
CleanExiHS_NUPL1
ExpressionAtlasiQ9BVL2 baseline and differential
GenevisibleiQ9BVL2 HS

Family and domain databases

InterProiView protein in InterPro
IPR024882 Nucleoporin_p58/p45
PANTHERiPTHR13437 PTHR13437, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUP58_HUMAN
AccessioniPrimary (citable) accession number: Q9BVL2
Secondary accession number(s): A6NI12
, B4DZJ1, O43160, Q5JRG2, Q5JRG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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