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Entry version 178 (12 Aug 2020)
Sequence version 4 (16 Nov 2011)
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Protein

Kinesin-like protein KIFC3

Gene

KIFC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi528 – 535ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9BVG8

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis [Q9BVG8-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIFC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIFC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000140859.15

Human Gene Nomenclature Database

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HGNCi
HGNC:6326, KIFC3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604535, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9BVG8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
3801

Open Targets

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OpenTargetsi
ENSG00000140859

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30112

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9BVG8, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1075119

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KIFC3

Domain mapping of disease mutations (DMDM)

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DMDMi
357529584

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254311 – 833Kinesin-like protein KIFC3Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei813PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BVG8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BVG8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BVG8

PeptideAtlas

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PeptideAtlasi
Q9BVG8

PRoteomics IDEntifications database

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PRIDEi
Q9BVG8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
6579
79201 [Q9BVG8-3]
79202 [Q9BVG8-2]
79203 [Q9BVG8-4]
79204 [Q9BVG8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BVG8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BVG8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140859, Expressed in cortex of kidney and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BVG8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BVG8, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000140859, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BVG8
With#Exp.IntAct
ABI2 [Q9NYB9]5EBI-2125614,EBI-743598
ATF2 [P15336]3EBI-2125614,EBI-1170906
BCL6 [P41182]3EBI-2125614,EBI-765407
C1orf109 [Q9NX04]4EBI-2125614,EBI-8643161
CBX8 [Q9HC52]3EBI-2125614,EBI-712912
CBY2 [Q8NA61]5EBI-2125614,EBI-741724
