UniProtKB - Q9BVC6 (TM109_HUMAN)
Protein
Transmembrane protein 109
Gene
TMEM109
Organism
Homo sapiens (Human)
Status
Functioni
May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).By similarity1 Publication
GO - Molecular functioni
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to gamma radiation Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: GO_Central
- negative regulation of cell death Source: MGI
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Voltage-gated channel |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9BVC6 |
Protein family/group databases
TCDBi | 1.A.74.1.2, the mitsugumin 23 (mg23) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 109Alternative name(s): Mitsugumin-23 Short name: Mg23 |
Gene namesi | Name:TMEM109 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28771, TMEM109 |
neXtProti | NX_Q9BVC6 |
VEuPathDBi | HostDB:ENSG00000110108.9 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Nucleus
- Nucleus outer membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- Sarcoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear outer membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 34 – 83 | LumenalBy similarityAdd BLAST | 50 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 135 | CytoplasmicBy similarityAdd BLAST | 31 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 157 – 185 | LumenalBy similarityAdd BLAST | 29 | |
Transmembranei | 186 – 205 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 206 – 243 | CytoplasmicBy similarityAdd BLAST | 38 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulumPathology & Biotechi
Organism-specific databases
DisGeNETi | 79073 |
OpenTargetsi | ENSG00000110108 |
PharmGKBi | PA142670760 |
Miscellaneous databases
Pharosi | Q9BVC6, Tbio |
Genetic variation databases
BioMutai | TMEM109 |
DMDMi | 74733312 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000044618 | 34 – 243 | Transmembrane protein 109Add BLAST | 210 |
Proteomic databases
EPDi | Q9BVC6 |
jPOSTi | Q9BVC6 |
MassIVEi | Q9BVC6 |
MaxQBi | Q9BVC6 |
PaxDbi | Q9BVC6 |
PeptideAtlasi | Q9BVC6 |
PRIDEi | Q9BVC6 |
ProteomicsDBi | 79198 |
TopDownProteomicsi | Q9BVC6 |
PTM databases
iPTMneti | Q9BVC6 |
PhosphoSitePlusi | Q9BVC6 |
SwissPalmi | Q9BVC6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110108, Expressed in ectocervix and 244 other tissues |
Genevisiblei | Q9BVC6, HS |
Organism-specific databases
HPAi | ENSG00000110108, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ9BVC6
Protein-protein interaction databases
BioGRIDi | 122524, 71 interactors |
IntActi | Q9BVC6, 48 interactors |
MINTi | Q9BVC6 |
STRINGi | 9606.ENSP00000227525 |
Miscellaneous databases
RNActi | Q9BVC6, protein |
Family & Domainsi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S0EJ, Eukaryota |
GeneTreei | ENSGT00390000015704 |
HOGENOMi | CLU_099892_0_0_1 |
InParanoidi | Q9BVC6 |
OMAi | TLSQVMW |
OrthoDBi | 1631905at2759 |
PhylomeDBi | Q9BVC6 |
TreeFami | TF332238 |
Family and domain databases
InterProi | View protein in InterPro IPR039492, TMEM109 |
PANTHERi | PTHR14550, PTHR14550, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9BVC6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP
60 70 80 90 100
VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS
110 120 130 140 150
GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG
160 170 180 190 200
LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS
210 220 230 240
RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001309 mRNA Translation: AAH01309.1 |
CCDSi | CCDS7996.1 |
RefSeqi | NP_076997.1, NM_024092.2 |
Genome annotation databases
Ensembli | ENST00000227525; ENSP00000227525; ENSG00000110108 ENST00000536171; ENSP00000443990; ENSG00000110108 |
GeneIDi | 79073 |
KEGGi | hsa:79073 |
UCSCi | uc001nqg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC001309 mRNA Translation: AAH01309.1 |
CCDSi | CCDS7996.1 |
RefSeqi | NP_076997.1, NM_024092.2 |
3D structure databases
SMRi | Q9BVC6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122524, 71 interactors |
IntActi | Q9BVC6, 48 interactors |
MINTi | Q9BVC6 |
STRINGi | 9606.ENSP00000227525 |
Protein family/group databases
TCDBi | 1.A.74.1.2, the mitsugumin 23 (mg23) family |
PTM databases
iPTMneti | Q9BVC6 |
PhosphoSitePlusi | Q9BVC6 |
SwissPalmi | Q9BVC6 |
Genetic variation databases
BioMutai | TMEM109 |
DMDMi | 74733312 |
Proteomic databases
EPDi | Q9BVC6 |
jPOSTi | Q9BVC6 |
MassIVEi | Q9BVC6 |
MaxQBi | Q9BVC6 |
PaxDbi | Q9BVC6 |
PeptideAtlasi | Q9BVC6 |
PRIDEi | Q9BVC6 |
ProteomicsDBi | 79198 |
TopDownProteomicsi | Q9BVC6 |
Protocols and materials databases
Antibodypediai | 2041, 67 antibodies |
Genome annotation databases
Ensembli | ENST00000227525; ENSP00000227525; ENSG00000110108 ENST00000536171; ENSP00000443990; ENSG00000110108 |
GeneIDi | 79073 |
KEGGi | hsa:79073 |
UCSCi | uc001nqg.4, human |
Organism-specific databases
CTDi | 79073 |
DisGeNETi | 79073 |
GeneCardsi | TMEM109 |
HGNCi | HGNC:28771, TMEM109 |
HPAi | ENSG00000110108, Low tissue specificity |
neXtProti | NX_Q9BVC6 |
OpenTargetsi | ENSG00000110108 |
PharmGKBi | PA142670760 |
VEuPathDBi | HostDB:ENSG00000110108.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0EJ, Eukaryota |
GeneTreei | ENSGT00390000015704 |
HOGENOMi | CLU_099892_0_0_1 |
InParanoidi | Q9BVC6 |
OMAi | TLSQVMW |
OrthoDBi | 1631905at2759 |
PhylomeDBi | Q9BVC6 |
TreeFami | TF332238 |
Enzyme and pathway databases
PathwayCommonsi | Q9BVC6 |
Miscellaneous databases
BioGRID-ORCSi | 79073, 7 hits in 1001 CRISPR screens |
ChiTaRSi | TMEM109, human |
GenomeRNAii | 79073 |
Pharosi | Q9BVC6, Tbio |
PROi | PR:Q9BVC6 |
RNActi | Q9BVC6, protein |
Gene expression databases
Bgeei | ENSG00000110108, Expressed in ectocervix and 244 other tissues |
Genevisiblei | Q9BVC6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039492, TMEM109 |
PANTHERi | PTHR14550, PTHR14550, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM109_HUMAN | |
Accessioni | Q9BVC6Primary (citable) accession number: Q9BVC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM