NTMT1

Functionⁱ

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.4 Publications

Catalytic activityⁱ

3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein].2 Publications

2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	69	S-adenosyl-L-methionine; via carbonyl oxygenCombined sources2 Publications	1
Binding siteⁱ	74	S-adenosyl-L-methionineCombined sources2 Publications	1
Binding siteⁱ	135	S-adenosyl-L-methionine; via carbonyl oxygenCombined sources2 Publications	1

GO - Molecular functionⁱ

histone methyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26543159
N-terminal protein N-methyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26543159
protein methyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20481588
- 20668449

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromosome segregation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20668449
histone methylation
Source: UniProtKB
Inferred from direct assayⁱ
- 26543159
N-terminal peptidyl-alanine trimethylation Source: Ensembl
N-terminal peptidyl-glycine methylation
Source: UniProtKB
Inferred from direct assayⁱ
- 26543159
N-terminal peptidyl-proline dimethylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20481588
- 20668449
N-terminal peptidyl-serine dimethylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20668449
N-terminal peptidyl-serine trimethylation
Source: UniProtKB
Inferred from direct assayⁱ
- 20668449
spindle organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20668449

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, Transferase
Ligand	S-adenosyl-L-methionine

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000148335-MONOMER
BRENDAⁱ	2.1.1.244 2681

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC:2.1.1.2441 Publication) Alternative name(s): Alpha N-terminal protein methyltransferase 1A Methyltransferase-like protein 11A N-terminal RCC1 methyltransferase X-Pro-Lys N-terminal protein methyltransferase 1A Short name: NTM1A Cleaved into the following chain: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed
Gene namesⁱ	Name:NTMT1 Synonyms:C9orf32, METTL11A, NRMT, NRMT1 ORF Names:AD-003
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148335.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23373 NTMT1
MIMⁱ	613560 gene
neXtProtⁱ	NX_Q9BV86

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	19	Y → A or F: Decreased methyltransferase activity with CENPA. 1 Publication	1
Mutagenesisⁱ	19	Y → A: Reduced methyltransferase activity with CENPA. 1 Publication	1
Mutagenesisⁱ	20	W → A, M or Y: Nearly abolishes methyltransferase activity with CENPA. 1 Publication	1
Mutagenesisⁱ	136	W → L: Strongly reduces methyltransferase activity with CENPA. 1 Publication	1
Mutagenesisⁱ	167	D → A: Does not affect methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	167	D → N or Q: Abolishes methyltransferase activity with CENPA. 1 Publication	1
Mutagenesisⁱ	168	N → A: Decreased methyltransferase activity. 2 Publications	1
Mutagenesisⁱ	168	N → K: Loss of methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	177	D → A: Induces a slight decrease in methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	177	D → K: Induces a strong decrease in methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	177	D → N: Strongly reduces methyltransferase activity with CENPA. 1 Publication	1
Mutagenesisⁱ	180	D → A: Induces a decrease in methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	180	D → K: Induces a strong decrease in methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	180	D → N: Reduced methyltransferase activity with CENPA. 1 Publication	1
Mutagenesisⁱ	182	S → A: Induces a slight decrease in methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	182	S → K: Induces a strong decrease in methyltransferase activity. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000148335
PharmGKBⁱ	PA162395788

Polymorphism and mutation databases

DMDMⁱ	74761281

DMDMⁱ

74761281

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000423228	1 – 223	N-terminal Xaa-Pro-Lys N-methyltransferase 1Add BLAST	223
Initiator methionineⁱ		Removed; alternateCombined sources1 Publication
ChainⁱPRO_0000119288	2 – 223	N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processedAdd BLAST	222

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1
Modified residueⁱ	2	N-acetylthreonine; in N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processedCombined sources1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9BV86
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BV86
PaxDbⁱ	Q9BV86
PeptideAtlas More...PeptideAtlasⁱ	Q9BV86
PRIDEⁱ	Q9BV86
ProteomicsDBⁱ	79180 79181 [Q9BV86-2]
TopDownProteomicsⁱ	Q9BV86-1 [Q9BV86-1]

PTM databases

iPTMnetⁱ	Q9BV86
PhosphoSitePlusⁱ	Q9BV86

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148335 Expressed in 196 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_METTL11A
ExpressionAtlasⁱ	Q9BV86 baseline and differential
Genevisibleⁱ	Q9BV86 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020092 HPA058420

HPAⁱ

HPA020092
HPA058420

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RCC1	P18754	4	EBI-373016,EBI-992720

With

Entry

#Exp.

