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Protein

Dual specificity protein phosphatase 23

Gene

DUSP23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).2 Publications

Caution

Was originally erroneously termed DUSP25.Curated

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Kineticsi

  1. KM=1.498 mM for p-nitrophenylphosphate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei95Phosphocysteine intermediatePROSITE-ProRule annotation1

    GO - Molecular functioni

    • phosphatase activity Source: UniProtKB
    • protein serine/threonine phosphatase activity Source: GO_Central
    • protein tyrosine/serine/threonine phosphatase activity Source: UniProtKB
    • protein tyrosine phosphatase activity Source: GO_Central

    GO - Biological processi

    Keywordsi

    Molecular functionHydrolase, Protein phosphatase

    Enzyme and pathway databases

    SABIO-RKiQ9BVJ7

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 23 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Low molecular mass dual specificity phosphatase 3
    Short name:
    LDP-3
    VH1-like phosphatase Z
    Gene namesi
    Name:DUSP23
    Synonyms:LDP3, VHZ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000158716.8
    HGNCiHGNC:21480 DUSP23
    neXtProtiNX_Q9BVJ7

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi54935
    OpenTargetsiENSG00000158716
    PharmGKBiPA134983082

    Chemistry databases

    ChEMBLiCHEMBL2396506
    DrugBankiDB04214 4-Nitrophenyl Phosphate

    Polymorphism and mutation databases

    BioMutaiDUSP23
    DMDMi73620828

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemovedCombined sources
    ChainiPRO_00000948352 – 150Dual specificity protein phosphatase 23Add BLAST149

    Proteomic databases

    EPDiQ9BVJ7
    MaxQBiQ9BVJ7
    PaxDbiQ9BVJ7
    PeptideAtlasiQ9BVJ7
    PRIDEiQ9BVJ7
    ProteomicsDBi79212

    PTM databases

    DEPODiQ9BVJ7
    iPTMnetiQ9BVJ7
    PhosphoSitePlusiQ9BVJ7
    SwissPalmiQ9BVJ7

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.2 Publications

    Gene expression databases

    BgeeiENSG00000158716 Expressed in 187 organ(s), highest expression level in left adrenal gland
    CleanExiHS_DUSP23
    ExpressionAtlasiQ9BVJ7 baseline and differential
    GenevisibleiQ9BVJ7 HS

    Organism-specific databases

    HPAiHPA028211
    HPA045792

    Interactioni

    Binary interactionsi

    Protein-protein interaction databases

    BioGridi120275, 68 interactors
    IntActiQ9BVJ7, 32 interactors
    MINTiQ9BVJ7
    STRINGi9606.ENSP00000357087

    Chemistry databases

    BindingDBiQ9BVJ7

    Structurei

    Secondary structure

    1150
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliQ9BVJ7
    SMRiQ9BVJ7
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BVJ7

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini75 – 140Tyrosine-protein phosphataseAdd BLAST66

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1720 Eukaryota
    COG2453 LUCA
    GeneTreeiENSGT00390000010254
    HOGENOMiHOG000108423
    HOVERGENiHBG056524
    InParanoidiQ9BVJ7
    KOiK14165
    OMAiAVHCMHG
    OrthoDBiEOG091G0XEO
    PhylomeDBiQ9BVJ7
    TreeFamiTF105125

    Family and domain databases

    Gene3Di3.90.190.10, 1 hit
    InterProiView protein in InterPro
    IPR000340 Dual-sp_phosphatase_cat-dom
    IPR029021 Prot-tyrosine_phosphatase-like
    IPR016130 Tyr_Pase_AS
    IPR003595 Tyr_Pase_cat
    IPR000387 TYR_PHOSPHATASE_dom
    IPR020422 TYR_PHOSPHATASE_DUAL_dom
    PfamiView protein in Pfam
    PF00782 DSPc, 1 hit
    SMARTiView protein in SMART
    SM00195 DSPc, 1 hit
    SM00404 PTPc_motif, 1 hit
    SUPFAMiSSF52799 SSF52799, 1 hit
    PROSITEiView protein in PROSITE
    PS00383 TYR_PHOSPHATASE_1, 1 hit
    PS50056 TYR_PHOSPHATASE_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BVJ7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDLGVRHLV SLTERGPPHS
    60 70 80 90 100
    DSCPGLTLHR LRIPDFCPPA PDQIDRFVQI VDEANARGEA VGVHCALGFG
    110 120 130 140 150
    RTGTMLACYL VKERGLAAGD AIAEIRRLRP GSIETYEQEK AVFQFYQRTK
    Length:150
    Mass (Da):16,588
    Last modified:June 1, 2001 - v1
    Checksum:i4B72EFA0434B1B5F
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti132S → P in BAA91172 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_051756124E → V. Corresponds to variant dbSNP:rs11544443Ensembl.1
    Natural variantiVAR_023199131G → S. Corresponds to variant dbSNP:rs1129923Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB164404 mRNA Translation: BAD12141.1
    AK000449 mRNA Translation: BAA91172.1
    AL590560 Genomic DNA No translation available.
    BC001140 mRNA Translation: AAH01140.1
    CCDSiCCDS1187.1
    RefSeqiNP_001306587.1, NM_001319658.1
    NP_001306588.1, NM_001319659.1
    NP_060293.2, NM_017823.4
    UniGeneiHs.425801