CCDC102B [Q68D86]3EBI-2125614,EBI-10171570
CCDC136 - isoform 2 [Q96JN2-2]3EBI-2125614,EBI-10171416
CCDC28A [Q7Z6N9]3EBI-2125614,EBI-10258115
CCDC28A [Q8IWP9]3EBI-2125614,EBI-355471
CDK18 [Q07002]3EBI-2125614,EBI-746238
CDR2 [Q01850]3EBI-2125614,EBI-1181367
CEP170P1 [Q96L14]4EBI-2125614,EBI-743488
CEP55 [Q53EZ4]3EBI-2125614,EBI-747776
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-2125614,EBI-10181988
CLIP4 [Q8N3C7]3EBI-2125614,EBI-5655540
CREB5 - isoform 3 [Q02930-3]3EBI-2125614,EBI-10192698
CYTH4 [Q8WWE8]3EBI-2125614,EBI-10277443
DCTN2 [Q13561]3EBI-2125614,EBI-715074
DCX [O43602]3EBI-2125614,EBI-8646694
DEUP1 [Q05D60]3EBI-2125614,EBI-748597
DTNBP1 [Q96EV8]3EBI-2125614,EBI-465804
ESRRG [P62508]3EBI-2125614,EBI-2834260
FAM124A [Q86V42]3EBI-2125614,EBI-744506
FANCL [Q9NW38]3EBI-2125614,EBI-2339898
FCHSD2 [O94868]3EBI-2125614,EBI-1215612
FLJ13057 [Q53SE7]3EBI-2125614,EBI-10172181
GOLGA2 [Q08379]3EBI-2125614,EBI-618309
GORASP2 [Q9H8Y8]3EBI-2125614,EBI-739467
HAUS1 [Q96CS2]3EBI-2125614,EBI-2514791
HSBP1 [O75506]5EBI-2125614,EBI-748664
ICA1L [Q8NDH6]3EBI-2125614,EBI-10269733
ITGB3BP [Q13352]3EBI-2125614,EBI-712105
ITGB3BP - isoform 5 [Q13352-5]3EBI-2125614,EBI-10175826
KANSL1 [Q7Z3B3]4EBI-2125614,EBI-740244
KRT15 [P19012]3EBI-2125614,EBI-739566
KRT19 [P08727]3EBI-2125614,EBI-742756
KRT31 [Q15323]3EBI-2125614,EBI-948001
KRT40 [Q6A162]3EBI-2125614,EBI-10171697
KRT5 [P13647]3EBI-2125614,EBI-702187
KRT6A [P02538]5EBI-2125614,EBI-702198
KRT6B [P04259]3EBI-2125614,EBI-740907
KRT6C [P48668]3EBI-2125614,EBI-2564105
LENG1 [Q96BZ8]3EBI-2125614,EBI-726510
LIN37 [Q96GY3]3EBI-2125614,EBI-748884
LZTS2 [Q9BRK4]3EBI-2125614,EBI-741037
MCM7 [P33993]3EBI-2125614,EBI-355924
MED4 [Q9NPJ6]3EBI-2125614,EBI-394607
MFAP1 [P55081]3EBI-2125614,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]3EBI-2125614,EBI-10172526
MOS [P00540]3EBI-2125614,EBI-1757866
NDEL1 [Q9GZM8]3EBI-2125614,EBI-928842
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-2125614,EBI-10172876
NEFL [I6L9F6]3EBI-2125614,EBI-10178578
NUP62 [P37198]3EBI-2125614,EBI-347978
PHC2 [Q8IXK0]3EBI-2125614,EBI-713786
PRKAA2 [P54646]4EBI-2125614,EBI-1383852
PSMB1 [P20618]4EBI-2125614,EBI-372273
RAD51D [O75771]4EBI-2125614,EBI-1055693
RSPH14 [Q9UHP6]3EBI-2125614,EBI-748350
SCEL [O95171]3EBI-2125614,EBI-7543896
SIAH1 [Q8IUQ4]3EBI-2125614,EBI-747107
SMARCE1 [Q969G3]4EBI-2125614,EBI-455078
SOX5 [P35711]3EBI-2125614,EBI-3505701
SYCE1 [Q8N0S2]3EBI-2125614,EBI-6872807
TCEANC [Q8N8B7]3EBI-2125614,EBI-954696
TLE5 [Q08117]3EBI-2125614,EBI-717810
TNIP1 [Q15025]3EBI-2125614,EBI-357849
TPM3 [Q5VU62]3EBI-2125614,EBI-10184033
TRAF2 [Q12933]3EBI-2125614,EBI-355744