IntAct

Notes

RCC1

P18754

4

EBI-373016,EBI-992720

Protein-protein interaction databases

BioGridⁱ	118810, 25 interactors
Database of interacting proteins More...DIPⁱ	DIP-31241N
IntActⁱ	Q9BV86, 7 interactors
STRINGⁱ	9606.ENSP00000361558

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 4	Combined sources	3
Helixⁱ	9 – 21	Combined sources	13
Helixⁱ	27 – 30	Combined sources	4
Turnⁱ	31 – 33	Combined sources	3
Helixⁱ	35 – 37	Combined sources	3
Helixⁱ	38 – 54	Combined sources	17
Beta strandⁱ	55 – 58	Combined sources	4
Beta strandⁱ	63 – 68	Combined sources	6
Turnⁱ	71 – 73	Combined sources	3
Helixⁱ	74 – 78	Combined sources	5
Turnⁱ	79 – 83	Combined sources	5
Beta strandⁱ	85 – 92	Combined sources	8
Helixⁱ	94 – 103	Combined sources	10
Helixⁱ	105 – 110	Combined sources	6
Beta strandⁱ	111 – 116	Combined sources	6
Helixⁱ	119 – 121	Combined sources	3
Beta strandⁱ	129 – 136	Combined sources	8
Helixⁱ	138 – 140	Combined sources	3
Helixⁱ	143 – 156	Combined sources	14
Beta strandⁱ	157 – 177	Combined sources	21
Turnⁱ	178 – 181	Combined sources	4
Beta strandⁱ	182 – 186	Combined sources	5
Helixⁱ	187 – 196	Combined sources	10
Beta strandⁱ	200 – 206	Combined sources	7
Beta strandⁱ	216 – 223	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BV86
SMRⁱ	Q9BV86
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BV86

EvolutionaryTraceⁱ

Q9BV86

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	91 – 93	S-adenosyl-L-methionine bindingCombined sources2 Publications		3
Regionⁱ	119 – 120	S-adenosyl-L-methionine bindingCombined sources2 Publications		2

Sequence similaritiesⁱ

Belongs to the methyltransferase superfamily. NTM1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3178 Eukaryota ENOG410XS7T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008371
HOGENOMⁱ	HOG000161910
HOVERGENⁱ	HBG054992
InParanoidⁱ	Q9BV86
KEGG Orthology (KO) More...KOⁱ	K16219
OMAⁱ	IYHVYSL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NA7
PhylomeDBⁱ	Q9BV86
TreeFamⁱ	TF314174

Family and domain databases

InterProⁱ	View protein in InterPro IPR008576 MeTrfase_NTM1 IPR029063 SAM-dependent_MTases
PANTHERⁱ	PTHR12753 PTHR12753, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05891 Methyltransf_PK, 1 hit
PIRSFⁱ	PIRSF016958 DUF858_MeTrfase_lik, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BV86-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSEVIEDEK QFYSKAKTYW KQIPPTVDGM LGGYGHISSI DINSSRKFLQ 
        60         70         80         90        100
RFLREGPNKT GTSCALDCGA GIGRITKRLL LPLFREVDMV DITEDFLVQA 
       110        120        130        140        150
KTYLGEEGKR VRNYFCCGLQ DFTPEPDSYD VIWIQWVIGH LTDQHLAEFL 
       160        170        180        190        200
RRCKGSLRPN GIIVIKDNMA QEGVILDDVD SSVCRDLDVV RRIICSAGLS 
       210        220 
LLAEERQENL PDEIYHVYSF ALR

Length:223

Mass (Da):25,387

Last modified:January 23, 2007 - v3

Checksum:ⁱ4A0EC492D9B52C49

GO

Isoform 2 (identifier: Q9BV86-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
111-223: VRNYFCCGLQ...IYHVYSFALR → ATSPISTWPSSCGAARAASAPTASSSSKTTWPRRA

« Hide

        10         20         30         40         50
MTSEVIEDEK QFYSKAKTYW KQIPPTVDGM LGGYGHISSI DINSSRKFLQ 
        60         70         80         90        100
RFLREGPNKT GTSCALDCGA GIGRITKRLL LPLFREVDMV DITEDFLVQA 
       110        120        130        140 
KTYLGEEGKR ATSPISTWPS SCGAARAASA PTASSSSKTT WPRRA

Note: No experimental confirmation available.

