UniProtKB - Q9BVG8 (KIFC3_HUMAN)
Kinesin-like protein KIFC3
KIFC3
Functioni
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity).
Required for zonula adherens maintenance.
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 528 – 535 | ATP | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- microtubule binding Source: InterPro
- microtubule motor activity Source: ProtInc
- minus-end-directed microtubule motor activity Source: InterPro
GO - Biological processi
- epithelial cell-cell adhesion Source: UniProtKB
- Golgi organization Source: Ensembl
- microtubule-based movement Source: InterPro
- visual perception Source: ProtInc
- zonula adherens maintenance Source: UniProtKB
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BVG8 |
Reactomei | R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis [Q9BVG8-2] |
SignaLinki | Q9BVG8 |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIFC3 |
Gene namesi | Name:KIFC3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6326, KIFC3 |
MIMi | 604535, gene |
neXtProti | NX_Q9BVG8 |
VEuPathDBi | HostDB:ENSG00000140859 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
Other locations
- adherens junction 1 Publication
- Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity
Note: Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell-cell contacts.By similarity
Cytoskeleton
- centrosome Source: UniProtKB
- kinesin complex Source: ProtInc
- microtubule Source: UniProtKB-KW
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: Ensembl
Other locations
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- zonula adherens Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 3801 |
OpenTargetsi | ENSG00000140859 |
PharmGKBi | PA30112 |
Miscellaneous databases
Pharosi | Q9BVG8, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1075119 |
Genetic variation databases
BioMutai | KIFC3 |
DMDMi | 357529584 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125431 | 1 – 833 | Kinesin-like protein KIFC3Add BLAST | 833 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 813 | PhosphoserineCombined sources | 1 | |
Modified residuei | 817 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9BVG8 |
MassIVEi | Q9BVG8 |
MaxQBi | Q9BVG8 |
PaxDbi | Q9BVG8 |
PeptideAtlasi | Q9BVG8 |
PRIDEi | Q9BVG8 |
ProteomicsDBi | 6579 79201 [Q9BVG8-3] 79202 [Q9BVG8-2] 79203 [Q9BVG8-4] 79204 [Q9BVG8-5] |
PTM databases
iPTMneti | Q9BVG8 |
PhosphoSitePlusi | Q9BVG8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140859, Expressed in cortex of kidney and 183 other tissues |
ExpressionAtlasi | Q9BVG8, baseline and differential |
Genevisiblei | Q9BVG8, HS |
Organism-specific databases
HPAi | ENSG00000140859, Low tissue specificity |
Interactioni
Binary interactionsi
Q9BVG8
KIFC3 - isoform 4 [Q9BVG8-5]
GO - Molecular functioni
- identical protein binding Source: IntAct
- microtubule binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 110002, 251 interactors |
DIPi | DIP-52406N |
IntActi | Q9BVG8, 251 interactors |
MINTi | Q9BVG8 |
STRINGi | 9606.ENSP00000368976 |
Miscellaneous databases
RNActi | Q9BVG8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9BVG8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BVG8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 445 – 768 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 324 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 74 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 786 – 833 | DisorderedSequence analysisAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 102 – 362 | Sequence analysisAdd BLAST | 261 | |