TRIM23 [P36406]3EBI-2125614,EBI-740098
TRIM27 [P14373]3EBI-2125614,EBI-719493
TRIM41 [Q8WV44]3EBI-2125614,EBI-725997
TRIM54 [Q9BYV2]3EBI-2125614,EBI-2130429
TSG101 [Q99816]3EBI-2125614,EBI-346882
TSR2 [Q969E8]3EBI-2125614,EBI-746981
USP2 [O75604]3EBI-2125614,EBI-743272
ZBTB8A [Q96BR9]3EBI-2125614,EBI-742740
ZGPAT [Q8N5A5]4EBI-2125614,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-2125614,EBI-10183064
ZNF180 [Q9UJW8]3EBI-2125614,EBI-10322527
ZNF20 [P17024]3EBI-2125614,EBI-717634
ZNF572 [Q7Z3I7]6EBI-2125614,EBI-10172590
ZNF655 [Q8N720]3EBI-2125614,EBI-625509
KIFC3 - isoform 4 [Q9BVG8-5]
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-14069005,EBI-11096309
ABI3 [Q9P2A4]3EBI-14069005,EBI-742038
ANKRD23 [Q86SG2]3EBI-14069005,EBI-5661893
APPL2 [Q8NEU8]3EBI-14069005,EBI-741261
ATF2 [P15336]3EBI-14069005,EBI-1170906
AXIN2 [Q9Y2T1]3EBI-14069005,EBI-4400025
BARD1 [Q99728]3EBI-14069005,EBI-473181
BEGAIN [Q9BUH8]3EBI-14069005,EBI-742722
BFSP1 - isoform 2 [Q12934-2]3EBI-14069005,EBI-12123320
BYSL [Q13895]5EBI-14069005,EBI-358049
C1orf109 [Q9NX04]3EBI-14069005,EBI-8643161
C2CD6 [Q53TS8]3EBI-14069005,EBI-739879
CARD9 - isoform 2 [Q9H257-2]3EBI-14069005,EBI-11530605
CBFA2T2 - isoform 4 [O43439-4]3EBI-14069005,EBI-11954144
CBX8 [Q9HC52]3EBI-14069005,EBI-712912
CBY2 - isoform 2 [Q8NA61-2]3EBI-14069005,EBI-11524851
CCDC146 [Q8IYE0]3EBI-14069005,EBI-10749669
CCDC198 [E9PSE9]3EBI-14069005,EBI-11748295
CCDC36 [Q8IYA8]3EBI-14069005,EBI-8638439
CCHCR1 - isoform 1 [Q8TD31-1]4EBI-14069005,EBI-21238948
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-14069005,EBI-10175300
CCND3 [P30281]3EBI-14069005,EBI-375013
CDC37 [Q16543]3EBI-14069005,EBI-295634
CDKN1A [P38936]3EBI-14069005,EBI-375077
CDR2 [Q01850]3EBI-14069005,EBI-1181367
CEP55 [Q53EZ4]3EBI-14069005,EBI-747776
CLIP4 [Q8N3C7]3EBI-14069005,EBI-5655540
COG3 - isoform 2 [Q96JB2-2]3EBI-14069005,EBI-9091495
COG7 [A0A0S2Z604]3EBI-14069005,EBI-16430119
COG7 [P83436]6EBI-14069005,EBI-389534
CREB5 - isoform 3 [Q02930-3]3EBI-14069005,EBI-10192698
CWF19L2 [Q2TBE0]3EBI-14069005,EBI-5453285
DCTN2 [Q13561]3EBI-14069005,EBI-715074
DEUP1 [Q05D60]5EBI-14069005,EBI-748597
DISC1 - isoform 2 [Q9NRI5-2]3EBI-14069005,EBI-11988027
EIF3D [O15371]3EBI-14069005,EBI-353818
ENKD1 [Q9H0I2]3EBI-14069005,EBI-744099
EXOC5 [O00471]3EBI-14069005,EBI-949824
EXOC7 - isoform 1 [Q9UPT5-1]3EBI-14069005,EBI-6251402
EXOC8 [Q8IYI6]3EBI-14069005,EBI-742102
FAM161A [Q3B820]3EBI-14069005,EBI-719941
FAM90A1 [Q86YD7]3EBI-14069005,EBI-6658203
FANCL [Q9NW38]3EBI-14069005,EBI-2339898
FEM1A [Q9BSK4]3EBI-14069005,EBI-2515349
FLYWCH1 [Q4VC44]3EBI-14069005,EBI-719415
FOSL1 [P15407]3EBI-14069005,EBI-744510
