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UniProtKB - Q9BV86 (NTM1A_HUMAN)

Entry version 179 (02 Jun 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

N-terminal Xaa-Pro-Lys N-methyltransferase 1

Gene

NTMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352).

Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei69S-adenosyl-L-methionine; via carbonyl oxygenCombined sources2 Publications1
Binding sitei74S-adenosyl-L-methionineCombined sources2 Publications1
Binding sitei135S-adenosyl-L-methionine; via carbonyl oxygenCombined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:ENSG00000148335-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.244, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BV86

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC:2.1.1.2441 Publication)
Alternative name(s):
Alpha N-terminal protein methyltransferase 1A
Methyltransferase-like protein 11A
N-terminal RCC1 methyltransferase
X-Pro-Lys N-terminal protein methyltransferase 1A
Short name:
NTM1A
Cleaved into the following chain:
N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTMT1
Synonyms:C9orf32, METTL11A, NRMT, NRMT1
ORF Names:AD-003
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23373, NTMT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613560, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BV86

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000148335.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19Y → A or F: Decreased methyltransferase activity with CENPA. 1 Publication1
Mutagenesisi19Y → A: Reduced methyltransferase activity with CENPA. 1 Publication1
Mutagenesisi20W → A, M or Y: Nearly abolishes methyltransferase activity with CENPA. 1 Publication1
Mutagenesisi136W → L: Strongly reduces methyltransferase activity with CENPA. 1 Publication1
Mutagenesisi167D → A: Does not affect methyltransferase activity. 1 Publication1
Mutagenesisi167D → N or Q: Abolishes methyltransferase activity with CENPA. 1 Publication1
Mutagenesisi168N → A: Decreased methyltransferase activity. 2 Publications1
Mutagenesisi168N → K: Loss of methyltransferase activity. 1 Publication1
Mutagenesisi177D → A: Induces a slight decrease in methyltransferase activity. 1 Publication1
Mutagenesisi177D → K: Induces a strong decrease in methyltransferase activity. 1 Publication1
Mutagenesisi177D → N: Strongly reduces methyltransferase activity with CENPA. 1 Publication1
Mutagenesisi180D → A: Induces a decrease in methyltransferase activity. 1 Publication1
Mutagenesisi180D → K: Induces a strong decrease in methyltransferase activity. 1 Publication1
Mutagenesisi180D → N: Reduced methyltransferase activity with CENPA. 1 Publication1
Mutagenesisi182S → A: Induces a slight decrease in methyltransferase activity. 1 Publication1
Mutagenesisi182S → K: Induces a strong decrease in methyltransferase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		28989

Open Targets

More...OpenTargetsi		ENSG00000148335

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162395788

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BV86, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523442

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NTMT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74761281

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232281 – 223N-terminal Xaa-Pro-Lys N-methyltransferase 1Add BLAST223
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00001192882 – 223N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processedAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processedCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BV86

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BV86

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BV86

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BV86

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BV86

PeptideAtlas

More...PeptideAtlasi		Q9BV86

PRoteomics IDEntifications database

More...PRIDEi		Q9BV86

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		79180 [Q9BV86-1]
79181 [Q9BV86-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9BV86-1 [Q9BV86-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BV86

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9BV86

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BV86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148335, Expressed in left adrenal gland and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BV86, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BV86, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000148335, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118810, 32 interactors

Database of interacting proteins

More...DIPi		DIP-31241N

Protein interaction database and analysis system

More...IntActi		Q9BV86, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000483489

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9BV86

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BV86, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BV86

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9BV86

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni91 – 93S-adenosyl-L-methionine bindingCombined sources2 Publications3
Regioni119 – 120S-adenosyl-L-methionine bindingCombined sources2 Publications2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily. NTM1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3178, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008371

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055356_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BV86

