UniProtKB - Q9BVI4 (NOC4L_HUMAN)
Protein
Nucleolar complex protein 4 homolog
Gene
NOC4L
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- rRNA processing Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9BVI4 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleolar complex protein 4 homologShort name: NOC4 protein homolog Alternative name(s): NOC4-like protein Nucleolar complex-associated protein 4-like protein |
Gene namesi | Name:NOC4L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28461, NOC4L |
MIMi | 612819, gene |
neXtProti | NX_Q9BVI4 |
VEuPathDBi | HostDB:ENSG00000184967.6 |
Subcellular locationi
Nucleus
- Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication
- nucleolus 1 Publication
Nucleus
- Noc4p-Nop14p complex Source: GO_Central
- nuclear membrane Source: UniProtKB-SubCell
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
- small-subunit processome Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 297 – 317 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 347 – 367 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 375 – 395 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000184967 |
PharmGKBi | PA142671262 |
Miscellaneous databases
Pharosi | Q9BVI4, Tdark |
Genetic variation databases
BioMutai | NOC4L |
DMDMi | 73621312 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173484 | 1 – 516 | Nucleolar complex protein 4 homologAdd BLAST | 516 |
Proteomic databases
EPDi | Q9BVI4 |
jPOSTi | Q9BVI4 |
MassIVEi | Q9BVI4 |
MaxQBi | Q9BVI4 |
PaxDbi | Q9BVI4 |
PeptideAtlasi | Q9BVI4 |
PRIDEi | Q9BVI4 |
ProteomicsDBi | 79209 |
2D gel databases
SWISS-2DPAGEi | Q9BVI4 |
PTM databases
iPTMneti | Q9BVI4 |
PhosphoSitePlusi | Q9BVI4 |
SwissPalmi | Q9BVI4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184967, Expressed in right testis and 151 other tissues |
ExpressionAtlasi | Q9BVI4, baseline and differential |
Genevisiblei | Q9BVI4, HS |
Organism-specific databases
HPAi | ENSG00000184967, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9BVI4
Protein-protein interaction databases
BioGRIDi | 122508, 95 interactors |
DIPi | DIP-32938N |
IntActi | Q9BVI4, 53 interactors |
MINTi | Q9BVI4 |
STRINGi | 9606.ENSP00000328854 |
Miscellaneous databases
RNActi | Q9BVI4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CBF/MAK21 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2154, Eukaryota |
GeneTreei | ENSGT00390000016776 |
HOGENOMi | CLU_015945_3_0_1 |
InParanoidi | Q9BVI4 |
OMAi | TCTFMIH |
OrthoDBi | 891751at2759 |
PhylomeDBi | Q9BVI4 |
TreeFami | TF105812 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR005612, CCAAT-binding_factor IPR027193, Noc4 |
PANTHERi | PTHR12455, PTHR12455, 1 hit |
Pfami | View protein in Pfam PF03914, CBF, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9BVI4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV
60 70 80 90 100
RTCSRLFGAL LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC
110 120 130 140 150
NRLGELLGHP SFQVKELALS ALLKFVQLEG AHPLEKSKWE GNYLFPRELF
160 170 180 190 200
KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT RYHTMQAAVD AVARVTGQHP
210 220 230 240 250
EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW KVAHLKEHRR
260 270 280 290 300
VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL
310 320 330 340 350
GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL
360 370 380 390 400
ADLFLSSSHL PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA
410 420 430 440 450
CRVLVHRPHG PELDADPYDP GEEDPAQSRA LESSLWELQA LQRHYHPEVS
460 470 480 490 500
KAASVINQAL SMPEVSIAPL LELTAYEIFE RDLKKKGPEP VPLEFIPAQG
510
LLGRPGELCA QHFTLS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H303 | F5H303_HUMAN | Nucleolar complex protein 4 homolog | NOC4L | 270 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001191 mRNA Translation: AAH01191.1 BC007893 mRNA Translation: AAH07893.2 BC071958 mRNA Translation: AAH71958.1 |
CCDSi | CCDS9277.1 |
RefSeqi | NP_076983.1, NM_024078.2 |
Genome annotation databases
Ensembli | ENST00000330579; ENSP00000328854; ENSG00000184967 ENST00000672504; ENSP00000500901; ENSG00000288146 |
GeneIDi | 79050 |
KEGGi | hsa:79050 |
UCSCi | uc001ujz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001191 mRNA Translation: AAH01191.1 BC007893 mRNA Translation: AAH07893.2 BC071958 mRNA Translation: AAH71958.1 |
CCDSi | CCDS9277.1 |
RefSeqi | NP_076983.1, NM_024078.2 |
3D structure databases
SMRi | Q9BVI4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122508, 95 interactors |
DIPi | DIP-32938N |
IntActi | Q9BVI4, 53 interactors |
MINTi | Q9BVI4 |
STRINGi | 9606.ENSP00000328854 |
PTM databases
iPTMneti | Q9BVI4 |
PhosphoSitePlusi | Q9BVI4 |
SwissPalmi | Q9BVI4 |
Genetic variation databases
BioMutai | NOC4L |
DMDMi | 73621312 |
2D gel databases
SWISS-2DPAGEi | Q9BVI4 |
Proteomic databases
EPDi | Q9BVI4 |
jPOSTi | Q9BVI4 |
MassIVEi | Q9BVI4 |
MaxQBi | Q9BVI4 |
PaxDbi | Q9BVI4 |
PeptideAtlasi | Q9BVI4 |
PRIDEi | Q9BVI4 |
ProteomicsDBi | 79209 |
Protocols and materials databases
Antibodypediai | 19475, 77 antibodies |
DNASUi | 79050 |
Genome annotation databases
Ensembli | ENST00000330579; ENSP00000328854; ENSG00000184967 ENST00000672504; ENSP00000500901; ENSG00000288146 |
GeneIDi | 79050 |
KEGGi | hsa:79050 |
UCSCi | uc001ujz.1, human |
Organism-specific databases
CTDi | 79050 |
GeneCardsi | NOC4L |
HGNCi | HGNC:28461, NOC4L |
HPAi | ENSG00000184967, Low tissue specificity |
MIMi | 612819, gene |
neXtProti | NX_Q9BVI4 |
OpenTargetsi | ENSG00000184967 |
PharmGKBi | PA142671262 |
VEuPathDBi | HostDB:ENSG00000184967.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2154, Eukaryota |
GeneTreei | ENSGT00390000016776 |
HOGENOMi | CLU_015945_3_0_1 |
InParanoidi | Q9BVI4 |
OMAi | TCTFMIH |
OrthoDBi | 891751at2759 |
PhylomeDBi | Q9BVI4 |
TreeFami | TF105812 |
Enzyme and pathway databases
PathwayCommonsi | Q9BVI4 |
Reactomei | R-HSA-6790901, rRNA modification in the nucleus and cytosol R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 79050, 607 hits in 881 CRISPR screens |
ChiTaRSi | NOC4L, human |
GenomeRNAii | 79050 |
Pharosi | Q9BVI4, Tdark |
PROi | PR:Q9BVI4 |
RNActi | Q9BVI4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184967, Expressed in right testis and 151 other tissues |
ExpressionAtlasi | Q9BVI4, baseline and differential |
Genevisiblei | Q9BVI4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR005612, CCAAT-binding_factor IPR027193, Noc4 |
PANTHERi | PTHR12455, PTHR12455, 1 hit |
Pfami | View protein in Pfam PF03914, CBF, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOC4L_HUMAN | |
Accessioni | Q9BVI4Primary (citable) accession number: Q9BVI4 Secondary accession number(s): Q8N2S5, Q96I14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families