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UniProtKB - Q9BVG8 (KIFC3_HUMAN)

Protein

Kinesin-like protein KIFC3

Gene

KIFC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi528 – 535ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • epithelial cell-cell adhesion Source: UniProtKB
  • Golgi organization Source: Ensembl
  • microtubule-based movement Source: GO_Central
  • visual perception Source: ProtInc
  • zonula adherens maintenance Source: UniProtKB
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIFC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIFC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000140859.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:6326 KIFC3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604535 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BVG8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3801

Open Targets

More...OpenTargetsi		ENSG00000140859

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30112

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075119

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIFC3

Domain mapping of disease mutations (DMDM)

More...DMDMi		357529584

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254311 – 833Kinesin-like protein KIFC3Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei813PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BVG8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BVG8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BVG8

PeptideAtlas

More...PeptideAtlasi		Q9BVG8

PRoteomics IDEntifications database

More...PRIDEi		Q9BVG8

ProteomicsDB human proteome resource

More...ProteomicsDBi		79201
79202 [Q9BVG8-2]
79203 [Q9BVG8-4]
79204 [Q9BVG8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BVG8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BVG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140859 Expressed in 168 organ(s), highest expression level in cortex of kidney

CleanEx database of gene expression profiles

More...CleanExi		HS_KIFC3

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BVG8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BVG8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA021240

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-2125614,EBI-743598
AESQ081173EBI-2125614,EBI-717810
ATF2P153363EBI-2125614,EBI-1170906
BCL6P411823EBI-2125614,EBI-765407
C1orf109Q9NX044EBI-2125614,EBI-8643161
CARD9Q9H257-24EBI-14069005,EBI-11530605
CBX8Q9HC523EBI-2125614,EBI-712912
CCDC102BQ68D863EBI-2125614,EBI-10171570
CCDC136Q96JN2-23EBI-2125614,EBI-10171416
CCDC28AQ7Z6N93EBI-2125614,EBI-10258115
CCDC28AQ8IWP93EBI-2125614,EBI-355471
CCHCR1Q8TD31-34EBI-14069005,EBI-10175300
CDK18Q070023EBI-2125614,EBI-746238
CDR2Q018503EBI-2125614,EBI-1181367
CEP170P1Q96L144EBI-2125614,EBI-743488
CEP55Q53EZ43EBI-2125614,EBI-747776
CEP57L1Q8IYX8-23EBI-2125614,EBI-10181988
CLIP4Q8N3C73EBI-2125614,EBI-5655540
COG7A0A0S2Z6043EBI-14069005,EBI-16430119
COG7P834365EBI-14069005,EBI-389534
CREB5Q02930-33EBI-2125614,EBI-10192698
CYTH4Q8WWE83EBI-2125614,EBI-10277443
DCTN2Q135613EBI-2125614,EBI-715074
DCXO436023EBI-2125614,EBI-8646694
DEUP1Q05D603EBI-2125614,EBI-748597
DTNBP1Q96EV83EBI-2125614,EBI-465804
ESRRGP625083EBI-2125614,EBI-2834260
EXOC5O004714EBI-14069005,EBI-949824
FAM124AQ86V423EBI-2125614,EBI-744506
FAM208BQ5VWN64EBI-14069005,EBI-745958
FANCLQ9NW383EBI-2125614,EBI-2339898
FCHSD2O948683EBI-2125614,EBI-1215612
FLJ13057Q53SE73EBI-2125614,EBI-10172181
GOLGA2Q083793EBI-2125614,EBI-618309
GORASP2Q9H8Y83EBI-2125614,EBI-739467
HAUS1Q96CS23EBI-2125614,EBI-2514791
HSBP1O755065EBI-2125614,EBI-748664
ICA1LQ8NDH63EBI-2125614,EBI-10269733
ITGB3BPQ133523EBI-2125614,EBI-712105
ITGB3BPQ13352-53EBI-2125614,EBI-10175826
KANK2Q63ZY34EBI-14069005,EBI-2556193
KANSL1Q7Z3B33EBI-2125614,EBI-740244
KRT15P190123EBI-2125614,EBI-739566
KRT19P087273EBI-2125614,EBI-742756
KRT31Q153233EBI-2125614,EBI-948001
KRT40Q6A1623EBI-2125614,EBI-10171697
KRT5P136473EBI-2125614,EBI-702187
KRT6AP025385EBI-2125614,EBI-702198
KRT6BP042593EBI-2125614,EBI-740907
KRT6CP486683EBI-2125614,EBI-2564105
LENG1Q96BZ83EBI-2125614,EBI-726510
LIN37Q96GY33EBI-2125614,EBI-748884
LNX1Q8TBB14EBI-14069005,EBI-739832
LZTS2Q9BRK43EBI-2125614,EBI-741037
MCM7P339933EBI-2125614,EBI-355924
MED4Q9NPJ63EBI-2125614,EBI-394607
MFAP1P550813EBI-2125614,EBI-1048159
MID2Q9UJV3-24EBI-14069005,EBI-10172526
MOSP005403EBI-2125614,EBI-1757866
NDEL1Q9GZM83EBI-2125614,EBI-928842
NECAB2Q7Z6G3-23EBI-2125614,EBI-10172876
NEFLI6L9F63EBI-14069005,EBI-10178578
NEFLP071963EBI-14069005,EBI-475646
NUP62P371983EBI-2125614,EBI-347978
PHC2Q8IXK03EBI-2125614,EBI-713786
PRKAA2P546464EBI-2125614,EBI-1383852
PSMB1P206183EBI-2125614,EBI-372273
RAD51DO757713EBI-2125614,EBI-1055693
RSPH14Q9UHP63EBI-2125614,EBI-748350
SCELO951713EBI-2125614,EBI-7543896
SIAH1Q8IUQ43EBI-2125614,EBI-747107
SMARCE1Q969G34EBI-2125614,EBI-455078
SOX5P357113EBI-2125614,EBI-3505701
SPERTQ8NA615EBI-2125614,EBI-741724
SPERTQ8NA61-24EBI-14069005,EBI-11524851
SYCE1Q8N0S23EBI-2125614,EBI-6872807
TCEANCQ8N8B73EBI-2125614,EBI-954696
TNIP1Q150253EBI-2125614,EBI-357849
TPM3Q5VU623EBI-2125614,EBI-10184033
TRAF2Q129333EBI-2125614,EBI-355744
TRIM23P364063EBI-2125614,EBI-740098
TRIM27P143733EBI-2125614,EBI-719493
TRIM41Q8WV443EBI-2125614,EBI-725997
TRIM54Q9BYV23EBI-2125614,EBI-2130429
TSG101Q998163EBI-2125614,EBI-346882
TSR2Q969E83EBI-2125614,EBI-746981
USP2O756043EBI-2125614,EBI-743272
ZBTB8AQ96BR93EBI-2125614,EBI-742740
ZGPATA0A0S2Z6H03EBI-14069005,EBI-16428984
ZGPATQ8N5A54EBI-2125614,EBI-3439227
ZGPATQ8N5A5-25EBI-14069005,EBI-10183064
ZNF180Q9UJW83EBI-2125614,EBI-10322527
ZNF20P170243EBI-2125614,EBI-717634
ZNF572Q7Z3I76EBI-2125614,EBI-10172590
ZNF655Q8N7203EBI-2125614,EBI-625509
ZNF688A0A0S2Z5X43EBI-14069005,EBI-16429014

