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Entry version 147 (07 Apr 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Leucine-rich repeat-containing protein 61

Gene

LRRC61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BV99

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 61
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC61
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:21704, LRRC61

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BV99

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000127399.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
65999

Open Targets

More...
OpenTargetsi
ENSG00000127399

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485530

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BV99, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC61

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761282

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002367961 – 259Leucine-rich repeat-containing protein 61Add BLAST259

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BV99

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BV99

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BV99

PeptideAtlas

More...
PeptideAtlasi
Q9BV99

PRoteomics IDEntifications database

More...
PRIDEi
Q9BV99

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79188

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BV99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BV99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127399, Expressed in left adrenal gland cortex and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BV99, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BV99, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000127399, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122446, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BV99, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352642

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BV99, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BV99

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati32 – 53LRR 1Add BLAST22
Repeati54 – 75LRR 2Add BLAST22
Repeati76 – 97LRR 3Add BLAST22
Repeati98 – 119LRR 4Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 178LRRCTAdd BLAST41

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0531, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006479

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1073482_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BV99

Identification of Orthologs from Complete Genome Data

More...
OMAi
WESWPTR

Database of Orthologous Groups

More...
OrthoDBi
1411446at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BV99

TreeFam database of animal gene trees

More...
TreeFami
TF329333

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BV99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPPAEKPGE AGGLQITPQL LKSRTGEFSL ESILLLKLRG LGLADLGCLG
60 70 80 90 100
ECLGLEWLDL SGNALTHLGP LASLRQLAVL NVSNNRLTGL EPLATCENLQ
110 120 130 140 150
SLNAAGNLLA TPGQLQCLAG LPCLEYLRLR DPLARLSNPL CANPSYWAAV
160 170 180 190 200
RELLPGLKVI DGERVIGRGS EFYQLCRDLD SSLRPSSSPG PRATEAQPWV
210 220 230 240 250
EPGYWESWPS RSSSILEEAC RQFQDTLQEC WDLDRQASDS LAQAEQVLSS

AGPTSSFVF
Length:259
Mass (Da):28,014
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B63B0DFE743847A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051123143N → S1 PublicationCorresponds to variant dbSNP:rs3735169Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK098061 mRNA Translation: BAG53572.1
AC005586 Genomic DNA Translation: AAS00383.1
CH471173 Genomic DNA Translation: EAW54123.1
CH471173 Genomic DNA Translation: EAW54124.1
CH471173 Genomic DNA Translation: EAW54125.1
BC001354 mRNA Translation: AAH01354.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5901.1

NCBI Reference Sequences

More...
RefSeqi
NP_001136400.1, NM_001142928.1
NP_076431.1, NM_023942.2
XP_006716158.1, XM_006716095.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323078; ENSP00000339047; ENSG00000127399
ENST00000359623; ENSP00000352642; ENSG00000127399
ENST00000493307; ENSP00000420560; ENSG00000127399

Database of genes from NCBI RefSeq genomes

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GeneIDi
65999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65999

UCSC genome browser

More...
UCSCi
uc003wgw.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098061 mRNA Translation: BAG53572.1
AC005586 Genomic DNA Translation: AAS00383.1
CH471173 Genomic DNA Translation: EAW54123.1
CH471173 Genomic DNA Translation: EAW54124.1
CH471173 Genomic DNA Translation: EAW54125.1
BC001354 mRNA Translation: AAH01354.1
CCDSiCCDS5901.1
RefSeqiNP_001136400.1, NM_001142928.1
NP_076431.1, NM_023942.2
XP_006716158.1, XM_006716095.2

3D structure databases

SMRiQ9BV99
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122446, 26 interactors
IntActiQ9BV99, 16 interactors
STRINGi9606.ENSP00000352642

PTM databases

iPTMnetiQ9BV99
PhosphoSitePlusiQ9BV99

Genetic variation databases

BioMutaiLRRC61
DMDMi74761282

Proteomic databases

MassIVEiQ9BV99
MaxQBiQ9BV99
PaxDbiQ9BV99
PeptideAtlasiQ9BV99
PRIDEiQ9BV99
ProteomicsDBi79188

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18601, 52 antibodies

The DNASU plasmid repository

More...
DNASUi
65999

Genome annotation databases

EnsembliENST00000323078; ENSP00000339047; ENSG00000127399
ENST00000359623; ENSP00000352642; ENSG00000127399
ENST00000493307; ENSP00000420560; ENSG00000127399
GeneIDi65999
KEGGihsa:65999
UCSCiuc003wgw.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65999
DisGeNETi65999

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC61
HGNCiHGNC:21704, LRRC61
HPAiENSG00000127399, Tissue enhanced (lymphoid)
neXtProtiNX_Q9BV99
OpenTargetsiENSG00000127399
PharmGKBiPA143485530
VEuPathDBiHostDB:ENSG00000127399.14

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0531, Eukaryota
GeneTreeiENSGT00390000006479
HOGENOMiCLU_1073482_0_0_1
InParanoidiQ9BV99
OMAiWESWPTR
OrthoDBi1411446at2759
PhylomeDBiQ9BV99
TreeFamiTF329333

Enzyme and pathway databases

PathwayCommonsiQ9BV99

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
65999, 2 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC61, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65999
PharosiQ9BV99, Tdark

Protein Ontology

More...
PROi
PR:Q9BV99
RNActiQ9BV99, protein

Gene expression databases

BgeeiENSG00000127399, Expressed in left adrenal gland cortex and 192 other tissues
ExpressionAtlasiQ9BV99, baseline and differential
GenevisibleiQ9BV99, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13855, LRR_8, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC61_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BV99
Secondary accession number(s): B3KUW0, D3DWY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: April 7, 2021
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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