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Protein

Target of rapamycin complex subunit LST8

Gene

MLST8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein serine/threonine kinase activator activity Source: WormBase

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-8943724 Regulation of PTEN gene transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9BVC4

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BVC4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Target of rapamycin complex subunit LST8
Short name:
TORC subunit LST8
Alternative name(s):
G protein beta subunit-like
Short name:
Gable
Short name:
Protein GbetaL
Mammalian lethal with SEC13 protein 8
Short name:
mLST8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLST8
Synonyms:GBL, LST8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167965.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24825 MLST8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612190 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BVC4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi72S → D: Impairs interaction with MTOR. 1 Publication1
Mutagenesisi192G → D: Abolishes interaction with MTOR. 1 Publication1
Mutagenesisi320F → S: Impairs interaction with MTOR. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
64223

Open Targets

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OpenTargetsi
ENSG00000167965

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165450213

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MLST8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761285

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003264991 – 326Target of rapamycin complex subunit LST8Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Isoform 3 (identifier: Q9BVC4-4)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BVC4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BVC4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BVC4

PeptideAtlas

More...
PeptideAtlasi
Q9BVC4

PRoteomics IDEntifications database

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PRIDEi
Q9BVC4

ProteomicsDB human proteome resource

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ProteomicsDBi
79194
79195 [Q9BVC4-3]
79196 [Q9BVC4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BVC4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed, with highest levels in skeletal muscle, heart and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167965 Expressed in 203 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BVC4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BVC4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB019935
HPA041841

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB.8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122113, 60 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9BVC4

Database of interacting proteins

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DIPi
DIP-39481N

Protein interaction database and analysis system

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IntActi
Q9BVC4, 26 interactors

Molecular INTeraction database

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MINTi
Q9BVC4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380313

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BVC4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BVC4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 37WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST37
Repeati40 – 80WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati83 – 122WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati126 – 165WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati168 – 207WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati218 – 257WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati268 – 309WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat LST8 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0315 Eukaryota
ENOG410XPVD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014795

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054763

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BVC4

KEGG Orthology (KO)

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KOi
K08266

Identification of Orthologs from Complete Genome Data

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OMAi
AGNNKGN

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BVC4

TreeFam database of animal gene trees

More...
TreeFami
TF318577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037588 MLST8
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom

The PANTHER Classification System

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PANTHERi
PTHR19842 PTHR19842, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00400 WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BVC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNTSPGTVGS DPVILATAGY DHTVRFWQAH SGICTRTVQH QDSQVNALEV
60 70 80 90 100
TPDRSMIAAA GYQHIRMYDL NSNNPNPIIS YDGVNKNIAS VGFHEDGRWM
110 120 130 140 150
YTGGEDCTAR IWDLRSRNLQ CQRIFQVNAP INCVCLHPNQ AELIVGDQSG
160 170 180 190 200
AIHIWDLKTD HNEQLIPEPE VSITSAHIDP DASYMAAVNS TGNCYVWNLT
210 220 230 240 250
GGIGDEVTQL IPKTKIPAHT RYALQCRFSP DSTLLATCSA DQTCKIWRTS
260 270 280 290 300
NFSLMTELSI KSGNPGESSR GWMWGCAFSG DSQYIVTASS DNLARLWCVE
310 320
TGEIKREYGG HQKAVVCLAF NDSVLG
Length:326
Mass (Da):35,876
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43A600D4EF2B6543
GO
Isoform 2 (identifier: Q9BVC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Show »
Length:260
Mass (Da):28,728
Checksum:i92BC4236276B1274
GO
Isoform 3 (identifier: Q9BVC4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEHAPWSPGASSRARAGHTM
     192-198: GNCYVWN → APRHLLG
     199-326: Missing.

Show »
Length:217
Mass (Da):23,850
Checksum:i3B611C65EAE88115
GO
Isoform 4 (identifier: Q9BVC4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Missing.

