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Protein

Sister chromatid cohesion protein DCC1

Gene

DSCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, DNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein DCC1
Alternative name(s):
Defective in sister chromatid cohesion protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSCC1
Synonyms:DCC1
ORF Names:UNQ9337/PRO34008
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000136982.5

Human Gene Nomenclature Database

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HGNCi
HGNC:24453 DSCC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613203 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BVC3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79075

Open Targets

More...
OpenTargetsi
ENSG00000136982

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162384079

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DSCC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
167012058

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003180641 – 393Sister chromatid cohesion protein DCC1Add BLAST393

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BVC3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BVC3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BVC3

PeptideAtlas

More...
PeptideAtlasi
Q9BVC3

PRoteomics IDEntifications database

More...
PRIDEi
Q9BVC3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79193

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9BVC3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BVC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136982 Expressed in 206 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_DSCC1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BVC3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023780
HPA024401

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CTF18-RFC complex which consists of CTF8, CTF18, DSCC1 and the RFC complex (PubMed:12766176). Interacts with CTF8 and CTF18 (PubMed:12766176). Interacts with DDX11 (PubMed:18499658).2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122526, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BVC3

Protein interaction database and analysis system

More...
IntActi
Q9BVC3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000322180

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BVC3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BVC3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DCC1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0798 Eukaryota
ENOG41108M8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017400

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008115

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105358

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVC3

KEGG Orthology (KO)

More...
KOi
K11271

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTDERTY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0AGT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BVC3

TreeFam database of animal gene trees

More...
TreeFami
TF106104

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019128 Dcc1

The PANTHER Classification System

More...
PANTHERi
PTHR13395 PTHR13395, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09724 Dcc1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BVC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRTRDEVDA TLQIAKLNAA ELLPAVHCLG FGPGASGAAA GDFCLLELEP
60 70 80 90 100
TLCQQLEDGH SLVIRGDKDE QAVLCSKDKT YDLKIADTSN MLLFIPGCKT
110 120 130 140 150
PDQLKKEDSH CNIIHTEIFG FSNNYWELRR RRPKLKKLKK LLMENPYEGP
160 170 180 190 200
DSQKEKDSNS SKYTTEDLLD QIQASEEEIM TQLQVLNACK IGGYWRILEF
210 220 230 240 250
DYEMKLLNHV TQLVDSESWS FGKVPLNTCL QELGPLEPEE MIEHCLKCYG
260 270 280 290 300
KKYVDEGEVY FELDADKICR AAARMLLQNA VKFNLAEFQE VWQQSVPEGM
310 320 330 340 350
VTSLDQLKGL ALVDRHSRPE IIFLLKVDDL PEDNQERFNS LFSLREKWTE
360 370 380 390
EDIAPYIQDL CGEKQTIGAL LTKYSHSSMQ NGVKVYNSRR PIS
Length:393
Mass (Da):44,825
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAF6C66B7151FA65
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038682376H → R2 PublicationsCorresponds to variant dbSNP:rs1055130Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358866 mRNA Translation: AAQ89225.1
AK054585 mRNA Translation: BAB70767.1
BC001316 mRNA Translation: AAH01316.1
BC001531 mRNA Translation: AAH01531.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6330.1

NCBI Reference Sequences

More...
RefSeqi
NP_076999.2, NM_024094.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.315167

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313655; ENSP00000322180; ENSG00000136982

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79075

UCSC genome browser

More...
UCSCi
uc003yov.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358866 mRNA Translation: AAQ89225.1
AK054585 mRNA Translation: BAB70767.1
BC001316 mRNA Translation: AAH01316.1
BC001531 mRNA Translation: AAH01531.1
CCDSiCCDS6330.1
RefSeqiNP_076999.2, NM_024094.2
UniGeneiHs.315167

3D structure databases

ProteinModelPortaliQ9BVC3
SMRiQ9BVC3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122526, 21 interactors
CORUMiQ9BVC3
IntActiQ9BVC3, 2 interactors
STRINGi9606.ENSP00000322180

PTM databases

iPTMnetiQ9BVC3
PhosphoSitePlusiQ9BVC3

Polymorphism and mutation databases

BioMutaiDSCC1
DMDMi167012058

Proteomic databases

EPDiQ9BVC3
MaxQBiQ9BVC3
PaxDbiQ9BVC3
PeptideAtlasiQ9BVC3
PRIDEiQ9BVC3
ProteomicsDBi79193
TopDownProteomicsiQ9BVC3

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79075
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313655; ENSP00000322180; ENSG00000136982
GeneIDi79075
KEGGihsa:79075
UCSCiuc003yov.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79075
DisGeNETi79075
EuPathDBiHostDB:ENSG00000136982.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DSCC1
HGNCiHGNC:24453 DSCC1
HPAiHPA023780
HPA024401
MIMi613203 gene
neXtProtiNX_Q9BVC3
OpenTargetsiENSG00000136982
PharmGKBiPA162384079

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0798 Eukaryota
ENOG41108M8 LUCA
GeneTreeiENSGT00390000017400
HOGENOMiHOG000008115
HOVERGENiHBG105358
InParanoidiQ9BVC3
KOiK11271
OMAiCTDERTY
OrthoDBiEOG091G0AGT
PhylomeDBiQ9BVC3
TreeFamiTF106104

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DSCC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DCC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79075

Protein Ontology

More...
PROi
PR:Q9BVC3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136982 Expressed in 206 organ(s), highest expression level in secondary oocyte
CleanExiHS_DSCC1
GenevisibleiQ9BVC3 HS

Family and domain databases

InterProiView protein in InterPro
IPR019128 Dcc1
PANTHERiPTHR13395 PTHR13395, 1 hit
PfamiView protein in Pfam
PF09724 Dcc1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVC3
Secondary accession number(s): Q969N5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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