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Protein

Dual specificity protein phosphatase 26

Gene

DUSP26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).4 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • p53 binding Source: UniProtKB
  • phosphoprotein phosphatase activity Source: UniProtKB
  • phosphoserine phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  • protein tyrosine phosphatase activity Source: UniProtKB
  • RNA polymerase II activating transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
SIGNORiQ9BV47

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase SKRP3
Low-molecular-mass dual-specificity phosphatase 4
Short name:
DSP-4
Short name:
LDP-4
Mitogen-activated protein kinase phosphatase 8
Short name:
MAP kinase phosphatase 8
Short name:
MKP-8
Novel amplified gene in thyroid anaplastic cancer
Gene namesi
Name:DUSP26
Synonyms:DUSP24, LDP4, MKP8, NATA1, SKRP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000133878.8
HGNCiHGNC:28161 DUSP26
neXtProtiNX_Q9BV47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi152C → A or S: Loss of activity. 3 Publications1

Organism-specific databases

DisGeNETi78986
OpenTargetsiENSG00000133878
PharmGKBiPA142671921

Chemistry databases

ChEMBLiCHEMBL2295562

Polymorphism and mutation databases

BioMutaiDUSP26
DMDMi74752374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002922191 – 211Dual specificity protein phosphatase 26Add BLAST211

Proteomic databases

PaxDbiQ9BV47
PeptideAtlasiQ9BV47
PRIDEiQ9BV47
ProteomicsDBi79169
79170 [Q9BV47-2]

PTM databases

DEPODiQ9BV47
iPTMnetiQ9BV47
PhosphoSitePlusiQ9BV47

Expressioni

Tissue specificityi

Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.4 Publications

Gene expression databases

BgeeiENSG00000133878 Expressed in 168 organ(s), highest expression level in quadriceps femoris
CleanExiHS_DUSP26
ExpressionAtlasiQ9BV47 baseline and differential
GenevisibleiQ9BV47 HS

Organism-specific databases

HPAiHPA018221

Interactioni

Subunit structurei

Interacts with HSF4.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122457, 25 interactors
IntActiQ9BV47, 7 interactors
MINTiQ9BV47
STRINGi9606.ENSP00000256261

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BV47
SMRiQ9BV47
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BV47

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 206Tyrosine-protein phosphataseAdd BLAST146

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233767
HOVERGENiHBG001524
InParanoidiQ9BV47
KOiK14165
OMAiYLMIRQN
OrthoDBiEOG091G0249
PhylomeDBiQ9BV47
TreeFamiTF105128

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BV47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCPGNWLWAS MTFMARFSRS SSRSPVRTRG TLEEMPTVQH PFLNVFELER
60 70 80 90 100
LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR
110 120 130 140 150
GTPEAYEGLG IRYLGVEAHD SPAFDMSIHF QTAADFIHRA LSQPGGKILV
160 170 180 190 200
HCAVGVSRSA TLVLAYLMLY HHLTLVEAIK KVKDHRGIIP NRGFLRQLLA
210
LDRRLRQGLE A
Length:211
Mass (Da):23,946
Last modified:June 1, 2001 - v1
Checksum:i60E944304905086D
GO
Isoform 2 (identifier: Q9BV47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:86
Mass (Da):9,652
Checksum:i4DD29AFD5989528B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHD0E5RHD0_HUMAN
Dual-specificity protein phosphatas...
DUSP26
145Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264061 – 125Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902194 mRNA Translation: AAX07132.1
AB158288 mRNA Translation: BAD82942.1
AB237597 mRNA Translation: BAE46506.1
AB103376 mRNA Translation: BAD91015.1
AK055704 mRNA Translation: BAB70991.1
CH471080 Genomic DNA Translation: EAW63392.1
CH471080 Genomic DNA Translation: EAW63393.1
CH471080 Genomic DNA Translation: EAW63394.1
BC001613 mRNA Translation: AAH01613.1
BC003115 mRNA Translation: AAH03115.1
BC067804 mRNA Translation: AAH67804.1
CCDSiCCDS6092.1 [Q9BV47-1]
RefSeqiNP_001292044.1, NM_001305115.1 [Q9BV47-1]
NP_001292045.1, NM_001305116.1 [Q9BV47-1]
NP_076930.1, NM_024025.2 [Q9BV47-1]
UniGeneiHs.8719