Coiled coili | 395 – 432 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 30 – 46 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 798 – 819 | Polar residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0239, Eukaryota |
GeneTreei | ENSGT00940000154022 |
HOGENOMi | CLU_001485_12_6_1 |
InParanoidi | Q9BVG8 |
OMAi | RHDMQKC |
OrthoDBi | 364605at2759 |
TreeFami | TF105238 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027325, KIFC3-like IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR47972:SF5, PTHR47972:SF5, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT
60 70 80 90 100
GPGRLRTGRG KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL
110 120 130 140 150
YLTLQVEHLK EKLISQAQEV SRLRSELGGT DLEKHRDLLM VENERLRQEM
160 170 180 190 200
RRCEAELQEL RTKPAGPCPG CEHSQESAQL RDKLSQLQLE MAESKGMLSE
210 220 230 240 250
LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS HETIASLRAQ
260 270 280 290 300
SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL
310 320 330 340 350
QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA
360 370 380 390 400
QVEMKAVHEN LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL
410 420 430 440 450
RSVKAEIGQA IEEVNSNNQE LLRKYRRELQ LRKKCHNELV RLKGNIRVIA
460 470 480 490 500
RVRPVTKEDG EGPEATNAVT FDADDDSIIH LLHKGKPVSF ELDKVFSPQA
510 520 530 540 550
SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG TAENPGINQR
560 570 580 590 600
ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP
610 620 630 640 650
DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL
660 670 680 690 700
LIVTVRGVDC STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS
710 720 730 740 750
LSALGDVIAA LRSRQGHVPF RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK
760 770 780 790 800
NTSETLYSLK FAERVRSVEL GPGLRRAELG SWSSQEHLEW EPACQTPQPS
810 820 830
ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV
The sequence of this isoform differs from the canonical sequence as follows:
626-637: FEFGHTNRTTEF → WRREPLTTATLL
638-833: Missing.
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H3M2 | F5H3M2_HUMAN | Kinesin-like protein | KIFC3 | 724 | Annotation score: | ||
B7Z896 | B7Z896_HUMAN | Kinesin-like protein | KIFC3 | 684 | Annotation score: | ||
H3BTL6 | H3BTL6_HUMAN | Kinesin-like protein | KIFC3 | 280 | Annotation score: | ||
A0A0C4DGM9 | A0A0C4DGM9_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 498 | Annotation score: | ||
H3BUC0 | H3BUC0_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 196 | Annotation score: | ||
H3BTU1 | H3BTU1_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 147 | Annotation score: | ||
H3BPE2 | H3BPE2_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 132 | Annotation score: | ||
H3BSN2 | H3BSN2_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 190 | Annotation score: | ||
H3BMQ3 | H3BMQ3_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 167 | Annotation score: | ||
H3BMR0 | H3BMR0_HUMAN | Kinesin-like protein KIFC3 | KIFC3 | 70 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | M → L in AAC24153 (PubMed:9782090).Curated | 1 | |
Sequence conflicti | 185 | S → P in AAH34234 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 281 | H → S in AAH08014 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 736 | D → G in AAH34234 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028114 | 391 | G → V1 PublicationCorresponds to variant dbSNP:rs17854089Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043724 | 1 – 139 | Missing in isoform 4. 1 PublicationAdd BLAST | 139 | |
Alternative sequenceiVSP_057224 | 1 | M → MCASACKDTAAWCPEEAAEP QAM in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_022361 | 626 – 637 | FEFGH…RTTEF → WRREPLTTATLL in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_022362 | 638 – 833 | Missing in isoform 3. 1 PublicationAdd BLAST | 196 | |