Identification of Orthologs from Complete Genome Data

More...OMAi		KYWSEVP

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BV86

TreeFam database of animal gene trees

More...TreeFami		TF314174

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008576, MeTrfase_NTM1
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR12753, PTHR12753, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05891, Methyltransf_PK, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF016958, DUF858_MeTrfase_lik, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BV86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSEVIEDEK QFYSKAKTYW KQIPPTVDGM LGGYGHISSI DINSSRKFLQ 
        60         70         80         90        100
RFLREGPNKT GTSCALDCGA GIGRITKRLL LPLFREVDMV DITEDFLVQA 
       110        120        130        140        150
KTYLGEEGKR VRNYFCCGLQ DFTPEPDSYD VIWIQWVIGH LTDQHLAEFL 
       160        170        180        190        200
RRCKGSLRPN GIIVIKDNMA QEGVILDDVD SSVCRDLDVV RRIICSAGLS 
       210        220 
LLAEERQENL PDEIYHVYSF ALR
Length:223
Mass (Da):25,387
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A0EC492D9B52C49
GO
Isoform 2 (identifier: Q9BV86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-223: VRNYFCCGLQ...IYHVYSFALR → ATSPISTWPSSCGAARAASAPTASSSSKTTWPRRA

Show »
Length:145
Mass (Da):15,896
Checksum:i4D5E90507357F03B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R338S4R338_HUMAN
N-terminal Xaa-Pro-Lys N-methyltran...
NTMT1
135Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3J7S4R3J7_HUMAN
N-terminal Xaa-Pro-Lys N-methyltran...
NTMT1
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R344S4R344_HUMAN
N-terminal Xaa-Pro-Lys N-methyltran...
NTMT1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25P → L in BAF85021 (PubMed:14702039).Curated1
Sequence conflicti39S → SS in AAF14859 (PubMed:10931946).Curated1
Sequence conflicti131V → A in BAF83646 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039886111 – 223VRNYF…SFALR → ATSPISTWPSSCGAARAASA PTASSSSKTTWPRRA in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF110776 mRNA Translation: AAF14859.1
AK290957 mRNA Translation: BAF83646.1
AK292332 mRNA Translation: BAF85021.1
AK298840 mRNA Translation: BAG60968.1
AL590369 Genomic DNA No translation available.
BC001396 mRNA Translation: AAH01396.1
BC033234 mRNA Translation: AAH33234.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35160.1 [Q9BV86-1]
CCDS69682.1 [Q9BV86-2]

NCBI Reference Sequences

More...RefSeqi		NP_001273725.1, NM_001286796.1 [Q9BV86-1]
NP_001273726.1, NM_001286797.1 [Q9BV86-1]
NP_001273727.1, NM_001286798.1 [Q9BV86-1]
NP_001273728.1, NM_001286799.1 [Q9BV86-1]
NP_001273729.1, NM_001286800.1 [Q9BV86-2]
NP_001273730.1, NM_001286801.1 [Q9BV86-2]
NP_001273731.1, NM_001286802.1
NP_001273732.1, NM_001286803.1
NP_054783.2, NM_014064.3 [Q9BV86-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372480; ENSP00000361558; ENSG00000148335 [Q9BV86-1]
ENST00000372481; ENSP00000361559; ENSG00000148335 [Q9BV86-2]
ENST00000372483; ENSP00000361561; ENSG00000148335 [Q9BV86-1]
ENST00000372486; ENSP00000361564; ENSG00000148335 [Q9BV86-1]
ENST00000611055; ENSP00000483489; ENSG00000148335 [Q9BV86-1]
ENST00000613644; ENSP00000478521; ENSG00000148335 [Q9BV86-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		28989