GADD45GIP1 [Q8TAE8]3EBI-14069005,EBI-372506
GEM [P55040]3EBI-14069005,EBI-744104
GIGYF1 [O75420]3EBI-14069005,EBI-947774
GMCL1 [Q96IK5]3EBI-14069005,EBI-2548508
GOLGA1 [Q92805]3EBI-14069005,EBI-6164177
GOLGA2 [Q08379]3EBI-14069005,EBI-618309
GORASP2 [Q9H8Y8]3EBI-14069005,EBI-739467
hCG_1987119 [A0A024R8L2]3EBI-14069005,EBI-14103818
HMG20A [Q9NP66]3EBI-14069005,EBI-740641
HSBP1 [O75506]3EBI-14069005,EBI-748664
HSF2BP [O75031]3EBI-14069005,EBI-7116203
IGFN1 - isoform 5 [Q86VF2-5]3EBI-14069005,EBI-11955401
IKZF3 [Q9UKT9]3EBI-14069005,EBI-747204
IL16 - isoform 2 [Q14005-2]3EBI-14069005,EBI-17178971
IQUB [Q8NA54]3EBI-14069005,EBI-10220600
ITGB3BP [Q13352]3EBI-14069005,EBI-712105
KANK2 [Q63ZY3]3EBI-14069005,EBI-2556193
KDM1A [O60341]3EBI-14069005,EBI-710124
KIAA0753 [Q2KHM9]3EBI-14069005,EBI-2805604
itself3EBI-14069005,EBI-14069005
KRT14 [P02533]3EBI-14069005,EBI-702178
KRT15 [P19012]3EBI-14069005,EBI-739566
KRT16 [P08779]3EBI-14069005,EBI-356410
KRT18 [P05783]3EBI-14069005,EBI-297888
KRT26 [Q7Z3Y9]3EBI-14069005,EBI-12084444
KRT3 [P12035]3EBI-14069005,EBI-2430095
KRT31 [Q15323]3EBI-14069005,EBI-948001
KRT32 [Q14532]3EBI-14069005,EBI-1044146
KRT35 [Q92764]3EBI-14069005,EBI-1058674
KRT38 [O76015]3EBI-14069005,EBI-1047263
KRT5 [P13647]3EBI-14069005,EBI-702187
KRT6A [P02538]3EBI-14069005,EBI-702198
KRT6B [P04259]3EBI-14069005,EBI-740907
KRT6C [P48668]3EBI-14069005,EBI-2564105
KRT75 [O95678]3EBI-14069005,EBI-2949715
KRT76 [Q01546]3EBI-14069005,EBI-2952745
KRTAP19-5 [Q3LI72]3EBI-14069005,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-14069005,EBI-12805508
LBX1 [P52954]3EBI-14069005,EBI-20141748
LENG1 [Q96BZ8]3EBI-14069005,EBI-726510
LNX1 [Q8TBB1]3EBI-14069005,EBI-739832
LZTS1 [Q9Y250]3EBI-14069005,EBI-1216080
LZTS2 [Q9BRK4]3EBI-14069005,EBI-741037
MBD3L1 [Q8WWY6]3EBI-14069005,EBI-12516603
MCC [P23508]3EBI-14069005,EBI-307531
MED4 [Q9NPJ6]3EBI-14069005,EBI-394607
MFAP1 [P55081]3EBI-14069005,EBI-1048159
MGC50722 [Q8IVT4]3EBI-14069005,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-14069005,EBI-10172526
MKRN3 [Q13064]3EBI-14069005,EBI-2340269
MRFAP1 [Q9Y605]3EBI-14069005,EBI-995714
MTUS2 - isoform 2 [Q5JR59-3]5EBI-14069005,EBI-11522433
NAB2 [Q15742]3EBI-14069005,EBI-8641936
NDC80 [O14777]3EBI-14069005,EBI-715849
NEBL [O76041]3EBI-14069005,EBI-2880203
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-14069005,EBI-10172876
NEFL [I6L9F6]3EBI-14069005,EBI-10178578
NEFL [P07196]3EBI-14069005,EBI-475646
NSMF - isoform 2 [Q6X4W1-2]3EBI-14069005,EBI-12028784
PFDN6 [O15212]3EBI-14069005,EBI-356973
PIAS2 - isoform PIAS2-alpha [O75928-2]3EBI-14069005,EBI-348567
PIBF1 [Q4G0R1]3EBI-14069005,EBI-14066006