Genome annotation databases

EnsembliENST00000256261; ENSP00000256261; ENSG00000133878 [Q9BV47-1]
ENST00000523956; ENSP00000429176; ENSG00000133878 [Q9BV47-1]
GeneIDi78986
KEGGihsa:78986
UCSCiuc003xjp.4 human [Q9BV47-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902194 mRNA Translation: AAX07132.1
AB158288 mRNA Translation: BAD82942.1
AB237597 mRNA Translation: BAE46506.1
AB103376 mRNA Translation: BAD91015.1
AK055704 mRNA Translation: BAB70991.1
CH471080 Genomic DNA Translation: EAW63392.1
CH471080 Genomic DNA Translation: EAW63393.1
CH471080 Genomic DNA Translation: EAW63394.1
BC001613 mRNA Translation: AAH01613.1
BC003115 mRNA Translation: AAH03115.1
BC067804 mRNA Translation: AAH67804.1
CCDSiCCDS6092.1 [Q9BV47-1]
RefSeqiNP_001292044.1, NM_001305115.1 [Q9BV47-1]
NP_001292045.1, NM_001305116.1 [Q9BV47-1]
NP_076930.1, NM_024025.2 [Q9BV47-1]
UniGeneiHs.8719

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E0TX-ray1.67A61-211[»]
4B04X-ray2.20A/B/C/D61-211[»]
4HRFX-ray1.68A/B/C/D61-211[»]
5GTJX-ray2.00A/B/C/D39-211[»]
ProteinModelPortaliQ9BV47
SMRiQ9BV47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122457, 25 interactors
IntActiQ9BV47, 7 interactors
MINTiQ9BV47
STRINGi9606.ENSP00000256261

Chemistry databases

ChEMBLiCHEMBL2295562

PTM databases

DEPODiQ9BV47
iPTMnetiQ9BV47
PhosphoSitePlusiQ9BV47

Polymorphism and mutation databases

BioMutaiDUSP26
DMDMi74752374

Proteomic databases

PaxDbiQ9BV47
PeptideAtlasiQ9BV47
PRIDEiQ9BV47
ProteomicsDBi79169
79170 [Q9BV47-2]

Protocols and materials databases

DNASUi78986
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256261; ENSP00000256261; ENSG00000133878 [Q9BV47-1]
ENST00000523956; ENSP00000429176; ENSG00000133878 [Q9BV47-1]
GeneIDi78986
KEGGihsa:78986
UCSCiuc003xjp.4 human [Q9BV47-1]

Organism-specific databases

CTDi78986
DisGeNETi78986
EuPathDBiHostDB:ENSG00000133878.8
GeneCardsiDUSP26
HGNCiHGNC:28161 DUSP26
HPAiHPA018221
neXtProtiNX_Q9BV47
OpenTargetsiENSG00000133878
PharmGKBiPA142671921
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233767
HOVERGENiHBG001524
InParanoidiQ9BV47
KOiK14165
OMAiYLMIRQN
OrthoDBiEOG091G0249
PhylomeDBiQ9BV47
TreeFamiTF105128

Enzyme and pathway databases

BRENDAi3.1.3.16 2681
SIGNORiQ9BV47

Miscellaneous databases

EvolutionaryTraceiQ9BV47
GenomeRNAii78986
PROiPR:Q9BV47

Gene expression databases

BgeeiENSG00000133878 Expressed in 168 organ(s), highest expression level in quadriceps femoris
CleanExiHS_DUSP26
ExpressionAtlasiQ9BV47 baseline and differential
GenevisibleiQ9BV47 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS26_HUMAN
AccessioniPrimary (citable) accession number: Q9BV47
Secondary accession number(s): D3DSV8, Q9BTW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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