Show »
Length:325
Mass (Da):35,748
Checksum:iCF41EB9312C1788A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR05A0A0A0MR05_HUMAN
Target of rapamycin complex subunit...
MLST8
327Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN58H3BN58_HUMAN
Target of rapamycin complex subunit...
MLST8
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR25H3BR25_HUMAN
Target of rapamycin complex subunit...
MLST8
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPT1H3BPT1_HUMAN
Target of rapamycin complex subunit...
MLST8
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSZ4H3BSZ4_HUMAN
Target of rapamycin complex subunit...
MLST8
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPU5H3BPU5_HUMAN
Target of rapamycin complex subunit...
MLST8
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM50H3BM50_HUMAN
Target of rapamycin complex subunit...
MLST8
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2E7I3L2E7_HUMAN
Target of rapamycin complex subunit...
MLST8
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ74H3BQ74_HUMAN
Target of rapamycin complex subunit...
MLST8
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR38H3BR38_HUMAN
Target of rapamycin complex subunit...
MLST8
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAW85539 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti56M → V in BAB13990 (PubMed:14702039).Curated1
Sequence conflicti153H → Y in AAH88354 (PubMed:15489334).Curated1
Sequence conflicti248R → G in AAO73410 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0326651 – 66Missing in isoform 2. 2 PublicationsAdd BLAST66
Alternative sequenceiVSP_0326661M → MEHAPWSPGASSRARAGHTM in isoform 3. 1 Publication1
Alternative sequenceiVSP_04736844Missing in isoform 4. Curated1
Alternative sequenceiVSP_032667192 – 198GNCYVWN → APRHLLG in isoform 3. 1 Publication7
Alternative sequenceiVSP_032668199 – 326Missing in isoform 3. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY223837 mRNA Translation: AAO73410.1
AK021536 mRNA Translation: BAG51036.1
AK022227 mRNA Translation: BAB13990.1
AK302201 mRNA Translation: BAG63562.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85538.1
CH471112 Genomic DNA Translation: EAW85539.1 Sequence problems.
CH471112 Genomic DNA Translation: EAW85541.1
CH471112 Genomic DNA Translation: EAW85542.1
BC001313 mRNA Translation: AAH01313.1
BC017119 mRNA Translation: AAH17119.1
BC052292 mRNA Translation: AAH52292.1
BC088354 mRNA Translation: AAH88354.1
AF195883 mRNA Translation: AAF04308.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10462.2 [Q9BVC4-1]
CCDS58409.1 [Q9BVC4-5]

NCBI Reference Sequences

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RefSeqi
NP_001186102.1, NM_001199173.1 [Q9BVC4-1]
NP_001186103.1, NM_001199174.1 [Q9BVC4-1]
NP_001186104.1, NM_001199175.1 [Q9BVC4-5]
NP_071767.3, NM_022372.4 [Q9BVC4-1]
XP_016879037.1, XM_017023548.1 [Q9BVC4-3]
XP_016879038.1, XM_017023549.1 [Q9BVC4-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.29203

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382450; ENSP00000371888; ENSG00000167965 [Q9BVC4-5]
ENST00000397124; ENSP00000380313; ENSG00000167965 [Q9BVC4-1]
ENST00000564088; ENSP00000457870; ENSG00000167965 [Q9BVC4-1]
ENST00000565250; ENSP00000455046; ENSG00000167965 [Q9BVC4-1]
ENST00000569417; ENSP00000456405; ENSG00000167965 [Q9BVC4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64223