PIN1 [Q13526]3EBI-14069005,EBI-714158
PNMA5 [Q96PV4]3EBI-14069005,EBI-10171633
PPP1R13B [Q96KQ4]3EBI-14069005,EBI-1105153
PRDM6 [Q9NQX0]3EBI-14069005,EBI-11320284
PRPF18 [Q99633]3EBI-14069005,EBI-2798416
PRPF31 [Q8WWY3]3EBI-14069005,EBI-1567797
PRPH [P41219]3EBI-14069005,EBI-752074
PSMB1 [P20618]3EBI-14069005,EBI-372273
RABIF [P47224]3EBI-14069005,EBI-713992
RAD51D [O75771]3EBI-14069005,EBI-1055693
RAD54L2 [Q9Y4B4]3EBI-14069005,EBI-948156
RBM41 [Q96IZ5]3EBI-14069005,EBI-740773
RSPH14 [Q9UHP6]3EBI-14069005,EBI-748350
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-14069005,EBI-11984663
SCNM1 [Q9BWG6]3EBI-14069005,EBI-748391
SCOC - isoform 3 [Q9UIL1-3]3EBI-14069005,EBI-10692913
SHISA6 [Q6ZSJ9]3EBI-14069005,EBI-12037847
SORBS3 [O60504]3EBI-14069005,EBI-741237
SOX5 - isoform 4 [P35711-4]3EBI-14069005,EBI-11954419
SPATA2 [Q9UM82]3EBI-14069005,EBI-744066
SPATC1L - isoform 2 [Q9H0A9-2]3EBI-14069005,EBI-11995806
SSX2IP [Q9Y2D8]3EBI-14069005,EBI-2212028
STMN3 [Q9NZ72]3EBI-14069005,EBI-725557
STX11 [O75558]7EBI-14069005,EBI-714135
STX1A [Q16623]3EBI-14069005,EBI-712466
SYCE2 [Q6PIF2]3EBI-14069005,EBI-11958386
SYT6 - isoform 2 [Q5T7P8-2]3EBI-14069005,EBI-10246152
SYTL4 [Q96C24]3EBI-14069005,EBI-747142
TASOR2 [Q5VWN6]6EBI-14069005,EBI-745958
TBC1D22B [Q9NU19]3EBI-14069005,EBI-8787464
TFIP11 [Q9UBB9]3EBI-14069005,EBI-1105213
TLE5 - isoform 2 [Q08117-2]3EBI-14069005,EBI-11741437
TNIP1 [Q15025]3EBI-14069005,EBI-357849
TNNI1 [P19237]3EBI-14069005,EBI-746692
TRAF2 [Q12933]3EBI-14069005,EBI-355744
TRIM14 [Q14142]3EBI-14069005,EBI-2820256
TRIM54 [Q9BYV2]3EBI-14069005,EBI-2130429
TSGA10IP [Q3SY00]3EBI-14069005,EBI-10241197
TSR2 [Q969E8]3EBI-14069005,EBI-746981
USH1G [Q495M9]3EBI-14069005,EBI-8601749
USP2 [O75604]3EBI-14069005,EBI-743272
VIM [P08670]3EBI-14069005,EBI-353844
VPS52 [Q8N1B4]3EBI-14069005,EBI-2799833
WASF3 - isoform 2 [Q9UPY6-2]3EBI-14069005,EBI-12026286
ZBED1 [O96006]3EBI-14069005,EBI-740037
ZBTB16 [Q05516]3EBI-14069005,EBI-711925
ZBTB8A [Q96BR9]3EBI-14069005,EBI-742740
ZGPAT [A0A0S2Z6H0]3EBI-14069005,EBI-16428984
ZGPAT - isoform 2 [Q8N5A5-2]6EBI-14069005,EBI-10183064
ZNF180 - isoform 4 [Q9UJW8-4]3EBI-14069005,EBI-12055755
ZNF20 [P17024]3EBI-14069005,EBI-717634
ZNF250 - isoform 3 [P15622-3]3EBI-14069005,EBI-10177272
ZNF417 [Q8TAU3]3EBI-14069005,EBI-740727
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-14069005,EBI-740232
ZNF572 [Q7Z3I7]4EBI-14069005,EBI-10172590
ZNF655 [Q8N720]3EBI-14069005,EBI-625509
ZNF688 [A0A0S2Z5X4]3EBI-14069005,EBI-16429014
ZNF774 [Q6NX45]3EBI-14069005,EBI-10251462
ZNF785 [A8K8V0]3EBI-14069005,EBI-3925400
ZNF835 [Q9Y2P0]3EBI-14069005,EBI-5667516
ZRANB1 [Q9UGI0]3EBI-14069005,EBI-527853

