NOC4L

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

rRNA processing Source: UniProtKB

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nucleolar complex protein 4 homolog Short name: NOC4 protein homolog Alternative name(s): NOC4-like protein Nucleolar complex-associated protein 4-like protein
Gene namesⁱ	Name:NOC4L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184967.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28461 NOC4L
MIMⁱ	612819 gene
neXtProtⁱ	NX_Q9BVI4

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	297 – 317	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	347 – 367	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	375 – 395	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000184967
PharmGKBⁱ	PA142671262

Polymorphism and mutation databases

BioMutaⁱ	NOC4L
DMDMⁱ	73621312

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000173484	1 – 516	Nucleolar complex protein 4 homologAdd BLAST		516

Proteomic databases

EPDⁱ	Q9BVI4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BVI4
PaxDbⁱ	Q9BVI4
PeptideAtlas More...PeptideAtlasⁱ	Q9BVI4
PRIDEⁱ	Q9BVI4
ProteomicsDBⁱ	79209

2D gel databases

SWISS-2DPAGEⁱ	Q9BVI4

SWISS-2DPAGEⁱ

Q9BVI4

PTM databases

iPTMnetⁱ	Q9BVI4
PhosphoSitePlusⁱ	Q9BVI4
SwissPalmⁱ	Q9BVI4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000184967 Expressed in 136 organ(s), highest expression level in right testis
CleanExⁱ	HS_NOC4L
ExpressionAtlasⁱ	Q9BVI4 baseline and differential
Genevisibleⁱ	Q9BVI4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053424

HPAⁱ

HPA053424

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BHLHE40	O14503	3	EBI-395927,EBI-711810
DNAJA3	Q96EY1-2	3	EBI-395927,EBI-3952284
IKZF1	Q13422	3	EBI-395927,EBI-745305
KRT15	P19012	4	EBI-395927,EBI-739566
USHBP1	Q8N6Y0	2	EBI-395927,EBI-739895

Protein-protein interaction databases

BioGridⁱ	122508, 61 interactors
Database of interacting proteins More...DIPⁱ	DIP-32938N
IntActⁱ	Q9BVI4, 32 interactors
Molecular INTeraction database More...MINTⁱ	Q9BVI4
STRINGⁱ	9606.ENSP00000328854

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BVI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CBF/MAK21 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2154 Eukaryota ENOG410YJPG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016776
HOGENOMⁱ	HOG000158314
HOVERGENⁱ	HBG060855
InParanoidⁱ	Q9BVI4
KEGG Orthology (KO) More...KOⁱ	K14771
OMAⁱ	CTFMIHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07EE
PhylomeDBⁱ	Q9BVI4
TreeFamⁱ	TF105812

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR005612 CCAAT-binding_factor IPR027193 Noc4
PANTHERⁱ	PTHR12455 PTHR12455, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03914 CBF, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9BVI4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV 
        60         70         80         90        100
RTCSRLFGAL LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC 
       110        120        130        140        150
NRLGELLGHP SFQVKELALS ALLKFVQLEG AHPLEKSKWE GNYLFPRELF 
       160        170        180        190        200
KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT RYHTMQAAVD AVARVTGQHP 
       210        220        230        240        250
EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW KVAHLKEHRR 
       260        270        280        290        300
VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL 
       310        320        330        340        350
GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL 
       360        370        380        390        400
ADLFLSSSHL PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA 
       410        420        430        440        450
CRVLVHRPHG PELDADPYDP GEEDPAQSRA LESSLWELQA LQRHYHPEVS 
       460        470        480        490        500
KAASVINQAL SMPEVSIAPL LELTAYEIFE RDLKKKGPEP VPLEFIPAQG 
       510 
LLGRPGELCA QHFTLS

Length:516

Mass (Da):58,468

Last modified:June 1, 2001 - v1

Checksum:ⁱ656D835CB4207DF8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5H303	F5H303_HUMAN		Nucleolar complex protein 4 homolog Nucleolar complex protein 4 homolog	NOC4L	270	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001191 mRNA Translation: AAH01191.1 BC007893 mRNA Translation: AAH07893.2 BC071958 mRNA Translation: AAH71958.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9277.1
NCBI Reference Sequences More...RefSeqⁱ	NP_076983.1, NM_024078.2
UniGeneⁱ	Hs.558536