    Genome annotation databases

    EnsembliENST00000368107; ENSP00000357087; ENSG00000158716
    ENST00000368108; ENSP00000357088; ENSG00000158716
    ENST00000368109; ENSP00000357089; ENSG00000158716
    GeneIDi54935
    KEGGihsa:54935
    UCSCiuc001ftz.2 human

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB164404 mRNA Translation: BAD12141.1
    AK000449 mRNA Translation: BAA91172.1
    AL590560 Genomic DNA No translation available.
    BC001140 mRNA Translation: AAH01140.1
    CCDSiCCDS1187.1
    RefSeqiNP_001306587.1, NM_001319658.1
    NP_001306588.1, NM_001319659.1
    NP_060293.2, NM_017823.4
    UniGeneiHs.425801

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2IMGX-ray1.93A2-150[»]
    4ERCX-ray1.15A/B1-150[»]
    ProteinModelPortaliQ9BVJ7
    SMRiQ9BVJ7
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi120275, 68 interactors
    IntActiQ9BVJ7, 32 interactors
    MINTiQ9BVJ7
    STRINGi9606.ENSP00000357087

    Chemistry databases

    BindingDBiQ9BVJ7
    ChEMBLiCHEMBL2396506
    DrugBankiDB04214 4-Nitrophenyl Phosphate

    PTM databases

    DEPODiQ9BVJ7
    iPTMnetiQ9BVJ7
    PhosphoSitePlusiQ9BVJ7
    SwissPalmiQ9BVJ7

    Polymorphism and mutation databases

    BioMutaiDUSP23
    DMDMi73620828

    Proteomic databases

    EPDiQ9BVJ7
    MaxQBiQ9BVJ7
    PaxDbiQ9BVJ7
    PeptideAtlasiQ9BVJ7
    PRIDEiQ9BVJ7
    ProteomicsDBi79212

    Protocols and materials databases

    DNASUi54935
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000368107; ENSP00000357087; ENSG00000158716
    ENST00000368108; ENSP00000357088; ENSG00000158716
    ENST00000368109; ENSP00000357089; ENSG00000158716
    GeneIDi54935
    KEGGihsa:54935
    UCSCiuc001ftz.2 human

    Organism-specific databases

    CTDi54935
    DisGeNETi54935
    EuPathDBiHostDB:ENSG00000158716.8
    GeneCardsiDUSP23
    HGNCiHGNC:21480 DUSP23
    HPAiHPA028211
    HPA045792
    neXtProtiNX_Q9BVJ7
    OpenTargetsiENSG00000158716
    PharmGKBiPA134983082
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1720 Eukaryota
    COG2453 LUCA
    GeneTreeiENSGT00390000010254
    HOGENOMiHOG000108423
    HOVERGENiHBG056524
    InParanoidiQ9BVJ7
    KOiK14165
    OMAiAVHCMHG
    OrthoDBiEOG091G0XEO
    PhylomeDBiQ9BVJ7
    TreeFamiTF105125

    Enzyme and pathway databases

    SABIO-RKiQ9BVJ7

    Miscellaneous databases

    EvolutionaryTraceiQ9BVJ7
    GeneWikiiDUSP23
    GenomeRNAii54935
    PROiPR:Q9BVJ7

    Gene expression databases

    BgeeiENSG00000158716 Expressed in 187 organ(s), highest expression level in left adrenal gland
    CleanExiHS_DUSP23
    ExpressionAtlasiQ9BVJ7 baseline and differential
    GenevisibleiQ9BVJ7 HS

    Family and domain databases

    Gene3Di3.90.190.10, 1 hit
    InterProiView protein in InterPro
    IPR000340 Dual-sp_phosphatase_cat-dom
    IPR029021 Prot-tyrosine_phosphatase-like
    IPR016130 Tyr_Pase_AS
    IPR003595 Tyr_Pase_cat
    IPR000387 TYR_PHOSPHATASE_dom
    IPR020422 TYR_PHOSPHATASE_DUAL_dom
    PfamiView protein in Pfam
    PF00782 DSPc, 1 hit
    SMARTiView protein in SMART
    SM00195 DSPc, 1 hit
    SM00404 PTPc_motif, 1 hit
    SUPFAMiSSF52799 SSF52799, 1 hit
    PROSITEiView protein in PROSITE
    PS00383 TYR_PHOSPHATASE_1, 1 hit
    PS50056 TYR_PHOSPHATASE_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiDUS23_HUMAN
    AccessioniPrimary (citable) accession number: Q9BVJ7
    Secondary accession number(s): Q9NX48
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: June 1, 2001
    Last modified: November 7, 2018
    This is version 154 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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    Main funding by: National Institutes of Health

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