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110002, 127 interactors

Database of interacting proteins

More...
DIPi
DIP-52406N

Protein interaction database and analysis system

More...
IntActi
Q9BVG8, 245 interactors

Molecular INTeraction database

More...
MINTi
Q9BVG8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368976

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BVG8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1833
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BVG8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BVG8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini445 – 768Kinesin motorPROSITE-ProRule annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili102 – 362Sequence analysisAdd BLAST261
Coiled coili395 – 432Sequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0239, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154022

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001485_12_6_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVG8

KEGG Orthology (KO)

More...
KOi
K10406

Identification of Orthologs from Complete Genome Data

More...
OMAi
TNERCEG

Database of Orthologous Groups

More...
OrthoDBi
364605at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105238

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027325, KIFC3-like
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24115, PTHR24115, 1 hit
PTHR24115:SF387, PTHR24115:SF387, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00225, Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00129, KISc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BVG8-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPSRRTWNL GATPSLRGLW RVGRAPEPEP GMARPAPAPA SPAARPFPHT
60 70 80 90 100
GPGRLRTGRG KDTPVCGDED SSARSAARPA LAQCRALSVD WAGPGSPHGL
110 120 130 140 150
YLTLQVEHLK EKLISQAQEV SRLRSELGGT DLEKHRDLLM VENERLRQEM
160 170 180 190 200
RRCEAELQEL RTKPAGPCPG CEHSQESAQL RDKLSQLQLE MAESKGMLSE
210 220 230 240 250
LNLEVQQKTD RLAEVELRLK DCLAEKAQEE ERLSRRLRDS HETIASLRAQ
260 270 280 290 300
SPPVKYVIKT VEVESSKTKQ ALSESQARNQ HLQEQVAMQR QVLKEMEQQL
310 320 330 340 350
QSSHQLTARL RAQIAMYESE LERAHGQMLE EMQSLEEDKN RAIEEAFARA
360 370 380 390 400
QVEMKAVHEN LAGVRTNLLT LQPALRTLTN DYNGLKRQVR GFPLLLQEAL
410 420 430 440 450
RSVKAEIGQA IEEVNSNNQE LLRKYRRELQ LRKKCHNELV RLKGNIRVIA
460 470 480 490 500
RVRPVTKEDG EGPEATNAVT FDADDDSIIH LLHKGKPVSF ELDKVFSPQA
510 520 530 540 550
SQQDVFQEVQ ALVTSCIDGF NVCIFAYGQT GAGKTYTMEG TAENPGINQR
560 570 580 590 600
ALQLLFSEVQ EKASDWEYTI TVSAAEIYNE VLRDLLGKEP QEKLEIRLCP
610 620 630 640 650
DGSGQLYVPG LTEFQVQSVD DINKVFEFGH TNRTTEFTNL NEHSSRSHAL
660 670 680 690 700
LIVTVRGVDC STGLRTTGKL NLVDLAGSER VGKSGAEGSR LREAQHINKS
710 720 730 740 750
LSALGDVIAA LRSRQGHVPF RNSKLTYLLQ DSLSGDSKTL MVVQVSPVEK
760 770 780 790 800
NTSETLYSLK FAERVRSVEL GPGLRRAELG SWSSQEHLEW EPACQTPQPS
810 820 830
ARAHSAPSSG TSSRPGSIRR KLQPSGKSRP LPV
Length:833
Mass (Da):92,775
Last modified:November 16, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50983587270BDC2F
GO
Isoform 2 (identifier: Q9BVG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     826-833: GKSRPLPV → A

Show »
Length:826
Mass (Da):92,011
Checksum:iFA9B17728E570AE8
GO
Isoform 3 (identifier: Q9BVG8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     626-637: FEFGHTNRTTEF → WRREPLTTATLL
     638-833: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:637
Mass (Da):71,607
Checksum:i367120F4FC3C3B78
GO
Isoform 4 (identifier: Q9BVG8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     826-833: GKSRPLPV → A

Show »
Length:687
Mass (Da):77,089
Checksum:iEA21C203FC8B29A8
GO
Isoform 5 (identifier: Q9BVG8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCASACKDTAAWCPEEAAEPQAM
     826-833: GKSRPLPV → A

