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Protein

E3 ubiquitin-protein ligase TRIM62

Gene

TRIM62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 54RING-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri88 – 128B box-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: CACAO
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM62 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM62Curated
Tripartite motif-containing protein 62
Gene namesi
Name:TRIM62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116525.13
HGNCiHGNC:25574 TRIM62
neXtProtiNX_Q9BVG3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55223
OpenTargetsiENSG00000116525
PharmGKBiPA134890243

Polymorphism and mutation databases

BioMutaiTRIM62
DMDMi74752380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495741 – 475E3 ubiquitin-protein ligase TRIM62Add BLAST475

Post-translational modificationi

Polyubiquitinated, autoubiquitinated in the presence of UBE2D2.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9BVG3
PaxDbiQ9BVG3
PeptideAtlasiQ9BVG3
PRIDEiQ9BVG3
ProteomicsDBi79199

PTM databases

iPTMnetiQ9BVG3
PhosphoSitePlusiQ9BVG3

Expressioni

Gene expression databases

BgeeiENSG00000116525 Expressed in 195 organ(s), highest expression level in oocyte
CleanExiHS_TRIM62
GenevisibleiQ9BVG3 HS

Organism-specific databases

HPAiHPA050061

Interactioni

Subunit structurei

Interacts with the ubiquitin-conjugating enzyme, UBE2D2.1 Publication

Protein-protein interaction databases

BioGridi120518, 11 interactors
IntActiQ9BVG3, 20 interactors
MINTiQ9BVG3
STRINGi9606.ENSP00000291416

Structurei

3D structure databases

ProteinModelPortaliQ9BVG3
SMRiQ9BVG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 475B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili127 – 241Sequence analysisAdd BLAST115

Domaini

The RING finger is required for ubiquitin ligase activity.

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 54RING-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri88 – 128B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITEQ Eukaryota
ENOG410XNZK LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
HOVERGENiHBG103330
InParanoidiQ9BVG3
KOiK12030
OMAiFQDISPV
OrthoDBiEOG091G051S
PhylomeDBiQ9BVG3
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd13744 SPRY_PRY_TRIM62, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035830 PRY/SPRY_TRIM62
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BVG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC
60 70 80 90 100
PECRRTFAEP ALAPSLKLAN IVERYSSFPL DAILNARRAA RPCQAHDKVK
110 120 130 140 150
LFCLTDRALL CFFCDEPALH EQHQVTGIDD AFDELQRELK DQLQALQDSE
160 170 180 190 200
REHTEALQLL KRQLAETKSS TKSLRTTIGE AFERLHRLLR ERQKAMLEEL
210 220 230 240 250
EADTARTLTD IEQKVQRYSQ QLRKVQEGAQ ILQERLAETD RHTFLAGVAS
260 270 280 290 300
LSERLKGKIH ETNLTYEDFP TSKYTGPLQY TIWKSLFQDI HPVPAALTLD
310 320 330 340 350
PGTAHQRLIL SDDCTIVAYG NLHPQPLQDS PKRFDVEVSV LGSEAFSSGV
360 370 380 390 400
HYWEVVVAEK TQWVIGLAHE AASRKGSIQI QPSRGFYCIV MHDGNQYSAC
410 420 430 440 450
TEPWTRLNVR DKLDKVGVFL DYDQGLLIFY NADDMSWLYT FREKFPGKLC
460 470
SYFSPGQSHA NGKNVQPLRI NTVRI
Length:475
Mass (Da):54,268
Last modified:June 1, 2001 - v1
Checksum:iDC15CA9B795DFBB0
GO
Isoform 2 (identifier: Q9BVG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MACSLKDELLCSICL → MPEKTAVDQPWTQAL
     16-136: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):40,490
Checksum:iED5ED8F092F7EDA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102F → L in BAA91792 (PubMed:14702039).Curated1
Sequence conflicti474R → L in BAA91792 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0554411 – 15MACSL…CSICL → MPEKTAVDQPWTQAL in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_05544216 – 136Missing in isoform 2. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001621 mRNA Translation: BAA91792.1
AK122896 mRNA Translation: BAG53787.1
AK300177 mRNA Translation: BAG61956.1
AL662907 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07466.1
CH471059 Genomic DNA Translation: EAX07467.1
BC001222 mRNA Translation: AAH01222.1
BC007999 mRNA Translation: AAH07999.1
BC011689 mRNA Translation: AAH11689.1
BC012152 mRNA Translation: AAH12152.1
CCDSiCCDS376.1 [Q9BVG3-1]
CCDS81297.1 [Q9BVG3-2]
RefSeqiNP_001317412.1, NM_001330483.1 [Q9BVG3-2]
NP_060677.2, NM_018207.2 [Q9BVG3-1]
UniGeneiHs.656006

