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Entry version 174 (29 Sep 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Nucleoporin p58/p45

Gene

NUP58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

By similarity

Miscellaneous

In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9BVL2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408, ISG15 antiviral mechanism
R-HSA-159227, Transport of the SLBP independent Mature mRNA
R-HSA-159230, Transport of the SLBP Dependant Mature mRNA
R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276, NS1 Mediated Effects on Host Pathways
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746, Nuclear import of Rev protein
R-HSA-180910, Vpr-mediated nuclear import of PICs
R-HSA-191859, snRNP Assembly
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-4085377, SUMOylation of SUMOylation proteins
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4615885, SUMOylation of DNA replication proteins
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9BVL2

Protein family/group databases

Transport Classification Database

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TCDBi
1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoporin p58/p45Curated
Alternative name(s):
58 kDa nucleoporinImported
Nucleoporin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP58Imported
Synonyms:KIAA0410, NUPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20261, NUP58

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607615, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9BVL2

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000139496

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
9818

Open Targets

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OpenTargetsi
ENSG00000139496

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134981903

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9BVL2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUP58

Domain mapping of disease mutations (DMDM)

More...
DMDMi
44888845

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048921 – 599Nucleoporin p58/p45Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei331PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BVL2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BVL2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BVL2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BVL2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BVL2

PeptideAtlas

More...
PeptideAtlasi
Q9BVL2

PRoteomics IDEntifications database

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PRIDEi
Q9BVL2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1238
79216 [Q9BVL2-1]
79217 [Q9BVL2-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9BVL2, 54 sites, 2 O-linked glycans (54 sites)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BVL2

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9BVL2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000139496, Expressed in testis and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BVL2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BVL2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139496, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58.

Interacts with NUTF2.

Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BVL2
With#Exp.IntAct
ABI3 [Q9P2A4]7EBI-2811583,EBI-742038
AGR2 [O95994]5EBI-2811583,EBI-712648
AKAP9 - isoform 3 [Q99996-3]3EBI-2811583,EBI-11022349
AMBN [Q9NP70]3EBI-2811583,EBI-11893530
ARHGAP29 - isoform 2 [Q52LW3-2]3EBI-2811583,EBI-22012297
ASB9 - isoform 3 [Q96DX5-3]3EBI-2811583,EBI-25843552
ASIC4 - isoform 3 [Q96FT7-4]3EBI-2811583,EBI-9089489
ATP5IF1 [Q9UII2]3EBI-2811583,EBI-718459
BAHD1 [Q8TBE0]3EBI-2811583,EBI-742750
BCAS2 [O75934]3EBI-2811583,EBI-1050106
BCL3 [P20749]3EBI-2811583,EBI-958997
BRK1 [Q8WUW1]3EBI-2811583,EBI-2837444
BRME1 [Q0VDD7]3EBI-2811583,EBI-741210
CD209 - isoform 10 [Q9NNX6-10]3EBI-2811583,EBI-12300031
CHMP7 [Q8WUX9]3EBI-2811583,EBI-749253
COG3 - isoform 2 [Q96JB2-2]6EBI-2811583,EBI-9091495
COG6 [Q9Y2V7]3EBI-2811583,EBI-3866319
COG8 [Q96MW5]3EBI-2811583,EBI-720875
COL25A1 [Q8NE08]3EBI-2811583,EBI-25836642
COPS4 [Q9BT78]3EBI-2811583,EBI-742413
COX7A1 [P24310]3EBI-2811583,EBI-25876196
DCTN3 - isoform 2 [O75935-2]3EBI-2811583,EBI-12091947
DELE1 [Q14154]3EBI-2811583,EBI-2805660
DPP9 - isoform 2 [Q86TI2-2]3EBI-2811583,EBI-21529239
DPYS [Q14117]3EBI-2811583,EBI-12275416
DSN1 [Q9H410]3EBI-2811583,EBI-1001144
E4F1 [H3BUJ7]3EBI-2811583,EBI-10178160
EIF3F [O00303]3EBI-2811583,EBI-711990
ELK3 [P41970]3EBI-2811583,EBI-1758534
ERGIC1 [Q969X5]3EBI-2811583,EBI-781527
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-2811583,EBI-21567429
FAM168B - isoform 2 [A1KXE4-2]3EBI-2811583,EBI-12193763
FANCG [O15287]3EBI-2811583,EBI-81610
FYCO1 - isoform 2 [Q9BQS8-2]3EBI-2811583,EBI-25905795
GABPB1 - isoform 2 [Q06547-2]3EBI-2811583,EBI-618189
GABPB1 - isoform 3 [Q06547-3]3EBI-2811583,EBI-9088619
GINS3 [Q9BRX5]3EBI-2811583,EBI-2857315
GKN1 [Q9NS71]3EBI-2811583,EBI-3933251
HAUS1 [Q96CS2]3EBI-2811583,EBI-2514791
HAUS7 [Q99871]3EBI-2811583,EBI-395719
HTT [P42858]7EBI-2811583,EBI-466029
ICA1L - isoform 2 [Q8NDH6-2]3EBI-2811583,EBI-12141931
IFI35 - isoform 2 [P80217-2]3EBI-2811583,EBI-12823003
IFT20 - isoform 2 [Q8IY31-2]3EBI-2811583,EBI-11742277
IFT20 - isoform 3 [Q8IY31-3]3EBI-2811583,EBI-9091197
ITGB3BP [Q13352]6EBI-2811583,EBI-712105
KIAA0355 [A1A512]3EBI-2811583,EBI-25844799
KIAA0408 [Q6ZU52]3EBI-2811583,EBI-739493
KLC3 [Q6P597]3EBI-2811583,EBI-1643885
KLF3 [P57682]3EBI-2811583,EBI-8472267
KLF5 [Q13887]3EBI-2811583,EBI-2696013
KRT27 [Q7Z3Y8]3EBI-2811583,EBI-3044087
KRT28 [Q7Z3Y7]3EBI-2811583,EBI-11980489
KRT33B [Q14525]6EBI-2811583,EBI-1049638
