UniProtKB - Q9BVJ6 (UT14A_HUMAN)
Protein
U3 small nucleolar RNA-associated protein 14 homolog A
Gene
UTP14A
Organism
Homo sapiens (Human)
Status
Functioni
May be required for ribosome biogenesis.By similarity
Miscellaneous
The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- rRNA processing Source: Reactome
Keywordsi
Biological process | Ribosome biogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9BVJ6 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: U3 small nucleolar RNA-associated protein 14 homolog AAlternative name(s): Antigen NY-CO-16 Serologically defined colon cancer antigen 16 |
Gene namesi | Name:UTP14A Synonyms:SDCCAG16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10665, UTP14A |
MIMi | 300508, gene |
neXtProti | NX_Q9BVJ6 |
VEuPathDBi | HostDB:ENSG00000156697.12 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: Reactome
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10813 |
OpenTargetsi | ENSG00000156697 |
PharmGKBi | PA35595 |
Miscellaneous databases
Pharosi | Q9BVJ6, Tdark |
Genetic variation databases
BioMutai | UTP14A |
DMDMi | 68566226 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065733 | 1 – 771 | U3 small nucleolar RNA-associated protein 14 homolog AAdd BLAST | 771 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 52 | PhosphoserineCombined sources | 1 | |
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Cross-linki | 122 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 205 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 405 | PhosphoserineCombined sources | 1 | |
Modified residuei | 407 | PhosphoserineCombined sources | 1 | |
Modified residuei | 433 | CitrullineBy similarity | 1 | |
Modified residuei | 437 | PhosphoserineCombined sources | 1 | |
Modified residuei | 445 | PhosphoserineCombined sources | 1 | |
Cross-linki | 449 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 453 | PhosphoserineCombined sources | 1 | |
Cross-linki | 519 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 569 | PhosphoserineCombined sources | 1 | |
Modified residuei | 589 | CitrullineBy similarity | 1 | |
Cross-linki | 733 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Citrullinated by PADI4.By similarity
Keywords - PTMi
Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BVJ6 |
jPOSTi | Q9BVJ6 |
MassIVEi | Q9BVJ6 |
MaxQBi | Q9BVJ6 |
PaxDbi | Q9BVJ6 |
PeptideAtlasi | Q9BVJ6 |
PRIDEi | Q9BVJ6 |
ProteomicsDBi | 19917 79210 [Q9BVJ6-1] 79211 [Q9BVJ6-2] |
2D gel databases
SWISS-2DPAGEi | Q9BVJ6 |
PTM databases
iPTMneti | Q9BVJ6 |
PhosphoSitePlusi | Q9BVJ6 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000156697, Expressed in oocyte and 222 other tissues |
ExpressionAtlasi | Q9BVJ6, baseline and differential |
Genevisiblei | Q9BVJ6, HS |
Organism-specific databases
HPAi | ENSG00000156697, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DHX37.