Show »
Length:848
Mass (Da):94,276
Checksum:i23229203DAE90BDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H3M2F5H3M2_HUMAN
Kinesin-like protein
KIFC3
724Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z896B7Z896_HUMAN
Kinesin-like protein
KIFC3
684Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTL6H3BTL6_HUMAN
Kinesin-like protein
KIFC3
280Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGM9A0A0C4DGM9_HUMAN
Kinesin-like protein KIFC3
KIFC3
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUC0H3BUC0_HUMAN
Kinesin-like protein KIFC3
KIFC3
196Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE2H3BPE2_HUMAN
Kinesin-like protein KIFC3
KIFC3
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSN2H3BSN2_HUMAN
Kinesin-like protein KIFC3
KIFC3
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNZ0H3BNZ0_HUMAN
Kinesin-like protein KIFC3
KIFC3
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRQ1H3BRQ1_HUMAN
Kinesin-like protein KIFC3
KIFC3
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTU1H3BTU1_HUMAN
Kinesin-like protein KIFC3
KIFC3
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34234 differs from that shown. Intron retention.Curated
The sequence AAH41132 differs from that shown. Intron retention.Curated
The sequence AAH47051 differs from that shown. Intron retention.Curated
The sequence BAD92527 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150M → L in AAC24153 (PubMed:9782090).Curated1
Sequence conflicti185S → P in AAH34234 (PubMed:15489334).Curated1
Sequence conflicti281H → S in AAH08014 (PubMed:15489334).Curated1
Sequence conflicti736D → G in AAH34234 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028114391G → V1 PublicationCorresponds to variant dbSNP:rs17854089Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437241 – 139Missing in isoform 4. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_0572241M → MCASACKDTAAWCPEEAAEP QAM in isoform 5. 1 Publication1
Alternative sequenceiVSP_022361626 – 637FEFGH…RTTEF → WRREPLTTATLL in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_022362638 – 833Missing in isoform 3. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_021018826 – 833GKSRPLPV → A in isoform 2, isoform 4 and isoform 5. 4 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK291737 mRNA Translation: BAF84426.1
AK296995 mRNA Translation: BAH12470.1
AB209290 mRNA Translation: BAD92527.1 Different initiation.
AC010543 Genomic DNA No translation available.
AC092118 Genomic DNA No translation available.
FO082293 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82955.1
BC001211 mRNA Translation: AAH01211.2
BC008014 mRNA Translation: AAH08014.1
BC034234 mRNA Translation: AAH34234.1 Different initiation.
BC041132 mRNA Translation: AAH41132.1 Different initiation.
BC047051 mRNA Translation: AAH47051.1 Sequence problems.
AF004426 mRNA Translation: AAC24153.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10789.2 [Q9BVG8-3]
CCDS45493.1 [Q9BVG8-2]
CCDS45494.1 [Q9BVG8-5]
CCDS81989.1 [Q9BVG8-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001123571.1, NM_001130099.1 [Q9BVG8-5]
NP_001123572.1, NM_001130100.1 [Q9BVG8-2]
NP_001305639.1, NM_001318710.1 [Q9BVG8-6]
NP_001305640.1, NM_001318711.1
NP_001305641.1, NM_001318712.1
NP_001305642.1, NM_001318713.1
NP_001305643.1, NM_001318714.1 [Q9BVG8-5]
NP_001305644.1, NM_001318715.1 [Q9BVG8-5]
NP_005541.3, NM_005550.3 [Q9BVG8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379655; ENSP00000368976; ENSG00000140859 [Q9BVG8-3]
ENST00000421376; ENSP00000396399; ENSG00000140859 [Q9BVG8-5]
ENST00000445690; ENSP00000401696; ENSG00000140859 [Q9BVG8-2]
ENST00000465878; ENSP00000454659; ENSG00000140859 [Q9BVG8-5]
ENST00000541240; ENSP00000442008; ENSG00000140859 [Q9BVG8-6]
ENST00000562903; ENSP00000456239; ENSG00000140859 [Q9BVG8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3801