Show »

Length:145

Mass (Da):15,896

Checksum:ⁱ4D5E90507357F03B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

S4R338	S4R338_HUMAN	N-terminal Xaa-Pro-Lys N-methyltran... N-terminal Xaa-Pro-Lys N-methyltransferase 1	NTMT1	135	Annotation score:
S4R3J7	S4R3J7_HUMAN	N-terminal Xaa-Pro-Lys N-methyltran... N-terminal Xaa-Pro-Lys N-methyltransferase 1	NTMT1	109	Annotation score:
S4R344	S4R344_HUMAN	N-terminal Xaa-Pro-Lys N-methyltran... N-terminal Xaa-Pro-Lys N-methyltransferase 1	NTMT1	70	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	P → L in BAF85021 (PubMed:14702039).Curated	1
Sequence conflictⁱ	39	S → SS in AAF14859 (PubMed:10931946).Curated	1
Sequence conflictⁱ	131	V → A in BAF83646 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039886	111 – 223	VRNYF…SFALR → ATSPISTWPSSCGAARAASA PTASSSSKTTWPRRA in isoform 2. 1 PublicationAdd BLAST		113

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF110776 mRNA Translation: AAF14859.1 AK290957 mRNA Translation: BAF83646.1 AK292332 mRNA Translation: BAF85021.1 AK298840 mRNA Translation: BAG60968.1 AL590369 Genomic DNA No translation available. BC001396 mRNA Translation: AAH01396.1 BC033234 mRNA Translation: AAH33234.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35160.1 [Q9BV86-1] CCDS69682.1 [Q9BV86-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273725.1, NM_001286796.1 [Q9BV86-1] NP_001273726.1, NM_001286797.1 [Q9BV86-1] NP_001273727.1, NM_001286798.1 [Q9BV86-1] NP_001273728.1, NM_001286799.1 [Q9BV86-1] NP_001273729.1, NM_001286800.1 [Q9BV86-2] NP_001273730.1, NM_001286801.1 [Q9BV86-2] NP_001273731.1, NM_001286802.1 NP_001273732.1, NM_001286803.1 NP_054783.2, NM_014064.3 [Q9BV86-1]
UniGeneⁱ	Hs.744027

Genome annotation databases

Ensemblⁱ	ENST00000372480; ENSP00000361558; ENSG00000148335 [Q9BV86-1] ENST00000372481; ENSP00000361559; ENSG00000148335 [Q9BV86-2] ENST00000372483; ENSP00000361561; ENSG00000148335 [Q9BV86-1] ENST00000372486; ENSP00000361564; ENSG00000148335 [Q9BV86-1] ENST00000611055; ENSP00000483489; ENSG00000148335 [Q9BV86-1] ENST00000613644; ENSP00000478521; ENSG00000148335 [Q9BV86-1]
GeneIDⁱ	28989
KEGGⁱ	hsa:28989
UCSC genome browser More...UCSCⁱ	uc004byd.3 human [Q9BV86-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BV86	Chromosome 9 open reading frame 32, isoform CRA_a		HUMAN		223	UniRef100_Q9BV86
Alpha N-terminal protein methyltransferase 1A		MACMU		223
N-terminal Xaa-Pro-Lys N-methyltransferase 1		MACFA		223
Uncharacterized protein		COLAP		223
Uncharacterized protein		CERAT		223
+9

Protein	Similar proteins		Species	Score	Length	Source
Q9BV86	Chromosome 9 open reading frame 32, isoform CRA_a		HUMAN		223	UniRef90_Q9BV86
Alpha N-terminal protein methyltransferase 1A		MACMU		223
N-terminal Xaa-Pro-Lys N-methyltransferase 1		MACFA		223
Uncharacterized protein		COLAP		223
Uncharacterized protein		CERAT		223
+10
Q9BV86-2	NTMT1 isoform 8		PONAB		145	UniRef90_Q9BV86-2
NTMT1 isoform 8		PANTR		145
Uncharacterized protein		PANPA		145
UPI000533D232		SAIBB		145
UPI0005F40E06		COLAP		145
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9BV86	N-terminal Xaa-Pro-Lys N-methyltransferase 1		XENTR		224	UniRef50_Q9BV86
N-terminal Xaa-Pro-Lys N-methyltransferase 1-A		XENLA		224
Chromosome 9 open reading frame 32, isoform CRA_a		HUMAN		223
Alpha N-terminal protein methyltransferase 1A		MACMU		223
N-terminal Xaa-Pro-Lys N-methyltransferase 1		MACFA		223
+71
Q9BV86-2	NTMT1 isoform 8		PONAB		145	UniRef50_Q9BV86-2
NTMT1 isoform 8		PANTR		145
Uncharacterized protein		PANPA		145
N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X3		URSMA		145
UPI000533D232		SAIBB		145
+5

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF110776 mRNA Translation: AAF14859.1 AK290957 mRNA Translation: BAF83646.1 AK292332 mRNA Translation: BAF85021.1 AK298840 mRNA Translation: BAG60968.1 AL590369 Genomic DNA No translation available. BC001396 mRNA Translation: AAH01396.1 BC033234 mRNA Translation: AAH33234.1
CCDSⁱ	CCDS35160.1 [Q9BV86-1] CCDS69682.1 [Q9BV86-2]
RefSeqⁱ	NP_001273725.1, NM_001286796.1 [Q9BV86-1] NP_001273726.1, NM_001286797.1 [Q9BV86-1] NP_001273727.1, NM_001286798.1 [Q9BV86-1] NP_001273728.1, NM_001286799.1 [Q9BV86-1] NP_001273729.1, NM_001286800.1 [Q9BV86-2] NP_001273730.1, NM_001286801.1 [Q9BV86-2] NP_001273731.1, NM_001286802.1 NP_001273732.1, NM_001286803.1 NP_054783.2, NM_014064.3 [Q9BV86-1]
UniGeneⁱ	Hs.744027