1 PublicationBinary interactionsi
Hide detailsQ9BVJ6
Protein-protein interaction databases
BioGRIDi | 116026, 135 interactors |
DIPi | DIP-32505N |
IntActi | Q9BVJ6, 71 interactors |
MINTi | Q9BVJ6 |
STRINGi | 9606.ENSP00000377944 |
Miscellaneous databases
RNActi | Q9BVJ6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 40 – 67 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 216 – 290 | Sequence analysisAdd BLAST | 75 | |
Coiled coili | 317 – 347 | Sequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the UTP14 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2172, Eukaryota |
GeneTreei | ENSGT00390000008142 |
HOGENOMi | CLU_012635_1_0_1 |
InParanoidi | Q9BVJ6 |
OMAi | HRNTSKW |
OrthoDBi | 370022at2759 |
PhylomeDBi | Q9BVJ6 |
TreeFami | TF314531 |
Family and domain databases
InterProi | View protein in InterPro IPR006709, SSU_processome_Utp14 |
PANTHERi | PTHR14150, PTHR14150, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BVJ6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTANRLAESL LALSQQEELA DLPKDYLLSE SEDEGDNDGE RKHQKLLEAI
60 70 80 90 100
SSLDGKNRRK LAERSEASLK VSEFNVSSEG SGEKLVLADL LEPVKTSSSL
110 120 130 140 150
ATVKKQLSRV KSKKTVELPL NKEEIERIHR EVAFNKTAQV LSKWDPVVLK
160 170 180 190 200
NRQAEQLVFP LEKEEPAIAP IEHVLSGWKA RTPLEQEIFN LLHKNKQPVT
210 220 230 240 250
DPLLTPVEKA SLRAMSLEEA KMRRAELQRA RALQSYYEAK ARREKKIKSK
260 270 280 290 300
KYHKVVKKGK AKKALKEFEQ LRKVNPAAAL EELEKIEKAR MMERMSLKHQ
310 320 330 340 350
NSGKWAKSKA IMAKYDLEAR QAMQEQLSKN KELTQKLQVA SESEEEEGGT
360 370 380 390 400
EDVEELLVPD VVNEVQMNAD GPNPWMLRSC TSDTKEAATQ EDPEQLPELE
410 420 430 440 450
AHGVSESEGE ERPVAEEEIL LREFEERRSL RKRSELSQDA EPAGSQETKD
460 470 480 490 500
SGSQEVLSEL RVLSQKLKEN HQSRKQKASS EGTIPQVQRE EPAPEEEEPL
510 520 530 540 550
LLQRPERVQT LEELEELGKE ECFQNKELPR PVLEGQQSER TPNNRPDAPK
560 570 580 590 600
EKKKKEQMID LQNLLTTQSP SVKSLAVPTI EELEDEEERN HRQMIKEAFA
610 620 630 640 650
GDDVIRDFLK EKREAVEASK PKDVDLTLPG WGEWGGVGLK PSAKKRRRFL
660 670 680 690 700
IKAPEGPPRK DKNLPNVIIN EKRNIHAAAH QVRVLPYPFT HHWQFERTIQ
710 720 730 740 750
TPIGSTWNTQ RAFQKLTTPK VVTKPGHIIN PIKAEDVGYR SSSRSDLSVI
760 770
QRNPKRITTR HKKQLKKCSV D
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RJY0 | X6RJY0_HUMAN | U3 small nucleolar RNA-associated p... | UTP14A | 320 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_078693 | 120 | Missing 1 Publication | 1 | |
Natural variantiVAR_022811 | 487 | V → A. Corresponds to variant dbSNP:rs2281278Ensembl. | 1 | |
Natural variantiVAR_069181 | 771 | D → G1 PublicationCorresponds to variant dbSNP:rs1055032Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014475 | 1 – 12 | MTANR…ESLLA → MKGDFRKKKSEA in isoform 2. CuratedAdd BLAST | 12 | |
Alternative sequenceiVSP_014476 | 13 – 180 | Missing in isoform 2. CuratedAdd BLAST | 168 | |
Alternative sequenceiVSP_046389 | 128 – 179 | Missing in isoform 3. 1 PublicationAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291918 mRNA Translation: BAF84607.1 AK298578 mRNA Translation: BAG60770.1 AL034405 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11820.1 BC001149 mRNA Translation: AAH01149.1 BC009649 mRNA Translation: AAH09649.1 BC014987 mRNA Translation: AAH14987.1 |