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110002, 123 interactors

Database of interacting proteins

More...DIPi		DIP-52406N

Protein interaction database and analysis system

More...IntActi		Q9BVG8, 236 interactors

Molecular INTeraction database

More...MINTi		Q9BVG8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000368976

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1833
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WDEX-ray1.85A443-770[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9BVG8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BVG8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9BVG8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini445 – 768Kinesin motorPROSITE-ProRule annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili102 – 362Sequence analysisAdd BLAST261
Coiled coili395 – 432Sequence analysisAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0239 Eukaryota
COG5059 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154022

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000116164

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052259

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BVG8

KEGG Orthology (KO)

More...KOi		K10406

Identification of Orthologs from Complete Genome Data

More...OMAi		IKYVIKT

Database of Orthologous Groups

More...OrthoDBi		364605at2759

TreeFam database of animal gene trees

More...TreeFami		TF105238

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027325 KIFC3
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR24115 PTHR24115, 1 hit
PTHR24115:SF387 PTHR24115:SF387, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00225 Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BVG8-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT 
        60         70         80         90        100
GPGRLRTGRG KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL 
       110        120        130        140        150
YLTLQVEHLK EKLISQAQEV SRLRSELGGT DLEKHRDLLM VENERLRQEM 
       160        170        180        190        200
RRCEAELQEL RTKPAGPCPG CEHSQESAQL RDKLSQLQLE MAESKGMLSE 
       210        220        230        240        250
LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS HETIASLRAQ 
       260        270        280        290        300
SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL 
       310        320        330        340        350
QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA 
       360        370        380        390        400
QVEMKAVHEN LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL 
       410        420        430        440        450
RSVKAEIGQA IEEVNSNNQE LLRKYRRELQ LRKKCHNELV RLKGNIRVIA 
       460        470        480        490        500
RVRPVTKEDG EGPEATNAVT FDADDDSIIH LLHKGKPVSF ELDKVFSPQA 
       510        520        530        540        550
SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG TAENPGINQR 
       560        570        580        590        600
ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP 
       610        620        630        640        650
DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL 
       660        670        680        690        700
LIVTVRGVDC STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS 
       710        720        730        740        750
LSALGDVIAA LRSRQGHVPF RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK 
       760        770        780        790        800
NTSETLYSLK FAERVRSVEL GPGLRRAELG SWSSQEHLEW EPACQTPQPS 
       810        820        830 
ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV
Note: No experimental confirmation available.
Length:833
Mass (Da):92,775
Last modified:November 16, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50983587270BDC2F
GO
Isoform 2 (identifier: Q9BVG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     826-833: GKSRPLPV → A