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64223

UCSC genome browser

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UCSCi
uc002coz.4 human [Q9BVC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY223837 mRNA Translation: AAO73410.1
AK021536 mRNA Translation: BAG51036.1
AK022227 mRNA Translation: BAB13990.1
AK302201 mRNA Translation: BAG63562.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85538.1
CH471112 Genomic DNA Translation: EAW85539.1 Sequence problems.
CH471112 Genomic DNA Translation: EAW85541.1
CH471112 Genomic DNA Translation: EAW85542.1
BC001313 mRNA Translation: AAH01313.1
BC017119 mRNA Translation: AAH17119.1
BC052292 mRNA Translation: AAH52292.1
BC088354 mRNA Translation: AAH88354.1
AF195883 mRNA Translation: AAF04308.1
CCDSiCCDS10462.2 [Q9BVC4-1]
CCDS58409.1 [Q9BVC4-5]
RefSeqiNP_001186102.1, NM_001199173.1 [Q9BVC4-1]
NP_001186103.1, NM_001199174.1 [Q9BVC4-1]
NP_001186104.1, NM_001199175.1 [Q9BVC4-5]
NP_071767.3, NM_022372.4 [Q9BVC4-1]
XP_016879037.1, XM_017023548.1 [Q9BVC4-3]
XP_016879038.1, XM_017023549.1 [Q9BVC4-3]
UniGeneiHs.29203

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JSNX-ray3.20C/D1-326[»]
4JSPX-ray3.30C/D1-326[»]
4JSVX-ray3.50C/D1-326[»]
4JSXX-ray3.50C/D1-326[»]
4JT5X-ray3.45C/D1-323[»]
4JT6X-ray3.60C/D1-326[»]
5FLCelectron microscopy5.90D/H1-326[»]
5H64electron microscopy4.40C/c1-326[»]
5WBUX-ray3.42C/D1-326[»]
5WBYX-ray3.10C/D1-326[»]
5ZCSelectron microscopy4.90C/D1-326[»]
6BCUelectron microscopy3.43D/E1-326[»]
6BCXelectron microscopy3.00D/E1-326[»]
ProteinModelPortaliQ9BVC4
SMRiQ9BVC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122113, 60 interactors
CORUMiQ9BVC4
DIPiDIP-39481N
IntActiQ9BVC4, 26 interactors
MINTiQ9BVC4
STRINGi9606.ENSP00000380313

PTM databases

iPTMnetiQ9BVC4
PhosphoSitePlusiQ9BVC4

Polymorphism and mutation databases

BioMutaiMLST8
DMDMi74761285

Proteomic databases

EPDiQ9BVC4
MaxQBiQ9BVC4
PaxDbiQ9BVC4
PeptideAtlasiQ9BVC4
PRIDEiQ9BVC4
ProteomicsDBi79194
79195 [Q9BVC4-3]
79196 [Q9BVC4-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64223
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382450; ENSP00000371888; ENSG00000167965 [Q9BVC4-5]
ENST00000397124; ENSP00000380313; ENSG00000167965 [Q9BVC4-1]
ENST00000564088; ENSP00000457870; ENSG00000167965 [Q9BVC4-1]
ENST00000565250; ENSP00000455046; ENSG00000167965 [Q9BVC4-1]
ENST00000569417; ENSP00000456405; ENSG00000167965 [Q9BVC4-1]
GeneIDi64223
KEGGihsa:64223
UCSCiuc002coz.4 human [Q9BVC4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64223
DisGeNETi64223
EuPathDBiHostDB:ENSG00000167965.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MLST8

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0012725
HGNCiHGNC:24825 MLST8
HPAiCAB019935
HPA041841
MIMi612190 gene
neXtProtiNX_Q9BVC4
OpenTargetsiENSG00000167965
PharmGKBiPA165450213

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0315 Eukaryota
ENOG410XPVD LUCA
GeneTreeiENSGT00390000014795
HOVERGENiHBG054763
InParanoidiQ9BVC4
KOiK08266
OMAiAGNNKGN
PhylomeDBiQ9BVC4
TreeFamiTF318577

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-8943724 Regulation of PTEN gene transcription
SignaLinkiQ9BVC4
SIGNORiQ9BVC4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MLST8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MLST8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64223

Protein Ontology

More...
PROi
PR:Q9BVC4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167965 Expressed in 203 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ9BVC4 baseline and differential
GenevisibleiQ9BVC4 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR037588 MLST8
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PANTHERiPTHR19842 PTHR19842, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLST8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVC4
Secondary accession number(s): B3KMM4
, B4DY00, D3DU88, Q5M800, Q86Y18, Q8WUI5, Q9HA66, Q9UJV6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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