CCDSi | CCDS14615.1 [Q9BVJ6-1] CCDS55489.1 [Q9BVJ6-3] |
RefSeqi | NP_001159693.1, NM_001166221.1 [Q9BVJ6-3] NP_006640.2, NM_006649.3 [Q9BVJ6-1] |
Genome annotation databases
Ensembli | ENST00000394422; ENSP00000377944; ENSG00000156697 [Q9BVJ6-1] ENST00000425117; ENSP00000388669; ENSG00000156697 [Q9BVJ6-3] |
GeneIDi | 10813 |
KEGGi | hsa:10813 |
UCSCi | uc004euz.4, human [Q9BVJ6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291918 mRNA Translation: BAF84607.1 AK298578 mRNA Translation: BAG60770.1 AL034405 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11820.1 BC001149 mRNA Translation: AAH01149.1 BC009649 mRNA Translation: AAH09649.1 BC014987 mRNA Translation: AAH14987.1 |
CCDSi | CCDS14615.1 [Q9BVJ6-1] CCDS55489.1 [Q9BVJ6-3] |
RefSeqi | NP_001159693.1, NM_001166221.1 [Q9BVJ6-3] NP_006640.2, NM_006649.3 [Q9BVJ6-1] |
3D structure databases
SMRi | Q9BVJ6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116026, 135 interactors |
DIPi | DIP-32505N |
IntActi | Q9BVJ6, 71 interactors |
MINTi | Q9BVJ6 |
STRINGi | 9606.ENSP00000377944 |
PTM databases
iPTMneti | Q9BVJ6 |
PhosphoSitePlusi | Q9BVJ6 |
Genetic variation databases
BioMutai | UTP14A |
DMDMi | 68566226 |
2D gel databases
SWISS-2DPAGEi | Q9BVJ6 |
Proteomic databases
EPDi | Q9BVJ6 |
jPOSTi | Q9BVJ6 |
MassIVEi | Q9BVJ6 |
MaxQBi | Q9BVJ6 |
PaxDbi | Q9BVJ6 |
PeptideAtlasi | Q9BVJ6 |
PRIDEi | Q9BVJ6 |
ProteomicsDBi | 19917 79210 [Q9BVJ6-1] 79211 [Q9BVJ6-2] |
Protocols and materials databases
Antibodypediai | 30118, 153 antibodies |
CPTCi | Q9BVJ6, 1 antibody |
DNASUi | 10813 |
Genome annotation databases
Ensembli | ENST00000394422; ENSP00000377944; ENSG00000156697 [Q9BVJ6-1] ENST00000425117; ENSP00000388669; ENSG00000156697 [Q9BVJ6-3] |
GeneIDi | 10813 |
KEGGi | hsa:10813 |
UCSCi | uc004euz.4, human [Q9BVJ6-1] |
Organism-specific databases
CTDi | 10813 |
DisGeNETi | 10813 |
GeneCardsi | UTP14A |
HGNCi | HGNC:10665, UTP14A |
HPAi | ENSG00000156697, Low tissue specificity |
MIMi | 300508, gene |
neXtProti | NX_Q9BVJ6 |
OpenTargetsi | ENSG00000156697 |
PharmGKBi | PA35595 |
VEuPathDBi | HostDB:ENSG00000156697.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2172, Eukaryota |
GeneTreei | ENSGT00390000008142 |
HOGENOMi | CLU_012635_1_0_1 |
InParanoidi | Q9BVJ6 |
OMAi | HRNTSKW |
OrthoDBi | 370022at2759 |
PhylomeDBi | Q9BVJ6 |
TreeFami | TF314531 |
Enzyme and pathway databases
PathwayCommonsi | Q9BVJ6 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 10813, 227 hits in 509 CRISPR screens |
ChiTaRSi | UTP14A, human |
GeneWikii | UTP14A |
GenomeRNAii | 10813 |
Pharosi | Q9BVJ6, Tdark |
PROi | PR:Q9BVJ6 |
RNActi | Q9BVJ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156697, Expressed in oocyte and 222 other tissues |
ExpressionAtlasi | Q9BVJ6, baseline and differential |
Genevisiblei | Q9BVJ6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006709, SSU_processome_Utp14 |
PANTHERi | PTHR14150, PTHR14150, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UT14A_HUMAN | |
Accessioni | Q9BVJ6Primary (citable) accession number: Q9BVJ6 Secondary accession number(s): A8K7A3 Q5JYF1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants