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Entry version 132 (26 Feb 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Protein PBDC1

Gene

PBDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PBDC1
Alternative name(s):
Polysaccharide biosynthesis domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBDC1
Synonyms:CXorf26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28790 PBDC1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BVG4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000102390

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394657

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BVG4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PBDC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733325

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002541051 – 233Protein PBDC1Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei126PhosphoserineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BVG4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BVG4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BVG4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BVG4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BVG4

PeptideAtlas

More...
PeptideAtlasi
Q9BVG4

PRoteomics IDEntifications database

More...
PRIDEi
Q9BVG4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79200

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BVG4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVG4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102390 Expressed in epithelial cell of pancreas and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BVG4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BVG4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003155

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119416, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BVG4, 13 interactors

Molecular INTeraction database

More...
MINTi
Q9BVG4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362456

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BVG4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BVG4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PBDC1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4093 Eukaryota
ENOG4111SHF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016333

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_103791_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVG4

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIEIARC

Database of Orthologous Groups

More...
OrthoDBi
1420225at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BVG4

TreeFam database of animal gene trees

More...
TreeFami
TF314442

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3560.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023139 PBDC1-like_dom_sf
IPR008476 PBDC1_metazoa/fungi
IPR021148 Polysacc_synth_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13410 PTHR13410, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04669 Polysacc_synt_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BVG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATSGTDEP VSGELVSVAH ALSLPAESYG NDPDIEMAWA MRAMQHAEVY
60 70 80 90 100
YKLISSVDPQ FLKLTKVDDQ IYSEFRKNFE TLRIDVLDPE ELKSESAKEK
110 120 130 140 150
WRPFCLKFNG IVEDFNYGTL LRLDCSQGYT EENTIFAPRI QFFAIEIARN
160 170 180 190 200
REGYNKAVYI SVQDKEGEKG VNNGGEKRAD SGEEENTKNG GEKGADSGEE
210 220 230
KEEGINREDK TDKGGEKGKE ADKEINKSGE KAM
Length:233
Mass (Da):26,057
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31FD39EC70B9A9C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NDF3A6NDF3_HUMAN
Protein PBDC1
PBDC1
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC001220 mRNA Translation: AAH01220.1
BC051894 mRNA Translation: AAH51894.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14432.1

NCBI Reference Sequences

More...
RefSeqi
NP_001287817.1, NM_001300888.1
NP_057584.2, NM_016500.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373358; ENSP00000362456; ENSG00000102390

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51260

UCSC genome browser

More...
UCSCi
uc004ecl.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001220 mRNA Translation: AAH01220.1
BC051894 mRNA Translation: AAH51894.1
CCDSiCCDS14432.1
RefSeqiNP_001287817.1, NM_001300888.1
NP_057584.2, NM_016500.3

3D structure databases

SMRiQ9BVG4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119416, 18 interactors
IntActiQ9BVG4, 13 interactors
MINTiQ9BVG4
STRINGi9606.ENSP00000362456

PTM databases

iPTMnetiQ9BVG4
PhosphoSitePlusiQ9BVG4

Polymorphism and mutation databases

BioMutaiPBDC1
DMDMi74733325

Proteomic databases

EPDiQ9BVG4
jPOSTiQ9BVG4
MassIVEiQ9BVG4
MaxQBiQ9BVG4
PaxDbiQ9BVG4
PeptideAtlasiQ9BVG4
PRIDEiQ9BVG4
ProteomicsDBi79200

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51260

Genome annotation databases

EnsembliENST00000373358; ENSP00000362456; ENSG00000102390
GeneIDi51260
KEGGihsa:51260
UCSCiuc004ecl.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51260

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PBDC1
HGNCiHGNC:28790 PBDC1
HPAiHPA003155
neXtProtiNX_Q9BVG4
OpenTargetsiENSG00000102390
PharmGKBiPA128394657

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4093 Eukaryota
ENOG4111SHF LUCA
GeneTreeiENSGT00390000016333
HOGENOMiCLU_103791_0_0_1
InParanoidiQ9BVG4
OMAiCIEIARC
OrthoDBi1420225at2759
PhylomeDBiQ9BVG4
TreeFamiTF314442

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PBDC1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51260
PharosiQ9BVG4 Tdark

Protein Ontology

More...
PROi
PR:Q9BVG4
RNActiQ9BVG4 protein

Gene expression databases

BgeeiENSG00000102390 Expressed in epithelial cell of pancreas and 194 other tissues
ExpressionAtlasiQ9BVG4 baseline and differential
GenevisibleiQ9BVG4 HS

Family and domain databases

Gene3Di1.10.3560.10, 1 hit
InterProiView protein in InterPro
IPR023139 PBDC1-like_dom_sf
IPR008476 PBDC1_metazoa/fungi
IPR021148 Polysacc_synth_dom
PANTHERiPTHR13410 PTHR13410, 1 hit
PfamiView protein in Pfam
PF04669 Polysacc_synt_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPBDC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: February 26, 2020
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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