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:28989

UCSC genome browser

More...UCSCi		uc004byd.3, human [Q9BV86-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110776 mRNA Translation: AAF14859.1
AK290957 mRNA Translation: BAF83646.1
AK292332 mRNA Translation: BAF85021.1
AK298840 mRNA Translation: BAG60968.1
AL590369 Genomic DNA No translation available.
BC001396 mRNA Translation: AAH01396.1
BC033234 mRNA Translation: AAH33234.1
CCDSiCCDS35160.1 [Q9BV86-1]
CCDS69682.1 [Q9BV86-2]
RefSeqiNP_001273725.1, NM_001286796.1 [Q9BV86-1]
NP_001273726.1, NM_001286797.1 [Q9BV86-1]
NP_001273727.1, NM_001286798.1 [Q9BV86-1]
NP_001273728.1, NM_001286799.1 [Q9BV86-1]
NP_001273729.1, NM_001286800.1 [Q9BV86-2]
NP_001273730.1, NM_001286801.1 [Q9BV86-2]
NP_001273731.1, NM_001286802.1
NP_001273732.1, NM_001286803.1
NP_054783.2, NM_014064.3 [Q9BV86-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EX4X-ray1.75A/B2-222[»]
5CVDX-ray1.30A/B1-223[»]
5CVEX-ray1.50A/B1-223[»]
5E1BX-ray1.65A/B2-223[»]
5E1DX-ray1.45A/B2-223[»]
5E1MX-ray1.75A/B2-223[»]
5E1OX-ray2.00A/B2-223[»]
5E2AX-ray1.75A/B2-223[»]
5E2BX-ray1.95A/B2-223[»]
6DTNX-ray1.48B2-223[»]
6KDQX-ray1.50A/B1-223[»]
6PVAX-ray1.84B2-223[»]
6PVBX-ray1.50B2-223[»]
6WH8X-ray1.73A/B2-223[»]
6WJ7X-ray1.42B2-223[»]
SMRiQ9BV86
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118810, 32 interactors
DIPiDIP-31241N
IntActiQ9BV86, 14 interactors
STRINGi9606.ENSP00000483489

Chemistry databases

BindingDBiQ9BV86
ChEMBLiCHEMBL4523442

PTM databases

iPTMnetiQ9BV86
MetOSiteiQ9BV86
PhosphoSitePlusiQ9BV86

Genetic variation databases

BioMutaiNTMT1
DMDMi74761281

Proteomic databases

EPDiQ9BV86
jPOSTiQ9BV86
MassIVEiQ9BV86
MaxQBiQ9BV86
PaxDbiQ9BV86
PeptideAtlasiQ9BV86
PRIDEiQ9BV86
ProteomicsDBi79180 [Q9BV86-1]
79181 [Q9BV86-2]
TopDownProteomicsiQ9BV86-1 [Q9BV86-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17874, 158 antibodies

The DNASU plasmid repository

More...DNASUi		28989

Genome annotation databases

EnsembliENST00000372480; ENSP00000361558; ENSG00000148335 [Q9BV86-1]
ENST00000372481; ENSP00000361559; ENSG00000148335 [Q9BV86-2]
ENST00000372483; ENSP00000361561; ENSG00000148335 [Q9BV86-1]
ENST00000372486; ENSP00000361564; ENSG00000148335 [Q9BV86-1]
ENST00000611055; ENSP00000483489; ENSG00000148335 [Q9BV86-1]
ENST00000613644; ENSP00000478521; ENSG00000148335 [Q9BV86-1]
GeneIDi28989
KEGGihsa:28989
UCSCiuc004byd.3, human [Q9BV86-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		28989
DisGeNETi28989

GeneCards: human genes, protein and diseases

More...GeneCardsi		NTMT1
HGNCiHGNC:23373, NTMT1
HPAiENSG00000148335, Low tissue specificity
MIMi613560, gene
neXtProtiNX_Q9BV86
OpenTargetsiENSG00000148335
PharmGKBiPA162395788
VEuPathDBiHostDB:ENSG00000148335.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3178, Eukaryota
GeneTreeiENSGT00390000008371
HOGENOMiCLU_055356_3_1_1
InParanoidiQ9BV86
OMAiKYWSEVP
PhylomeDBiQ9BV86
TreeFamiTF314174

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000148335-MONOMER
BRENDAi2.1.1.244, 2681
PathwayCommonsiQ9BV86

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		28989, 11 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NTMT1, human
EvolutionaryTraceiQ9BV86

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		28989
PharosiQ9BV86, Tbio

Protein Ontology

More...PROi		PR:Q9BV86
RNActiQ9BV86, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148335, Expressed in left adrenal gland and 214 other tissues
ExpressionAtlasiQ9BV86, baseline and differential
GenevisibleiQ9BV86, HS

Family and domain databases

InterProiView protein in InterPro
IPR008576, MeTrfase_NTM1
IPR029063, SAM-dependent_MTases
PANTHERiPTHR12753, PTHR12753, 1 hit
PfamiView protein in Pfam
PF05891, Methyltransf_PK, 1 hit
PIRSFiPIRSF016958, DUF858_MeTrfase_lik, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTM1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BV86
Secondary accession number(s): A8K4J2
, A8K8G7, Q5SZB9, Q9UI28
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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