Show »
Length:826
Mass (Da):92,011
Checksum:iFA9B17728E570AE8
GO
Isoform 3 (identifier: Q9BVG8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-637: FEFGHTNRTTEF → WRREPLTTATLL
     638-833: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:637
Mass (Da):71,607
Checksum:i367120F4FC3C3B78
GO
Isoform 4 (identifier: Q9BVG8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     826-833: GKSRPLPV → A

Note: No experimental confirmation available.
Show »
Length:687
Mass (Da):77,089
Checksum:iEA21C203FC8B29A8
GO
Isoform 5 (identifier: Q9BVG8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCASACKDTAAWCPEEAAEPQAM
     826-833: GKSRPLPV → A

Note: No experimental confirmation available.
Show »
Length:848
Mass (Da):94,276
Checksum:i23229203DAE90BDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3M2F5H3M2_HUMAN
Kinesin-like protein
KIFC3
724Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z896B7Z896_HUMAN
Kinesin-like protein
KIFC3
684Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTL6H3BTL6_HUMAN
Kinesin-like protein
KIFC3
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGM9A0A0C4DGM9_HUMAN
Kinesin-like protein KIFC3
KIFC3
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUC0H3BUC0_HUMAN
Kinesin-like protein KIFC3
KIFC3
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE2H3BPE2_HUMAN
Kinesin-like protein KIFC3
KIFC3
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSN2H3BSN2_HUMAN
Kinesin-like protein KIFC3
KIFC3
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV47H3BV47_HUMAN
Kinesin-like protein KIFC3
KIFC3
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTN1H3BTN1_HUMAN
Kinesin-like protein KIFC3
KIFC3
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMZ5H3BMZ5_HUMAN
Kinesin-like protein KIFC3
KIFC3
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34234 differs from that shown. Intron retention.Curated
The sequence AAH41132 differs from that shown. Intron retention.Curated
The sequence AAH47051 differs from that shown. Intron retention.Curated
The sequence BAD92527 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150M → L in AAC24153 (PubMed:9782090).Curated1
Sequence conflicti185S → P in AAH34234 (PubMed:15489334).Curated1
Sequence conflicti281H → S in AAH08014 (PubMed:15489334).Curated1
Sequence conflicti736D → G in AAH34234 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028114391G → V1 PublicationCorresponds to variant dbSNP:rs17854089Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437241 – 139Missing in isoform 4. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_0572241M → MCASACKDTAAWCPEEAAEP QAM in isoform 5. 1 Publication1
Alternative sequenceiVSP_022361626 – 637FEFGH…RTTEF → WRREPLTTATLL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_022362638 – 833Missing in isoform 3. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_021018826 – 833GKSRPLPV → A in isoform 2, isoform 4 and isoform 5. 4 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK291737 mRNA Translation: BAF84426.1
AK296995 mRNA Translation: BAH12470.1
AB209290 mRNA Translation: BAD92527.1 Different initiation.
AC010543 Genomic DNA No translation available.
AC092118 Genomic DNA No translation available.
FO082293 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82955.1
BC001211 mRNA Translation: AAH01211.2
BC008014 mRNA Translation: AAH08014.1
BC034234 mRNA Translation: AAH34234.1 Different initiation.
BC041132 mRNA Translation: AAH41132.1 Different initiation.
BC047051 mRNA Translation: AAH47051.1 Sequence problems.
AF004426 mRNA Translation: AAC24153.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10789.2 [Q9BVG8-3]
CCDS45493.1 [Q9BVG8-2]
CCDS45494.1 [Q9BVG8-5]
CCDS81989.1 [Q9BVG8-6]

NCBI Reference Sequences

More...RefSeqi		NP_001123571.1, NM_001130099.1 [Q9BVG8-5]
NP_001123572.1, NM_001130100.1 [Q9BVG8-2]
NP_001305639.1, NM_001318710.1 [Q9BVG8-6]
NP_001305640.1, NM_001318711.1
NP_001305641.1, NM_001318712.1
NP_001305642.1, NM_001318713.1
NP_001305643.1, NM_001318714.1 [Q9BVG8-5]
NP_001305644.1, NM_001318715.1 [Q9BVG8-5]
NP_005541.3, NM_005550.3 [Q9BVG8-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.23131