LGALS9C [Q6DKI2]3EBI-2811583,EBI-9088829
LRRC61 [Q9BV99]3EBI-2811583,EBI-2350424
MAOB [P27338]3EBI-2811583,EBI-3911344
MED21 [Q13503]3EBI-2811583,EBI-394678
MEIS2 - isoform 4 [O14770-4]3EBI-2811583,EBI-8025850
METTL27 [Q8N6F8]3EBI-2811583,EBI-8487781
MIS18A [Q9NYP9]6EBI-2811583,EBI-1104552
MRI1 [Q9BV20]3EBI-2811583,EBI-747381
MT2A [P02795]3EBI-2811583,EBI-996616
NELFCD [Q8IXH7]3EBI-2811583,EBI-536725
NEUROD1 [Q13562]3EBI-2811583,EBI-3908303
NUP54 [Q7Z3B4]12EBI-2811583,EBI-741048
NUP62 [P37198]7EBI-2811583,EBI-347978
OIP5 [O43482]3EBI-2811583,EBI-536879
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-2811583,EBI-25830200
PADI3 [Q9ULW8]3EBI-2811583,EBI-10488185
PAIP2 [Q9BPZ3]3EBI-2811583,EBI-2957445
PCDHGC3 [Q9BR81]3EBI-2811583,EBI-22012354
PIGP [P57054]3EBI-2811583,EBI-17630288
PKNOX1 [P55347]6EBI-2811583,EBI-1373569
PKNOX2 [Q96KN3]3EBI-2811583,EBI-2692890
PMF1 [Q6P1K2]3EBI-2811583,EBI-713832
PNKD - isoform 3 [Q8N490-3]3EBI-2811583,EBI-25879276
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-2811583,EBI-25835994
PSMC2 [P35998]3EBI-2811583,EBI-359710
REX1BD [Q96EN9]3EBI-2811583,EBI-745810
RGR - isoform 3 [P47804-3]3EBI-2811583,EBI-25834767
RNF31 [Q96EP0]3EBI-2811583,EBI-948111
SCAPER - isoform 3 [Q9BY12-3]3EBI-2811583,EBI-25837959
SMARCD1 [Q96GM5]3EBI-2811583,EBI-358489
SPATA12 [Q7Z6I5]3EBI-2811583,EBI-10696971
STAM - isoform 2 [Q92783-2]3EBI-2811583,EBI-12025738
STAM2 [O75886]3EBI-2811583,EBI-373258
STAT4 [Q14765]3EBI-2811583,EBI-1186538
STX19 [Q8N4C7]3EBI-2811583,EBI-8484990
SYCE3 [A1L190]3EBI-2811583,EBI-10283466
TADA3 [O75528]3EBI-2811583,EBI-473249
TEN1 [Q86WV5]3EBI-2811583,EBI-2562799
TEX12 [Q9BXU0]3EBI-2811583,EBI-12090309
TMTC1 - isoform 4 [Q8IUR5-4]3EBI-2811583,EBI-9089156
TRAF1 [Q13077]9EBI-2811583,EBI-359224
TRIM69 - isoform 2 [Q86WT6-2]3EBI-2811583,EBI-11525489
TSACC [Q96A04]3EBI-2811583,EBI-740411
TSC1 [Q86WV8]3EBI-2811583,EBI-12806590
TSPAN2 [O60636]3EBI-2811583,EBI-3914288
TTC33 [Q6PID6]3EBI-2811583,EBI-2555404
UBE2A [P49459]3EBI-2811583,EBI-2339348
UBQLN1 - isoform 2 [Q9UMX0-2]3EBI-2811583,EBI-10173939
UBQLN2 [Q9UHD9]3EBI-2811583,EBI-947187
UBQLN3 [Q9H347]3EBI-2811583,EBI-25832660
VPS37A [Q8NEZ2]3EBI-2811583,EBI-2850578
VSX2 [P58304]3EBI-2811583,EBI-6427899
YRDC [Q86U90]3EBI-2811583,EBI-21659356
ZBTB8OS - isoform 2 [Q8IWT0-2]3EBI-2811583,EBI-12956041
ZNF488 - isoform 2 [Q96MN9-2]3EBI-2811583,EBI-25831733
ZWINT [O95229]3EBI-2811583,EBI-1001132
B7Z3E83EBI-2811583,EBI-25831617