Alternative sequenceiVSP_021018 | 826 – 833 | GKSRPLPV → A in isoform 2, isoform 4 and isoform 5. 4 Publications | 8 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000379655; ENSP00000368976; ENSG00000140859 ENST00000421376; ENSP00000396399; ENSG00000140859 [Q9BVG8-5] ENST00000445690; ENSP00000401696; ENSG00000140859 [Q9BVG8-2] ENST00000465878; ENSP00000454659; ENSG00000140859 [Q9BVG8-5] ENST00000541240; ENSP00000442008; ENSG00000140859 [Q9BVG8-6] ENST00000562903; ENSP00000456239; ENSG00000140859 [Q9BVG8-5] |
GeneIDi | 3801 |
KEGGi | hsa:3801 |
MANE-Selecti | ENST00000445690.7; ENSP00000401696.2; NM_001130100.2; NP_001123572.1 [Q9BVG8-2] |
UCSCi | uc002emm.4, human [Q9BVG8-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5WDE | X-ray | 1.85 | A | 443-770 | [»] | |
SMRi | Q9BVG8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110002, 251 interactors |
DIPi | DIP-52406N |
IntActi | Q9BVG8, 251 interactors |
MINTi | Q9BVG8 |
STRINGi | 9606.ENSP00000368976 |
Chemistry databases
ChEMBLi | CHEMBL1075119 |
PTM databases
iPTMneti | Q9BVG8 |
PhosphoSitePlusi | Q9BVG8 |
Genetic variation databases
BioMutai | KIFC3 |
DMDMi | 357529584 |
Proteomic databases
jPOSTi | Q9BVG8 |
MassIVEi | Q9BVG8 |
MaxQBi | Q9BVG8 |
PaxDbi | Q9BVG8 |
PeptideAtlasi | Q9BVG8 |
PRIDEi | Q9BVG8 |
ProteomicsDBi | 6579 79201 [Q9BVG8-3] 79202 [Q9BVG8-2] 79203 [Q9BVG8-4] 79204 [Q9BVG8-5] |
Protocols and materials databases
Antibodypediai | 15192, 97 antibodies from 25 providers |
DNASUi | 3801 |
Genome annotation databases
Ensembli | ENST00000379655; ENSP00000368976; ENSG00000140859 ENST00000421376; ENSP00000396399; ENSG00000140859 [Q9BVG8-5] ENST00000445690; ENSP00000401696; ENSG00000140859 [Q9BVG8-2] ENST00000465878; ENSP00000454659; ENSG00000140859 [Q9BVG8-5] ENST00000541240; ENSP00000442008; ENSG00000140859 [Q9BVG8-6] ENST00000562903; ENSP00000456239; ENSG00000140859 [Q9BVG8-5] |
GeneIDi | 3801 |
KEGGi | hsa:3801 |
MANE-Selecti | ENST00000445690.7; ENSP00000401696.2; NM_001130100.2; NP_001123572.1 [Q9BVG8-2] |
UCSCi | uc002emm.4, human [Q9BVG8-3] |
Organism-specific databases
CTDi | 3801 |
DisGeNETi | 3801 |
GeneCardsi | KIFC3 |
HGNCi | HGNC:6326, KIFC3 |
HPAi | ENSG00000140859, Low tissue specificity |
MIMi | 604535, gene |
neXtProti | NX_Q9BVG8 |
OpenTargetsi | ENSG00000140859 |
PharmGKBi | PA30112 |
VEuPathDBi | HostDB:ENSG00000140859 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0239, Eukaryota |
GeneTreei | ENSGT00940000154022 |
HOGENOMi | CLU_001485_12_6_1 |
InParanoidi | Q9BVG8 |
OMAi | RHDMQKC |
OrthoDBi | 364605at2759 |
TreeFami | TF105238 |
Enzyme and pathway databases
PathwayCommonsi | Q9BVG8 |
Reactomei | R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis [Q9BVG8-2] |
SignaLinki | Q9BVG8 |
Miscellaneous databases
BioGRID-ORCSi | 3801, 1 hit in 1042 CRISPR screens |
ChiTaRSi | KIFC3, human |
EvolutionaryTracei | Q9BVG8 |
GeneWikii | KIFC3 |
GenomeRNAii | 3801 |
Pharosi | Q9BVG8, Tbio |
PROi | PR:Q9BVG8 |
RNActi | Q9BVG8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140859, Expressed in cortex of kidney and 183 other tissues |
ExpressionAtlasi | Q9BVG8, baseline and differential |
Genevisiblei | Q9BVG8, HS |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027325, KIFC3-like IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR47972:SF5, PTHR47972:SF5, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KIFC3_HUMAN | |
Accessioni | Q9BVG8Primary (citable) accession number: Q9BVG8 Secondary accession number(s): A8K6S2 Q96HW6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 23, 2022 | |
This is version 185 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families