Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TRIM62

Gene

TRIM62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri11 – 54RING-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri88 – 128B box-typePROSITE-ProRule annotationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: CACAO
  • zinc ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-877300 Interferon gamma signaling

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM62 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase TRIM62Curated
Tripartite motif-containing protein 62
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM62
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116525.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25574 TRIM62

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BVG3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55223

Open Targets

More...
OpenTargetsi
ENSG00000116525

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134890243

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM62

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752380

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002495741 – 475E3 ubiquitin-protein ligase TRIM62Add BLAST475

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated, autoubiquitinated in the presence of UBE2D2.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BVG3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BVG3

PeptideAtlas

More...
PeptideAtlasi
Q9BVG3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BVG3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79199

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BVG3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVG3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116525 Expressed in 195 organ(s), highest expression level in oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_TRIM62

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BVG3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050061

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the ubiquitin-conjugating enzyme, UBE2D2.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120518, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BVG3, 20 interactors

Molecular INTeraction database

More...
MINTi
Q9BVG3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291416

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BVG3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BVG3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini277 – 475B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili127 – 241Sequence analysisAdd BLAST115

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING finger is required for ubiquitin ligase activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 54RING-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri88 – 128B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITEQ Eukaryota
ENOG410XNZK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234133

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103330

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVG3

KEGG Orthology (KO)

More...
KOi
K12030

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQDISPV

Database of Orthologous Groups

More...
OrthoDBi
423686at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BVG3

TreeFam database of animal gene trees

More...
TreeFami
TF342569

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit
cd13744 SPRY_PRY_TRIM62, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035830 PRY/SPRY_TRIM62
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BVG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC
60 70 80 90 100
PECRRTFAEP ALAPSLKLAN IVERYSSFPL DAILNARRAA RPCQAHDKVK
110 120 130 140 150
LFCLTDRALL CFFCDEPALH EQHQVTGIDD AFDELQRELK DQLQALQDSE
160 170 180 190 200
REHTEALQLL KRQLAETKSS TKSLRTTIGE AFERLHRLLR ERQKAMLEEL
210 220 230 240 250
EADTARTLTD IEQKVQRYSQ QLRKVQEGAQ ILQERLAETD RHTFLAGVAS
260 270 280 290 300
LSERLKGKIH ETNLTYEDFP TSKYTGPLQY TIWKSLFQDI HPVPAALTLD
310 320 330 340 350
PGTAHQRLIL SDDCTIVAYG NLHPQPLQDS PKRFDVEVSV LGSEAFSSGV
360 370 380 390 400
HYWEVVVAEK TQWVIGLAHE AASRKGSIQI QPSRGFYCIV MHDGNQYSAC
410 420 430 440 450
TEPWTRLNVR DKLDKVGVFL DYDQGLLIFY NADDMSWLYT FREKFPGKLC
460 470
SYFSPGQSHA NGKNVQPLRI NTVRI
Length:475
Mass (Da):54,268
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC15CA9B795DFBB0
GO
Isoform 2 (identifier: Q9BVG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MACSLKDELLCSICL → MPEKTAVDQPWTQAL
     16-136: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):40,490
Checksum:iED5ED8F092F7EDA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102F → L in BAA91792 (PubMed:14702039).Curated1
Sequence conflicti474R → L in BAA91792 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0554411 – 15MACSL…CSICL → MPEKTAVDQPWTQAL in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_05544216 – 136Missing in isoform 2. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001621 mRNA Translation: BAA91792.1
AK122896 mRNA Translation: BAG53787.1
AK300177 mRNA Translation: BAG61956.1
AL662907 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07466.1
CH471059 Genomic DNA Translation: EAX07467.1
BC001222 mRNA Translation: AAH01222.1
BC007999 mRNA Translation: AAH07999.1
BC011689 mRNA Translation: AAH11689.1
BC012152 mRNA Translation: AAH12152.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS376.1 [Q9BVG3-1]
CCDS81297.1 [Q9BVG3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001317412.1, NM_001330483.1 [Q9BVG3-2]
NP_060677.2, NM_018207.2 [Q9BVG3-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.656006

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291416; ENSP00000291416; ENSG00000116525 [Q9BVG3-1]
ENST00000543586; ENSP00000441173; ENSG00000116525 [Q9BVG3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55223

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55223

UCSC genome browser

More...
UCSCi
uc001bxb.4 human [Q9BVG3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001621 mRNA Translation: BAA91792.1
AK122896 mRNA Translation: BAG53787.1
AK300177 mRNA Translation: BAG61956.1
AL662907 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07466.1
CH471059 Genomic DNA Translation: EAX07467.1
BC001222 mRNA Translation: AAH01222.1
BC007999 mRNA Translation: AAH07999.1
BC011689 mRNA Translation: AAH11689.1
BC012152 mRNA Translation: AAH12152.1
CCDSiCCDS376.1 [Q9BVG3-1]
CCDS81297.1 [Q9BVG3-2]
RefSeqiNP_001317412.1, NM_001330483.1 [Q9BVG3-2]
NP_060677.2, NM_018207.2 [Q9BVG3-1]
UniGeneiHs.656006

3D structure databases

ProteinModelPortaliQ9BVG3
SMRiQ9BVG3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120518, 11 interactors
IntActiQ9BVG3, 20 interactors
MINTiQ9BVG3
STRINGi9606.ENSP00000291416

PTM databases

iPTMnetiQ9BVG3
PhosphoSitePlusiQ9BVG3

Polymorphism and mutation databases

BioMutaiTRIM62
DMDMi74752380

Proteomic databases

EPDiQ9BVG3
PaxDbiQ9BVG3
PeptideAtlasiQ9BVG3
PRIDEiQ9BVG3
ProteomicsDBi79199

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291416; ENSP00000291416; ENSG00000116525 [Q9BVG3-1]
ENST00000543586; ENSP00000441173; ENSG00000116525 [Q9BVG3-2]
GeneIDi55223
KEGGihsa:55223
UCSCiuc001bxb.4 human [Q9BVG3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55223
DisGeNETi55223
EuPathDBiHostDB:ENSG00000116525.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM62
HGNCiHGNC:25574 TRIM62
HPAiHPA050061
neXtProtiNX_Q9BVG3
OpenTargetsiENSG00000116525
PharmGKBiPA134890243

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITEQ Eukaryota
ENOG410XNZK LUCA
GeneTreeiENSGT00940000158433
HOGENOMiHOG000234133
HOVERGENiHBG103330
InParanoidiQ9BVG3
KOiK12030
OMAiFQDISPV
OrthoDBi423686at2759
PhylomeDBiQ9BVG3
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIM62 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55223

Protein Ontology

More...
PROi
PR:Q9BVG3

Gene expression databases

BgeeiENSG00000116525 Expressed in 195 organ(s), highest expression level in oocyte
CleanExiHS_TRIM62
GenevisibleiQ9BVG3 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd13744 SPRY_PRY_TRIM62, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035830 PRY/SPRY_TRIM62
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI62_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVG3
Secondary accession number(s): B3KVH5
, B4DTE4, D3DPR1, Q9NVG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again