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3801

UCSC genome browser

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UCSCi
uc002emm.4, human [Q9BVG8-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291737 mRNA Translation: BAF84426.1
AK296995 mRNA Translation: BAH12470.1
AB209290 mRNA Translation: BAD92527.1 Different initiation.
AC010543 Genomic DNA No translation available.
AC092118 Genomic DNA No translation available.
FO082293 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82955.1
BC001211 mRNA Translation: AAH01211.2
BC008014 mRNA Translation: AAH08014.1
BC034234 mRNA Translation: AAH34234.1 Different initiation.
BC041132 mRNA Translation: AAH41132.1 Different initiation.
BC047051 mRNA Translation: AAH47051.1 Sequence problems.
AF004426 mRNA Translation: AAC24153.1
CCDSiCCDS10789.2 [Q9BVG8-3]
CCDS45493.1 [Q9BVG8-2]
CCDS45494.1 [Q9BVG8-5]
CCDS81989.1 [Q9BVG8-6]
RefSeqiNP_001123571.1, NM_001130099.1 [Q9BVG8-5]
NP_001123572.1, NM_001130100.1 [Q9BVG8-2]
NP_001305639.1, NM_001318710.1 [Q9BVG8-6]
NP_001305640.1, NM_001318711.1
NP_001305641.1, NM_001318712.1
NP_001305642.1, NM_001318713.1
NP_001305643.1, NM_001318714.1 [Q9BVG8-5]
NP_001305644.1, NM_001318715.1 [Q9BVG8-5]
NP_005541.3, NM_005550.3 [Q9BVG8-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WDEX-ray1.85A443-770[»]
SMRiQ9BVG8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110002, 127 interactors
DIPiDIP-52406N
IntActiQ9BVG8, 245 interactors
MINTiQ9BVG8
STRINGi9606.ENSP00000368976

Chemistry databases

ChEMBLiCHEMBL1075119

PTM databases

iPTMnetiQ9BVG8
PhosphoSitePlusiQ9BVG8

Polymorphism and mutation databases

BioMutaiKIFC3
DMDMi357529584

Proteomic databases

jPOSTiQ9BVG8
MassIVEiQ9BVG8
PaxDbiQ9BVG8
PeptideAtlasiQ9BVG8
PRIDEiQ9BVG8
ProteomicsDBi6579
79201 [Q9BVG8-3]
79202 [Q9BVG8-2]
79203 [Q9BVG8-4]
79204 [Q9BVG8-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
15192, 90 antibodies

The DNASU plasmid repository

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DNASUi
3801

Genome annotation databases

EnsembliENST00000379655; ENSP00000368976; ENSG00000140859 [Q9BVG8-3]
ENST00000421376; ENSP00000396399; ENSG00000140859 [Q9BVG8-5]
ENST00000445690; ENSP00000401696; ENSG00000140859 [Q9BVG8-2]
ENST00000465878; ENSP00000454659; ENSG00000140859 [Q9BVG8-5]
ENST00000541240; ENSP00000442008; ENSG00000140859 [Q9BVG8-6]
ENST00000562903; ENSP00000456239; ENSG00000140859 [Q9BVG8-5]
GeneIDi3801
KEGGihsa:3801
UCSCiuc002emm.4, human [Q9BVG8-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3801
DisGeNETi3801
EuPathDBiHostDB:ENSG00000140859.15

GeneCards: human genes, protein and diseases

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GeneCardsi
KIFC3
HGNCiHGNC:6326, KIFC3
HPAiENSG00000140859, Low tissue specificity
MIMi604535, gene
neXtProtiNX_Q9BVG8
OpenTargetsiENSG00000140859
PharmGKBiPA30112

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0239, Eukaryota
GeneTreeiENSGT00940000154022
HOGENOMiCLU_001485_12_6_1
InParanoidiQ9BVG8
KOiK10406
OMAiTNERCEG
OrthoDBi364605at2759
TreeFamiTF105238

Enzyme and pathway databases

PathwayCommonsiQ9BVG8
ReactomeiR-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis [Q9BVG8-2]

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
3801, 1 hit in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIFC3, human
EvolutionaryTraceiQ9BVG8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIFC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3801
PharosiQ9BVG8, Tbio

Protein Ontology

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PROi
PR:Q9BVG8
RNActiQ9BVG8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140859, Expressed in cortex of kidney and 182 other tissues
ExpressionAtlasiQ9BVG8, baseline and differential
GenevisibleiQ9BVG8, HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027325, KIFC3-like
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
PANTHERiPTHR24115, PTHR24115, 1 hit
PTHR24115:SF387, PTHR24115:SF387, 1 hit
PfamiView protein in Pfam
PF00225, Kinesin, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00129, KISc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIFC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVG8
Secondary accession number(s): A8K6S2
, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: November 16, 2011
Last modified: August 12, 2020
This is version 178 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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