Genome annotation databases

Ensemblⁱ	ENST00000330579; ENSP00000328854; ENSG00000184967
GeneIDⁱ	79050
KEGGⁱ	hsa:79050
UCSC genome browser More...UCSCⁱ	uc001ujz.1 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BVI4	Uncharacterized protein		PANPA		517	UniRef90_Q9BVI4
Uncharacterized protein		PAPAN		516
Uncharacterized protein		MACNE		516
Nucleolar complex associated 4 homolog		MACMU		516
Uncharacterized protein		RHIBE		516
+28

Protein	Similar proteins		Species	Score	Length	Source
Q9BVI4	Uncharacterized protein		PANPA		517	UniRef50_Q9BVI4
Uncharacterized protein		MACNE		516
Uncharacterized protein		PAPAN		516
Uncharacterized protein		CHLSB		516
NOC4L isoform 2		PANTR		516
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001191 mRNA Translation: AAH01191.1 BC007893 mRNA Translation: AAH07893.2 BC071958 mRNA Translation: AAH71958.1
CCDSⁱ	CCDS9277.1
RefSeqⁱ	NP_076983.1, NM_024078.2
UniGeneⁱ	Hs.558536

3D structure databases

ProteinModelPortalⁱ	Q9BVI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122508, 61 interactors
DIPⁱ	DIP-32938N
IntActⁱ	Q9BVI4, 32 interactors
MINTⁱ	Q9BVI4
STRINGⁱ	9606.ENSP00000328854

PTM databases

iPTMnetⁱ	Q9BVI4
PhosphoSitePlusⁱ	Q9BVI4
SwissPalmⁱ	Q9BVI4

Polymorphism and mutation databases

BioMutaⁱ	NOC4L
DMDMⁱ	73621312

2D gel databases

SWISS-2DPAGEⁱ	Q9BVI4

SWISS-2DPAGEⁱ

Q9BVI4

Proteomic databases

EPDⁱ	Q9BVI4
MaxQBⁱ	Q9BVI4
PaxDbⁱ	Q9BVI4
PeptideAtlasⁱ	Q9BVI4
PRIDEⁱ	Q9BVI4
ProteomicsDBⁱ	79209

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79050
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000330579; ENSP00000328854; ENSG00000184967
GeneIDⁱ	79050
KEGGⁱ	hsa:79050
UCSCⁱ	uc001ujz.1 human

Organism-specific databases

CTDⁱ	79050
EuPathDBⁱ	HostDB:ENSG00000184967.6
GeneCardsⁱ	NOC4L
HGNCⁱ	HGNC:28461 NOC4L
HPAⁱ	HPA053424
MIMⁱ	612819 gene
neXtProtⁱ	NX_Q9BVI4
OpenTargetsⁱ	ENSG00000184967
PharmGKBⁱ	PA142671262
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2154 Eukaryota ENOG410YJPG LUCA
GeneTreeⁱ	ENSGT00390000016776
HOGENOMⁱ	HOG000158314
HOVERGENⁱ	HBG060855
InParanoidⁱ	Q9BVI4
KOⁱ	K14771
OMAⁱ	CTFMIHR
OrthoDBⁱ	EOG091G07EE
PhylomeDBⁱ	Q9BVI4
TreeFamⁱ	TF105812

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	NOC4L human
GenomeRNAiⁱ	79050
Protein Ontology More...PROⁱ	PR:Q9BVI4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184967 Expressed in 136 organ(s), highest expression level in right testis
CleanExⁱ	HS_NOC4L
ExpressionAtlasⁱ	Q9BVI4 baseline and differential
Genevisibleⁱ	Q9BVI4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR005612 CCAAT-binding_factor IPR027193 Noc4
PANTHERⁱ	PTHR12455 PTHR12455, 1 hit
Pfamⁱ	View protein in Pfam PF03914 CBF, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NOC4L_HUMAN
Accessionⁱ	Q9BVI4Primary (citable) accession number: Q9BVI4 Secondary accession number(s): Q8N2S5, Q96I14
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BVI4 (NOC4L_HUMAN)

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Nucleolar complex protein 4 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