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Protein

Transmembrane protein 109

Gene

TMEM109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:23542032). Can form voltage-gated calcium and potassium channels in vitro (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to gamma radiation Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: GO_Central
  • negative regulation of cell death Source: MGI
  • regulation of ion transmembrane transport Source: UniProtKB-KW

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.74.1.2 the mitsugumin 23 (mg23) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 109
Alternative name(s):
Mitsugumin-23
Short name:
Mg23
Gene namesi
Name:TMEM109
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110108.9
HGNCiHGNC:28771 TMEM109
neXtProtiNX_Q9BVC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 83LumenalBy similarityAdd BLAST50
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 135CytoplasmicBy similarityAdd BLAST31
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 185LumenalBy similarityAdd BLAST29
Transmembranei186 – 205HelicalSequence analysisAdd BLAST20
Topological domaini206 – 243CytoplasmicBy similarityAdd BLAST38

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110108
PharmGKBiPA142670760

Polymorphism and mutation databases

BioMutaiTMEM109
DMDMi74733312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004461834 – 243Transmembrane protein 109Add BLAST210

Proteomic databases

EPDiQ9BVC6
MaxQBiQ9BVC6
PaxDbiQ9BVC6
PeptideAtlasiQ9BVC6
PRIDEiQ9BVC6
ProteomicsDBi79198
TopDownProteomicsiQ9BVC6

PTM databases

iPTMnetiQ9BVC6
PhosphoSitePlusiQ9BVC6
SwissPalmiQ9BVC6

Expressioni

Gene expression databases

BgeeiENSG00000110108 Expressed in 230 organ(s), highest expression level in myometrium
CleanExiHS_TMEM109
GenevisibleiQ9BVC6 HS

Organism-specific databases

HPAiHPA011785

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with CRYAB (PubMed:23542032).By similarity1 Publication

Protein-protein interaction databases

BioGridi122524, 21 interactors
IntActiQ9BVC6, 40 interactors
MINTiQ9BVC6

Structurei

3D structure databases

ProteinModelPortaliQ9BVC6
SMRiQ9BVC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIBB Eukaryota
ENOG410XXDM LUCA
GeneTreeiENSGT00390000015704
HOGENOMiHOG000126892
HOVERGENiHBG083664
InParanoidiQ9BVC6
OMAiTLSQVMW
OrthoDBiEOG091G0S01
PhylomeDBiQ9BVC6
TreeFamiTF332238

Family and domain databases

InterProiView protein in InterPro
IPR039492 TMEM109
PANTHERiPTHR14550 PTHR14550, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BVC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP
60 70 80 90 100
VDVLTQIGRS VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS
110 120 130 140 150
GIAAQLLNAL GLAGDYLAQG LKLSPGQVQT FLLWGAGALV VYWLLSLLLG
160 170 180 190 200
LVLALLGRIL WGLKLVIFLA GFVALMRSVP DPSTRALLLL ALLILYALLS
210 220 230 240
RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV EEE
Length:243
Mass (Da):26,210
Last modified:June 1, 2001 - v1
Checksum:iE405591236B94BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001309 mRNA Translation: AAH01309.1
CCDSiCCDS7996.1
RefSeqiNP_076997.1, NM_024092.2
UniGeneiHs.13662

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108
ENST00000536171; ENSP00000443990; ENSG00000110108
GeneIDi79073
KEGGihsa:79073
UCSCiuc001nqg.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001309 mRNA Translation: AAH01309.1
CCDSiCCDS7996.1
RefSeqiNP_076997.1, NM_024092.2
UniGeneiHs.13662

3D structure databases

ProteinModelPortaliQ9BVC6
SMRiQ9BVC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122524, 21 interactors
IntActiQ9BVC6, 40 interactors
MINTiQ9BVC6

Protein family/group databases

TCDBi1.A.74.1.2 the mitsugumin 23 (mg23) family

PTM databases

iPTMnetiQ9BVC6
PhosphoSitePlusiQ9BVC6
SwissPalmiQ9BVC6

Polymorphism and mutation databases

BioMutaiTMEM109
DMDMi74733312

Proteomic databases

EPDiQ9BVC6
MaxQBiQ9BVC6
PaxDbiQ9BVC6
PeptideAtlasiQ9BVC6
PRIDEiQ9BVC6
ProteomicsDBi79198
TopDownProteomicsiQ9BVC6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227525; ENSP00000227525; ENSG00000110108
ENST00000536171; ENSP00000443990; ENSG00000110108
GeneIDi79073
KEGGihsa:79073
UCSCiuc001nqg.4 human

Organism-specific databases

CTDi79073
EuPathDBiHostDB:ENSG00000110108.9
GeneCardsiTMEM109
HGNCiHGNC:28771 TMEM109
HPAiHPA011785
neXtProtiNX_Q9BVC6
OpenTargetsiENSG00000110108
PharmGKBiPA142670760
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBB Eukaryota
ENOG410XXDM LUCA
GeneTreeiENSGT00390000015704
HOGENOMiHOG000126892
HOVERGENiHBG083664
InParanoidiQ9BVC6
OMAiTLSQVMW
OrthoDBiEOG091G0S01
PhylomeDBiQ9BVC6
TreeFamiTF332238

Miscellaneous databases

ChiTaRSiTMEM109 human
GenomeRNAii79073
PROiPR:Q9BVC6

Gene expression databases

BgeeiENSG00000110108 Expressed in 230 organ(s), highest expression level in myometrium
CleanExiHS_TMEM109
GenevisibleiQ9BVC6 HS

Family and domain databases

InterProiView protein in InterPro
IPR039492 TMEM109
PANTHERiPTHR14550 PTHR14550, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM109_HUMAN
AccessioniPrimary (citable) accession number: Q9BVC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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