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Protein

Nucleolar complex protein 4 homolog

Gene

NOC4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 4 homolog
Short name:
NOC4 protein homolog
Alternative name(s):
NOC4-like protein
Nucleolar complex-associated protein 4-like protein
Gene namesi
Name:NOC4L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000184967.6
HGNCiHGNC:28461 NOC4L
MIMi612819 gene
neXtProtiNX_Q9BVI4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184967
PharmGKBiPA142671262

Polymorphism and mutation databases

BioMutaiNOC4L
DMDMi73621312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734841 – 516Nucleolar complex protein 4 homologAdd BLAST516

Proteomic databases

EPDiQ9BVI4
MaxQBiQ9BVI4
PaxDbiQ9BVI4
PeptideAtlasiQ9BVI4
PRIDEiQ9BVI4
ProteomicsDBi79209

2D gel databases

SWISS-2DPAGEiQ9BVI4

PTM databases

iPTMnetiQ9BVI4
PhosphoSitePlusiQ9BVI4
SwissPalmiQ9BVI4

Expressioni

Gene expression databases

BgeeiENSG00000184967 Expressed in 136 organ(s), highest expression level in right testis
CleanExiHS_NOC4L
ExpressionAtlasiQ9BVI4 baseline and differential
GenevisibleiQ9BVI4 HS

Organism-specific databases

HPAiHPA053424

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122508, 61 interactors
DIPiDIP-32938N
IntActiQ9BVI4, 32 interactors
MINTiQ9BVI4
STRINGi9606.ENSP00000328854

Structurei

3D structure databases

ProteinModelPortaliQ9BVI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2154 Eukaryota
ENOG410YJPG LUCA
GeneTreeiENSGT00390000016776
HOGENOMiHOG000158314
HOVERGENiHBG060855
InParanoidiQ9BVI4
KOiK14771
OMAiCTFMIHR
OrthoDBiEOG091G07EE
PhylomeDBiQ9BVI4
TreeFamiTF105812

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005612 CCAAT-binding_factor
IPR027193 Noc4
PANTHERiPTHR12455 PTHR12455, 1 hit
PfamiView protein in Pfam
PF03914 CBF, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BVI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEREPGAAGV RRALGRRLEA VLASRSEANA VFDILAVLQS EDQEEIQEAV
60 70 80 90 100
RTCSRLFGAL LERGELFVGQ LPSEEMVMTG SQGATRKYKV WMRHRYHSCC
110 120 130 140 150
NRLGELLGHP SFQVKELALS ALLKFVQLEG AHPLEKSKWE GNYLFPRELF
160 170 180 190 200
KLVVGGLLSP EEDQSLLLSQ FREYLDYDDT RYHTMQAAVD AVARVTGQHP
210 220 230 240 250
EVPPAFWNNA FTLLSAVSLP RREPTVSSFY VKRAELWDTW KVAHLKEHRR
260 270 280 290 300
VFQAMWLSFL KHKLPLSLYK KVLLIVHDAI LPQLAQPTLM IDFLTRACDL
310 320 330 340 350
GGALSLLALN GLFILIHKHN LEYPDFYRKL YGLLDPSVFH VKYRARFFHL
360 370 380 390 400
ADLFLSSSHL PAYLVAAFAK RLARLALTAP PEALLMVLPF ICNLLRRHPA
410 420 430 440 450
CRVLVHRPHG PELDADPYDP GEEDPAQSRA LESSLWELQA LQRHYHPEVS
460 470 480 490 500
KAASVINQAL SMPEVSIAPL LELTAYEIFE RDLKKKGPEP VPLEFIPAQG
510
LLGRPGELCA QHFTLS
Length:516
Mass (Da):58,468
Last modified:June 1, 2001 - v1
Checksum:i656D835CB4207DF8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H303F5H303_HUMAN
Nucleolar complex protein 4 homolog
NOC4L
270Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001191 mRNA Translation: AAH01191.1
BC007893 mRNA Translation: AAH07893.2
BC071958 mRNA Translation: AAH71958.1
CCDSiCCDS9277.1
RefSeqiNP_076983.1, NM_024078.2
UniGeneiHs.558536

Genome annotation databases

EnsembliENST00000330579; ENSP00000328854; ENSG00000184967
GeneIDi79050
KEGGihsa:79050
UCSCiuc001ujz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001191 mRNA Translation: AAH01191.1
BC007893 mRNA Translation: AAH07893.2
BC071958 mRNA Translation: AAH71958.1
CCDSiCCDS9277.1
RefSeqiNP_076983.1, NM_024078.2
UniGeneiHs.558536

3D structure databases

ProteinModelPortaliQ9BVI4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122508, 61 interactors
DIPiDIP-32938N
IntActiQ9BVI4, 32 interactors
MINTiQ9BVI4
STRINGi9606.ENSP00000328854

PTM databases

iPTMnetiQ9BVI4
PhosphoSitePlusiQ9BVI4
SwissPalmiQ9BVI4

Polymorphism and mutation databases

BioMutaiNOC4L
DMDMi73621312

2D gel databases

SWISS-2DPAGEiQ9BVI4

Proteomic databases

EPDiQ9BVI4
MaxQBiQ9BVI4
PaxDbiQ9BVI4
PeptideAtlasiQ9BVI4
PRIDEiQ9BVI4
ProteomicsDBi79209

Protocols and materials databases

DNASUi79050
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330579; ENSP00000328854; ENSG00000184967
GeneIDi79050
KEGGihsa:79050
UCSCiuc001ujz.1 human

Organism-specific databases

CTDi79050
EuPathDBiHostDB:ENSG00000184967.6
GeneCardsiNOC4L
HGNCiHGNC:28461 NOC4L
HPAiHPA053424
MIMi612819 gene
neXtProtiNX_Q9BVI4
OpenTargetsiENSG00000184967
PharmGKBiPA142671262
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2154 Eukaryota
ENOG410YJPG LUCA
GeneTreeiENSGT00390000016776
HOGENOMiHOG000158314
HOVERGENiHBG060855
InParanoidiQ9BVI4
KOiK14771
OMAiCTFMIHR
OrthoDBiEOG091G07EE
PhylomeDBiQ9BVI4
TreeFamiTF105812

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiNOC4L human
GenomeRNAii79050
PROiPR:Q9BVI4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184967 Expressed in 136 organ(s), highest expression level in right testis
CleanExiHS_NOC4L
ExpressionAtlasiQ9BVI4 baseline and differential
GenevisibleiQ9BVI4 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR005612 CCAAT-binding_factor
IPR027193 Noc4
PANTHERiPTHR12455 PTHR12455, 1 hit
PfamiView protein in Pfam
PF03914 CBF, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOC4L_HUMAN
AccessioniPrimary (citable) accession number: Q9BVI4
Secondary accession number(s): Q8N2S5, Q96I14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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