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2EX4	X-ray	1.75	A/B	2-222	[»]
	5CVD	X-ray	1.30	A/B	1-223	[»]
	5CVE	X-ray	1.50	A/B	1-223	[»]
	5E1B	X-ray	1.65	A/B	2-223	[»]
	5E1D	X-ray	1.45	A/B	2-223	[»]
	5E1M	X-ray	1.75	A/B	2-223	[»]
	5E1O	X-ray	2.00	A/B	2-223	[»]
	5E2A	X-ray	1.75	A/B	2-223	[»]
	5E2B	X-ray	1.95	A/B	2-223	[»]
ProteinModelPortalⁱ	Q9BV86
SMRⁱ	Q9BV86
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118810, 25 interactors
DIPⁱ	DIP-31241N
IntActⁱ	Q9BV86, 7 interactors
STRINGⁱ	9606.ENSP00000361558

PTM databases

iPTMnetⁱ	Q9BV86
PhosphoSitePlusⁱ	Q9BV86

Polymorphism and mutation databases

DMDMⁱ	74761281

DMDMⁱ

74761281

Proteomic databases

EPDⁱ	Q9BV86
MaxQBⁱ	Q9BV86
PaxDbⁱ	Q9BV86
PeptideAtlasⁱ	Q9BV86
PRIDEⁱ	Q9BV86
ProteomicsDBⁱ	79180 79181 [Q9BV86-2]
TopDownProteomicsⁱ	Q9BV86-1 [Q9BV86-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000372480; ENSP00000361558; ENSG00000148335 [Q9BV86-1] ENST00000372481; ENSP00000361559; ENSG00000148335 [Q9BV86-2] ENST00000372483; ENSP00000361561; ENSG00000148335 [Q9BV86-1] ENST00000372486; ENSP00000361564; ENSG00000148335 [Q9BV86-1] ENST00000611055; ENSP00000483489; ENSG00000148335 [Q9BV86-1] ENST00000613644; ENSP00000478521; ENSG00000148335 [Q9BV86-1]
GeneIDⁱ	28989
KEGGⁱ	hsa:28989
UCSCⁱ	uc004byd.3 human [Q9BV86-1]

Organism-specific databases

CTDⁱ	28989
EuPathDBⁱ	HostDB:ENSG00000148335.14
GeneCardsⁱ	NTMT1
H-InvDBⁱ	HIX0008452
HGNCⁱ	HGNC:23373 NTMT1
HPAⁱ	HPA020092 HPA058420
MIMⁱ	613560 gene
neXtProtⁱ	NX_Q9BV86
OpenTargetsⁱ	ENSG00000148335
PharmGKBⁱ	PA162395788
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3178 Eukaryota ENOG410XS7T LUCA
GeneTreeⁱ	ENSGT00390000008371
HOGENOMⁱ	HOG000161910
HOVERGENⁱ	HBG054992
InParanoidⁱ	Q9BV86
KOⁱ	K16219
OMAⁱ	IYHVYSL
OrthoDBⁱ	EOG091G0NA7
PhylomeDBⁱ	Q9BV86
TreeFamⁱ	TF314174

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000148335-MONOMER
BRENDAⁱ	2.1.1.244 2681

Miscellaneous databases

ChiTaRSⁱ	NTMT1 human
EvolutionaryTraceⁱ	Q9BV86
GenomeRNAiⁱ	28989
Protein Ontology More...PROⁱ	PR:Q9BV86
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148335 Expressed in 196 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_METTL11A
ExpressionAtlasⁱ	Q9BV86 baseline and differential
Genevisibleⁱ	Q9BV86 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008576 MeTrfase_NTM1 IPR029063 SAM-dependent_MTases
PANTHERⁱ	PTHR12753 PTHR12753, 1 hit
Pfamⁱ	View protein in Pfam PF05891 Methyltransf_PK, 1 hit
PIRSFⁱ	PIRSF016958 DUF858_MeTrfase_lik, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NTM1A_HUMAN
Accessionⁱ	Q9BV86Primary (citable) accession number: Q9BV86 Secondary accession number(s): A8K4J2 , A8K8G7, Q5SZB9, Q9UI28
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q9BV86 (NTM1A_HUMAN)

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N-terminal Xaa-Pro-Lys N-methyltransferase 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