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000379655; ENSP00000368976; ENSG00000140859 [Q9BVG8-3]
ENST00000421376; ENSP00000396399; ENSG00000140859 [Q9BVG8-5]
ENST00000445690; ENSP00000401696; ENSG00000140859 [Q9BVG8-2]
ENST00000465878; ENSP00000454659; ENSG00000140859 [Q9BVG8-5]
ENST00000541240; ENSP00000442008; ENSG00000140859 [Q9BVG8-6]
ENST00000562903; ENSP00000456239; ENSG00000140859 [Q9BVG8-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3801

UCSC genome browser

More...UCSCi		uc002emm.4 human [Q9BVG8-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291737 mRNA Translation: BAF84426.1
AK296995 mRNA Translation: BAH12470.1
AB209290 mRNA Translation: BAD92527.1 Different initiation.
AC010543 Genomic DNA No translation available.
AC092118 Genomic DNA No translation available.
FO082293 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82955.1
BC001211 mRNA Translation: AAH01211.2
BC008014 mRNA Translation: AAH08014.1
BC034234 mRNA Translation: AAH34234.1 Different initiation.
BC041132 mRNA Translation: AAH41132.1 Different initiation.
BC047051 mRNA Translation: AAH47051.1 Sequence problems.
AF004426 mRNA Translation: AAC24153.1
CCDSiCCDS10789.2 [Q9BVG8-3]
CCDS45493.1 [Q9BVG8-2]
CCDS45494.1 [Q9BVG8-5]
CCDS81989.1 [Q9BVG8-6]
RefSeqiNP_001123571.1, NM_001130099.1 [Q9BVG8-5]
NP_001123572.1, NM_001130100.1 [Q9BVG8-2]
NP_001305639.1, NM_001318710.1 [Q9BVG8-6]
NP_001305640.1, NM_001318711.1
NP_001305641.1, NM_001318712.1
NP_001305642.1, NM_001318713.1
NP_001305643.1, NM_001318714.1 [Q9BVG8-5]
NP_001305644.1, NM_001318715.1 [Q9BVG8-5]
NP_005541.3, NM_005550.3 [Q9BVG8-3]
UniGeneiHs.23131

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WDEX-ray1.85A443-770[»]
ProteinModelPortaliQ9BVG8
SMRiQ9BVG8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110002, 123 interactors
DIPiDIP-52406N
IntActiQ9BVG8, 236 interactors
MINTiQ9BVG8
STRINGi9606.ENSP00000368976

Chemistry databases

ChEMBLiCHEMBL1075119

PTM databases

iPTMnetiQ9BVG8
PhosphoSitePlusiQ9BVG8

Polymorphism and mutation databases

BioMutaiKIFC3
DMDMi357529584

Proteomic databases

EPDiQ9BVG8
jPOSTiQ9BVG8
PaxDbiQ9BVG8
PeptideAtlasiQ9BVG8
PRIDEiQ9BVG8
ProteomicsDBi79201
79202 [Q9BVG8-2]
79203 [Q9BVG8-4]
79204 [Q9BVG8-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3801
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379655; ENSP00000368976; ENSG00000140859 [Q9BVG8-3]
ENST00000421376; ENSP00000396399; ENSG00000140859 [Q9BVG8-5]
ENST00000445690; ENSP00000401696; ENSG00000140859 [Q9BVG8-2]
ENST00000465878; ENSP00000454659; ENSG00000140859 [Q9BVG8-5]
ENST00000541240; ENSP00000442008; ENSG00000140859 [Q9BVG8-6]
ENST00000562903; ENSP00000456239; ENSG00000140859 [Q9BVG8-5]
GeneIDi3801
KEGGihsa:3801
UCSCiuc002emm.4 human [Q9BVG8-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3801
DisGeNETi3801
EuPathDBiHostDB:ENSG00000140859.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIFC3
HGNCiHGNC:6326 KIFC3
HPAiHPA021240
MIMi604535 gene
neXtProtiNX_Q9BVG8
OpenTargetsiENSG00000140859
PharmGKBiPA30112

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0239 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000154022
HOGENOMiHOG000116164
HOVERGENiHBG052259
InParanoidiQ9BVG8
KOiK10406
OMAiIKYVIKT
OrthoDBi364605at2759
TreeFamiTF105238

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIFC3 human
EvolutionaryTraceiQ9BVG8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KIFC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3801

Protein Ontology

More...PROi		PR:Q9BVG8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140859 Expressed in 168 organ(s), highest expression level in cortex of kidney
CleanExiHS_KIFC3
ExpressionAtlasiQ9BVG8 baseline and differential
GenevisibleiQ9BVG8 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027325 KIFC3
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF387 PTHR24115:SF387, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIFC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVG8
Secondary accession number(s): A8K6S2
, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 16, 2011
Last modified: January 16, 2019
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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