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115157, 78 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-873, Nuclear pore complex

Protein interaction database and analysis system

More...
IntActi
Q9BVL2, 146 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371155

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BVL2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BVL2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati7 – 812
Repeati30 – 3122
Repeati44 – 4532
Repeati63 – 6442
Repeati68 – 6952
Repeati488 – 48962
Repeati492 – 49372
Repeati513 – 51482
Repeati519 – 52092
Repeati529 – 530102
Repeati531 – 532112
Repeati545 – 546122
Repeati568 – 569132
Repeati578 – 579142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni7 – 57914 X 2 AA repeats of F-GAdd BLAST573
Regioni213 – 247DisorderedSequence analysisAdd BLAST35
Regioni579 – 599DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili256 – 276Sequence analysisAdd BLAST21
Coiled coili314 – 381Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi224 – 244Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRD8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111111

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034851_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVL2

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTKSTKF

Database of Orthologous Groups

More...
OrthoDBi
885529at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BVL2

TreeFam database of animal gene trees

More...
TreeFami
TF106502

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024882, Nucleoporin_p58/p45

The PANTHER Classification System

More...
PANTHERi
PTHR13437, PTHR13437, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BVL2-1) [UniParc]FASTAAdd to basket
Also known as: p58

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST
60 70 80 90 100
STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTIT TGLTLGTPAT
110 120 130 140 150
TSAATTGFSL GFNKPAASAT PFALPITSTS ASGLTLSSAL TSTPAASTGF
160 170 180 190 200
TLNNLGGTTA TTTTASTGLS LGGALAGLGG SLFQSTNTGT SGLGQNALGL
210 220 230 240 250
TLGTTAATST AGNEGLGGID FSSSSDKKSD KTGTRPEDSK ALKDENLPPV
260 270 280 290 300
ICQDVENLQK FVKEQKQVQE EISRMSSKAM LKVQEDIKAL KQLLSLAANG
310 320 330 340 350
IQRNTLNIDK LKIETAQELK NAEIALRTQK TPPGLQHEYA APADYFRILV
360 370 380 390 400
QQFEVQLQQY RQQIEELENH LATQANNSHI TPQDLSMAMQ KIYQTFVALA
410 420 430 440 450
AQLQSIHENV KVLKEQYLGY RKMFLGDAVD VFETRRAEAK KWQNTPRVTT
460 470 480 490 500
GPTPFSTMPN AAAVAMAATL TQQQQPATGP QPSLGVSFGT PFGSGIGTGL
510 520 530 540 550
QSSGLGSSNL GGFGTSSGFG CSTTGASTFG FGTTNKPSGS LSAGFGSSST
560 570 580 590
SGFNFSNPGI TASAGLTFGV SNPASAGFGT GGQLLQLKKP PAGNKRGKR
Length:599
Mass (Da):60,897
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CC32E2A1B9E5132
GO
Isoform 2 (identifier: Q9BVL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-485: PQPSLG → LNAFKL
     486-599: Missing.

Show »
Length:485
Mass (Da):50,210
Checksum:iFC22003B927D904F
GO
Isoform 3 (identifier: Q9BVL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-95: Missing.

Show »
Length:587
Mass (Da):59,754
Checksum:i741B3A6CA2FAE06A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JRG1Q5JRG1_HUMAN
Nucleoporin p58/p45
NUP58
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYF2H7BYF2_HUMAN
Nucleoporin p58/p45
NUP58
510Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBZ1F8WBZ1_HUMAN
Nucleoporin p58/p45
NUP58
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC35F8WC35_HUMAN
Nucleoporin p58/p45
NUP58
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCJ8F8WCJ8_HUMAN
Nucleoporin p58/p45
NUP58
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA23706 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05057034A → T1 PublicationCorresponds to variant dbSNP:rs11556093Ensembl.1
Natural variantiVAR_050571166S → P. Corresponds to variant dbSNP:rs12871608Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04565884 – 95Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_007946480 – 485PQPSLG → LNAFKL in isoform 2. 1 Publication6
Alternative sequenceiVSP_007947486 – 599Missing in isoform 2. 1 PublicationAdd BLAST114

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007870 mRNA Translation: BAA23706.2 Different initiation.
AK302946 mRNA Translation: BAG64103.1
AL138958 Genomic DNA No translation available.
AL590787 Genomic DNA No translation available.
AL646102 Genomic DNA No translation available.
BC001104 mRNA Translation: AAH01104.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31949.1 [Q9BVL2-3]
CCDS9314.1 [Q9BVL2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001008564.1, NM_001008564.1 [Q9BVL2-3]
NP_054808.1, NM_014089.3 [Q9BVL2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381718; ENSP00000371137; ENSG00000139496 [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496 [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496 [Q9BVL2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9818

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9818

UCSC genome browser

More...
UCSCi
uc001uqg.2, human [Q9BVL2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007870 mRNA Translation: BAA23706.2 Different initiation.
AK302946 mRNA Translation: BAG64103.1
AL138958 Genomic DNA No translation available.
AL590787 Genomic DNA No translation available.
AL646102 Genomic DNA No translation available.
BC001104 mRNA Translation: AAH01104.1
CCDSiCCDS31949.1 [Q9BVL2-3]
CCDS9314.1 [Q9BVL2-1]
RefSeqiNP_001008564.1, NM_001008564.1 [Q9BVL2-3]
NP_054808.1, NM_014089.3 [Q9BVL2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JO7X-ray1.75A/C/E/G341-428[»]
4JO9X-ray2.50B341-426[»]
4JQ5X-ray2.20A/B/C/D/E/F/G/H/I/J/K/L341-425[»]
5IJNelectron microscopy21.40G/M/S/Y1-599[»]
5IJOelectron microscopy21.40G/M/S/Y1-599[»]
SMRiQ9BVL2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115157, 78 interactors
ComplexPortaliCPX-873, Nuclear pore complex
IntActiQ9BVL2, 146 interactors
STRINGi9606.ENSP00000371155

