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Protein

U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Gene

SNRNP25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

GO - Biological processi

  • mRNA splicing, via spliceosome Source: Reactome
  • RNA splicing Source: HGNC

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U11/U12 small nuclear ribonucleoprotein 25 kDa protein
Short name:
U11/U12 snRNP 25 kDa protein
Short name:
U11/U12-25K
Alternative name(s):
Minus-99 protein
Gene namesi
Name:SNRNP25
Synonyms:C16orf33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000161981.10
HGNCiHGNC:14161 SNRNP25
neXtProtiNX_Q9BV90

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi79622
OpenTargetsiENSG00000161981
PharmGKBiPA164726099

Polymorphism and mutation databases

BioMutaiSNRNP25
DMDMi68052377

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149241 – 132U11/U12 small nuclear ribonucleoprotein 25 kDa proteinAdd BLAST132

Proteomic databases

PaxDbiQ9BV90
PeptideAtlasiQ9BV90
PRIDEiQ9BV90
ProteomicsDBi79183

PTM databases

iPTMnetiQ9BV90
PhosphoSitePlusiQ9BV90

Expressioni

Gene expression databases

BgeeiENSG00000161981
CleanExiHS_SNRNP25
ExpressionAtlasiQ9BV90 baseline and differential
GenevisibleiQ9BV90 HS

Organism-specific databases

HPAiHPA041183
HPA044248

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122752, 14 interactors
CORUMiQ9BV90
IntActiQ9BV90, 19 interactors
MINTiQ9BV90
STRINGi9606.ENSP00000372482

Structurei

3D structure databases

ProteinModelPortaliQ9BV90
SMRiQ9BV90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 132Ubiquitin-likePROSITE-ProRule annotationAdd BLAST92

Phylogenomic databases

eggNOGiENOG410IW7F Eukaryota
ENOG4111HGM LUCA
GeneTreeiENSGT00390000002628
HOGENOMiHOG000232002
HOVERGENiHBG054397
InParanoidiQ9BV90
KOiK13153
OMAiSWRYVWR
OrthoDBiEOG091G0WEO
PhylomeDBiQ9BV90
TreeFamiTF329506

Family and domain databases

InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BV90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFQEGLAM VVQDPLLCDL PIQVTLEEVN SQIALEYGQA MTVRVCKMDG
60 70 80 90 100
EVMPVVVVQS ATVLDLKKAI QRYVQLKQER EGGIQHISWS YVWRTYHLTS
110 120 130
AGEKLTEDRK KLRDYGIRNR DEVSFIKKLR QK
Length:132
Mass (Da):15,270
Last modified:June 1, 2001 - v1
Checksum:iFC1C3FC39611226A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106T → A in BAB15505 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026593 mRNA Translation: BAB15505.1
DQ431198 Genomic DNA Translation: ABD95904.1
AE006462 Genomic DNA Translation: AAK61211.1
BC001381 mRNA Translation: AAH01381.1
BC009179 mRNA Translation: AAH09179.1
BK005201 mRNA Translation: DAA05499.1
CCDSiCCDS10396.1
RefSeqiNP_078847.1, NM_024571.3
UniGeneiHs.15277

Genome annotation databases

EnsembliENST00000383018; ENSP00000372482; ENSG00000161981
GeneIDi79622
KEGGihsa:79622
UCSCiuc059ofp.1 human

Similar proteinsi

Entry informationi

Entry nameiSNR25_HUMAN
AccessioniPrimary (citable) accession number: Q9BV90
Secondary accession number(s): Q1W6H3, Q6IEF8, Q9H5W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

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