Genome annotation databases

EnsembliENST00000291416; ENSP00000291416; ENSG00000116525 [Q9BVG3-1]
ENST00000543586; ENSP00000441173; ENSG00000116525 [Q9BVG3-2]
GeneIDi55223
KEGGihsa:55223
UCSCiuc001bxb.4 human [Q9BVG3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001621 mRNA Translation: BAA91792.1
AK122896 mRNA Translation: BAG53787.1
AK300177 mRNA Translation: BAG61956.1
AL662907 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07466.1
CH471059 Genomic DNA Translation: EAX07467.1
BC001222 mRNA Translation: AAH01222.1
BC007999 mRNA Translation: AAH07999.1
BC011689 mRNA Translation: AAH11689.1
BC012152 mRNA Translation: AAH12152.1
CCDSiCCDS376.1 [Q9BVG3-1]
CCDS81297.1 [Q9BVG3-2]
RefSeqiNP_001317412.1, NM_001330483.1 [Q9BVG3-2]
NP_060677.2, NM_018207.2 [Q9BVG3-1]
UniGeneiHs.656006

3D structure databases

ProteinModelPortaliQ9BVG3
SMRiQ9BVG3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120518, 11 interactors
IntActiQ9BVG3, 20 interactors
MINTiQ9BVG3
STRINGi9606.ENSP00000291416

PTM databases

iPTMnetiQ9BVG3
PhosphoSitePlusiQ9BVG3

Polymorphism and mutation databases

BioMutaiTRIM62
DMDMi74752380

Proteomic databases

EPDiQ9BVG3
PaxDbiQ9BVG3
PeptideAtlasiQ9BVG3
PRIDEiQ9BVG3
ProteomicsDBi79199

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291416; ENSP00000291416; ENSG00000116525 [Q9BVG3-1]
ENST00000543586; ENSP00000441173; ENSG00000116525 [Q9BVG3-2]
GeneIDi55223
KEGGihsa:55223
UCSCiuc001bxb.4 human [Q9BVG3-1]

Organism-specific databases

CTDi55223
DisGeNETi55223
EuPathDBiHostDB:ENSG00000116525.13
GeneCardsiTRIM62
HGNCiHGNC:25574 TRIM62
HPAiHPA050061
neXtProtiNX_Q9BVG3
OpenTargetsiENSG00000116525
PharmGKBiPA134890243
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITEQ Eukaryota
ENOG410XNZK LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000234133
HOVERGENiHBG103330
InParanoidiQ9BVG3
KOiK12030
OMAiFQDISPV
OrthoDBiEOG091G051S
PhylomeDBiQ9BVG3
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRSiTRIM62 human
GenomeRNAii55223
PROiPR:Q9BVG3

Gene expression databases

BgeeiENSG00000116525 Expressed in 195 organ(s), highest expression level in oocyte
CleanExiHS_TRIM62
GenevisibleiQ9BVG3 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd13744 SPRY_PRY_TRIM62, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035830 PRY/SPRY_TRIM62
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI62_HUMAN
AccessioniPrimary (citable) accession number: Q9BVG3
Secondary accession number(s): B3KVH5
, B4DTE4, D3DPR1, Q9NVG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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