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Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
Gene namesi
Name:DSCC1
Synonyms:DCC1
ORF Names:UNQ9337/PRO34008
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000136982.5
HGNCiHGNC:24453 DSCC1
MIMi613203 gene
neXtProtiNX_Q9BVC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79075
OpenTargetsiENSG00000136982
PharmGKBiPA162384079

Polymorphism and mutation databases

BioMutaiDSCC1
DMDMi167012058

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003180641 – 393Sister chromatid cohesion protein DCC1Add BLAST393

Proteomic databases

EPDiQ9BVC3
MaxQBiQ9BVC3
PaxDbiQ9BVC3
PeptideAtlasiQ9BVC3
PRIDEiQ9BVC3
ProteomicsDBi79193
TopDownProteomicsiQ9BVC3

PTM databases

iPTMnetiQ9BVC3
PhosphoSitePlusiQ9BVC3

Expressioni

Gene expression databases

BgeeiENSG00000136982 Expressed in 206 organ(s), highest expression level in secondary oocyte
CleanExiHS_DSCC1
GenevisibleiQ9BVC3 HS

Organism-specific databases

HPAiHPA023780
HPA024401

Interactioni

Subunit structurei

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex (PubMed:12766176). Interacts with CTF8 and CTF18 (PubMed:12766176). Interacts with DDX11 (PubMed:18499658).2 Publications

Protein-protein interaction databases

BioGridi122526, 20 interactors
CORUMiQ9BVC3
IntActiQ9BVC3, 2 interactors
STRINGi9606.ENSP00000322180

Structurei

3D structure databases

ProteinModelPortaliQ9BVC3
SMRiQ9BVC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCC1 family.Curated

Phylogenomic databases

eggNOGiKOG0798 Eukaryota
ENOG41108M8 LUCA
GeneTreeiENSGT00390000017400
HOGENOMiHOG000008115
HOVERGENiHBG105358
InParanoidiQ9BVC3
KOiK11271
OMAiFSLREKW
OrthoDBiEOG091G0AGT
PhylomeDBiQ9BVC3
TreeFamiTF106104

Family and domain databases

InterProiView protein in InterPro
IPR019128 Dcc1
PANTHERiPTHR13395 PTHR13395, 1 hit
PfamiView protein in Pfam
PF09724 Dcc1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BVC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRTRDEVDA TLQIAKLNAA ELLPAVHCLG FGPGASGAAA GDFCLLELEP
60 70 80 90 100
TLCQQLEDGH SLVIRGDKDE QAVLCSKDKT YDLKIADTSN MLLFIPGCKT
110 120 130 140 150
PDQLKKEDSH CNIIHTEIFG FSNNYWELRR RRPKLKKLKK LLMENPYEGP
160 170 180 190 200
DSQKEKDSNS SKYTTEDLLD QIQASEEEIM TQLQVLNACK IGGYWRILEF
210 220 230 240 250
DYEMKLLNHV TQLVDSESWS FGKVPLNTCL QELGPLEPEE MIEHCLKCYG
260 270 280 290 300
KKYVDEGEVY FELDADKICR AAARMLLQNA VKFNLAEFQE VWQQSVPEGM
310 320 330 340 350
VTSLDQLKGL ALVDRHSRPE IIFLLKVDDL PEDNQERFNS LFSLREKWTE
360 370 380 390
EDIAPYIQDL CGEKQTIGAL LTKYSHSSMQ NGVKVYNSRR PIS
Length:393
Mass (Da):44,825
Last modified:February 5, 2008 - v2
Checksum:iAAF6C66B7151FA65
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038682376H → R2 PublicationsCorresponds to variant dbSNP:rs1055130Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358866 mRNA Translation: AAQ89225.1
AK054585 mRNA Translation: BAB70767.1
BC001316 mRNA Translation: AAH01316.1
BC001531 mRNA Translation: AAH01531.1
CCDSiCCDS6330.1
RefSeqiNP_076999.2, NM_024094.2
UniGeneiHs.315167

Genome annotation databases

EnsembliENST00000313655; ENSP00000322180; ENSG00000136982
GeneIDi79075
KEGGihsa:79075
UCSCiuc003yov.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDCC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BVC3
Secondary accession number(s): Q969N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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