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

GlyGeniQ9BVL2, 54 sites, 2 O-linked glycans (54 sites)
iPTMnetiQ9BVL2
MetOSiteiQ9BVL2
PhosphoSitePlusiQ9BVL2

Genetic variation databases

BioMutaiNUP58
DMDMi44888845

Proteomic databases

EPDiQ9BVL2
jPOSTiQ9BVL2
MassIVEiQ9BVL2
MaxQBiQ9BVL2
PaxDbiQ9BVL2
PeptideAtlasiQ9BVL2
PRIDEiQ9BVL2
ProteomicsDBi1238
79216 [Q9BVL2-1]
79217 [Q9BVL2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22561, 84 antibodies

The DNASU plasmid repository

More...
DNASUi
9818

Genome annotation databases

EnsembliENST00000381718; ENSP00000371137; ENSG00000139496 [Q9BVL2-3]
ENST00000381736; ENSP00000371155; ENSG00000139496 [Q9BVL2-1]
ENST00000463407; ENSP00000418555; ENSG00000139496 [Q9BVL2-2]
GeneIDi9818
KEGGihsa:9818
UCSCiuc001uqg.2, human [Q9BVL2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9818
DisGeNETi9818

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NUP58
HGNCiHGNC:20261, NUP58
HPAiENSG00000139496, Low tissue specificity
MIMi607615, gene
neXtProtiNX_Q9BVL2
OpenTargetsiENSG00000139496
PharmGKBiPA134981903
VEuPathDBiHostDB:ENSG00000139496

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QRD8, Eukaryota
GeneTreeiENSGT00730000111111
HOGENOMiCLU_034851_2_0_1
InParanoidiQ9BVL2
OMAiFTKSTKF
OrthoDBi885529at2759
PhylomeDBiQ9BVL2
TreeFamiTF106502

Enzyme and pathway databases

PathwayCommonsiQ9BVL2
ReactomeiR-HSA-1169408, ISG15 antiviral mechanism
R-HSA-159227, Transport of the SLBP independent Mature mRNA
R-HSA-159230, Transport of the SLBP Dependant Mature mRNA
R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054, Rev-mediated nuclear export of HIV RNA
R-HSA-168271, Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276, NS1 Mediated Effects on Host Pathways
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-168333, NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822, Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746, Nuclear import of Rev protein
R-HSA-180910, Vpr-mediated nuclear import of PICs
R-HSA-191859, snRNP Assembly
R-HSA-3108214, SUMOylation of DNA damage response and repair proteins
R-HSA-3232142, SUMOylation of ubiquitinylation proteins
R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453, Regulation of HSF1-mediated heat shock response
R-HSA-4085377, SUMOylation of SUMOylation proteins
R-HSA-4551638, SUMOylation of chromatin organization proteins
R-HSA-4570464, SUMOylation of RNA binding proteins
R-HSA-4615885, SUMOylation of DNA replication proteins
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5619107, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-6784531, tRNA processing in the nucleus
R-HSA-9609690, HCMV Early Events
R-HSA-9610379, HCMV Late Events
R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation
SIGNORiQ9BVL2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9818, 290 hits in 1034 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NUP58, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NUPL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9818
PharosiQ9BVL2, Tbio

Protein Ontology

More...
PROi
PR:Q9BVL2
RNActiQ9BVL2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139496, Expressed in testis and 226 other tissues
ExpressionAtlasiQ9BVL2, baseline and differential
GenevisibleiQ9BVL2, HS

Family and domain databases

InterProiView protein in InterPro
IPR024882, Nucleoporin_p58/p45
PANTHERiPTHR13437, PTHR13437, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP58_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVL2
Secondary accession number(s): A6NI12
, B4DZJ1, O43160, Q5JRG2, Q5JRG5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2001
Last modified: September 29, 2021
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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