TMEM109

Functionⁱ

May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

voltage-gated ion channel activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to gamma radiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 23542032
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of cell death
Source: MGI
Inferred from mutant phenotypeⁱ
- 23542032
regulation of ion transmembrane transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Voltage-gated channel
Biological process	Ion transport, Transport

Protein family/group databases

TCDBⁱ	1.A.74.1.2 the mitsugumin 23 (mg23) family

TCDBⁱ

1.A.74.1.2 the mitsugumin 23 (mg23) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 109 Alternative name(s): Mitsugumin-23 Short name: Mg23
Gene namesⁱ	Name:TMEM109
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110108.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28771 TMEM109
neXtProtⁱ	NX_Q9BVC6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	34 – 83	LumenalBy similarityAdd BLAST	50
Transmembraneⁱ	84 – 104	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	105 – 135	CytoplasmicBy similarityAdd BLAST	31
Transmembraneⁱ	136 – 156	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	157 – 185	LumenalBy similarityAdd BLAST	29
Transmembraneⁱ	186 – 205	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	206 – 243	CytoplasmicBy similarityAdd BLAST	38

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000110108
PharmGKBⁱ	PA142670760

Polymorphism and mutation databases

BioMutaⁱ	TMEM109
DMDMⁱ	74733312

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 33	Sequence analysisAdd BLAST		33
ChainⁱPRO_0000044618	34 – 243	Transmembrane protein 109Add BLAST		210

Proteomic databases

EPDⁱ	Q9BVC6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BVC6
PaxDbⁱ	Q9BVC6
PeptideAtlas More...PeptideAtlasⁱ	Q9BVC6
PRIDEⁱ	Q9BVC6
ProteomicsDBⁱ	79198
TopDownProteomicsⁱ	Q9BVC6

PTM databases

iPTMnetⁱ	Q9BVC6
PhosphoSitePlusⁱ	Q9BVC6
SwissPalmⁱ	Q9BVC6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000110108 Expressed in 230 organ(s), highest expression level in myometrium
CleanExⁱ	HS_TMEM109
Genevisibleⁱ	Q9BVC6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA011785

HPAⁱ

HPA011785

Interactionⁱ

Subunit structureⁱ

Homooligomer (By similarity). Interacts with CRYAB (PubMed:23542032).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	122524, 21 interactors
IntActⁱ	Q9BVC6, 40 interactors
Molecular INTeraction database More...MINTⁱ	Q9BVC6

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BVC6
SMRⁱ	Q9BVC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIBB Eukaryota ENOG410XXDM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015704
HOGENOMⁱ	HOG000126892
HOVERGENⁱ	HBG083664
InParanoidⁱ	Q9BVC6
OMAⁱ	TLSQVMW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0S01
PhylomeDBⁱ	Q9BVC6
TreeFamⁱ	TF332238

Family and domain databases

InterProⁱ	View protein in InterPro IPR039492 TMEM109
PANTHERⁱ	PTHR14550 PTHR14550, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9BVC6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP 
        60         70         80         90        100
VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS 
       110        120        130        140        150
GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG 
       160        170        180        190        200
LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS 
       210        220        230        240 
RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE

Length:243

Mass (Da):26,210

Last modified:June 1, 2001 - v1

Checksum:ⁱE405591236B94BB3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001309 mRNA Translation: AAH01309.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7996.1
NCBI Reference Sequences More...RefSeqⁱ	NP_076997.1, NM_024092.2
UniGeneⁱ	Hs.13662

Genome annotation databases

Ensemblⁱ	ENST00000227525; ENSP00000227525; ENSG00000110108 ENST00000536171; ENSP00000443990; ENSG00000110108
GeneIDⁱ	79073
KEGGⁱ	hsa:79073
UCSC genome browser More...UCSCⁱ	uc001nqg.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BVC6	Uncharacterized protein		AOTNA		245	UniRef90_Q9BVC6
Transmembrane protein 109		CALJA		245
Transmembrane protein 109		SAIBB		245
Uncharacterized protein		Cebus capucinus imitator		245
Uncharacterized protein		RHIBE		243
+20

Protein	Similar proteins		Species	Score	Length	Source
Q9BVC6	Uncharacterized protein		Cebus capucinus imitator		245	UniRef50_Q9BVC6
Transmembrane protein 109		CALJA		245
Transmembrane protein 109		SAIBB		245
Uncharacterized protein		AOTNA		245
Uncharacterized protein		NOMLE		243
+32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC001309 mRNA Translation: AAH01309.1
CCDSⁱ	CCDS7996.1
RefSeqⁱ	NP_076997.1, NM_024092.2
UniGeneⁱ	Hs.13662

3D structure databases

ProteinModelPortalⁱ	Q9BVC6
SMRⁱ	Q9BVC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122524, 21 interactors
IntActⁱ	Q9BVC6, 40 interactors
MINTⁱ	Q9BVC6

Protein family/group databases

TCDBⁱ	1.A.74.1.2 the mitsugumin 23 (mg23) family

TCDBⁱ

1.A.74.1.2 the mitsugumin 23 (mg23) family

PTM databases

iPTMnetⁱ	Q9BVC6
PhosphoSitePlusⁱ	Q9BVC6
SwissPalmⁱ	Q9BVC6

Polymorphism and mutation databases

BioMutaⁱ	TMEM109
DMDMⁱ	74733312

Proteomic databases

EPDⁱ	Q9BVC6
MaxQBⁱ	Q9BVC6
PaxDbⁱ	Q9BVC6
PeptideAtlasⁱ	Q9BVC6
PRIDEⁱ	Q9BVC6
ProteomicsDBⁱ	79198
TopDownProteomicsⁱ	Q9BVC6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000227525; ENSP00000227525; ENSG00000110108 ENST00000536171; ENSP00000443990; ENSG00000110108
GeneIDⁱ	79073
KEGGⁱ	hsa:79073
UCSCⁱ	uc001nqg.4 human

Organism-specific databases

CTDⁱ	79073
EuPathDBⁱ	HostDB:ENSG00000110108.9
GeneCardsⁱ	TMEM109
HGNCⁱ	HGNC:28771 TMEM109
HPAⁱ	HPA011785
neXtProtⁱ	NX_Q9BVC6
OpenTargetsⁱ	ENSG00000110108
PharmGKBⁱ	PA142670760
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIBB Eukaryota ENOG410XXDM LUCA
GeneTreeⁱ	ENSGT00390000015704
HOGENOMⁱ	HOG000126892
HOVERGENⁱ	HBG083664
InParanoidⁱ	Q9BVC6
OMAⁱ	TLSQVMW
OrthoDBⁱ	EOG091G0S01
PhylomeDBⁱ	Q9BVC6
TreeFamⁱ	TF332238

Miscellaneous databases

ChiTaRSⁱ	TMEM109 human
GenomeRNAiⁱ	79073
Protein Ontology More...PROⁱ	PR:Q9BVC6

Gene expression databases

Bgeeⁱ	ENSG00000110108 Expressed in 230 organ(s), highest expression level in myometrium
CleanExⁱ	HS_TMEM109
Genevisibleⁱ	Q9BVC6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039492 TMEM109
PANTHERⁱ	PTHR14550 PTHR14550, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM109_HUMAN
Accessionⁱ	Q9BVC6Primary (citable) accession number: Q9BVC6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BVC6 (TM109_HUMAN)

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Transmembrane protein 109

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Extracellular region or secreted

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